Basic Information

Terpenoid ID TKC129193
Chirality TKC015673
Cell line 0
Protein target 16
DiseaseNCIT 0
ORDO 0
ICD 53

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC129193 HepG2 22387.0 nM Potency C3728 Orphanet_449
TKC129193 CHO Chinese Hamster Ovary; CHO-ori 170460.0 nM IC50
TKC129193 MDCK MDCK (NBL-2); NBL-2; Madin-Darby Canine Kidney; Madin Darby Canine Kidney 21000.0 nM CC50

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC129193 Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 TDP1 12995 nM Potency
TKC129193 P07900 Heat shock protein HSP 90-alpha HSP90AA1 3791 nM AC50
TKC129193 Q9NPD5 Solute carrier organic anion transporter family member 1B3 SLCO1B3 131 % Inhibition
TKC129193 Q9Y6L6 Solute carrier organic anion transporter family member 1B1 SLCO1B1 159 % Inhibition
TKC129193 O75874 Isocitrate dehydrogenase [NADP] cytoplasmic IDH1 29093 nM Potency
TKC129193 P43220 Glucagon-like peptide 1 receptor GLP1R 10000 nM Potency
TKC129193 P84022 Mothers against decapentaplegic homolog 3 SMAD3 35481 nM Potency
TKC129193 Q16236 Nuclear factor erythroid 2-related factor 2 NFE2L2 32643 nM Potency
TKC129193 Q99700 Ataxin-2 ATXN2 39811 nM Potency
TKC129193 O75164 Lysine-specific demethylase 4A KDM4A 44668 nM Potency
TKC129193 O75496 Geminin GMNN 9200 nM Potency
TKC129193 Q13148 TAR DNA-binding protein 43 TARDBP 14125 nM Potency
TKC129193 Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 PIN1 50119 nM Potency
TKC129193 P0A0J7 Quinolone resistance protein NorA norA 15000 nM IC50
TKC129193 Q8WZA2 Rap guanine nucleotide exchange factor 4 RAPGEF4 56234 nM Potency
TKC129193 Q8IL32 Heat shock protein 90, putative PF3D7_1443900 2863 nM AC50
TKC129193 A5Z1V5 Cell division protein FtsZ ftsZ 24000 nM IC50
TKC129193 P0A031 Cell division protein FtsZ ftsZ 4 ug.mL-1 MIC
TKC129193 P9WN95 Cell division protein FtsZ ftsZ 11000 nM Kd

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
P07900 HS90A_HUMAN Acute upper respiratory infection [ICD-11: CA07]
P07900 HS90A_HUMAN Asthma [ICD-11: CA23]
P07900 HS90A_HUMAN Vasomotor/allergic rhinitis [ICD-11: CA08]
P07900 HS90A_HUMAN Breast cancer [ICD-11: 2C60-2C6Y]
P07900 HS90A_HUMAN Multiple myeloma [ICD-11: 2A83]
P07900 HS90A_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P07900 HS90A_HUMAN Lung cancer [ICD-11: 2C25]
P07900 HS90A_HUMAN Malignant haematopoietic neoplasm [ICD-11: 2B33]
P07900 HS90A_HUMAN Mature B-cell leukaemia [ICD-11: 2A82]
P07900 HS90A_HUMAN Stomach cancer [ICD-11: 2B72]
P07900 HS90A_HUMAN Alzheimer disease [ICD-11: 8A20]
P07900 HS90A_HUMAN Encephalopathy [ICD-11: 8E47]
P07900 HS90A_HUMAN Mature B-cell lymphoma [ICD-11: 2A85]
P07900 HS90A_HUMAN Melanoma [ICD-11: 2C30]
P07900 HS90A_HUMAN Neuropathy [ICD-11: 8C0Z]
P07900 HS90A_HUMAN Ovarian cancer [ICD-11: 2C73]
P07900 HS90A_HUMAN Diabetes mellitus [ICD-11: 5A10]
P07900 HS90A_HUMAN Renal cell carcinoma [ICD-11: 2C90]
P07900 HS90A_HUMAN Unspecific body region injury [ICD-11: ND56]
O75874 IDHC_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
O75874 IDHC_HUMAN Liver cancer [ICD-11: 2C12]
O75874 IDHC_HUMAN Malignant haematopoietic neoplasm [ICD-11: 2B33]
O75874 IDHC_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
O75874 IDHC_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
O75874 IDHC_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P43220 GLP1R_HUMAN Cardiovascular disease [ICD-11: BA00-BE2Z]
P43220 GLP1R_HUMAN Obesity [ICD-11: 5B80-5B81]
P43220 GLP1R_HUMAN Type 2 diabetes mellitus [ICD-11: 5A11]
P43220 GLP1R_HUMAN Type-1/2 diabete [ICD-11: 5A10-5A11]
P43220 GLP1R_HUMAN Acute diabete complication [ICD-11: 5A2Y]
P43220 GLP1R_HUMAN Diabetes mellitus [ICD-11: 5A10]
P43220 GLP1R_HUMAN Dyspepsia [ICD-11: MD92]
P43220 GLP1R_HUMAN Irritable bowel syndrome [ICD-11: DD91]
P43220 GLP1R_HUMAN Intracranial injury [ICD-11: NA07]
P43220 GLP1R_HUMAN Non-alcoholic fatty liver disease [ICD-11: DB92]
P84022 SMAD3_HUMAN Herpes simplex infection [ICD-11: 1F00]
P84022 SMAD3_HUMAN Kidney fibrosis [ICD-11: GC01]
Q16236 NF2L2_HUMAN Ataxic disorder [ICD-11: 8A03]
Q16236 NF2L2_HUMAN Breast cancer [ICD-11: 2C60-2C6Y]
Q16236 NF2L2_HUMAN Glaucoma [ICD-11: 9C61]
Q16236 NF2L2_HUMAN Lung cancer [ICD-11: 2C25]
Q16236 NF2L2_HUMAN Macular degeneration [ICD-11: 9B75]
Q16236 NF2L2_HUMAN Melanoma [ICD-11: 2C30]
Q16236 NF2L2_HUMAN Mental/behavioural/neurodevelopmental disorder [ICD-11: 6E20-6E8Z]
Q16236 NF2L2_HUMAN Pulmonary hypertension [ICD-11: BB01]
Q16236 NF2L2_HUMAN Subarachnoid haemorrhage [ICD-11: 8B01]
Q16236 NF2L2_HUMAN Urinary system clinical sympton [ICD-11: MF8Y]
Q16236 NF2L2_HUMAN Non-alcoholic fatty liver disease [ICD-11: DB92]
Q16236 NF2L2_HUMAN Alpha-1-antitrypsin deficiency [ICD-11: 5C5A]
Q16236 NF2L2_HUMAN Motor neuron disease [ICD-11: 8B60]
Q16236 NF2L2_HUMAN Multiple sclerosis [ICD-11: 8A40]
Q13148 TADBP_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
Q13148 TADBP_HUMAN Alzheimer disease [ICD-11: 8A20]
Q13526 PIN1_HUMAN Lung cancer [ICD-11: 2C25]
Q13526 PIN1_HUMAN Nasopharyngeal cancer [ICD-11: 2B6B]