Basic Information

Terpenoid ID TKC122982
Cell line 0
Protein target 2
DiseaseNCIT 0
ORDO 0
ICD 1

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC122982 A549 98200.0 nM IC50 C3512
TKC122982 PC-3 PC3; PC.3 18280.0 nM IC50 C4863
TKC122982 DU-145 DU-145; Du-145; DU 145; DU_145; DU.145; Duke University 145 22730.0 nM IC50 C4863
TKC122982 MCF7 21430.0 nM IC50 C4194
TKC122982 MDA-MB-231 MDA_MB_231; MDA-MB 231; MDA.MB.231; MDA MB 231; MDA MB231; MDA Mb231; MDA-MB231; MDAMB-231; MDAMB231; MDA-231; MDA-231P; MDA231; MDA231-BRE; MB231; MD Anderson-Metastatic Breast-231 564000.0 nM IC50 C5214

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC122982 Q9NPD5 Solute carrier organic anion transporter family member 1B3 SLCO1B3 103 % Inhibition
TKC122982 Q9Y6L6 Solute carrier organic anion transporter family member 1B1 SLCO1B1 110 % Inhibition
TKC122982 O75874 Isocitrate dehydrogenase [NADP] cytoplasmic IDH1 101 % Activity
TKC122982 P0DTD1 Replicase polyprotein 1ab rep 11 % Inhibition
TKC122982 Q9WKE8 Reverse transcriptase reverse transcriptase >200 ug.mL-1 IC50
TKC122982 Q9F4F7 4'-phosphopantetheinyl transferase ffp ffp 56234 nM Potency
TKC122982 P06746 DNA polymerase beta POLB 43400 nM IC50
TKC122982 P06766 DNA polymerase beta Polb >500000 nM IC50
TKC122982 P09884 DNA polymerase alpha catalytic subunit POLA1 >500000 nM IC50
TKC122982 P11388 DNA topoisomerase 2-alpha TOP2A >500000 nM IC50
TKC122982 P34969 5-hydroxytryptamine receptor 7 HTR7 0 % Inhibition

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
O75874 IDHC_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
O75874 IDHC_HUMAN Liver cancer [ICD-11: 2C12]
O75874 IDHC_HUMAN Malignant haematopoietic neoplasm [ICD-11: 2B33]
O75874 IDHC_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
O75874 IDHC_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
O75874 IDHC_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P06746 DPOLB_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P09884 DPOLA_HUMAN Virus infection [ICD-11: 1A24-1D9Z]
P11388 TOP2A_HUMAN Kaposi sarcoma [ICD-11: 2B57]
P11388 TOP2A_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P11388 TOP2A_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
P11388 TOP2A_HUMAN Mature T-cell lymphoma [ICD-11: 2A90]
P34969 5HT7R_HUMAN Alzheimer disease [ICD-11: 8A20]
P34969 5HT7R_HUMAN Attention deficit hyperactivity disorder [ICD-11: 6A05]
P34969 5HT7R_HUMAN Bipolar disorder [ICD-11: 6A60]
P34969 5HT7R_HUMAN Depression [ICD-11: 6A70-6A7Z]
P34969 5HT7R_HUMAN Mild neurocognitive disorder [ICD-11: 6D71]
P34969 5HT7R_HUMAN Parkinsonism [ICD-11: 8A00]
P34969 5HT7R_HUMAN Schizophrenia [ICD-11: 6A20]
P34969 5HT7R_HUMAN Sleep-wake disorder [ICD-11: 7A00-7B2Z]
P34969 5HT7R_HUMAN Mental/behavioural/neurodevelopmental disorder [ICD-11: 6E20-6E8Z]