Basic Information
| Terpenoid ID | TKC122980 |
|
| Chirality | TKC206029 | |
| Cell line | 0 | |
| Protein target | 4 | |
| DiseaseNCIT | 0 | |
| ORDO | 0 | |
| ICD | 34 |
| Terpenoid ID | TKC122980 |
|
| Chirality | TKC206029 | |
| Cell line | 0 | |
| Protein target | 4 | |
| DiseaseNCIT | 0 | |
| ORDO | 0 | |
| ICD | 34 |
| ID | Cell Line | Synonyms | Value | Unit | Type | NCIt | ORDO |
|---|---|---|---|---|---|---|---|
| TKC122980 | HOP-62 | HOP 62; Hop 62; HOP.62; HOP62; Hop62; Hopkins-62 | 100000.0 | nM | GI50 | C3512 | |
| TKC122980 | U-251 | U-251 MG; U-251-MG; U-251_MG; U251-MG; U251MG; U-251; U251; U251n; U251N; 251 MG; 251MG; 251 MG(6) | 100000.0 | nM | GI50 | C60781 | Orphanet_94 |
| TKC122980 | OVCAR-8 | OVCAR 8; NIH:OVCAR-8; OVCAR8; Ovcar8; OVCAR.8; OVCA8 | 100000.0 | nM | GI50 | C105555 | |
| TKC122980 | BGC-823 | BGC823 | 10.0 | ug.mL-1 | IC50 | C27677 | |
| TKC122980 | Hepatocyte | 18.0 | % | Inhibition | |||
| TKC122980 | 1A9 | A2780/1A9; A2780(1A9); 1A9 | 11.0 | ug ml-1 | ED50 | C7979 | Orphanet_454723 |
| TKC122980 | 1A9/ptx-10 | A2780/1A9; A2780(1A9); 1A9 | 10.0 | ug ml-1 | ED50 | C7979 | Orphanet_454723 |
| TKC122980 | RAW264.7 | RAW264 | 21.0 | % | Inhibition | C21604 | |
| TKC122980 | HeLa | HELA; Hela; He La; He-La; HeLa-CCL2; Henrietta Lacks cells; Helacyton gartleri | 46220.0 | nM | IC50 | C27677 | |
| TKC122980 | HepG2 | 99.0 | % | Survival | C3728 | Orphanet_449 | |
| TKC122980 | C6 | C-6; C 6; RGC-6; RGC6; RGc6 | 104.0 | % | Activity | C64069 | |
| TKC122980 | SN12C | SN-12C | 100000.0 | nM | GI50 | C9385 | Orphanet_217071 |
| TKC122980 | MDA-N | MDAN | 100000.0 | nM | GI50 | C3802 | |
| TKC122980 | ACHN | 100000.0 | nM | GI50 | C6975 | Orphanet_319298 | |
| TKC122980 | NCI-H23 | NCI.H23; NCI H23; H-23; H23; NCIH23 | 100000.0 | nM | GI50 | C3512 | |
| TKC122980 | HOP-92 | HOP 92; HOP.92; HOP92; Hop92; Hopkins-92 | 100000.0 | nM | GI50 | C2926 | |
| TKC122980 | UO-31 | UO.31; UO31; U031 | 100000.0 | nM | GI50 | C9385 | Orphanet_217071 |
| TKC122980 | HL-60 | HL 60; HL.60 HL60; Human Leukemia-60 | 10000.0 | nM | GI50 | C9154 | Orphanet_519 |
| TKC122980 | DU-145 | DU-145; Du-145; DU 145; DU_145; DU.145; Duke University 145 | 100000.0 | nM | GI50 | C4863 | |
| TKC122980 | SF-539 | SF-539; SF-539 BT; SF.539; SF 539 | 100000.0 | nM | GI50 | C3796 | Orphanet_251576 |
| TKC122980 | SK-MEL-5 | SK-Mel-5; SK MEL 5; SK.MEL.5; SK-MEL5; SKMel-5; SKMEL-5; SKMEL5; SKMel5; SKmel5; AA-Mel | 100000.0 | nM | GI50 | C3510 | |
| TKC122980 | Malme-3M | MALME-3M; MALME 3M; Malme-3 M; MALME.3M; Malme3M; MALME3M; Malme-3 Monolayer | 100000.0 | nM | GI50 | C3224 | |
| TKC122980 | K562 | K562; K.562; K 562; KO; GM05372; GM05372E | 100000.0 | nM | GI50 | C9110 | Orphanet_521 |
| TKC122980 | OVCAR-3 | Ovcar-3; OVCAR 3; OVCAR.3; NIH:OVCAR-3; NIH:Ovcar-3; NIH:OVCAR3; NIH-OVCAR-3; NIHOVCAR3; OVCAR3; Ovcar3 | 100000.0 | nM | GI50 | C105555 | |
| TKC122980 | MOLT-4 | Molt-4; MOLT 4; Molt 4; MOLT.4; MOLT4; Molt4; GM02219; GM02219C; GM2219C; GM02219D | 100000.0 | nM | GI50 | C9142 | Orphanet_99861 |
| TKC122980 | NCI/ADR-RES | NCI/ADR-RES; NCI.ADR.RES; NCIADR.RES; NCI/ADRRES; NCIADRRES; ADR-RES; MCF-7/ADR; MCF-7/ADR-RES; MCF-7/AdrR; MCF-7/Adr; MCF-7/adr; MCF-7ADR; MCF7-ADR; MCF7ADR; OVCAR-8/ADR; OVCAR8/ADR | 100000.0 | nM | GI50 | C105555 | |
| TKC122980 | OVCAR-5 | OVCAR 5; NIH:OVCAR-5; OVCAR.5; OVCAR5; Ovcar5; OVCA5 | 100000.0 | nM | GI50 | C105555 | |
| TKC122980 | SNB-19 | SNB.19; SNB19; Surgical Neurology Branch-19 | 100000.0 | nM | GI50 | C60781 | Orphanet_94 |
| TKC122980 | SR | SR-786; SR786 | 100000.0 | nM | GI50 | C37193 | Orphanet_300895 |
| TKC122980 | TK-10 | TK.10; TK 10; TK10 | 100000.0 | nM | GI50 | C4033 | Orphanet_319276 |
| TKC122980 | SW-620 | SW-620; SW 620; SW.620 | 100000.0 | nM | GI50 | C4349 | |
| TKC122980 | KM12 | KM-12; KM.12 | 100000.0 | nM | GI50 | C4910 | |
| TKC122980 | NCI-H522 | NCI.H522; H522; H-522; NCI-522; NCI522; NCIH522 | 100000.0 | nM | GI50 | C3512 | |
| TKC122980 | M14 | M14-MEL; UCLA-SO-M14; UCLA SO M14; UCLA-SO-14; UCLASO-M14; Melanoma 14; M-14 | 100000.0 | nM | GI50 | C3802 | |
| TKC122980 | NCI-H322M | NCI.H322M; H322M; H-322M; H-322m | 100000.0 | nM | GI50 | C2923 | |
| TKC122980 | RPMI-8226 | RPMI 8226; RPMI.8226; RPMI8226; RPMI no. 8226; RPMI no 8226; RPMI #8226; 8226; RPMI 8226/S; RPMI-8226S; RPMI8226/S; 8226/S; Roswell Park Memorial Institute 8226; GM02132; GM2132; GM 2132; GM02132C; Simpson | 100000.0 | nM | GI50 | C3242 | Orphanet_29073 |
| TKC122980 | OVCAR-4 | OVCAR 4; NIH:OVCAR-4; NIH:OVCAR4; OVCAR.4; OVCAR4; Ovcar4 | 100000.0 | nM | GI50 | C105555 | |
| TKC122980 | LOX IMVI | LOX/IMVI; LOX IMVI; LOXIM-VI; LOXIMVI; LOX | 100000.0 | nM | GI50 | C3802 | |
| TKC122980 | SK-MEL-2 | SK-Mel-2; SK-Mel 2; SK-mel-2; SK-MEL2; SK.MEL.2; SK Mel 2; SK MEL 2; SKMEL-2; SKMEL2; SKmel2; SK-ML2; SKml2 | 100000.0 | nM | GI50 | C3224 | |
| TKC122980 | HCC 2998 | HCC-2998; HCC.2998; HCC 2998; Hamon Cancer Center 2998 | 100000.0 | nM | GI50 | C4349 | |
| TKC122980 | SNB-75 | SNB.75; SNB75; Surgical Neurology Branch-75 | 100000.0 | nM | GI50 | C3058 | Orphanet_360 |
| TKC122980 | HCT-15 | HCT-15; HCT.15; HCT15 | 100000.0 | nM | GI50 | C4349 | |
| TKC122980 | HCT-116 | HCT-116; HCT.116; HCT_116; HCT116; HCT116wt; CoCL2 | 100000.0 | nM | GI50 | C4910 | |
| TKC122980 | SF-268 | SF-268; SF.268; SF 268 | 100000.0 | nM | GI50 | C60781 | Orphanet_94 |
| TKC122980 | EKVX | 100000.0 | nM | GI50 | C3512 | ||
| TKC122980 | NCI-H460 | NCI.H460; H460; H-460; NCIH460; NCI-HUT-460; NCI-460 | 100000.0 | nM | GI50 | C4450 | |
| TKC122980 | CAKI-1 | CAL 1; Centre Antoine Lacassagne-1 | 100000.0 | nM | GI50 | C3224 | |
| TKC122980 | MDA-MB-435 | MDA-MB435; MDAMB435; MDA.MB.435; MDA-435; MDA 435; MDA435; MD Anderson-Metastatic Breast-435 | 100000.0 | nM | GI50 | C3802 | |
| TKC122980 | IGROV-1 | Igrov-1; IGROV 1; IGR-OV1; IGROV1; Igrov1; IGR.OV1; IGROV; OV1/P; OV1/p; OV1-P | 100000.0 | nM | GI50 | C7979 | Orphanet_454723 |
| TKC122980 | SF-295 | SF-295; SF.295; SF 295 | 100000.0 | nM | GI50 | C3058 | Orphanet_360 |
| TKC122980 | Hs-578T | HS 578T; Hs-578T; HS-578T; Hs_578t; Hs-578-T; HS-578-T; Hs 578.T; HS578T; Hs578T; Hs578t; HS0578T; 578T; HS578; Hs578; Homo sapiens No. 578, tumor cells | 100000.0 | nM | GI50 | C4194 | |
| TKC122980 | 786-0 | 786-o; 786O; 786-0; 786.O; 786-O RCC; RCC 786-O; RCC_7860; RCC 7860; 7860; 786-0WT | 100000.0 | nM | GI50 | C9385 | Orphanet_217071 |
| TKC122980 | UACC-257 | UACC 257; UACC.257; UACC257; University of Arizona Cell Culture-257 | 100000.0 | nM | GI50 | C3224 | |
| TKC122980 | CCRF-CEM | CCRF/CEM; CCRFCEM; CCRF.CEM; CCRF CEM; CCRF; CEM; CEM-CCRF; CEM-CCRF (CAMR); CCRF/CEM/0; CEM/0; CEM-0; CCRF-CEM/S; GM03671; GM03671C | 100000.0 | nM | GI50 | C7953 | Orphanet_99861 |
| TKC122980 | NCI-H226 | NCI.H226; NCI H226; H226; H-226; HUT-226; HUT 226; NCIH226 | 100000.0 | nM | GI50 | C45662 | Orphanet_50251 |
| TKC122980 | SK-MEL-28 | SK-Mel-28; SK.MEL.28; SK-MEL 28; SK MEL-28; SK MEL 28; SK Mel 28; SKMel-28; SKMEL-28; SK-MEL28; SK-Mel28; SK Mel28; SKMEL28; SKMel28; SKmel28; SKML-28; SK28; AU-Mel; P-36; P36 | 100000.0 | nM | GI50 | C3510 | |
| TKC122980 | COLO 205 | Colo 205; CoLo 205; COLO-205; Colo-205; COLO.205; Colo205; COLO205; Co 205; Colorado 205 | 100000.0 | nM | GI50 | C4349 | |
| TKC122980 | ECV-304 | ECV 304; ECV304; ECV; E304; T24(ECV304) | 61000.0 | nM | IC50 | C4912 | |
| TKC122980 | HEp-2 | Hep-2; HEP-2; Hep2 (HeLa derivative); HEp-2/HeLa; Hep 2; Hep2; HEp2; HEP2; H.Ep.-2; H.Ep. #2; H.Ep. No. 2; Hep II; Human Epidermoid carcinoma #2; Human Epithelioma-2 | 11400.0 | nM | IC50 | C27677 |
| ID | Uniport | Pref_name | Gene name | value | unit | type |
|---|---|---|---|---|---|---|
| TKC122980 | P08684 | Cytochrome P450 3A4 | CYP3A4 | >100000 | nM | IC50 |
| TKC122980 | Q9NPD5 | Solute carrier organic anion transporter family member 1B3 | SLCO1B3 | 93 | % | Inhibition |
| TKC122980 | Q9Y6L6 | Solute carrier organic anion transporter family member 1B1 | SLCO1B1 | 92 | % | Inhibition |
| TKC122980 | O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | IDH1 | 99 | % | Activity |
| TKC122980 | O42275 | Acetylcholinesterase | ache | 14 | % | Inhibition |
| TKC122980 | P0DTD1 | Replicase polyprotein 1ab | rep | 4 | % | Inhibition |
| TKC122980 | P10635 | Cytochrome P450 2D6 | CYP2D6 | >100000 | nM | IC50 |
| TKC122980 | P81908 | Cholinesterase | BCHE | -2 | % | Inhibition |
| TKC122980 | P06746 | DNA polymerase beta | POLB | 26300 | nM | IC50 |
| TKC122980 | P49798 | Regulator of G-protein signaling 4 | RGS4 | 7 | nM | Potency |
| TKC122980 | P14679 | Tyrosinase | TYR | 14 | % | Inhibition |
| TKC122980 | P00734 | Prothrombin | F2 | 9200 | nM | IC50 |
| TKC122980 | P27487 | Dipeptidyl peptidase 4 | DPP4 | 28840 | nM | IC50 |
| Uniport ID | Uniport Name | ICD-11 |
|---|---|---|
| P08684 | CP3A4_HUMAN | Solid tumour/cancer [ICD-11: 2A00-2F9Z] |
| P08684 | CP3A4_HUMAN | Atopic eczema [ICD-11: EA80] |
| P08684 | CP3A4_HUMAN | Anxiety disorder [ICD-11: 6B00-6B0Z] |
| O75874 | IDHC_HUMAN | Acute myeloid leukaemia [ICD-11: 2A60] |
| O75874 | IDHC_HUMAN | Liver cancer [ICD-11: 2C12] |
| O75874 | IDHC_HUMAN | Malignant haematopoietic neoplasm [ICD-11: 2B33] |
| O75874 | IDHC_HUMAN | Solid tumour/cancer [ICD-11: 2A00-2F9Z] |
| O75874 | IDHC_HUMAN | Acute myeloid leukaemia [ICD-11: 2A60] |
| O75874 | IDHC_HUMAN | Solid tumour/cancer [ICD-11: 2A00-2F9Z] |
| P10635 | CP2D6_HUMAN | Insomnia [ICD-11: 7A00-7A0Z] |
| P10635 | CP2D6_HUMAN | Malaria [ICD-11: 1F40-1F45] |
| P10635 | CP2D6_HUMAN | Migraine [ICD-11: 8A80] |
| P06746 | DPOLB_HUMAN | Solid tumour/cancer [ICD-11: 2A00-2F9Z] |
| P14679 | TYRO_HUMAN | Acquired hypermelanosis [ICD-11: ED60] |
| P14679 | TYRO_HUMAN | Acquired hypomelanotic disorder [ICD-11: ED63] |
| P14679 | TYRO_HUMAN | Melanoma [ICD-11: 2C30] |
| P14679 | TYRO_HUMAN | Acquired melanotic macule/lentigine [ICD-11: ED61] |
| P14679 | TYRO_HUMAN | Mineral absorption/transport disorder [ICD-11: 5C64] |
| P14679 | TYRO_HUMAN | Skin pigmentation genetic disorder [ICD-11: EC23] |
| P14679 | TYRO_HUMAN | Rheumatoid arthritis [ICD-11: FA20] |
| P00734 | THRB_HUMAN | Asthma [ICD-11: CA23] |
| P00734 | THRB_HUMAN | Bleeding disorder [ICD-11: GA20-GA21] |
| P00734 | THRB_HUMAN | Coagulation defect [ICD-11: 3B10] |
| P00734 | THRB_HUMAN | Ischaemic/haemorrhagic stroke [ICD-11: 8B20] |
| P00734 | THRB_HUMAN | Multiple sclerosis [ICD-11: 8A40] |
| P00734 | THRB_HUMAN | Myocardial infarction [ICD-11: BA41-BA43] |
| P00734 | THRB_HUMAN | Nutritional deficiency [ICD-11: 5B50-5B71] |
| P00734 | THRB_HUMAN | Thrombocytopenia [ICD-11: 3B64] |
| P00734 | THRB_HUMAN | Thrombosis [ICD-11: DB61-GB90] |
| P00734 | THRB_HUMAN | Coronary thrombosis [ICD-11: BA43] |
| P00734 | THRB_HUMAN | Angina pectoris [ICD-11: BA40] |
| P00734 | THRB_HUMAN | Cardiovascular disease [ICD-11: BA00-BE2Z] |
| P00734 | THRB_HUMAN | Cerebral ischaemic stroke [ICD-11: 8B11] |
| P00734 | THRB_HUMAN | Type 2 diabetes mellitus [ICD-11: 5A11] |
| P00734 | THRB_HUMAN | Atopic eczema [ICD-11: EA80] |
| P00734 | THRB_HUMAN | Supraventricular tachyarrhythmia [ICD-11: BC81] |
| P00734 | THRB_HUMAN | Dissociative neurological symptom disorder [ICD-11: 6B60] |
| P00734 | THRB_HUMAN | Genetic cardiac arrhythmia [ICD-11: BC65] |
| P00734 | THRB_HUMAN | Pregnancy/childbirth/puerperium maternal infection [ICD-11: JB63] |
| P00734 | THRB_HUMAN | Solid tumour/cancer [ICD-11: 2A00-2F9Z] |
| P27487 | DPP4_HUMAN | Acute diabete complication [ICD-11: 5A2Y] |
| P27487 | DPP4_HUMAN | Chronic arterial occlusive disease [ICD-11: BD4Z] |
| P27487 | DPP4_HUMAN | Type 2 diabetes mellitus [ICD-11: 5A11] |
| P27487 | DPP4_HUMAN | Diabetes mellitus [ICD-11: 5A10] |
| P27487 | DPP4_HUMAN | Metabolic disorder [ICD-11: 5C50-5D2Z] |
| P27487 | DPP4_HUMAN | Autism spectrum disorder [ICD-11: 6A02] |
| P27487 | DPP4_HUMAN | Psoriasis [ICD-11: EA90] |
| P27487 | DPP4_HUMAN | Malignant haematopoietic neoplasm [ICD-11: 2B33] |
| P27487 | DPP4_HUMAN | Myocardial infarction [ICD-11: BA41-BA43] |
| P27487 | DPP4_HUMAN | Colon cancer [ICD-11: 2B90] |
| P27487 | DPP4_HUMAN | Lung cancer [ICD-11: 2C25] |
| P27487 | DPP4_HUMAN | Hypo-glycaemia [ICD-11: 5A41] |
| P27487 | DPP4_HUMAN | Transplanted organ/tissue [ICD-11: QB63] |