Basic Information

Terpenoid ID TKC118006
Cell line 0
Protein target 5
DiseaseNCIT 0
ORDO 0
ICD 27

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC118006 NCI/ADR-RES NCI/ADR-RES; NCI.ADR.RES; NCIADR.RES; NCI/ADRRES; NCIADRRES; ADR-RES; MCF-7/ADR; MCF-7/ADR-RES; MCF-7/AdrR; MCF-7/Adr; MCF-7/adr; MCF-7ADR; MCF7-ADR; MCF7ADR; OVCAR-8/ADR; OVCAR8/ADR 257.0 nM GI50 C105555
TKC118006 U-251 U-251 MG; U-251-MG; U-251_MG; U251-MG; U251MG; U-251; U251; U251n; U251N; 251 MG; 251MG; 251 MG(6) 314.0 nM GI50 C60781 Orphanet_94
TKC118006 SN12C SN-12C 42.0 nM GI50 C9385 Orphanet_217071
TKC118006 MDA-N MDAN 136.0 nM GI50 C3802
TKC118006 NCI-H23 NCI.H23; NCI H23; H-23; H23; NCIH23 157.0 nM GI50 C3512
TKC118006 UO-31 UO.31; UO31; U031 308.0 nM GI50 C9385 Orphanet_217071
TKC118006 ACHN 91.0 nM GI50 C6975 Orphanet_319298
TKC118006 HL-60 HL 60; HL.60 HL60; Human Leukemia-60 118.0 nM GI50 C9154 Orphanet_519
TKC118006 HOP-92 HOP 92; HOP.92; HOP92; Hop92; Hopkins-92 341.0 nM GI50 C2926
TKC118006 SF-539 SF-539; SF-539 BT; SF.539; SF 539 81.0 nM GI50 C3796 Orphanet_251576
TKC118006 DU-145 DU-145; Du-145; DU 145; DU_145; DU.145; Duke University 145 115.0 nM GI50 C4863
TKC118006 SK-MEL-5 SK-Mel-5; SK MEL 5; SK.MEL.5; SK-MEL5; SKMel-5; SKMEL-5; SKMEL5; SKMel5; SKmel5; AA-Mel 99.0 nM GI50 C3510
TKC118006 Malme-3M MALME-3M; MALME 3M; Malme-3 M; MALME.3M; Malme3M; MALME3M; Malme-3 Monolayer 225.0 nM GI50 C3224
TKC118006 K562 K562; K.562; K 562; KO; GM05372; GM05372E 184.0 nM GI50 C9110 Orphanet_521
TKC118006 A498 A498 294.0 nM GI50 C9385 Orphanet_217071
TKC118006 OVCAR-3 Ovcar-3; OVCAR 3; OVCAR.3; NIH:OVCAR-3; NIH:Ovcar-3; NIH:OVCAR3; NIH-OVCAR-3; NIHOVCAR3; OVCAR3; Ovcar3 146.0 nM GI50 C105555
TKC118006 HOP-62 HOP 62; Hop 62; HOP.62; HOP62; Hop62; Hopkins-62 114.0 nM GI50 C3512
TKC118006 MOLT-4 Molt-4; MOLT 4; Molt 4; MOLT.4; MOLT4; Molt4; GM02219; GM02219C; GM2219C; GM02219D 88.0 nM GI50 C9142 Orphanet_99861
TKC118006 OVCAR-8 OVCAR 8; NIH:OVCAR-8; OVCAR8; Ovcar8; OVCAR.8; OVCA8 307.0 nM GI50 C105555
TKC118006 OVCAR-5 OVCAR 5; NIH:OVCAR-5; OVCAR.5; OVCAR5; Ovcar5; OVCA5 478.0 nM GI50 C105555
TKC118006 SNB-19 SNB.19; SNB19; Surgical Neurology Branch-19 713.0 nM GI50 C60781 Orphanet_94
TKC118006 MDA-MB-231 MDA_MB_231; MDA-MB 231; MDA.MB.231; MDA MB 231; MDA MB231; MDA Mb231; MDA-MB231; MDAMB-231; MDAMB231; MDA-231; MDA-231P; MDA231; MDA231-BRE; MB231; MD Anderson-Metastatic Breast-231 1138.0 nM GI50 C5214
TKC118006 SR SR-786; SR786 409.0 nM GI50 C37193 Orphanet_300895
TKC118006 TK-10 TK.10; TK 10; TK10 167.0 nM GI50 C4033 Orphanet_319276
TKC118006 SW-620 SW-620; SW 620; SW.620 243.0 nM GI50 C4349
TKC118006 NCI-H522 NCI.H522; H522; H-522; NCI-522; NCI522; NCIH522 39.0 nM GI50 C3512
TKC118006 M14 M14-MEL; UCLA-SO-M14; UCLA SO M14; UCLA-SO-14; UCLASO-M14; Melanoma 14; M-14 528.0 nM GI50 C3802
TKC118006 KM12 KM-12; KM.12 402.0 nM GI50 C4910
TKC118006 NCI-H322M NCI.H322M; H322M; H-322M; H-322m 325.0 nM GI50 C2923
TKC118006 RPMI-8226 RPMI 8226; RPMI.8226; RPMI8226; RPMI no. 8226; RPMI no 8226; RPMI #8226; 8226; RPMI 8226/S; RPMI-8226S; RPMI8226/S; 8226/S; Roswell Park Memorial Institute 8226; GM02132; GM2132; GM 2132; GM02132C; Simpson 270.0 nM GI50 C3242 Orphanet_29073
TKC118006 OVCAR-4 OVCAR 4; NIH:OVCAR-4; NIH:OVCAR4; OVCAR.4; OVCAR4; Ovcar4 107.0 nM GI50 C105555
TKC118006 BT-549 BT 549; BT.549; BT549 207.0 nM GI50 C4194
TKC118006 LOX IMVI LOX/IMVI; LOX IMVI; LOXIM-VI; LOXIMVI; LOX 184.0 nM GI50 C3802
TKC118006 SK-MEL-2 SK-Mel-2; SK-Mel 2; SK-mel-2; SK-MEL2; SK.MEL.2; SK Mel 2; SK MEL 2; SKMEL-2; SKMEL2; SKmel2; SK-ML2; SKml2 397.0 nM GI50 C3224
TKC118006 A549 81.0 nM GI50 C3512
TKC118006 HCC 2998 HCC-2998; HCC.2998; HCC 2998; Hamon Cancer Center 2998 2080.0 nM GI50 C4349
TKC118006 SNB-75 SNB.75; SNB75; Surgical Neurology Branch-75 400.0 nM GI50 C3058 Orphanet_360
TKC118006 HCT-15 HCT-15; HCT.15; HCT15 192.0 nM GI50 C4349
TKC118006 SF-268 SF-268; SF.268; SF 268 126.0 nM GI50 C60781 Orphanet_94
TKC118006 HCT-116 HCT-116; HCT.116; HCT_116; HCT116; HCT116wt; CoCL2 163.0 nM GI50 C4910
TKC118006 MCF7 463.0 nM GI50 C4194
TKC118006 EKVX 175.0 nM GI50 C3512
TKC118006 PC-3 PC3; PC.3 203.0 nM GI50 C4863
TKC118006 SK-OV-3 SKOV-3; SK-OV3; SK.OV.3; SKOV3; Skov3; SKO3 114.0 nM GI50 C7978
TKC118006 T47D 384.0 nM GI50 C4194
TKC118006 NCI-H460 NCI.H460; H460; H-460; NCIH460; NCI-HUT-460; NCI-460 112.0 nM GI50 C4450
TKC118006 UACC-62 UACC 62; UACC.62; UACC62; University of Arizona Cell Culture-62 430.0 nM GI50 C3224
TKC118006 CAKI-1 CAL 1; Centre Antoine Lacassagne-1 102.0 nM GI50 C3224
TKC118006 MDA-MB-435 MDA-MB435; MDAMB435; MDA.MB.435; MDA-435; MDA 435; MDA435; MD Anderson-Metastatic Breast-435 344.0 nM GI50 C3802
TKC118006 SF-295 SF-295; SF.295; SF 295 133.0 nM GI50 C3058 Orphanet_360
TKC118006 Hs-578T HS 578T; Hs-578T; HS-578T; Hs_578t; Hs-578-T; HS-578-T; Hs 578.T; HS578T; Hs578T; Hs578t; HS0578T; 578T; HS578; Hs578; Homo sapiens No. 578, tumor cells 525.0 nM GI50 C4194
TKC118006 IGROV-1 Igrov-1; IGROV 1; IGR-OV1; IGROV1; Igrov1; IGR.OV1; IGROV; OV1/P; OV1/p; OV1-P 448.0 nM GI50 C7979 Orphanet_454723
TKC118006 786-0 786-o; 786O; 786-0; 786.O; 786-O RCC; RCC 786-O; RCC_7860; RCC 7860; 7860; 786-0WT 137.0 nM GI50 C9385 Orphanet_217071
TKC118006 UACC-257 UACC 257; UACC.257; UACC257; University of Arizona Cell Culture-257 370.0 nM GI50 C3224
TKC118006 CCRF-CEM CCRF/CEM; CCRFCEM; CCRF.CEM; CCRF CEM; CCRF; CEM; CEM-CCRF; CEM-CCRF (CAMR); CCRF/CEM/0; CEM/0; CEM-0; CCRF-CEM/S; GM03671; GM03671C 6531.0 nM GI50 C7953 Orphanet_99861
TKC118006 NCI-H226 NCI.H226; NCI H226; H226; H-226; HUT-226; HUT 226; NCIH226 540.0 nM GI50 C45662 Orphanet_50251
TKC118006 HT-29 HT 29; HT29 233.0 nM GI50 C4349
TKC118006 SK-MEL-28 SK-Mel-28; SK.MEL.28; SK-MEL 28; SK MEL-28; SK MEL 28; SK Mel 28; SKMel-28; SKMEL-28; SK-MEL28; SK-Mel28; SK Mel28; SKMEL28; SKMel28; SKmel28; SKML-28; SK28; AU-Mel; P-36; P36 845.0 nM GI50 C3510
TKC118006 RXF 393 RXF393L; RXF-393 L; RXF-393; RXF 393; RXF.393; RXF393; RXF 393NL 47.0 nM GI50 C9385 Orphanet_217071
TKC118006 COLO 205 Colo 205; CoLo 205; COLO-205; Colo-205; COLO.205; Colo205; COLO205; Co 205; Colorado 205 618.0 nM GI50 C4349

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC118006 Q16637 Survival motor neuron protein SMN1,SMN2 501 nM Potency
TKC118006 Q16637 Survival motor neuron protein SMN1,SMN2 501 nM Potency
TKC118006 Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 TDP1 920 nM Potency
TKC118006 Q96QE3 ATPase family AAA domain-containing protein 5 ATAD5 199 nM Potency
TKC118006 P04637 Cellular tumor antigen p53 TP53 100 nM Potency
TKC118006 Q64541 Sodium/potassium-transporting ATPase subunit alpha-4 Atp1a4 12 nM IC50

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
Q16637 SMN_HUMAN Muscular atrophy [ICD-11: 8B61]
Q16637 SMN_HUMAN Muscular atrophy [ICD-11: 8B61]
Q16637 SMN_HUMAN Muscular atrophy [ICD-11: 8B61]
Q16637 SMN_HUMAN Muscular atrophy [ICD-11: 8B61]
P04637 P53_HUMAN Arterial occlusive disease [ICD-11: BD40]
P04637 P53_HUMAN Lip/oral cavity/pharynx neoplasm [ICD-11: 2B6E]
P04637 P53_HUMAN Metastatic liver/bile duct neoplasm [ICD-11: 2D80]
P04637 P53_HUMAN Transplant rejection [ICD-11: NE84]
P04637 P53_HUMAN Ovarian dysfunction [ICD-11: 5A80]
P04637 P53_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
P04637 P53_HUMAN Bladder cancer [ICD-11: 2C94]
P04637 P53_HUMAN Brain cancer [ICD-11: 2A00]
P04637 P53_HUMAN Colorectal cancer [ICD-11: 2B91]
P04637 P53_HUMAN Esophageal cancer [ICD-11: 2B70]
P04637 P53_HUMAN Head and neck cancer [ICD-11: 2D42]
P04637 P53_HUMAN Mature B-cell leukaemia [ICD-11: 2A82]
P04637 P53_HUMAN Myelodysplastic syndrome [ICD-11: 2A37]
P04637 P53_HUMAN Ovarian cancer [ICD-11: 2C73]
P04637 P53_HUMAN Pancreatic cancer [ICD-11: 2C10]
P04637 P53_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P04637 P53_HUMAN Stomach cancer [ICD-11: 2B72]
P04637 P53_HUMAN Cervical cancer [ICD-11: 2C77]
P04637 P53_HUMAN Endometrial cancer [ICD-11: 2C76]
P04637 P53_HUMAN Fallopian tube cancer [ICD-11: 2C74]
P04637 P53_HUMAN Liposarcoma [ICD-11: 2B59]
P04637 P53_HUMAN Malignant haematopoietic neoplasm [ICD-11: 2B33]
P04637 P53_HUMAN Peritoneal cancer [ICD-11: 2C51]
P04637 P53_HUMAN Toxicity [ICD-11: N.A.]
P04637 P53_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P04637 P53_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
P04637 P53_HUMAN Kidney failure [ICD-11: GB60-GB6Z]
P04637 P53_HUMAN Hearing disorder [ICD-11: AB50-AB57]