Basic Information

Terpenoid ID TKC117993
Chirality TKC206889
Cell line 0
Protein target 20
DiseaseNCIT 0
ORDO 0
ICD 65

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC117993 HCT-116 HCT-116; HCT.116; HCT_116; HCT116; HCT116wt; CoCL2 21.0 % Survival C4910
TKC117993 HT-29 HT 29; HT29 58.0 % Survival C4349
TKC117993 Vero VERO; VeroCCL81; Vero 81; Vero-81; Verda reno 1220.0 nM CC50
TKC117993 SN12C SN-12C 418.0 nM GI50 C9385 Orphanet_217071
TKC117993 MDA-N MDAN 372.0 nM GI50 C3802
TKC117993 ACHN 142.0 nM GI50 C6975 Orphanet_319298
TKC117993 NCI-H23 NCI.H23; NCI H23; H-23; H23; NCIH23 265.0 nM GI50 C3512
TKC117993 UO-31 UO.31; UO31; U031 444.0 nM GI50 C9385 Orphanet_217071
TKC117993 HOP-92 HOP 92; HOP.92; HOP92; Hop92; Hopkins-92 1247.0 nM GI50 C2926
TKC117993 HL-60 HL 60; HL.60 HL60; Human Leukemia-60 347.0 nM GI50 C9154 Orphanet_519
TKC117993 DU-145 DU-145; Du-145; DU 145; DU_145; DU.145; Duke University 145 284.0 nM GI50 C4863
TKC117993 SF-539 SF-539; SF-539 BT; SF.539; SF 539 294.0 nM GI50 C3796 Orphanet_251576
TKC117993 SK-MEL-5 SK-Mel-5; SK MEL 5; SK.MEL.5; SK-MEL5; SKMel-5; SKMEL-5; SKMEL5; SKMel5; SKmel5; AA-Mel 288.0 nM GI50 C3510
TKC117993 Malme-3M MALME-3M; MALME 3M; Malme-3 M; MALME.3M; Malme3M; MALME3M; Malme-3 Monolayer 435.0 nM GI50 C3224
TKC117993 K562 K562; K.562; K 562; KO; GM05372; GM05372E 605.0 nM GI50 C9110 Orphanet_521
TKC117993 A498 A498 562.0 nM GI50 C9385 Orphanet_217071
TKC117993 OVCAR-3 Ovcar-3; OVCAR 3; OVCAR.3; NIH:OVCAR-3; NIH:Ovcar-3; NIH:OVCAR3; NIH-OVCAR-3; NIHOVCAR3; OVCAR3; Ovcar3 421.0 nM GI50 C105555
TKC117993 MOLT-4 Molt-4; MOLT 4; Molt 4; MOLT.4; MOLT4; Molt4; GM02219; GM02219C; GM2219C; GM02219D 112.0 nM GI50 C9142 Orphanet_99861
TKC117993 NCI/ADR-RES NCI/ADR-RES; NCI.ADR.RES; NCIADR.RES; NCI/ADRRES; NCIADRRES; ADR-RES; MCF-7/ADR; MCF-7/ADR-RES; MCF-7/AdrR; MCF-7/Adr; MCF-7/adr; MCF-7ADR; MCF7-ADR; MCF7ADR; OVCAR-8/ADR; OVCAR8/ADR 403.0 nM GI50 C105555
TKC117993 HOP-62 HOP 62; Hop 62; HOP.62; HOP62; Hop62; Hopkins-62 159.0 nM GI50 C3512
TKC117993 OVCAR-5 OVCAR 5; NIH:OVCAR-5; OVCAR.5; OVCAR5; Ovcar5; OVCA5 1419.0 nM GI50 C105555
TKC117993 OVCAR-8 OVCAR 8; NIH:OVCAR-8; OVCAR8; Ovcar8; OVCAR.8; OVCA8 498.0 nM GI50 C105555
TKC117993 SNB-19 SNB.19; SNB19; Surgical Neurology Branch-19 1581.0 nM GI50 C60781 Orphanet_94
TKC117993 MDA-MB-231 MDA_MB_231; MDA-MB 231; MDA.MB.231; MDA MB 231; MDA MB231; MDA Mb231; MDA-MB231; MDAMB-231; MDAMB231; MDA-231; MDA-231P; MDA231; MDA231-BRE; MB231; MD Anderson-Metastatic Breast-231 2655.0 nM GI50 C5214
TKC117993 SR SR-786; SR786 386.0 nM GI50 C37193 Orphanet_300895
TKC117993 TK-10 TK.10; TK 10; TK10 465.0 nM GI50 C4033 Orphanet_319276
TKC117993 SW-620 SW-620; SW 620; SW.620 528.0 nM GI50 C4349
TKC117993 NCI-H522 NCI.H522; H522; H-522; NCI-522; NCI522; NCIH522 94.0 nM GI50 C3512
TKC117993 KM12 KM-12; KM.12 1941.0 nM GI50 C4910
TKC117993 M14 M14-MEL; UCLA-SO-M14; UCLA SO M14; UCLA-SO-14; UCLASO-M14; Melanoma 14; M-14 1067.0 nM GI50 C3802
TKC117993 NCI-H322M NCI.H322M; H322M; H-322M; H-322m 918.0 nM GI50 C2923
TKC117993 RPMI-8226 RPMI 8226; RPMI.8226; RPMI8226; RPMI no. 8226; RPMI no 8226; RPMI #8226; 8226; RPMI 8226/S; RPMI-8226S; RPMI8226/S; 8226/S; Roswell Park Memorial Institute 8226; GM02132; GM2132; GM 2132; GM02132C; Simpson 506.0 nM GI50 C3242 Orphanet_29073
TKC117993 OVCAR-4 OVCAR 4; NIH:OVCAR-4; NIH:OVCAR4; OVCAR.4; OVCAR4; Ovcar4 298.0 nM GI50 C105555
TKC117993 LOX IMVI LOX/IMVI; LOX IMVI; LOXIM-VI; LOXIMVI; LOX 453.0 nM GI50 C3802
TKC117993 BT-549 BT 549; BT.549; BT549 355.0 nM GI50 C4194
TKC117993 HCC 2998 HCC-2998; HCC.2998; HCC 2998; Hamon Cancer Center 2998 4266.0 nM GI50 C4349
TKC117993 SNB-75 SNB.75; SNB75; Surgical Neurology Branch-75 1138.0 nM GI50 C3058 Orphanet_360
TKC117993 HCT-15 HCT-15; HCT.15; HCT15 413.0 nM GI50 C4349
TKC117993 SF-268 SF-268; SF.268; SF 268 397.0 nM GI50 C60781 Orphanet_94
TKC117993 EKVX 361.0 nM GI50 C3512
TKC117993 SK-OV-3 SKOV-3; SK-OV3; SK.OV.3; SKOV3; Skov3; SKO3 568.0 nM GI50 C7978
TKC117993 T47D 697.0 nM GI50 C4194
TKC117993 NCI-H460 NCI.H460; H460; H-460; NCIH460; NCI-HUT-460; NCI-460 195.0 nM GI50 C4450
TKC117993 UACC-62 UACC 62; UACC.62; UACC62; University of Arizona Cell Culture-62 1524.0 nM GI50 C3224
TKC117993 MDA-MB-435 MDA-MB435; MDAMB435; MDA.MB.435; MDA-435; MDA 435; MDA435; MD Anderson-Metastatic Breast-435 522.0 nM GI50 C3802
TKC117993 IGROV-1 Igrov-1; IGROV 1; IGR-OV1; IGROV1; Igrov1; IGR.OV1; IGROV; OV1/P; OV1/p; OV1-P 453.0 nM GI50 C7979 Orphanet_454723
TKC117993 SF-295 SF-295; SF.295; SF 295 457.0 nM GI50 C3058 Orphanet_360
TKC117993 786-0 786-o; 786O; 786-0; 786.O; 786-O RCC; RCC 786-O; RCC_7860; RCC 7860; 7860; 786-0WT 321.0 nM GI50 C9385 Orphanet_217071
TKC117993 Hs-578T HS 578T; Hs-578T; HS-578T; Hs_578t; Hs-578-T; HS-578-T; Hs 578.T; HS578T; Hs578T; Hs578t; HS0578T; 578T; HS578; Hs578; Homo sapiens No. 578, tumor cells 682.0 nM GI50 C4194
TKC117993 UACC-257 UACC 257; UACC.257; UACC257; University of Arizona Cell Culture-257 766.0 nM GI50 C3224
TKC117993 CCRF-CEM CCRF/CEM; CCRFCEM; CCRF.CEM; CCRF CEM; CCRF; CEM; CEM-CCRF; CEM-CCRF (CAMR); CCRF/CEM/0; CEM/0; CEM-0; CCRF-CEM/S; GM03671; GM03671C 488.0 nM GI50 C7953 Orphanet_99861
TKC117993 NCI-H226 NCI.H226; NCI H226; H226; H-226; HUT-226; HUT 226; NCIH226 1230.0 nM GI50 C45662 Orphanet_50251
TKC117993 SK-MEL-28 SK-Mel-28; SK.MEL.28; SK-MEL 28; SK MEL-28; SK MEL 28; SK Mel 28; SKMel-28; SKMEL-28; SK-MEL28; SK-Mel28; SK Mel28; SKMEL28; SKMel28; SKmel28; SKML-28; SK28; AU-Mel; P-36; P36 1730.0 nM GI50 C3510
TKC117993 RXF 393 RXF393L; RXF-393 L; RXF-393; RXF 393; RXF.393; RXF393; RXF 393NL 274.0 nM GI50 C9385 Orphanet_217071
TKC117993 COLO 205 Colo 205; CoLo 205; COLO-205; Colo-205; COLO.205; Colo205; COLO205; Co 205; Colorado 205 1358.0 nM GI50 C4349

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC117993 Q16637 Survival motor neuron protein SMN1,SMN2 35481 nM Potency
TKC117993 Q16637 Survival motor neuron protein SMN1,SMN2 35481 nM Potency
TKC117993 Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 TDP1 5174 nM Potency
TKC117993 Q9NPD5 Solute carrier organic anion transporter family member 1B3 SLCO1B3 89 % Inhibition
TKC117993 Q9Y6L6 Solute carrier organic anion transporter family member 1B1 SLCO1B1 71 % Inhibition
TKC117993 O75874 Isocitrate dehydrogenase [NADP] cytoplasmic IDH1 1158 nM Potency
TKC117993 P43220 Glucagon-like peptide 1 receptor GLP1R 1000 nM Potency
TKC117993 P84022 Mothers against decapentaplegic homolog 3 SMAD3 7080 nM Potency
TKC117993 Q06710 Paired box protein Pax-8 PAX8 <2220 nM AC50
TKC117993 Q16236 Nuclear factor erythroid 2-related factor 2 NFE2L2 259 nM Potency
TKC117993 Q99700 Ataxin-2 ATXN2 251 nM Potency
TKC117993 O75496 Geminin GMNN 326 nM Potency
TKC117993 P38398 Breast cancer type 1 susceptibility protein BRCA1 1259 nM Potency
TKC117993 P0DTD1 Replicase polyprotein 1ab rep 12 % Inhibition
TKC117993 P83916 Chromobox protein homolog 1 CBX1 100000 nM Potency
TKC117993 Q96QE3 ATPase family AAA domain-containing protein 5 ATAD5 580 nM Potency
TKC117993 B2RXH2 Lysine-specific demethylase 4E KDM4E 39811 nM Potency
TKC117993 O00255 Menin MEN1 35481 nM Potency
TKC117993 Q16665 Hypoxia-inducible factor 1-alpha HIF1A 2000 nM EC50
TKC117993 O15118 NPC intracellular cholesterol transporter 1 NPC1 1778 nM Potency
TKC117993 P51151 Ras-related protein Rab-9A RAB9A 1413 nM Potency
TKC117993 P04637 Cellular tumor antigen p53 TP53 501 nM Potency
TKC117993 P16473 Thyrotropin receptor TSHR 849 nM Potency
TKC117993 P11308 Transcriptional regulator ERG ERG 50119 nM Potency
TKC117993 O60755 Galanin receptor type 3 GALR3 >29888 nM IC50
TKC117993 Q64541 Sodium/potassium-transporting ATPase subunit alpha-4 Atp1a4 2 nM IC50

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
Q16637 SMN_HUMAN Muscular atrophy [ICD-11: 8B61]
Q16637 SMN_HUMAN Muscular atrophy [ICD-11: 8B61]
Q16637 SMN_HUMAN Muscular atrophy [ICD-11: 8B61]
Q16637 SMN_HUMAN Muscular atrophy [ICD-11: 8B61]
O75874 IDHC_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
O75874 IDHC_HUMAN Liver cancer [ICD-11: 2C12]
O75874 IDHC_HUMAN Malignant haematopoietic neoplasm [ICD-11: 2B33]
O75874 IDHC_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
O75874 IDHC_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
O75874 IDHC_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P43220 GLP1R_HUMAN Cardiovascular disease [ICD-11: BA00-BE2Z]
P43220 GLP1R_HUMAN Obesity [ICD-11: 5B80-5B81]
P43220 GLP1R_HUMAN Type 2 diabetes mellitus [ICD-11: 5A11]
P43220 GLP1R_HUMAN Type-1/2 diabete [ICD-11: 5A10-5A11]
P43220 GLP1R_HUMAN Acute diabete complication [ICD-11: 5A2Y]
P43220 GLP1R_HUMAN Diabetes mellitus [ICD-11: 5A10]
P43220 GLP1R_HUMAN Dyspepsia [ICD-11: MD92]
P43220 GLP1R_HUMAN Irritable bowel syndrome [ICD-11: DD91]
P43220 GLP1R_HUMAN Intracranial injury [ICD-11: NA07]
P43220 GLP1R_HUMAN Non-alcoholic fatty liver disease [ICD-11: DB92]
P84022 SMAD3_HUMAN Herpes simplex infection [ICD-11: 1F00]
P84022 SMAD3_HUMAN Kidney fibrosis [ICD-11: GC01]
Q16236 NF2L2_HUMAN Ataxic disorder [ICD-11: 8A03]
Q16236 NF2L2_HUMAN Breast cancer [ICD-11: 2C60-2C6Y]
Q16236 NF2L2_HUMAN Glaucoma [ICD-11: 9C61]
Q16236 NF2L2_HUMAN Lung cancer [ICD-11: 2C25]
Q16236 NF2L2_HUMAN Macular degeneration [ICD-11: 9B75]
Q16236 NF2L2_HUMAN Melanoma [ICD-11: 2C30]
Q16236 NF2L2_HUMAN Mental/behavioural/neurodevelopmental disorder [ICD-11: 6E20-6E8Z]
Q16236 NF2L2_HUMAN Pulmonary hypertension [ICD-11: BB01]
Q16236 NF2L2_HUMAN Subarachnoid haemorrhage [ICD-11: 8B01]
Q16236 NF2L2_HUMAN Urinary system clinical sympton [ICD-11: MF8Y]
Q16236 NF2L2_HUMAN Non-alcoholic fatty liver disease [ICD-11: DB92]
Q16236 NF2L2_HUMAN Alpha-1-antitrypsin deficiency [ICD-11: 5C5A]
Q16236 NF2L2_HUMAN Motor neuron disease [ICD-11: 8B60]
Q16236 NF2L2_HUMAN Multiple sclerosis [ICD-11: 8A40]
Q16665 HIF1A_HUMAN Adrenomedullary hyperfunction [ICD-11: 5A75]
Q16665 HIF1A_HUMAN Brain cancer [ICD-11: 2A00]
Q16665 HIF1A_HUMAN Lymphoma [ICD-11: 2A80-2A86]
Q16665 HIF1A_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
Q16665 HIF1A_HUMAN Pulmonary hypertension [ICD-11: BB01]
P51151 RAB9A_HUMAN Fungal infection [ICD-11: 1F29-1F2F]
P04637 P53_HUMAN Arterial occlusive disease [ICD-11: BD40]
P04637 P53_HUMAN Lip/oral cavity/pharynx neoplasm [ICD-11: 2B6E]
P04637 P53_HUMAN Metastatic liver/bile duct neoplasm [ICD-11: 2D80]
P04637 P53_HUMAN Transplant rejection [ICD-11: NE84]
P04637 P53_HUMAN Ovarian dysfunction [ICD-11: 5A80]
P04637 P53_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
P04637 P53_HUMAN Bladder cancer [ICD-11: 2C94]
P04637 P53_HUMAN Brain cancer [ICD-11: 2A00]
P04637 P53_HUMAN Colorectal cancer [ICD-11: 2B91]
P04637 P53_HUMAN Esophageal cancer [ICD-11: 2B70]
P04637 P53_HUMAN Head and neck cancer [ICD-11: 2D42]
P04637 P53_HUMAN Mature B-cell leukaemia [ICD-11: 2A82]
P04637 P53_HUMAN Myelodysplastic syndrome [ICD-11: 2A37]
P04637 P53_HUMAN Ovarian cancer [ICD-11: 2C73]
P04637 P53_HUMAN Pancreatic cancer [ICD-11: 2C10]
P04637 P53_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P04637 P53_HUMAN Stomach cancer [ICD-11: 2B72]
P04637 P53_HUMAN Cervical cancer [ICD-11: 2C77]
P04637 P53_HUMAN Endometrial cancer [ICD-11: 2C76]
P04637 P53_HUMAN Fallopian tube cancer [ICD-11: 2C74]
P04637 P53_HUMAN Liposarcoma [ICD-11: 2B59]
P04637 P53_HUMAN Malignant haematopoietic neoplasm [ICD-11: 2B33]
P04637 P53_HUMAN Peritoneal cancer [ICD-11: 2C51]
P04637 P53_HUMAN Toxicity [ICD-11: N.A.]
P04637 P53_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P04637 P53_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
P04637 P53_HUMAN Kidney failure [ICD-11: GB60-GB6Z]
P04637 P53_HUMAN Hearing disorder [ICD-11: AB50-AB57]
P16473 TSHR_HUMAN Hypo-thyroidism [ICD-11: 5A00]
P16473 TSHR_HUMAN Thyroid cancer [ICD-11: 2D10]