Basic Information

Terpenoid ID TKC117617
Cell line 0
Protein target 11
DiseaseNCIT 0
ORDO 0
ICD 30

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC117617 HEK293 316.0 nM Potency
TKC117617 WI-38 VA13 WI 38 VA13 subline 2RA; WI 38 VA-13 subline 2RA; WI 38VA13 subline 2RA; WI-38 VA13 sub 2 RA; WI38-VA13 subline 2RA; WI38 VA13/2RA; WI38VA13/2RA; VA13 2RA; WI-38 VA13; WI 38 VA 13; WI38-VA13; WI38/VA13; WI38VA13; VA-13; VA13; AG07217; AG7217 160000.0 nM IC50
TKC117617 HepG2 316.0 nM Potency C3728 Orphanet_449
TKC117617 A549 14.0 nM GI50 C3512
TKC117617 Vero VERO; VeroCCL81; Vero 81; Vero-81; Verda reno 460.0 nM CC50
TKC117617 SN12C SN-12C 37.0 nM GI50 C9385 Orphanet_217071
TKC117617 MDA-N MDAN 87.0 nM GI50 C3802
TKC117617 NCI-H23 NCI.H23; NCI H23; H-23; H23; NCIH23 37.0 nM GI50 C3512
TKC117617 UO-31 UO.31; UO31; U031 63.0 nM GI50 C9385 Orphanet_217071
TKC117617 ACHN 31.0 nM GI50 C6975 Orphanet_319298
TKC117617 HL-60 HL 60; HL.60 HL60; Human Leukemia-60 38.0 nM GI50 C9154 Orphanet_519
TKC117617 HOP-92 HOP 92; HOP.92; HOP92; Hop92; Hopkins-92 192.0 nM GI50 C2926
TKC117617 SF-539 SF-539; SF-539 BT; SF.539; SF 539 30.0 nM GI50 C3796 Orphanet_251576
TKC117617 DU-145 DU-145; Du-145; DU 145; DU_145; DU.145; Duke University 145 32.0 nM GI50 C4863
TKC117617 SK-MEL-5 SK-Mel-5; SK MEL 5; SK.MEL.5; SK-MEL5; SKMel-5; SKMEL-5; SKMEL5; SKMel5; SKmel5; AA-Mel 32.0 nM GI50 C3510
TKC117617 Malme-3M MALME-3M; MALME 3M; Malme-3 M; MALME.3M; Malme3M; MALME3M; Malme-3 Monolayer 36.0 nM GI50 C3224
TKC117617 A498 A498 98.0 nM GI50 C9385 Orphanet_217071
TKC117617 K562 K562; K.562; K 562; KO; GM05372; GM05372E 103.0 nM GI50 C9110 Orphanet_521
TKC117617 OVCAR-3 Ovcar-3; OVCAR 3; OVCAR.3; NIH:OVCAR-3; NIH:Ovcar-3; NIH:OVCAR3; NIH-OVCAR-3; NIHOVCAR3; OVCAR3; Ovcar3 39.0 nM GI50 C105555
TKC117617 MOLT-4 Molt-4; MOLT 4; Molt 4; MOLT.4; MOLT4; Molt4; GM02219; GM02219C; GM2219C; GM02219D 20.0 nM GI50 C9142 Orphanet_99861
TKC117617 HOP-62 HOP 62; Hop 62; HOP.62; HOP62; Hop62; Hopkins-62 49.0 nM GI50 C3512
TKC117617 NCI/ADR-RES NCI/ADR-RES; NCI.ADR.RES; NCIADR.RES; NCI/ADRRES; NCIADRRES; ADR-RES; MCF-7/ADR; MCF-7/ADR-RES; MCF-7/AdrR; MCF-7/Adr; MCF-7/adr; MCF-7ADR; MCF7-ADR; MCF7ADR; OVCAR-8/ADR; OVCAR8/ADR 74.0 nM GI50 C105555
TKC117617 U-251 U-251 MG; U-251-MG; U-251_MG; U251-MG; U251MG; U-251; U251; U251n; U251N; 251 MG; 251MG; 251 MG(6) 128.0 nM GI50 C60781 Orphanet_94
TKC117617 OVCAR-5 OVCAR 5; NIH:OVCAR-5; OVCAR.5; OVCAR5; Ovcar5; OVCA5 182.0 nM GI50 C105555
TKC117617 OVCAR-8 OVCAR 8; NIH:OVCAR-8; OVCAR8; Ovcar8; OVCAR.8; OVCA8 92.0 nM GI50 C105555
TKC117617 SNB-19 SNB.19; SNB19; Surgical Neurology Branch-19 381.0 nM GI50 C60781 Orphanet_94
TKC117617 MDA-MB-231 MDA_MB_231; MDA-MB 231; MDA.MB.231; MDA MB 231; MDA MB231; MDA Mb231; MDA-MB231; MDAMB-231; MDAMB231; MDA-231; MDA-231P; MDA231; MDA231-BRE; MB231; MD Anderson-Metastatic Breast-231 404.0 nM GI50 C5214
TKC117617 SR SR-786; SR786 31.0 nM GI50 C37193 Orphanet_300895
TKC117617 TK-10 TK.10; TK 10; TK10 80.0 nM GI50 C4033 Orphanet_319276
TKC117617 SW-620 SW-620; SW 620; SW.620 125.0 nM GI50 C4349
TKC117617 NCI-H522 NCI.H522; H522; H-522; NCI-522; NCI522; NCIH522 25.0 nM GI50 C3512
TKC117617 KM12 KM-12; KM.12 398.0 nM GI50 C4910
TKC117617 M14 M14-MEL; UCLA-SO-M14; UCLA SO M14; UCLA-SO-14; UCLASO-M14; Melanoma 14; M-14 172.0 nM GI50 C3802
TKC117617 NCI-H322M NCI.H322M; H322M; H-322M; H-322m 111.0 nM GI50 C2923
TKC117617 RPMI-8226 RPMI 8226; RPMI.8226; RPMI8226; RPMI no. 8226; RPMI no 8226; RPMI #8226; 8226; RPMI 8226/S; RPMI-8226S; RPMI8226/S; 8226/S; Roswell Park Memorial Institute 8226; GM02132; GM2132; GM 2132; GM02132C; Simpson 98.0 nM GI50 C3242 Orphanet_29073
TKC117617 OVCAR-4 OVCAR 4; NIH:OVCAR-4; NIH:OVCAR4; OVCAR.4; OVCAR4; Ovcar4 36.0 nM GI50 C105555
TKC117617 LOX IMVI LOX/IMVI; LOX IMVI; LOXIM-VI; LOXIMVI; LOX 58.0 nM GI50 C3802
TKC117617 BT-549 BT 549; BT.549; BT549 28.0 nM GI50 C4194
TKC117617 SK-MEL-2 SK-Mel-2; SK-Mel 2; SK-mel-2; SK-MEL2; SK.MEL.2; SK Mel 2; SK MEL 2; SKMEL-2; SKMEL2; SKmel2; SK-ML2; SKml2 218.0 nM GI50 C3224
TKC117617 HCC 2998 HCC-2998; HCC.2998; HCC 2998; Hamon Cancer Center 2998 161.0 nM GI50 C4349
TKC117617 SNB-75 SNB.75; SNB75; Surgical Neurology Branch-75 153.0 nM GI50 C3058 Orphanet_360
TKC117617 HCT-15 HCT-15; HCT.15; HCT15 84.0 nM GI50 C4349
TKC117617 HCT-116 HCT-116; HCT.116; HCT_116; HCT116; HCT116wt; CoCL2 33.0 nM GI50 C4910
TKC117617 SF-268 SF-268; SF.268; SF 268 43.0 nM GI50 C60781 Orphanet_94
TKC117617 EKVX 46.0 nM GI50 C3512
TKC117617 PC-3 PC3; PC.3 66.0 nM GI50 C4863
TKC117617 SK-OV-3 SKOV-3; SK-OV3; SK.OV.3; SKOV3; Skov3; SKO3 214.0 nM GI50 C7978
TKC117617 NCI-H460 NCI.H460; H460; H-460; NCIH460; NCI-HUT-460; NCI-460 29.0 nM GI50 C4450
TKC117617 T47D 222.0 nM GI50 C4194
TKC117617 UACC-62 UACC 62; UACC.62; UACC62; University of Arizona Cell Culture-62 211.0 nM GI50 C3224
TKC117617 MDA-MB-435 MDA-MB435; MDAMB435; MDA.MB.435; MDA-435; MDA 435; MDA435; MD Anderson-Metastatic Breast-435 179.0 nM GI50 C3802
TKC117617 CAKI-1 CAL 1; Centre Antoine Lacassagne-1 34.0 nM GI50 C3224
TKC117617 IGROV-1 Igrov-1; IGROV 1; IGR-OV1; IGROV1; Igrov1; IGR.OV1; IGROV; OV1/P; OV1/p; OV1-P 103.0 nM GI50 C7979 Orphanet_454723
TKC117617 SF-295 SF-295; SF.295; SF 295 39.0 nM GI50 C3058 Orphanet_360
TKC117617 Hs-578T HS 578T; Hs-578T; HS-578T; Hs_578t; Hs-578-T; HS-578-T; Hs 578.T; HS578T; Hs578T; Hs578t; HS0578T; 578T; HS578; Hs578; Homo sapiens No. 578, tumor cells 67.0 nM GI50 C4194
TKC117617 UACC-257 UACC 257; UACC.257; UACC257; University of Arizona Cell Culture-257 180.0 nM GI50 C3224
TKC117617 786-0 786-o; 786O; 786-0; 786.O; 786-O RCC; RCC 786-O; RCC_7860; RCC 7860; 7860; 786-0WT 46.0 nM GI50 C9385 Orphanet_217071
TKC117617 CCRF-CEM CCRF/CEM; CCRFCEM; CCRF.CEM; CCRF CEM; CCRF; CEM; CEM-CCRF; CEM-CCRF (CAMR); CCRF/CEM/0; CEM/0; CEM-0; CCRF-CEM/S; GM03671; GM03671C 200.0 nM IC50 C7953 Orphanet_99861
TKC117617 NCI-H226 NCI.H226; NCI H226; H226; H-226; HUT-226; HUT 226; NCIH226 288.0 nM GI50 C45662 Orphanet_50251
TKC117617 SK-MEL-28 SK-Mel-28; SK.MEL.28; SK-MEL 28; SK MEL-28; SK MEL 28; SK Mel 28; SKMel-28; SKMEL-28; SK-MEL28; SK-Mel28; SK Mel28; SKMEL28; SKMel28; SKmel28; SKML-28; SK28; AU-Mel; P-36; P36 324.0 nM GI50 C3510
TKC117617 HT-29 HT 29; HT29 99.0 nM GI50 C4349
TKC117617 RXF 393 RXF393L; RXF-393 L; RXF-393; RXF 393; RXF.393; RXF393; RXF 393NL 32.0 nM GI50 C9385 Orphanet_217071
TKC117617 COLO 205 Colo 205; CoLo 205; COLO-205; Colo-205; COLO.205; Colo205; COLO205; Co 205; Colorado 205 236.0 nM GI50 C4349
TKC117617 MCF7 800.0 nM IC50 C4194
TKC117617 HeLa HELA; Hela; He La; He-La; HeLa-CCL2; Henrietta Lacks cells; Helacyton gartleri 200.0 nM IC50 C27677
TKC117617 BJ 100.0 nM IC50

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC117617 Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 TDP1 8200 nM Potency
TKC117617 O75874 Isocitrate dehydrogenase [NADP] cytoplasmic IDH1 1300 nM Potency
TKC117617 P43220 Glucagon-like peptide 1 receptor GLP1R 891 nM Potency
TKC117617 P84022 Mothers against decapentaplegic homolog 3 SMAD3 1995 nM Potency
TKC117617 Q16236 Nuclear factor erythroid 2-related factor 2 NFE2L2 58 nM Potency
TKC117617 Q99700 Ataxin-2 ATXN2 89 nM Potency
TKC117617 Q9UNA4 DNA polymerase iota POLI 89125 nM Potency
TKC117617 O75496 Geminin GMNN 1458 nM Potency
TKC117617 P83916 Chromobox protein homolog 1 CBX1 89125 nM Potency
TKC117617 P63096 Guanine nucleotide-binding protein G GNAI1 50119 nM Potency
TKC117617 Q8IUX4 DNA dC->dU-editing enzyme APOBEC-3F APOBEC3F 15849 nM Potency
TKC117617 P05027 Sodium/potassium-transporting ATPase subunit beta-1 ATP1B1 75 % Activity

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
O75874 IDHC_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
O75874 IDHC_HUMAN Liver cancer [ICD-11: 2C12]
O75874 IDHC_HUMAN Malignant haematopoietic neoplasm [ICD-11: 2B33]
O75874 IDHC_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
O75874 IDHC_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
O75874 IDHC_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P43220 GLP1R_HUMAN Cardiovascular disease [ICD-11: BA00-BE2Z]
P43220 GLP1R_HUMAN Obesity [ICD-11: 5B80-5B81]
P43220 GLP1R_HUMAN Type 2 diabetes mellitus [ICD-11: 5A11]
P43220 GLP1R_HUMAN Type-1/2 diabete [ICD-11: 5A10-5A11]
P43220 GLP1R_HUMAN Acute diabete complication [ICD-11: 5A2Y]
P43220 GLP1R_HUMAN Diabetes mellitus [ICD-11: 5A10]
P43220 GLP1R_HUMAN Dyspepsia [ICD-11: MD92]
P43220 GLP1R_HUMAN Irritable bowel syndrome [ICD-11: DD91]
P43220 GLP1R_HUMAN Intracranial injury [ICD-11: NA07]
P43220 GLP1R_HUMAN Non-alcoholic fatty liver disease [ICD-11: DB92]
P84022 SMAD3_HUMAN Herpes simplex infection [ICD-11: 1F00]
P84022 SMAD3_HUMAN Kidney fibrosis [ICD-11: GC01]
Q16236 NF2L2_HUMAN Ataxic disorder [ICD-11: 8A03]
Q16236 NF2L2_HUMAN Breast cancer [ICD-11: 2C60-2C6Y]
Q16236 NF2L2_HUMAN Glaucoma [ICD-11: 9C61]
Q16236 NF2L2_HUMAN Lung cancer [ICD-11: 2C25]
Q16236 NF2L2_HUMAN Macular degeneration [ICD-11: 9B75]
Q16236 NF2L2_HUMAN Melanoma [ICD-11: 2C30]
Q16236 NF2L2_HUMAN Mental/behavioural/neurodevelopmental disorder [ICD-11: 6E20-6E8Z]
Q16236 NF2L2_HUMAN Pulmonary hypertension [ICD-11: BB01]
Q16236 NF2L2_HUMAN Subarachnoid haemorrhage [ICD-11: 8B01]
Q16236 NF2L2_HUMAN Urinary system clinical sympton [ICD-11: MF8Y]
Q16236 NF2L2_HUMAN Non-alcoholic fatty liver disease [ICD-11: DB92]
Q16236 NF2L2_HUMAN Alpha-1-antitrypsin deficiency [ICD-11: 5C5A]
Q16236 NF2L2_HUMAN Motor neuron disease [ICD-11: 8B60]
Q16236 NF2L2_HUMAN Multiple sclerosis [ICD-11: 8A40]