Basic Information

Terpenoid ID TKC116870
Cell line 0
Protein target 8
DiseaseNCIT 0
ORDO 0
ICD 17

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC116870 M19-MEL M-19; M19 492040.0 nM GI50 C3802
TKC116870 MDA-N MDAN 500035.0 nM GI50 C3802
TKC116870 SN12C SN-12C 495450.0 nM GI50 C9385 Orphanet_217071
TKC116870 NCI-H23 NCI.H23; NCI H23; H-23; H23; NCIH23 490908.0 nM GI50 C3512
TKC116870 ACHN 452898.0 nM GI50 C6975 Orphanet_319298
TKC116870 UO-31 UO.31; UO31; U031 443609.0 nM GI50 C9385 Orphanet_217071
TKC116870 HOP-92 HOP 92; HOP.92; HOP92; Hop92; Hopkins-92 401791.0 nM GI50 C2926
TKC116870 DU-145 DU-145; Du-145; DU 145; DU_145; DU.145; Duke University 145 342768.0 nM GI50 C4863
TKC116870 HL-60 HL 60; HL.60 HL60; Human Leukemia-60 309742.0 nM GI50 C9154 Orphanet_519
TKC116870 SF-539 SF-539; SF-539 BT; SF.539; SF 539 453942.0 nM GI50 C3796 Orphanet_251576
TKC116870 SK-MEL-5 SK-Mel-5; SK MEL 5; SK.MEL.5; SK-MEL5; SKMel-5; SKMEL-5; SKMEL5; SKMel5; SKmel5; AA-Mel 428549.0 nM GI50 C3510
TKC116870 Malme-3M MALME-3M; MALME 3M; Malme-3 M; MALME.3M; Malme3M; MALME3M; Malme-3 Monolayer 479733.0 nM GI50 C3224
TKC116870 A498 A498 346737.0 nM GI50 C9385 Orphanet_217071
TKC116870 K562 K562; K.562; K 562; KO; GM05372; GM05372E 448745.0 nM GI50 C9110 Orphanet_521
TKC116870 OVCAR-3 Ovcar-3; OVCAR 3; OVCAR.3; NIH:OVCAR-3; NIH:Ovcar-3; NIH:OVCAR3; NIH-OVCAR-3; NIHOVCAR3; OVCAR3; Ovcar3 478630.0 nM GI50 C105555
TKC116870 MOLT-4 Molt-4; MOLT 4; Molt 4; MOLT.4; MOLT4; Molt4; GM02219; GM02219C; GM2219C; GM02219D 374973.0 nM GI50 C9142 Orphanet_99861
TKC116870 HOP-62 HOP 62; Hop 62; HOP.62; HOP62; Hop62; Hopkins-62 466659.0 nM GI50 C3512
TKC116870 NCI/ADR-RES NCI/ADR-RES; NCI.ADR.RES; NCIADR.RES; NCI/ADRRES; NCIADRRES; ADR-RES; MCF-7/ADR; MCF-7/ADR-RES; MCF-7/AdrR; MCF-7/Adr; MCF-7/adr; MCF-7ADR; MCF7-ADR; MCF7ADR; OVCAR-8/ADR; OVCAR8/ADR 492040.0 nM GI50 C105555
TKC116870 U-251 U-251 MG; U-251-MG; U-251_MG; U251-MG; U251MG; U-251; U251; U251n; U251N; 251 MG; 251MG; 251 MG(6) 500035.0 nM GI50 C60781 Orphanet_94
TKC116870 OVCAR-8 OVCAR 8; NIH:OVCAR-8; OVCAR8; Ovcar8; OVCAR.8; OVCA8 462381.0 nM GI50 C105555
TKC116870 OVCAR-5 OVCAR 5; NIH:OVCAR-5; OVCAR.5; OVCAR5; Ovcar5; OVCA5 488652.0 nM GI50 C105555
TKC116870 DMS-273 DMS-273; DMS273; Darmouth Medical School 273 489779.0 nM GI50 C4917 Orphanet_70573
TKC116870 MDA-MB-231 MDA_MB_231; MDA-MB 231; MDA.MB.231; MDA MB 231; MDA MB231; MDA Mb231; MDA-MB231; MDAMB-231; MDAMB231; MDA-231; MDA-231P; MDA231; MDA231-BRE; MB231; MD Anderson-Metastatic Breast-231 327341.0 nM GI50 C5214
TKC116870 SNB-19 SNB.19; SNB19; Surgical Neurology Branch-19 500035.0 nM GI50 C60781 Orphanet_94
TKC116870 SR SR-786; SR786 318420.0 nM GI50 C37193 Orphanet_300895
TKC116870 TK-10 TK.10; TK 10; TK10 498884.0 nM GI50 C4033 Orphanet_319276
TKC116870 SW-620 SW-620; SW 620; SW.620 486407.0 nM GI50 C4349
TKC116870 NCI-H522 NCI.H522; H522; H-522; NCI-522; NCI522; NCIH522 319890.0 nM GI50 C3512
TKC116870 KM12 KM-12; KM.12 500035.0 nM GI50 C4910
TKC116870 XF498 XF-498; XF498 245471.0 nM GI50 C3058 Orphanet_360
TKC116870 M14 M14-MEL; UCLA-SO-M14; UCLA SO M14; UCLA-SO-14; UCLASO-M14; Melanoma 14; M-14 500035.0 nM GI50 C3802
TKC116870 NCI-H322M NCI.H322M; H322M; H-322M; H-322m 421697.0 nM GI50 C2923
TKC116870 RPMI-8226 RPMI 8226; RPMI.8226; RPMI8226; RPMI no. 8226; RPMI no 8226; RPMI #8226; 8226; RPMI 8226/S; RPMI-8226S; RPMI8226/S; 8226/S; Roswell Park Memorial Institute 8226; GM02132; GM2132; GM 2132; GM02132C; Simpson 449780.0 nM GI50 C3242 Orphanet_29073
TKC116870 OVCAR-4 OVCAR 4; NIH:OVCAR-4; NIH:OVCAR4; OVCAR.4; OVCAR4; Ovcar4 486407.0 nM GI50 C105555
TKC116870 LOX IMVI LOX/IMVI; LOX IMVI; LOXIM-VI; LOXIMVI; LOX 492040.0 nM GI50 C3802
TKC116870 BT-549 BT 549; BT.549; BT549 236592.0 nM GI50 C4194
TKC116870 P388 P-388 161808.0 nM GI50 C21602
TKC116870 KM-20L2 KM-20L2; KM 20L2; KM 2012 456037.0 nM GI50 C4349
TKC116870 SK-MEL-2 SK-Mel-2; SK-Mel 2; SK-mel-2; SK-MEL2; SK.MEL.2; SK Mel 2; SK MEL 2; SKMEL-2; SKMEL2; SKmel2; SK-ML2; SKml2 477529.0 nM GI50 C3224
TKC116870 HCC 2998 HCC-2998; HCC.2998; HCC 2998; Hamon Cancer Center 2998 371535.0 nM GI50 C4349
TKC116870 A549 446684.0 nM GI50 C3512
TKC116870 SNB-75 SNB.75; SNB75; Surgical Neurology Branch-75 292415.0 nM GI50 C3058 Orphanet_360
TKC116870 HCT-15 HCT-15; HCT.15; HCT15 487528.0 nM GI50 C4349
TKC116870 HCT-116 HCT-116; HCT.116; HCT_116; HCT116; HCT116wt; CoCL2 465586.0 nM GI50 C4910
TKC116870 SF-268 SF-268; SF.268; SF 268 488652.0 nM GI50 C60781 Orphanet_94
TKC116870 EKVX 318420.0 nM GI50 C3512
TKC116870 PC-3 PC3; PC.3 500035.0 nM GI50 C4863
TKC116870 MCF7 457088.0 nM GI50 C4194
TKC116870 SK-OV-3 SKOV-3; SK-OV3; SK.OV.3; SKOV3; Skov3; SKO3 478630.0 nM GI50 C7978
TKC116870 LXFL 529 LXFL-529L; LXFL529L; LXF 529 L; LXFL-529; LXFL 529; LXFL529; LXF 529 500035.0 nM GI50 C2926
TKC116870 DMS-114 DMS-114; DMS114; Darmouth Medical School 114 375837.0 nM GI50 C4917 Orphanet_70573
TKC116870 T47D 336512.0 nM GI50 C4194
TKC116870 NCI-H460 NCI.H460; H460; H-460; NCIH460; NCI-HUT-460; NCI-460 484172.0 nM GI50 C4450
TKC116870 CAKI-1 CAL 1; Centre Antoine Lacassagne-1 372392.0 nM GI50 C3224
TKC116870 UACC-62 UACC 62; UACC.62; UACC62; University of Arizona Cell Culture-62 322849.0 nM GI50 C3224
TKC116870 MDA-MB-435 MDA-MB435; MDAMB435; MDA.MB.435; MDA-435; MDA 435; MDA435; MD Anderson-Metastatic Breast-435 500035.0 nM GI50 C3802
TKC116870 P388/ADR 160694.0 nM GI50 C21602
TKC116870 SF-295 SF-295; SF.295; SF 295 500035.0 nM GI50 C3058 Orphanet_360
TKC116870 IGROV-1 Igrov-1; IGROV 1; IGR-OV1; IGROV1; Igrov1; IGR.OV1; IGROV; OV1/P; OV1/p; OV1-P 452898.0 nM GI50 C7979 Orphanet_454723
TKC116870 Hs-578T HS 578T; Hs-578T; HS-578T; Hs_578t; Hs-578-T; HS-578-T; Hs 578.T; HS578T; Hs578T; Hs578t; HS0578T; 578T; HS578; Hs578; Homo sapiens No. 578, tumor cells 319154.0 nM GI50 C4194
TKC116870 786-0 786-o; 786O; 786-0; 786.O; 786-O RCC; RCC 786-O; RCC_7860; RCC 7860; 7860; 786-0WT 500035.0 nM GI50 C9385 Orphanet_217071
TKC116870 RXF 631 RXF-631L; RXF631L; RXF 631; RXF-631; RXF631 472063.0 nM GI50 C9385 Orphanet_217071
TKC116870 UACC-257 UACC 257; UACC.257; UACC257; University of Arizona Cell Culture-257 389045.0 nM GI50 C3224
TKC116870 SNB-78 SNB78; Surgical Neurology Branch-78 460257.0 nM GI50 C3058 Orphanet_360
TKC116870 DLD-1 DLD 1; DLD1; CoCL3 500035.0 nM GI50 C4349
TKC116870 CCRF-CEM CCRF/CEM; CCRFCEM; CCRF.CEM; CCRF CEM; CCRF; CEM; CEM-CCRF; CEM-CCRF (CAMR); CCRF/CEM/0; CEM/0; CEM-0; CCRF-CEM/S; GM03671; GM03671C 430527.0 nM GI50 C7953 Orphanet_99861
TKC116870 NCI-H226 NCI.H226; NCI H226; H226; H-226; HUT-226; HUT 226; NCIH226 416869.0 nM GI50 C45662 Orphanet_50251
TKC116870 HT-29 HT 29; HT29 493174.0 nM GI50 C4349
TKC116870 SK-MEL-28 SK-Mel-28; SK.MEL.28; SK-MEL 28; SK MEL-28; SK MEL 28; SK Mel 28; SKMel-28; SKMEL-28; SK-MEL28; SK-Mel28; SK Mel28; SKMEL28; SKMel28; SKmel28; SKML-28; SK28; AU-Mel; P-36; P36 497737.0 nM GI50 C3510
TKC116870 RXF 393 RXF393L; RXF-393 L; RXF-393; RXF 393; RXF.393; RXF393; RXF 393NL 436516.0 nM GI50 C9385 Orphanet_217071
TKC116870 COLO 205 Colo 205; CoLo 205; COLO-205; Colo-205; COLO.205; Colo205; COLO205; Co 205; Colorado 205 479733.0 nM GI50 C4349
TKC116870 HOP-18 HOP 18; Hop 18; HOP18; Hop18; Hopkins-18 98401.0 nM GI50 C4450
TKC116870 SN12K1 458142.0 nM GI50 C9385 Orphanet_217071

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC116870 P10636 Microtubule-associated protein tau MAPT 8913 nM Potency
TKC116870 Q77YF9 Protein Vpr vpr 79433 nM Potency
TKC116870 P11511 Aromatase CYP19A1 35000 nM Ki
TKC116870 P11511 Aromatase CYP19A1 35000 nM Ki
TKC116870 O75496 Geminin GMNN 29093 nM Potency
TKC116870 P0DTD1 Replicase polyprotein 1ab rep 14 % Inhibition
TKC116870 P00811 Beta-lactamase ampC 631 nM Potency
TKC116870 Q96KQ7 Histone-lysine N-methyltransferase EHMT2 EHMT2 316 nM Potency
TKC116870 O94925 Glutaminase kidney isoform, mitochondrial GLS 35481 nM Potency
TKC116870 P02545 Prelamin-A/C LMNA 35481 nM Potency
TKC116870 P22443 Aromatase Cyp19a1 16 % Inhibition

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
P10636 TAU_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
P10636 TAU_HUMAN Alzheimer disease [ICD-11: 8A20]
P10636 TAU_HUMAN Mild neurocognitive disorder [ICD-11: 6D71]
P10636 TAU_HUMAN Choreiform disorder [ICD-11: 8A01]
P10636 TAU_HUMAN Parkinsonism [ICD-11: 8A00]
P10636 TAU_HUMAN Central nervous system disease [ICD-11: 8A04-8D87]
P10636 TAU_HUMAN Neurodegenerative disorder [ICD-11: 8A20-8A23]
P11511 CP19A_HUMAN Breast cancer [ICD-11: 2C60-2C6Y]
P11511 CP19A_HUMAN Cushing syndrome [ICD-11: 5A70]
P11511 CP19A_HUMAN Oesophagitis [ICD-11: DA24]
P11511 CP19A_HUMAN Endometriosis [ICD-11: GA10]
P11511 CP19A_HUMAN Neuropathy [ICD-11: 8C0Z]
P11511 CP19A_HUMAN Bladder cancer [ICD-11: 2C94]
P11511 CP19A_HUMAN Prostate disease [ICD-11: GA91]
P11511 CP19A_HUMAN Breast cancer [ICD-11: 2C60-2C6Y]
P11511 CP19A_HUMAN Cushing syndrome [ICD-11: 5A70]
P11511 CP19A_HUMAN Oesophagitis [ICD-11: DA24]
P11511 CP19A_HUMAN Endometriosis [ICD-11: GA10]
P11511 CP19A_HUMAN Neuropathy [ICD-11: 8C0Z]
P11511 CP19A_HUMAN Bladder cancer [ICD-11: 2C94]
P11511 CP19A_HUMAN Prostate disease [ICD-11: GA91]
Q96KQ7 EHMT2_HUMAN Breast cancer [ICD-11: 2C60-2C6Y]
Q96KQ7 EHMT2_HUMAN Postoperative inflammation [ICD-11: 1A00-CA43]
Q96KQ7 EHMT2_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]