Basic Information
| Terpenoid ID | TKC113063 |
|
| Chirality | TKC206776 | |
| Cell line | 0 | |
| Protein target | 26 | |
| DiseaseNCIT | 0 | |
| ORDO | 0 | |
| ICD | 56 |
| Terpenoid ID | TKC113063 |
|
| Chirality | TKC206776 | |
| Cell line | 0 | |
| Protein target | 26 | |
| DiseaseNCIT | 0 | |
| ORDO | 0 | |
| ICD | 56 |
| ID | Cell Line | Synonyms | Value | Unit | Type | NCIt | ORDO |
|---|---|---|---|---|---|---|---|
| TKC113063 | INS1 | INS1 | 7489.0 | nM | AC50 | C121566 | |
| TKC113063 | HepG2 | 35481.0 | nM | Potency | C3728 | Orphanet_449 | |
| TKC113063 | NCI-H23 | NCI.H23; NCI H23; H-23; H23; NCIH23 | 221.0 | nM | GI50 | C3512 | |
| TKC113063 | ACHN | 2000.0 | nM | IC50 | C6975 | Orphanet_319298 | |
| TKC113063 | UO-31 | UO.31; UO31; U031 | 1089.0 | nM | GI50 | C9385 | Orphanet_217071 |
| TKC113063 | HOP-92 | HOP 92; HOP.92; HOP92; Hop92; Hopkins-92 | 467.0 | nM | GI50 | C2926 | |
| TKC113063 | HL-60 | HL 60; HL.60 HL60; Human Leukemia-60 | 39.0 | nM | GI50 | C9154 | Orphanet_519 |
| TKC113063 | SF-539 | SF-539; SF-539 BT; SF.539; SF 539 | 1343.0 | nM | GI50 | C3796 | Orphanet_251576 |
| TKC113063 | Malme-3M | MALME-3M; MALME 3M; Malme-3 M; MALME.3M; Malme3M; MALME3M; Malme-3 Monolayer | 243.0 | nM | GI50 | C3224 | |
| TKC113063 | SK-MEL-5 | SK-Mel-5; SK MEL 5; SK.MEL.5; SK-MEL5; SKMel-5; SKMEL-5; SKMEL5; SKMel5; SKmel5; AA-Mel | 1679.0 | nM | GI50 | C3510 | |
| TKC113063 | K562 | K562; K.562; K 562; KO; GM05372; GM05372E | 193.0 | nM | GI50 | C9110 | Orphanet_521 |
| TKC113063 | OVCAR-3 | Ovcar-3; OVCAR 3; OVCAR.3; NIH:OVCAR-3; NIH:Ovcar-3; NIH:OVCAR3; NIH-OVCAR-3; NIHOVCAR3; OVCAR3; Ovcar3 | 1054.0 | nM | GI50 | C105555 | |
| TKC113063 | HOP-62 | HOP 62; Hop 62; HOP.62; HOP62; Hop62; Hopkins-62 | 2042.0 | nM | GI50 | C3512 | |
| TKC113063 | MOLT-4 | Molt-4; MOLT 4; Molt 4; MOLT.4; MOLT4; Molt4; GM02219; GM02219C; GM2219C; GM02219D | 187.0 | nM | GI50 | C9142 | Orphanet_99861 |
| TKC113063 | U-251 | U-251 MG; U-251-MG; U-251_MG; U251-MG; U251MG; U-251; U251; U251n; U251N; 251 MG; 251MG; 251 MG(6) | 247.0 | nM | GI50 | C60781 | Orphanet_94 |
| TKC113063 | OVCAR-8 | OVCAR 8; NIH:OVCAR-8; OVCAR8; Ovcar8; OVCAR.8; OVCA8 | 374.0 | nM | GI50 | C105555 | |
| TKC113063 | OVCAR-5 | OVCAR 5; NIH:OVCAR-5; OVCAR.5; OVCAR5; Ovcar5; OVCA5 | 1910.0 | nM | GI50 | C105555 | |
| TKC113063 | DMS-273 | DMS-273; DMS273; Darmouth Medical School 273 | 405.0 | nM | GI50 | C4917 | Orphanet_70573 |
| TKC113063 | SNB-19 | SNB.19; SNB19; Surgical Neurology Branch-19 | 2985.0 | nM | GI50 | C60781 | Orphanet_94 |
| TKC113063 | SR | SR-786; SR786 | 189.0 | nM | GI50 | C37193 | Orphanet_300895 |
| TKC113063 | TK-10 | TK.10; TK 10; TK10 | 641.0 | nM | GI50 | C4033 | Orphanet_319276 |
| TKC113063 | M19-MEL | M-19; M19 | 1500.0 | nM | GI50 | C3802 | |
| TKC113063 | SW-620 | SW-620; SW 620; SW.620 | 199.0 | nM | GI50 | C4349 | |
| TKC113063 | KM12 | KM-12; KM.12 | 3724.0 | nM | GI50 | C4910 | |
| TKC113063 | NCI-H522 | NCI.H522; H522; H-522; NCI-522; NCI522; NCIH522 | 34.0 | nM | GI50 | C3512 | |
| TKC113063 | M14 | M14-MEL; UCLA-SO-M14; UCLA SO M14; UCLA-SO-14; UCLASO-M14; Melanoma 14; M-14 | 423.0 | nM | GI50 | C3802 | |
| TKC113063 | XF498 | XF-498; XF498 | 1426.0 | nM | GI50 | C3058 | Orphanet_360 |
| TKC113063 | NCI-H322M | NCI.H322M; H322M; H-322M; H-322m | 4634.0 | nM | GI50 | C2923 | |
| TKC113063 | RPMI-8226 | RPMI 8226; RPMI.8226; RPMI8226; RPMI no. 8226; RPMI no 8226; RPMI #8226; 8226; RPMI 8226/S; RPMI-8226S; RPMI8226/S; 8226/S; Roswell Park Memorial Institute 8226; GM02132; GM2132; GM 2132; GM02132C; Simpson | 247.0 | nM | GI50 | C3242 | Orphanet_29073 |
| TKC113063 | OVCAR-4 | OVCAR 4; NIH:OVCAR-4; NIH:OVCAR4; OVCAR.4; OVCAR4; Ovcar4 | 566.0 | nM | GI50 | C105555 | |
| TKC113063 | SK-MEL-2 | SK-Mel-2; SK-Mel 2; SK-mel-2; SK-MEL2; SK.MEL.2; SK Mel 2; SK MEL 2; SKMEL-2; SKMEL2; SKmel2; SK-ML2; SKml2 | 601.0 | nM | GI50 | C3224 | |
| TKC113063 | KM-20L2 | KM-20L2; KM 20L2; KM 2012 | 392.0 | nM | GI50 | C4349 | |
| TKC113063 | A549 | 10100.0 | nM | IC50 | C3512 | ||
| TKC113063 | SNB-75 | SNB.75; SNB75; Surgical Neurology Branch-75 | 4112.0 | nM | GI50 | C3058 | Orphanet_360 |
| TKC113063 | HCC 2998 | HCC-2998; HCC.2998; HCC 2998; Hamon Cancer Center 2998 | 509.0 | nM | GI50 | C4349 | |
| TKC113063 | HCT-15 | HCT-15; HCT.15; HCT15 | 446.0 | nM | GI50 | C4349 | |
| TKC113063 | HCT-116 | HCT-116; HCT.116; HCT_116; HCT116; HCT116wt; CoCL2 | 282.0 | nM | GI50 | C4910 | |
| TKC113063 | SF-268 | SF-268; SF.268; SF 268 | 400.0 | nM | IC50 | C60781 | Orphanet_94 |
| TKC113063 | DMS-114 | DMS-114; DMS114; Darmouth Medical School 114 | 478.0 | nM | GI50 | C4917 | Orphanet_70573 |
| TKC113063 | LXFL 529 | LXFL-529L; LXFL529L; LXF 529 L; LXFL-529; LXFL 529; LXFL529; LXF 529 | 333.0 | nM | GI50 | C2926 | |
| TKC113063 | UACC-62 | UACC 62; UACC.62; UACC62; University of Arizona Cell Culture-62 | 1445.0 | nM | GI50 | C3224 | |
| TKC113063 | NCI-H460 | NCI.H460; H460; H-460; NCIH460; NCI-HUT-460; NCI-460 | 400.0 | nM | IC50 | C4450 | |
| TKC113063 | CAKI-1 | CAL 1; Centre Antoine Lacassagne-1 | 463.0 | nM | GI50 | C3224 | |
| TKC113063 | SF-295 | SF-295; SF.295; SF 295 | 4217.0 | nM | GI50 | C3058 | Orphanet_360 |
| TKC113063 | IGROV-1 | Igrov-1; IGROV 1; IGR-OV1; IGROV1; Igrov1; IGR.OV1; IGROV; OV1/P; OV1/p; OV1-P | 1164.0 | nM | GI50 | C7979 | Orphanet_454723 |
| TKC113063 | UACC-257 | UACC 257; UACC.257; UACC257; University of Arizona Cell Culture-257 | 1592.0 | nM | GI50 | C3224 | |
| TKC113063 | 786-0 | 786-o; 786O; 786-0; 786.O; 786-O RCC; RCC 786-O; RCC_7860; RCC 7860; 7860; 786-0WT | 401.0 | nM | GI50 | C9385 | Orphanet_217071 |
| TKC113063 | DLD-1 | DLD 1; DLD1; CoCL3 | 303.0 | nM | GI50 | C4349 | |
| TKC113063 | CCRF-CEM | CCRF/CEM; CCRFCEM; CCRF.CEM; CCRF CEM; CCRF; CEM; CEM-CCRF; CEM-CCRF (CAMR); CCRF/CEM/0; CEM/0; CEM-0; CCRF-CEM/S; GM03671; GM03671C | 113.0 | nM | GI50 | C7953 | Orphanet_99861 |
| TKC113063 | NCI-H226 | NCI.H226; NCI H226; H226; H-226; HUT-226; HUT 226; NCIH226 | 1300.0 | nM | GI50 | C45662 | Orphanet_50251 |
| TKC113063 | HT-29 | HT 29; HT29 | 417.0 | nM | GI50 | C4349 | |
| TKC113063 | SK-MEL-28 | SK-Mel-28; SK.MEL.28; SK-MEL 28; SK MEL-28; SK MEL 28; SK Mel 28; SKMel-28; SKMEL-28; SK-MEL28; SK-Mel28; SK Mel28; SKMEL28; SKMel28; SKmel28; SKML-28; SK28; AU-Mel; P-36; P36 | 550.0 | nM | GI50 | C3510 | |
| TKC113063 | COLO 205 | Colo 205; CoLo 205; COLO-205; Colo-205; COLO.205; Colo205; COLO205; Co 205; Colorado 205 | 406.0 | nM | GI50 | C4349 | |
| TKC113063 | TIG-3 | TIG3; Tig3; Tokyo Institute of Gerontology-3 | 90.0 | % | Activity | ||
| TKC113063 | WI-38 | Wi-38; WI 38; WI38; Wistar Institute-38; AG06814E; AG06814G; AG06814H; AG06814-J; AG06814J; AG06814-M; AG06814-N | 90.0 | % | Activity | ||
| TKC113063 | HeLa | HELA; Hela; He La; He-La; HeLa-CCL2; Henrietta Lacks cells; Helacyton gartleri | 3000.0 | nM | IC50 | C27677 | |
| TKC113063 | MCF7 | 570.0 | nM | IC50 | C4194 | ||
| TKC113063 | Vero | VERO; VeroCCL81; Vero 81; Vero-81; Verda reno | 1300.0 | nM | IC50 | ||
| TKC113063 | HEK-293T | Hek293T; HEK-293T; HEK 293T; HEK-293-T; HEK 293 T; 293-T; 293 T; 293T; Human Embryonic Kidney 293T; 293tsA1609neo | 299.0 | nM | IC50 | ||
| TKC113063 | A2780 | A-2780; 2780; A2780S; A2780par | 33.0 | nM | IC50 | C7979 | Orphanet_454723 |
| TKC113063 | ARPE-19 | ARPE19; Adult Retinal Pigment Epithelial cell line-19; NTC-200; NTC200 | 37.0 | nM | IC50 | ||
| TKC113063 | PANC-1 | Panc-1; PANC.1; Panc 1; PanC1; Panc1; PANC1; Panc-1-P | 1240.0 | nM | IC50 | C9120 | |
| TKC113063 | MIA PaCa-2 | MIA-PaCa-2; MIA-PACA-2; MIA-Pa-Ca-2; MIA Paca2; MIA PaCa2; MiaPaCa-2; MIAPACA-2; MiaPaca.2; MiaPaCa2; Miapaca2; MIAPaCa2; MIAPACA2; Mia PACA 2; MIAPaCa-2; PaCa2; MiaPaCa | 2930.0 | nM | IC50 | C9120 | |
| TKC113063 | BXPC-3 | BxPc-3; BXPC-3; Bx-PC3; BXPC3; BxPC3; BxPc3; Biopsy xenograft of Pancreatic Carcinoma line-3 | 2780.0 | nM | IC50 | C9120 | |
| TKC113063 | LNCaP | LNCAP; LNCap; Ln-Cap; Lymph Node Carcinoma of the prostate | 870.0 | nM | IC50 | C4863 | |
| TKC113063 | PC-3M | PC3-M; PC-3/M; PC3M; Pc3M | 410.0 | nM | IC50 | C4863 | |
| TKC113063 | Huh-7 | HuH-7; HUH-7; HuH7; Huh7; HUH7; HUH7.0; JTC-39; Japanese Tissue Culture-39 | 3630.0 | nM | CC50 | C7956 | Orphanet_210159 |
| ID | Uniport | Pref_name | Gene name | value | unit | type |
|---|---|---|---|---|---|---|
| TKC113063 | P10636 | Microtubule-associated protein tau | MAPT | 39811 | nM | Potency |
| TKC113063 | P11473 | Vitamin D3 receptor | VDR | 5805 | nM | Potency |
| TKC113063 | Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | TDP1 | 1300 | nM | Potency |
| TKC113063 | O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | IDH1 | 20596 | nM | Potency |
| TKC113063 | O95398 | Rap guanine nucleotide exchange factor 3 | RAPGEF3 | 70795 | nM | Potency |
| TKC113063 | P84022 | Mothers against decapentaplegic homolog 3 | SMAD3 | 581 | nM | Potency |
| TKC113063 | Q03431 | Parathyroid hormone/parathyroid hormone-related peptide receptor | PTH1R | 8913 | nM | Potency |
| TKC113063 | Q14191 | Werner syndrome ATP-dependent helicase | WRN | 50119 | nM | Potency |
| TKC113063 | Q16236 | Nuclear factor erythroid 2-related factor 2 | NFE2L2 | 12995 | nM | Potency |
| TKC113063 | Q932Y6 | Beta-lactamase | bla(tem-2) | 49766 | nM | IC50 |
| TKC113063 | Q99700 | Ataxin-2 | ATXN2 | 5623 | nM | Potency |
| TKC113063 | O43353 | Receptor-interacting serine/threonine-protein kinase 2 | RIPK2 | 2654 | nM | IC50 |
| TKC113063 | P27695 | DNA-(apurinic or apyrimidinic site) endonuclease | APEX1 | 28184 | nM | Potency |
| TKC113063 | Q9UNA4 | DNA polymerase iota | POLI | 12589 | nM | Potency |
| TKC113063 | O75496 | Geminin | GMNN | 517 | nM | Potency |
| TKC113063 | P01215 | Glycoprotein hormones alpha chain | CGA | 17783 | nM | Potency |
| TKC113063 | P32245 | Melanocortin receptor 4 | MC4R | >64575 | nM | IC50 |
| TKC113063 | Q96QE3 | ATPase family AAA domain-containing protein 5 | ATAD5 | 9196 | nM | Potency |
| TKC113063 | Q6W5P4 | Neuropeptide S receptor | NPSR1 | 5012 | nM | Potency |
| TKC113063 | Q9F4F7 | 4'-phosphopantetheinyl transferase ffp | ffp | 56234 | nM | Potency |
| TKC113063 | P06746 | DNA polymerase beta | POLB | 50119 | nM | Potency |
| TKC113063 | P49798 | Regulator of G-protein signaling 4 | RGS4 | 50119 | nM | Potency |
| TKC113063 | Q9Y253 | DNA polymerase eta | POLH | 50119 | nM | Potency |
| TKC113063 | P51450 | Nuclear receptor ROR-gamma | Rorc | 891 | nM | Potency |
| TKC113063 | P04798 | Cytochrome P450 1A1 | CYP1A1 | 50 | % | Inhibition |
| TKC113063 | P42858 | Huntingtin | HTT | 316 | nM | Potency |
| TKC113063 | O15118 | NPC intracellular cholesterol transporter 1 | NPC1 | 3162 | nM | Potency |
| TKC113063 | P51151 | Ras-related protein Rab-9A | RAB9A | 3548 | nM | Potency |
| TKC113063 | P17861 | X-box-binding protein 1 | XBP1 | >10000 | nM | IC50 |
| TKC113063 | P35639 | DNA damage-inducible transcript 3 protein | Ddit3 | >10000 | nM | IC50 |
| TKC113063 | P35639 | DNA damage-inducible transcript 3 protein | Ddit3 | >10000 | nM | IC50 |
| Uniport ID | Uniport Name | ICD-11 |
|---|---|---|
| P10636 | TAU_HUMAN | Acute myeloid leukaemia [ICD-11: 2A60] |
| P10636 | TAU_HUMAN | Alzheimer disease [ICD-11: 8A20] |
| P10636 | TAU_HUMAN | Mild neurocognitive disorder [ICD-11: 6D71] |
| P10636 | TAU_HUMAN | Choreiform disorder [ICD-11: 8A01] |
| P10636 | TAU_HUMAN | Parkinsonism [ICD-11: 8A00] |
| P10636 | TAU_HUMAN | Central nervous system disease [ICD-11: 8A04-8D87] |
| P10636 | TAU_HUMAN | Neurodegenerative disorder [ICD-11: 8A20-8A23] |
| P11473 | VDR_HUMAN | Chronic kidney disease [ICD-11: GB61] |
| P11473 | VDR_HUMAN | Hair/hair growth developmental defect [ICD-11: LC30] |
| P11473 | VDR_HUMAN | Hyper-parathyroidism [ICD-11: 5A51] |
| P11473 | VDR_HUMAN | Hypo-parathyroidism [ICD-11: 5A50] |
| P11473 | VDR_HUMAN | Mineral deficiency [ICD-11: 5B5K] |
| P11473 | VDR_HUMAN | Psoriasis [ICD-11: EA90] |
| P11473 | VDR_HUMAN | Vitamin deficiency [ICD-11: 5B55-5B5F] |
| P11473 | VDR_HUMAN | Low bone mass disorder [ICD-11: FB83] |
| P11473 | VDR_HUMAN | Acute myeloid leukaemia [ICD-11: 2A60] |
| P11473 | VDR_HUMAN | Prostate cancer [ICD-11: 2C82] |
| P11473 | VDR_HUMAN | Prostate disease [ICD-11: GA91] |
| P11473 | VDR_HUMAN | Abnormal micturition [ICD-11: MF50] |
| P11473 | VDR_HUMAN | Solid tumour/cancer [ICD-11: 2A00-2F9Z] |
| P11473 | VDR_HUMAN | Postoperative inflammation [ICD-11: 1A00-CA43] |
| P11473 | VDR_HUMAN | Acne vulgaris [ICD-11: ED80] |
| O75874 | IDHC_HUMAN | Acute myeloid leukaemia [ICD-11: 2A60] |
| O75874 | IDHC_HUMAN | Liver cancer [ICD-11: 2C12] |
| O75874 | IDHC_HUMAN | Malignant haematopoietic neoplasm [ICD-11: 2B33] |
| O75874 | IDHC_HUMAN | Solid tumour/cancer [ICD-11: 2A00-2F9Z] |
| O75874 | IDHC_HUMAN | Acute myeloid leukaemia [ICD-11: 2A60] |
| O75874 | IDHC_HUMAN | Solid tumour/cancer [ICD-11: 2A00-2F9Z] |
| O95398 | RPGF3_HUMAN | Epidermal dysplasias [ICD-11: EK90] |
| P84022 | SMAD3_HUMAN | Herpes simplex infection [ICD-11: 1F00] |
| P84022 | SMAD3_HUMAN | Kidney fibrosis [ICD-11: GC01] |
| Q03431 | PTH1R_HUMAN | Low bone mass disorder [ICD-11: FB83] |
| Q03431 | PTH1R_HUMAN | Hypo-parathyroidism [ICD-11: 5A50] |
| Q14191 | WRN_HUMAN | Mature T-cell lymphoma [ICD-11: 2A90] |
| Q16236 | NF2L2_HUMAN | Ataxic disorder [ICD-11: 8A03] |
| Q16236 | NF2L2_HUMAN | Breast cancer [ICD-11: 2C60-2C6Y] |
| Q16236 | NF2L2_HUMAN | Glaucoma [ICD-11: 9C61] |
| Q16236 | NF2L2_HUMAN | Lung cancer [ICD-11: 2C25] |
| Q16236 | NF2L2_HUMAN | Macular degeneration [ICD-11: 9B75] |
| Q16236 | NF2L2_HUMAN | Melanoma [ICD-11: 2C30] |
| Q16236 | NF2L2_HUMAN | Mental/behavioural/neurodevelopmental disorder [ICD-11: 6E20-6E8Z] |
| Q16236 | NF2L2_HUMAN | Pulmonary hypertension [ICD-11: BB01] |
| Q16236 | NF2L2_HUMAN | Subarachnoid haemorrhage [ICD-11: 8B01] |
| Q16236 | NF2L2_HUMAN | Urinary system clinical sympton [ICD-11: MF8Y] |
| Q16236 | NF2L2_HUMAN | Non-alcoholic fatty liver disease [ICD-11: DB92] |
| Q16236 | NF2L2_HUMAN | Alpha-1-antitrypsin deficiency [ICD-11: 5C5A] |
| Q16236 | NF2L2_HUMAN | Motor neuron disease [ICD-11: 8B60] |
| Q16236 | NF2L2_HUMAN | Multiple sclerosis [ICD-11: 8A40] |
| O43353 | RIPK2_HUMAN | Cardiovascular disease [ICD-11: BA00-BE2Z] |
| O43353 | RIPK2_HUMAN | Postoperative inflammation [ICD-11: 1A00-CA43] |
| P27695 | APEX1_HUMAN | Retinopathy [ICD-11: 9B71] |
| P27695 | APEX1_HUMAN | Solid tumour/cancer [ICD-11: 2A00-2F9Z] |
| P27695 | APEX1_HUMAN | Ocular cancer [ICD-11: 2D00-2D07] |
| P27695 | APEX1_HUMAN | Brain cancer [ICD-11: 2A00] |
| P27695 | APEX1_HUMAN | Melanoma [ICD-11: 2C30] |
| P32245 | MC4R_HUMAN | Acute diabete complication [ICD-11: 5A2Y] |
| P32245 | MC4R_HUMAN | Hypoactive sexual desire dysfunction [ICD-11: HA00] |
| P32245 | MC4R_HUMAN | Intellectual development disorder [ICD-11: LD90] |
| P32245 | MC4R_HUMAN | Large intestine motility disorder [ICD-11: DB32] |
| P32245 | MC4R_HUMAN | Obesity [ICD-11: 5B80-5B81] |
| P32245 | MC4R_HUMAN | Pituitary hypofunction [ICD-11: 5A61] |
| P32245 | MC4R_HUMAN | Sexual dysfunction [ICD-11: HA00-HA01] |
| P32245 | MC4R_HUMAN | Alzheimer disease [ICD-11: 8A20] |
| P32245 | MC4R_HUMAN | Asthma [ICD-11: CA23] |
| P32245 | MC4R_HUMAN | Breast cancer [ICD-11: 2C60-2C6Y] |
| P32245 | MC4R_HUMAN | General pain disorder [ICD-11: 8E43] |
| P32245 | MC4R_HUMAN | Atopic eczema [ICD-11: EA80] |
| P32245 | MC4R_HUMAN | Metabolic disorder [ICD-11: 5C50-5D2Z] |
| P32245 | MC4R_HUMAN | Type 2 diabetes mellitus [ICD-11: 5A11] |
| P32245 | MC4R_HUMAN | Anorexia nervosa [ICD-11: 6B80] |
| P32245 | MC4R_HUMAN | Cachexia [ICD-11: MG20] |
| P06746 | DPOLB_HUMAN | Solid tumour/cancer [ICD-11: 2A00-2F9Z] |
| P42858 | HD_HUMAN | Choreiform disorder [ICD-11: 8A01] |
| P51151 | RAB9A_HUMAN | Fungal infection [ICD-11: 1F29-1F2F] |