Basic Information

Terpenoid ID TKC110956
Cell line 0
Protein target 10
DiseaseNCIT 0
ORDO 0
ICD 23

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC110956 Bel-7402 Bel-7402; BEL 7402; Bel 7402; BEL7402; Bel7402 1210.0 nM IC50 C27677
TKC110956 Jurkat JURKAT; JM; JM-Jurkat; Jurkat-FHCRC; Jurkat FHCRC; FHCRC-11; FHCRC subclone 11; FCCH1024 3190.0 nM IC50 C7953 Orphanet_99861
TKC110956 HepG2 1259.0 nM Potency C3728 Orphanet_449

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC110956 Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 TDP1 3663 nM Potency
TKC110956 P08684 Cytochrome P450 3A4 CYP3A4 26 pmol/min Drug metabolism
TKC110956 O75874 Isocitrate dehydrogenase [NADP] cytoplasmic IDH1 820 nM Potency
TKC110956 P84022 Mothers against decapentaplegic homolog 3 SMAD3 3548 nM Potency
TKC110956 Q03431 Parathyroid hormone/parathyroid hormone-related peptide receptor PTH1R 44668 nM Potency
TKC110956 Q16236 Nuclear factor erythroid 2-related factor 2 NFE2L2 58 nM Potency
TKC110956 Q99700 Ataxin-2 ATXN2 224 nM Potency
TKC110956 P05177 Cytochrome P450 1A2 CYP1A2 <0 pmol/min Drug metabolism
TKC110956 P05181 Cytochrome P450 2E1 CYP2E1 <0 pmol/min Drug metabolism
TKC110956 P10635 Cytochrome P450 2D6 CYP2D6 <0 pmol/min Drug metabolism
TKC110956 P11509 Cytochrome P450 2A6 CYP2A6 <0 pmol/min Drug metabolism
TKC110956 P11712 Cytochrome P450 2C9 CYP2C9 <0 pmol/min Drug metabolism
TKC110956 P33261 Cytochrome P450 2C19 CYP2C19 <0 pmol/min Drug metabolism
TKC110956 Q96QE3 ATPase family AAA domain-containing protein 5 ATAD5 1835 nM Potency
TKC110956 O94925 Glutaminase kidney isoform, mitochondrial GLS 35481 nM Potency
TKC110956 P10632 Cytochrome P450 2C8 CYP2C8 <0 pmol/min Drug metabolism
TKC110956 P20813 Cytochrome P450 2B6 CYP2B6 <0 pmol/min Drug metabolism
TKC110956 O15118 NPC intracellular cholesterol transporter 1 NPC1 1259 nM Potency
TKC110956 P51151 Ras-related protein Rab-9A RAB9A 1122 nM Potency

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
P08684 CP3A4_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P08684 CP3A4_HUMAN Atopic eczema [ICD-11: EA80]
P08684 CP3A4_HUMAN Anxiety disorder [ICD-11: 6B00-6B0Z]
O75874 IDHC_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
O75874 IDHC_HUMAN Liver cancer [ICD-11: 2C12]
O75874 IDHC_HUMAN Malignant haematopoietic neoplasm [ICD-11: 2B33]
O75874 IDHC_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
O75874 IDHC_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
O75874 IDHC_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P84022 SMAD3_HUMAN Herpes simplex infection [ICD-11: 1F00]
P84022 SMAD3_HUMAN Kidney fibrosis [ICD-11: GC01]
Q03431 PTH1R_HUMAN Low bone mass disorder [ICD-11: FB83]
Q03431 PTH1R_HUMAN Hypo-parathyroidism [ICD-11: 5A50]
Q16236 NF2L2_HUMAN Ataxic disorder [ICD-11: 8A03]
Q16236 NF2L2_HUMAN Breast cancer [ICD-11: 2C60-2C6Y]
Q16236 NF2L2_HUMAN Glaucoma [ICD-11: 9C61]
Q16236 NF2L2_HUMAN Lung cancer [ICD-11: 2C25]
Q16236 NF2L2_HUMAN Macular degeneration [ICD-11: 9B75]
Q16236 NF2L2_HUMAN Melanoma [ICD-11: 2C30]
Q16236 NF2L2_HUMAN Mental/behavioural/neurodevelopmental disorder [ICD-11: 6E20-6E8Z]
Q16236 NF2L2_HUMAN Pulmonary hypertension [ICD-11: BB01]
Q16236 NF2L2_HUMAN Subarachnoid haemorrhage [ICD-11: 8B01]
Q16236 NF2L2_HUMAN Urinary system clinical sympton [ICD-11: MF8Y]
Q16236 NF2L2_HUMAN Non-alcoholic fatty liver disease [ICD-11: DB92]
Q16236 NF2L2_HUMAN Alpha-1-antitrypsin deficiency [ICD-11: 5C5A]
Q16236 NF2L2_HUMAN Motor neuron disease [ICD-11: 8B60]
Q16236 NF2L2_HUMAN Multiple sclerosis [ICD-11: 8A40]
P10635 CP2D6_HUMAN Insomnia [ICD-11: 7A00-7A0Z]
P10635 CP2D6_HUMAN Malaria [ICD-11: 1F40-1F45]
P10635 CP2D6_HUMAN Migraine [ICD-11: 8A80]
P11509 CP2A6_HUMAN Mycosis fungoides [ICD-11: 2B01]
P11509 CP2A6_HUMAN Psoriasis [ICD-11: EA90]
P11712 CP2C9_HUMAN Bacterial infection [ICD-11: 1A00-1C4Z]
P51151 RAB9A_HUMAN Fungal infection [ICD-11: 1F29-1F2F]