Basic Information

Terpenoid ID TKC108557
Chirality TKC108555
Cell line 0
Protein target 14
DiseaseNCIT 0
ORDO 0
ICD 72

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC108557 KB KB (HeLa derivative); HeLa-KB; Strain KB 7.0 nM IC50 C27677
TKC108557 A2780 A-2780; 2780; A2780S; A2780par 11.0 nM IC50 C7979 Orphanet_454723
TKC108557 MCF7 22.0 nM IC50 C4194
TKC108557 NCI-H460 NCI.H460; H460; H-460; NCIH460; NCI-HUT-460; NCI-460 7.0 nM IC50 C4450
TKC108557 PC-3 PC3; PC.3 1.0 nM IC50 C4863
TKC108557 RWPE-1 RWPE1 1730.0 nM IC50
TKC108557 CAL-51 CAL 51; CAL51; Cal51; Centre Antoine Lacassagne-51 61.0 % TGI C4872
TKC108557 1A9 A2780/1A9; A2780(1A9); 1A9 4.0 nM IC50 C7979 Orphanet_454723
TKC108557 CWR22R 22RV1; 22Rv-1; 22rV1; CWR-22rv1; CWR22-Rv1; CWR22R-V1; CWR22-R1; CWR22Rv1; CWR22R 1037.0 hr TIME C4863
TKC108557 HCT-116 HCT-116; HCT.116; HCT_116; HCT116; HCT116wt; CoCL2 4.0 nM IC50 C4910
TKC108557 SiHa Siha; SIHA 90.0 nM IC50 C27676 Orphanet_213767
TKC108557 MDA-MB-231 MDA_MB_231; MDA-MB 231; MDA.MB.231; MDA MB 231; MDA MB231; MDA Mb231; MDA-MB231; MDAMB-231; MDAMB231; MDA-231; MDA-231P; MDA231; MDA231-BRE; MB231; MD Anderson-Metastatic Breast-231 32.0 nM IC50 C5214
TKC108557 HEp-2 Hep-2; HEP-2; Hep2 (HeLa derivative); HEp-2/HeLa; Hep 2; Hep2; HEp2; HEP2; H.Ep.-2; H.Ep. #2; H.Ep. No. 2; Hep II; Human Epidermoid carcinoma #2; Human Epithelioma-2 60.0 nM IC50 C27677
TKC108557 Vero VERO; VeroCCL81; Vero 81; Vero-81; Verda reno 130.0 nM IC50
TKC108557 HEK293 110.0 nM IC50
TKC108557 HEY Hey 860.0 nM IC50 C105555
TKC108557 SK-OV-3 SKOV-3; SK-OV3; SK.OV.3; SKOV3; Skov3; SKO3 1.0 nM IC50 C7978
TKC108557 NCI/ADR-RES NCI/ADR-RES; NCI.ADR.RES; NCIADR.RES; NCI/ADRRES; NCIADRRES; ADR-RES; MCF-7/ADR; MCF-7/ADR-RES; MCF-7/AdrR; MCF-7/Adr; MCF-7/adr; MCF-7ADR; MCF7-ADR; MCF7ADR; OVCAR-8/ADR; OVCAR8/ADR 1531.0 nM IC50 C105555
TKC108557 A549 10.0 nM IC50 C3512
TKC108557 MV4-11 MV-4-11; MV-4:11; MV4:11; MV 4;11; MV4;11; MV411; MV(4;11); MV4II 1.0 nM GI50 C9163 Orphanet_514
TKC108557 SK-MEL19 SK-Mel-19; SKMEL-19; SkMEL-19; SK-MEL19; SK-Mel19; Sk Mel19; SKMEL19; AL-Mel 2.0 nM GI50 C3510
TKC108557 TERT-RPE1 hTERT RPE1; hTERT-RPE-1; hTERT RPE-1; hTERT-RPE; TERT-RPE1; RPE-1; RPE1; RPE1-hTERT; RPE1-hTert; RPE-hTERT 25000.0 nM IC50
TKC108557 CAPAN-1 CaPan-1; CAPAN-1; Capan 1; CAPAN 1; Capan1; CAPAN1 19.0 nM IC50 C9120
TKC108557 HL-60 HL 60; HL.60 HL60; Human Leukemia-60 47.0 nM IC50 C9154 Orphanet_519
TKC108557 K562 K562; K.562; K 562; KO; GM05372; GM05372E 16.0 nM IC50 C9110 Orphanet_521
TKC108557 Z-138 Z138 9.0 nM IC50 C4337 Orphanet_52416
TKC108557 U-251 U-251 MG; U-251-MG; U-251_MG; U251-MG; U251MG; U-251; U251; U251n; U251N; 251 MG; 251MG; 251 MG(6) 1.0 nM IC50 C60781 Orphanet_94
TKC108557 PC-3M PC3-M; PC-3/M; PC3M; Pc3M 92.0 % TGI C4863

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC108557 P68371 Tubulin beta-4B chain TUBB4B 4735 a.u. Activity
TKC108557 O75496 Geminin GMNN 8 nM Potency
TKC108557 P00533 Epidermal growth factor receptor EGFR 0.82 nM Kd
TKC108557 Q9F4F7 4'-phosphopantetheinyl transferase ffp ffp 6310 nM Potency
TKC108557 P51450 Nuclear receptor ROR-gamma Rorc 12589 nM Potency
TKC108557 O15438 ATP-binding cassette sub-family C member 3 ABCC3 133000 nM IC50
TKC108557 O15439 ATP-binding cassette sub-family C member 4 ABCC4 133000 nM IC50
TKC108557 O95342 Bile salt export pump ABCB11 41000 nM IC50
TKC108557 Q92887 ATP-binding cassette sub-family C member 2 ABCC2 133000 nM IC50
TKC108557 P25094 Peripheral myelin protein 22 Pmp22 6 nM Potency
TKC108557 P52732 Kinesin-like protein KIF11 KIF11 0.3 nM IC50
TKC108557 Q9HC29 Nucleotide-binding oligomerization domain-containing protein 2 NOD2 5012 nM IC50
TKC108557 P27169 Serum paraoxonase/arylesterase 1 PON1 665000 nM IC50
TKC108557 P43405 Tyrosine-protein kinase SYK SYK 0.2 nM IC50
TKC108557 P09652 Tubulin beta-4 chain 98 % Inhibition
TKC108557 Q02643 Growth hormone-releasing hormone receptor GHRHR 0.14 nM IC50

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
P00533 EGFR_HUMAN Non-small cell lung cancer [ICD-11: 2C25]
P00533 EGFR_HUMAN Lung cancer [ICD-11: 2C25]
P00533 EGFR_HUMAN Head and neck cancer [ICD-11: 2D42]
P00533 EGFR_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P00533 EGFR_HUMAN Angina pectoris [ICD-11: BA40]
P00533 EGFR_HUMAN Breast cancer [ICD-11: 2C60-2C6Y]
P00533 EGFR_HUMAN Colon cancer [ICD-11: 2B90]
P00533 EGFR_HUMAN Colorectal cancer [ICD-11: 2B91]
P00533 EGFR_HUMAN Diabetic foot ulcer [ICD-11: BD54]
P00533 EGFR_HUMAN Head and neck cancer [ICD-11: 2D42]
P00533 EGFR_HUMAN Hepatitis virus infection [ICD-11: 1E50-1E51]
P00533 EGFR_HUMAN Ischemia [ICD-11: 8B10-8B11]
P00533 EGFR_HUMAN Liver cancer [ICD-11: 2C12]
P00533 EGFR_HUMAN Lung cancer [ICD-11: 2C25]
P00533 EGFR_HUMAN Melanoma [ICD-11: 2C30]
P00533 EGFR_HUMAN Myelodysplastic syndrome [ICD-11: 2A37]
P00533 EGFR_HUMAN Pancreatic cancer [ICD-11: 2C10]
P00533 EGFR_HUMAN Renal cell carcinoma [ICD-11: 2C90]
P00533 EGFR_HUMAN Skin postprocedural disorder [ICD-11: EL8Y]
P00533 EGFR_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P00533 EGFR_HUMAN Stomach cancer [ICD-11: 2B72]
P00533 EGFR_HUMAN Unspecific body region injury [ICD-11: ND56]
P00533 EGFR_HUMAN Urethral cancer [ICD-11: 2C93]
P00533 EGFR_HUMAN Brain cancer [ICD-11: 2A00]
P00533 EGFR_HUMAN Hypopharyngeal cancer [ICD-11: 2B6D]
P00533 EGFR_HUMAN Nasopharyngeal cancer [ICD-11: 2B6B]
P00533 EGFR_HUMAN Metastatic biliary tract neoplasms [ICD-11: 2C14-2C17]
P00533 EGFR_HUMAN Chronic pain [ICD-11: MG30]
P00533 EGFR_HUMAN Lymphoma [ICD-11: 2A80-2A86]
P00533 EGFR_HUMAN Malignant mesenchymal neoplasm [ICD-11: 2B5D-2B5Y]
P00533 EGFR_HUMAN Non-small cell lung cancer [ICD-11: 2C25]
P00533 EGFR_HUMAN Intracerebral haemorrhage [ICD-11: 8B00]
P00533 EGFR_HUMAN Mature B-cell leukaemia [ICD-11: 2A82]
P00533 EGFR_HUMAN Metastatic lymph node neoplasm [ICD-11: 2D60]
P00533 EGFR_HUMAN Spinal cord/cranial nerve neoplasm [ICD-11: 2A02]
P00533 EGFR_HUMAN Testicular cancer [ICD-11: 2C80]
P00533 EGFR_HUMAN Esophageal cancer [ICD-11: 2B70]
P00533 EGFR_HUMAN Psoriasis [ICD-11: EA90]
P00533 EGFR_HUMAN Digestive system disease [ICD-11: DE2Z]
P00533 EGFR_HUMAN Cerebral ischaemia [ICD-11: 8B1Z]
P00533 EGFR_HUMAN Cryptosporidiosis [ICD-11: 1A32]
P00533 EGFR_HUMAN Diffuse large B-cell lymphoma [ICD-11: 2A81]
P00533 EGFR_HUMAN Gram-positive bacterial infection [ICD-11: 1B74-1F40]
P00533 EGFR_HUMAN Brain cancer [ICD-11: 2A00]
P00533 EGFR_HUMAN Liver cancer [ICD-11: 2C12]
P00533 EGFR_HUMAN Lung cancer [ICD-11: 2C25]
P00533 EGFR_HUMAN Pancreatic cancer [ICD-11: 2C10]
P52732 KIF11_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
P52732 KIF11_HUMAN Head and neck cancer [ICD-11: 2D42]
P52732 KIF11_HUMAN Multiple myeloma [ICD-11: 2A83]
P52732 KIF11_HUMAN Ovarian cancer [ICD-11: 2C73]
P52732 KIF11_HUMAN Renal cell carcinoma [ICD-11: 2C90]
P52732 KIF11_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P52732 KIF11_HUMAN Lymphoma [ICD-11: 2A80-2A86]
P52732 KIF11_HUMAN Malignant haematopoietic neoplasm [ICD-11: 2B33]
P52732 KIF11_HUMAN Liver cancer [ICD-11: 2C12]
P52732 KIF11_HUMAN Malignant haematopoietic neoplasm [ICD-11: 2B33]
Q9HC29 NOD2_HUMAN Diabetes mellitus [ICD-11: 5A10]
Q9HC29 NOD2_HUMAN Hepatitis virus infection [ICD-11: 1E50-1E51]
Q9HC29 NOD2_HUMAN Sepsis [ICD-11: 1G40-1G41]
P43405 KSYK_HUMAN Eczema [ICD-11: EA80-EA89]
P43405 KSYK_HUMAN Lymphoma [ICD-11: 2A80-2A86]
P43405 KSYK_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P43405 KSYK_HUMAN Rheumatoid arthritis [ICD-11: FA20]
P43405 KSYK_HUMAN Thrombocytopenia [ICD-11: 3B64]
P43405 KSYK_HUMAN Acquired hypomelanotic disorder [ICD-11: ED63]
P43405 KSYK_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
P43405 KSYK_HUMAN Atopic eczema [ICD-11: EA80]
P43405 KSYK_HUMAN B-cell lymphoma [ICD-11: 2A86]
P43405 KSYK_HUMAN Cutaneous lupus erythematosus [ICD-11: EB50-EB5Z]
P43405 KSYK_HUMAN Diffuse large B-cell lymphoma [ICD-11: 2A81]
P43405 KSYK_HUMAN Malignant haematopoietic neoplasm [ICD-11: 2B33]
P43405 KSYK_HUMAN Mature B-cell leukaemia [ICD-11: 2A82]
P43405 KSYK_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P43405 KSYK_HUMAN Urticaria [ICD-11: EB00-EB05]
P43405 KSYK_HUMAN Asthma [ICD-11: CA23]
P43405 KSYK_HUMAN Allergic/hypersensitivity disorder [ICD-11: 4A80-4A8Z]
P43405 KSYK_HUMAN Diabetes mellitus [ICD-11: 5A10]
P43405 KSYK_HUMAN Thrombosis [ICD-11: DB61-GB90]
Q02643 GHRHR_HUMAN Bone growth disorder [ICD-11: FB86]
Q02643 GHRHR_HUMAN Human immunodeficiency virus disease [ICD-11: 1C60-1C62]
Q02643 GHRHR_HUMAN Lipoatrophy/lipodystrophy [ICD-11: EF01]
Q02643 GHRHR_HUMAN Pituitary gland disorder [ICD-11: 5A60-5A61]