Basic Information

Terpenoid ID TKC108194
Chirality TKC028040
Cell line 0
Protein target 5
DiseaseNCIT 0
ORDO 0
ICD 6

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC108194 IGROV-1 Igrov-1; IGROV 1; IGR-OV1; IGROV1; Igrov1; IGR.OV1; IGROV; OV1/P; OV1/p; OV1-P 19011.0 nM GI50 C7979 Orphanet_454723
TKC108194 MDA-N MDAN 18281.0 nM GI50 C3802
TKC108194 SN12C SN-12C 18408.0 nM GI50 C9385 Orphanet_217071
TKC108194 ACHN 18408.0 nM GI50 C6975 Orphanet_319298
TKC108194 NCI-H23 NCI.H23; NCI H23; H-23; H23; NCIH23 17824.0 nM GI50 C3512
TKC108194 UO-31 UO.31; UO31; U031 16444.0 nM GI50 C9385 Orphanet_217071
TKC108194 HOP-92 HOP 92; HOP.92; HOP92; Hop92; Hopkins-92 16293.0 nM GI50 C2926
TKC108194 HL-60 HL 60; HL.60 HL60; Human Leukemia-60 31550.0 nM GI50 C9154 Orphanet_519
TKC108194 DU-145 DU-145; Du-145; DU 145; DU_145; DU.145; Duke University 145 17947.0 nM GI50 C4863
TKC108194 SK-MEL-5 SK-Mel-5; SK MEL 5; SK.MEL.5; SK-MEL5; SKMel-5; SKMEL-5; SKMEL5; SKMel5; SKmel5; AA-Mel 17539.0 nM GI50 C3510
TKC108194 SF-539 SF-539; SF-539 BT; SF.539; SF 539 14060.0 nM GI50 C3796 Orphanet_251576
TKC108194 Malme-3M MALME-3M; MALME 3M; Malme-3 M; MALME.3M; Malme3M; MALME3M; Malme-3 Monolayer 18621.0 nM GI50 C3224
TKC108194 K562 K562; K.562; K 562; KO; GM05372; GM05372E 17378.0 nM GI50 C9110 Orphanet_521
TKC108194 A498 A498 18880.0 nM GI50 C9385 Orphanet_217071
TKC108194 OVCAR-3 Ovcar-3; OVCAR 3; OVCAR.3; NIH:OVCAR-3; NIH:Ovcar-3; NIH:OVCAR3; NIH-OVCAR-3; NIHOVCAR3; OVCAR3; Ovcar3 18535.0 nM GI50 C105555
TKC108194 MOLT-4 Molt-4; MOLT 4; Molt 4; MOLT.4; MOLT4; Molt4; GM02219; GM02219C; GM2219C; GM02219D 13243.0 nM GI50 C9142 Orphanet_99861
TKC108194 NCI/ADR-RES NCI/ADR-RES; NCI.ADR.RES; NCIADR.RES; NCI/ADRRES; NCIADRRES; ADR-RES; MCF-7/ADR; MCF-7/ADR-RES; MCF-7/AdrR; MCF-7/Adr; MCF-7/adr; MCF-7ADR; MCF7-ADR; MCF7ADR; OVCAR-8/ADR; OVCAR8/ADR 15417.0 nM GI50 C105555
TKC108194 HOP-62 HOP 62; Hop 62; HOP.62; HOP62; Hop62; Hopkins-62 17219.0 nM GI50 C3512
TKC108194 U-251 U-251 MG; U-251-MG; U-251_MG; U251-MG; U251MG; U-251; U251; U251n; U251N; 251 MG; 251MG; 251 MG(6) 31333.0 nM GI50 C60781 Orphanet_94
TKC108194 OVCAR-8 OVCAR 8; NIH:OVCAR-8; OVCAR8; Ovcar8; OVCAR.8; OVCA8 18239.0 nM GI50 C105555
TKC108194 OVCAR-5 OVCAR 5; NIH:OVCAR-5; OVCAR.5; OVCAR5; Ovcar5; OVCA5 18030.0 nM GI50 C105555
TKC108194 MDA-MB-231 MDA_MB_231; MDA-MB 231; MDA.MB.231; MDA MB 231; MDA MB231; MDA Mb231; MDA-MB231; MDAMB-231; MDAMB231; MDA-231; MDA-231P; MDA231; MDA231-BRE; MB231; MD Anderson-Metastatic Breast-231 14997.0 nM GI50 C5214
TKC108194 SNB-19 SNB.19; SNB19; Surgical Neurology Branch-19 19231.0 nM GI50 C60781 Orphanet_94
TKC108194 SR SR-786; SR786 25468.0 nM GI50 C37193 Orphanet_300895
TKC108194 TK-10 TK.10; TK 10; TK10 14997.0 nM GI50 C4033 Orphanet_319276
TKC108194 SW-620 SW-620; SW 620; SW.620 28510.0 nM GI50 C4349
TKC108194 KM12 KM-12; KM.12 15922.0 nM GI50 C4910
TKC108194 NCI-H522 NCI.H522; H522; H-522; NCI-522; NCI522; NCIH522 14256.0 nM GI50 C3512
TKC108194 M14 M14-MEL; UCLA-SO-M14; UCLA SO M14; UCLA-SO-14; UCLASO-M14; Melanoma 14; M-14 16982.0 nM GI50 C3802
TKC108194 NCI-H322M NCI.H322M; H322M; H-322M; H-322m 15311.0 nM GI50 C2923
TKC108194 RPMI-8226 RPMI 8226; RPMI.8226; RPMI8226; RPMI no. 8226; RPMI no 8226; RPMI #8226; 8226; RPMI 8226/S; RPMI-8226S; RPMI8226/S; 8226/S; Roswell Park Memorial Institute 8226; GM02132; GM2132; GM 2132; GM02132C; Simpson 25645.0 nM GI50 C3242 Orphanet_29073
TKC108194 OVCAR-4 OVCAR 4; NIH:OVCAR-4; NIH:OVCAR4; OVCAR.4; OVCAR4; Ovcar4 15922.0 nM GI50 C105555
TKC108194 LOX IMVI LOX/IMVI; LOX IMVI; LOXIM-VI; LOXIMVI; LOX 16181.0 nM GI50 C3802
TKC108194 SK-MEL-2 SK-Mel-2; SK-Mel 2; SK-mel-2; SK-MEL2; SK.MEL.2; SK Mel 2; SK MEL 2; SKMEL-2; SKMEL2; SKmel2; SK-ML2; SKml2 16444.0 nM GI50 C3224
TKC108194 HCC 2998 HCC-2998; HCC.2998; HCC 2998; Hamon Cancer Center 2998 14521.0 nM GI50 C4349
TKC108194 A549 12883.0 nM GI50 C3512
TKC108194 SNB-75 SNB.75; SNB75; Surgical Neurology Branch-75 18664.0 nM GI50 C3058 Orphanet_360
TKC108194 HCT-116 HCT-116; HCT.116; HCT_116; HCT116; HCT116wt; CoCL2 19011.0 nM GI50 C4910
TKC108194 HCT-15 HCT-15; HCT.15; HCT15 18578.0 nM GI50 C4349
TKC108194 EKVX 18923.0 nM GI50 C3512
TKC108194 SF-268 SF-268; SF.268; SF 268 19454.0 nM GI50 C60781 Orphanet_94
TKC108194 PC-3 PC3; PC.3 17418.0 nM GI50 C4863
TKC108194 MCF7 12445.0 nM GI50 C4194
TKC108194 SK-OV-3 SKOV-3; SK-OV3; SK.OV.3; SKOV3; Skov3; SKO3 15417.0 nM GI50 C7978
TKC108194 NCI-H460 NCI.H460; H460; H-460; NCIH460; NCI-HUT-460; NCI-460 16558.0 nM GI50 C4450
TKC108194 T47D 22284.0 nM GI50 C4194
TKC108194 CAKI-1 CAL 1; Centre Antoine Lacassagne-1 16293.0 nM GI50 C3224
TKC108194 SF-295 SF-295; SF.295; SF 295 21727.0 nM GI50 C3058 Orphanet_360
TKC108194 MDA-MB-435 MDA-MB435; MDAMB435; MDA.MB.435; MDA-435; MDA 435; MDA435; MD Anderson-Metastatic Breast-435 40458.0 nM GI50 C3802
TKC108194 786-0 786-o; 786O; 786-0; 786.O; 786-O RCC; RCC 786-O; RCC_7860; RCC 7860; 7860; 786-0WT 17258.0 nM GI50 C9385 Orphanet_217071
TKC108194 Hs-578T HS 578T; Hs-578T; HS-578T; Hs_578t; Hs-578-T; HS-578-T; Hs 578.T; HS578T; Hs578T; Hs578t; HS0578T; 578T; HS578; Hs578; Homo sapiens No. 578, tumor cells 17338.0 nM GI50 C4194
TKC108194 UACC-257 UACC 257; UACC.257; UACC257; University of Arizona Cell Culture-257 15453.0 nM GI50 C3224
TKC108194 CCRF-CEM CCRF/CEM; CCRFCEM; CCRF.CEM; CCRF CEM; CCRF; CEM; CEM-CCRF; CEM-CCRF (CAMR); CCRF/CEM/0; CEM/0; CEM-0; CCRF-CEM/S; GM03671; GM03671C 26303.0 nM GI50 C7953 Orphanet_99861
TKC108194 HT-29 HT 29; HT29 15922.0 nM GI50 C4349
TKC108194 NCI-H226 NCI.H226; NCI H226; H226; H-226; HUT-226; HUT 226; NCIH226 15631.0 nM GI50 C45662 Orphanet_50251
TKC108194 SK-MEL-28 SK-Mel-28; SK.MEL.28; SK-MEL 28; SK MEL-28; SK MEL 28; SK Mel 28; SKMel-28; SKMEL-28; SK-MEL28; SK-Mel28; SK Mel28; SKMEL28; SKMel28; SKmel28; SKML-28; SK28; AU-Mel; P-36; P36 30339.0 nM GI50 C3510
TKC108194 RXF 393 RXF393L; RXF-393 L; RXF-393; RXF 393; RXF.393; RXF393; RXF 393NL 18365.0 nM GI50 C9385 Orphanet_217071
TKC108194 COLO 205 Colo 205; CoLo 205; COLO-205; Colo-205; COLO.205; Colo205; COLO205; Co 205; Colorado 205 19953.0 nM GI50 C4349

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC108194 P10635 Cytochrome P450 2D6 CYP2D6 31623 nM Potency
TKC108194 P11712 Cytochrome P450 2C9 CYP2C9 15849 nM Potency
TKC108194 P33261 Cytochrome P450 2C19 CYP2C19 12589 nM Potency
TKC108194 Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 39811 nM Potency
TKC108194 P15917 Lethal factor lef 31623 nM Potency

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
P10635 CP2D6_HUMAN Insomnia [ICD-11: 7A00-7A0Z]
P10635 CP2D6_HUMAN Malaria [ICD-11: 1F40-1F45]
P10635 CP2D6_HUMAN Migraine [ICD-11: 8A80]
P11712 CP2C9_HUMAN Bacterial infection [ICD-11: 1A00-1C4Z]
P15917 LEF_BACAN Sepsis [ICD-11: 1G40-1G41]
P15917 LEF_BACAN Corneal disease [ICD-11: 9A76-9A78]