Basic Information

Terpenoid ID TKC106909
Chirality TKC090107
Cell line 17
Protein target 1
DiseaseNCIT 17
ORDO 6
ICD 9

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC106909 PANC-1 Panc-1; PANC.1; Panc 1; PanC1; Panc1; PANC1; Panc-1-P 17.0 % Activity C9120
TKC106909 MIA PaCa-2 MIA-PaCa-2; MIA-PACA-2; MIA-Pa-Ca-2; MIA Paca2; MIA PaCa2; MiaPaCa-2; MIAPACA-2; MiaPaca.2; MiaPaCa2; Miapaca2; MIAPaCa2; MIAPACA2; Mia PACA 2; MIAPaCa-2; PaCa2; MiaPaCa 2.0 % Activity C9120
TKC106909 BXPC-3 BxPc-3; BXPC-3; Bx-PC3; BXPC3; BxPC3; BxPc3; Biopsy xenograft of Pancreatic Carcinoma line-3 7.0 % Activity C9120
TKC106909 CCRF-CEM CCRF/CEM; CCRFCEM; CCRF.CEM; CCRF CEM; CCRF; CEM; CEM-CCRF; CEM-CCRF (CAMR); CCRF/CEM/0; CEM/0; CEM-0; CCRF-CEM/S; GM03671; GM03671C 1990.0 nM GI50 C7953 Orphanet_99861
TKC106909 HL-60 HL 60; HL.60 HL60; Human Leukemia-60 1580.0 nM GI50 C9154 Orphanet_519
TKC106909 K562 K562; K.562; K 562; KO; GM05372; GM05372E 2510.0 nM GI50 C9110 Orphanet_521
TKC106909 NCI-H522 NCI.H522; H522; H-522; NCI-522; NCI522; NCIH522 2510.0 nM GI50 C3512
TKC106909 SW-620 SW-620; SW 620; SW.620 3980.0 nM GI50 C4349
TKC106909 M14 M14-MEL; UCLA-SO-M14; UCLA SO M14; UCLA-SO-14; UCLASO-M14; Melanoma 14; M-14 15800.0 nM GI50 C3802
TKC106909 MDA-MB-435 MDA-MB435; MDAMB435; MDA.MB.435; MDA-435; MDA 435; MDA435; MD Anderson-Metastatic Breast-435 7940.0 nM GI50 C3802
TKC106909 IGROV-1 Igrov-1; IGROV 1; IGR-OV1; IGROV1; Igrov1; IGR.OV1; IGROV; OV1/P; OV1/p; OV1-P 19900.0 nM GI50 C7979 Orphanet_454723
TKC106909 ACHN 15800.0 nM GI50 C6975 Orphanet_319298
TKC106909 CAKI-1 CAL 1; Centre Antoine Lacassagne-1 12500.0 nM GI50 C3224
TKC106909 TK-10 TK.10; TK 10; TK10 3160.0 nM GI50 C4033 Orphanet_319276
TKC106909 DU-145 DU-145; Du-145; DU 145; DU_145; DU.145; Duke University 145 5010.0 nM GI50 C4863
TKC106909 MCF7 5010.0 nM GI50 C4194
TKC106909 T47D 39800.0 nM GI50 C4194
TKC106909 MEC1 Mouse Epicardial Cells 1 5600.0 nM EC50

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC106909 Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH2 >40 % Inhibition

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
Q12809 KCNH2_HUMAN Heart failure [ICD-11: BD10-BD1Z]
Q12809 KCNH2_HUMAN Sleep-wake disorder [ICD-11: 7A00-7B2Z]
Q12809 KCNH2_HUMAN Malaria [ICD-11: 1F40-1F45]
Q12809 KCNH2_HUMAN Multiple sclerosis [ICD-11: 8A40]
Q12809 KCNH2_HUMAN Pain [ICD-11: MG30-MG3Z]
Q12809 KCNH2_HUMAN Cardiac arrhythmia [ICD-11: BC9Z]
Q12809 KCNH2_HUMAN Angina pectoris [ICD-11: BA40]
Q12809 KCNH2_HUMAN Genetic cardiac arrhythmia [ICD-11: BC65]
Q12809 KCNH2_HUMAN Ovarian cancer [ICD-11: 2C73]