Basic Information

Terpenoid ID TKC104488
Cell line 0
Protein target 1
DiseaseNCIT 0
ORDO 0
ICD 13

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC104488 SN12C SN-12C 21429.0 nM GI50 C9385 Orphanet_217071
TKC104488 MDA-N MDAN 17906.0 nM GI50 C3802
TKC104488 NCI-H23 NCI.H23; NCI H23; H-23; H23; NCIH23 26792.0 nM GI50 C3512
TKC104488 ACHN 19099.0 nM GI50 C6975 Orphanet_319298
TKC104488 UO-31 UO.31; UO31; U031 19364.0 nM GI50 C9385 Orphanet_217071
TKC104488 HOP-92 HOP 92; HOP.92; HOP92; Hop92; Hopkins-92 19011.0 nM GI50 C2926
TKC104488 HL-60 HL 60; HL.60 HL60; Human Leukemia-60 15136.0 nM GI50 C9154 Orphanet_519
TKC104488 SF-539 SF-539; SF-539 BT; SF.539; SF 539 20749.0 nM GI50 C3796 Orphanet_251576
TKC104488 DU-145 DU-145; Du-145; DU 145; DU_145; DU.145; Duke University 145 18836.0 nM GI50 C4863
TKC104488 SK-MEL-5 SK-Mel-5; SK MEL 5; SK.MEL.5; SK-MEL5; SKMel-5; SKMEL-5; SKMEL5; SKMel5; SKmel5; AA-Mel 25177.0 nM GI50 C3510
TKC104488 K562 K562; K.562; K 562; KO; GM05372; GM05372E 3639.0 nM GI50 C9110 Orphanet_521
TKC104488 OVCAR-3 Ovcar-3; OVCAR 3; OVCAR.3; NIH:OVCAR-3; NIH:Ovcar-3; NIH:OVCAR3; NIH-OVCAR-3; NIHOVCAR3; OVCAR3; Ovcar3 16711.0 nM GI50 C105555
TKC104488 A498 A498 27227.0 nM GI50 C9385 Orphanet_217071
TKC104488 MOLT-4 Molt-4; MOLT 4; Molt 4; MOLT.4; MOLT4; Molt4; GM02219; GM02219C; GM2219C; GM02219D 6109.0 nM GI50 C9142 Orphanet_99861
TKC104488 U-251 U-251 MG; U-251-MG; U-251_MG; U251-MG; U251MG; U-251; U251; U251n; U251N; 251 MG; 251MG; 251 MG(6) 22961.0 nM GI50 C60781 Orphanet_94
TKC104488 NCI/ADR-RES NCI/ADR-RES; NCI.ADR.RES; NCIADR.RES; NCI/ADRRES; NCIADRRES; ADR-RES; MCF-7/ADR; MCF-7/ADR-RES; MCF-7/AdrR; MCF-7/Adr; MCF-7/adr; MCF-7ADR; MCF7-ADR; MCF7ADR; OVCAR-8/ADR; OVCAR8/ADR 18880.0 nM GI50 C105555
TKC104488 OVCAR-8 OVCAR 8; NIH:OVCAR-8; OVCAR8; Ovcar8; OVCAR.8; OVCA8 19231.0 nM GI50 C105555
TKC104488 OVCAR-5 OVCAR 5; NIH:OVCAR-5; OVCAR.5; OVCAR5; Ovcar5; OVCA5 25351.0 nM GI50 C105555
TKC104488 SNB-19 SNB.19; SNB19; Surgical Neurology Branch-19 42855.0 nM GI50 C60781 Orphanet_94
TKC104488 MDA-MB-231 MDA_MB_231; MDA-MB 231; MDA.MB.231; MDA MB 231; MDA MB231; MDA Mb231; MDA-MB231; MDAMB-231; MDAMB231; MDA-231; MDA-231P; MDA231; MDA231-BRE; MB231; MD Anderson-Metastatic Breast-231 21878.0 nM GI50 C5214
TKC104488 TK-10 TK.10; TK 10; TK10 14791.0 nM GI50 C4033 Orphanet_319276
TKC104488 SW-620 SW-620; SW 620; SW.620 14521.0 nM GI50 C4349
TKC104488 NCI-H522 NCI.H522; H522; H-522; NCI-522; NCI522; NCIH522 11324.0 nM GI50 C3512
TKC104488 M14 M14-MEL; UCLA-SO-M14; UCLA SO M14; UCLA-SO-14; UCLASO-M14; Melanoma 14; M-14 24044.0 nM GI50 C3802
TKC104488 KM12 KM-12; KM.12 31842.0 nM GI50 C4910
TKC104488 NCI-H322M NCI.H322M; H322M; H-322M; H-322m 39628.0 nM GI50 C2923
TKC104488 RPMI-8226 RPMI 8226; RPMI.8226; RPMI8226; RPMI no. 8226; RPMI no 8226; RPMI #8226; 8226; RPMI 8226/S; RPMI-8226S; RPMI8226/S; 8226/S; Roswell Park Memorial Institute 8226; GM02132; GM2132; GM 2132; GM02132C; Simpson 8185.0 nM GI50 C3242 Orphanet_29073
TKC104488 OVCAR-4 OVCAR 4; NIH:OVCAR-4; NIH:OVCAR4; OVCAR.4; OVCAR4; Ovcar4 18578.0 nM GI50 C105555
TKC104488 LOX IMVI LOX/IMVI; LOX IMVI; LOXIM-VI; LOXIMVI; LOX 20137.0 nM GI50 C3802
TKC104488 BT-549 BT 549; BT.549; BT549 16788.0 nM GI50 C4194
TKC104488 SK-MEL-2 SK-Mel-2; SK-Mel 2; SK-mel-2; SK-MEL2; SK.MEL.2; SK Mel 2; SK MEL 2; SKMEL-2; SKMEL2; SKmel2; SK-ML2; SKml2 21727.0 nM GI50 C3224
TKC104488 A549 43451.0 nM GI50 C3512
TKC104488 SNB-75 SNB.75; SNB75; Surgical Neurology Branch-75 25704.0 nM GI50 C3058 Orphanet_360
TKC104488 HCC 2998 HCC-2998; HCC.2998; HCC 2998; Hamon Cancer Center 2998 21281.0 nM GI50 C4349
TKC104488 HCT-15 HCT-15; HCT.15; HCT15 12764.0 nM GI50 C4349
TKC104488 HCT-116 HCT-116; HCT.116; HCT_116; HCT116; HCT116wt; CoCL2 18323.0 nM GI50 C4910
TKC104488 SF-268 SF-268; SF.268; SF 268 22029.0 nM GI50 C60781 Orphanet_94
TKC104488 MCF7 22284.0 nM GI50 C4194
TKC104488 EKVX 16218.0 nM GI50 C3512
TKC104488 PC-3 PC3; PC.3 24210.0 nM GI50 C4863
TKC104488 T47D 20370.0 nM GI50 C4194
TKC104488 SK-OV-3 SKOV-3; SK-OV3; SK.OV.3; SKOV3; Skov3; SKO3 59293.0 nM GI50 C7978
TKC104488 UACC-62 UACC 62; UACC.62; UACC62; University of Arizona Cell Culture-62 13428.0 nM GI50 C3224
TKC104488 NCI-H460 NCI.H460; H460; H-460; NCIH460; NCI-HUT-460; NCI-460 26242.0 nM GI50 C4450
TKC104488 MDA-MB-435 MDA-MB435; MDAMB435; MDA.MB.435; MDA-435; MDA 435; MDA435; MD Anderson-Metastatic Breast-435 20797.0 nM GI50 C3802
TKC104488 CAKI-1 CAL 1; Centre Antoine Lacassagne-1 17906.0 nM GI50 C3224
TKC104488 IGROV-1 Igrov-1; IGROV 1; IGR-OV1; IGROV1; Igrov1; IGR.OV1; IGROV; OV1/P; OV1/p; OV1-P 17258.0 nM GI50 C7979 Orphanet_454723
TKC104488 SF-295 SF-295; SF.295; SF 295 36983.0 nM GI50 C3058 Orphanet_360
TKC104488 Hs-578T HS 578T; Hs-578T; HS-578T; Hs_578t; Hs-578-T; HS-578-T; Hs 578.T; HS578T; Hs578T; Hs578t; HS0578T; 578T; HS578; Hs578; Homo sapiens No. 578, tumor cells 34435.0 nM GI50 C4194
TKC104488 786-0 786-o; 786O; 786-0; 786.O; 786-O RCC; RCC 786-O; RCC_7860; RCC 7860; 7860; 786-0WT 17947.0 nM GI50 C9385 Orphanet_217071
TKC104488 CCRF-CEM CCRF/CEM; CCRFCEM; CCRF.CEM; CCRF CEM; CCRF; CEM; CEM-CCRF; CEM-CCRF (CAMR); CCRF/CEM/0; CEM/0; CEM-0; CCRF-CEM/S; GM03671; GM03671C 3972.0 nM GI50 C7953 Orphanet_99861
TKC104488 UACC-257 UACC 257; UACC.257; UACC257; University of Arizona Cell Culture-257 23933.0 nM GI50 C3224
TKC104488 NCI-H226 NCI.H226; NCI H226; H226; H-226; HUT-226; HUT 226; NCIH226 18578.0 nM GI50 C45662 Orphanet_50251
TKC104488 HT-29 HT 29; HT29 12531.0 nM GI50 C4349
TKC104488 SK-MEL-28 SK-Mel-28; SK.MEL.28; SK-MEL 28; SK MEL-28; SK MEL 28; SK Mel 28; SKMel-28; SKMEL-28; SK-MEL28; SK-Mel28; SK Mel28; SKMEL28; SKMel28; SKmel28; SKML-28; SK28; AU-Mel; P-36; P36 14093.0 nM GI50 C3510
TKC104488 COLO 205 Colo 205; CoLo 205; COLO-205; Colo-205; COLO.205; Colo205; COLO205; Co 205; Colorado 205 17219.0 nM GI50 C4349
TKC104488 PANC-1 Panc-1; PANC.1; Panc 1; PanC1; Panc1; PANC1; Panc-1-P 40600.0 nM EC50 C9120
TKC104488 MIA PaCa-2 MIA-PaCa-2; MIA-PACA-2; MIA-Pa-Ca-2; MIA Paca2; MIA PaCa2; MiaPaCa-2; MIAPACA-2; MiaPaca.2; MiaPaCa2; Miapaca2; MIAPaCa2; MIAPACA2; Mia PACA 2; MIAPaCa-2; PaCa2; MiaPaCa 32500.0 nM EC50 C9120

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC104488 P14324 Farnesyl pyrophosphate synthase FDPS 473 nM IC50
TKC104488 O95749 Geranylgeranyl pyrophosphate synthase GGPS1 >100000 nM IC50

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
P14324 FPPS_HUMAN Bone paget disease [ICD-11: FB85]
P14324 FPPS_HUMAN Focal/segmental autonomic disorder [ICD-11: 8D8A]
P14324 FPPS_HUMAN Low bone mass disorder [ICD-11: FB83]
P14324 FPPS_HUMAN Mineral excesses [ICD-11: 5B91]
P14324 FPPS_HUMAN Musculoskeletal system/connective tissue disease [ICD-11: FC0Z]
P14324 FPPS_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
P14324 FPPS_HUMAN Colorectal cancer [ICD-11: 2B91]
P14324 FPPS_HUMAN Mature T-cell lymphoma [ICD-11: 2A90]
P14324 FPPS_HUMAN Myelodysplastic syndrome [ICD-11: 2A37]
P14324 FPPS_HUMAN Myeloproliferative neoplasm [ICD-11: 2A20]
P14324 FPPS_HUMAN Pancreatic cancer [ICD-11: 2C10]
P14324 FPPS_HUMAN Sexually transmitted infection [ICD-11: 1A9Y-1A9Z]
P14324 FPPS_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]