Basic Information

Terpenoid ID TKC103159
Chirality TKC030034
Cell line 0
Protein target 26
DiseaseNCIT 0
ORDO 0
ICD 93

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC103159 C8166 C8166-CD4 2.0 ug.mL-1 CC50
TKC103159 JY JY-S 39.0 % Inhibition
TKC103159 A549 10.0 nM IC50 C3512
TKC103159 CAKI-1 CAL 1; Centre Antoine Lacassagne-1 7100.0 nM IC50 C3224
TKC103159 HepG2 760.0 nM IC50 C3728 Orphanet_449
TKC103159 MCF7 41.0 nM IC50 C4194
TKC103159 Bel-7402 Bel-7402; BEL 7402; Bel 7402; BEL7402; Bel7402 8.0 nM IC50 C27677
TKC103159 Hep 3B2 Hep 3B2_1-7; HEP3B217; Hep 3B2; HEP-3B2; HEP3B2; Hep-3B; HEP-3B; Hep 3B; Hep3B; HEP3B 310.0 nM IC50 C7955 Orphanet_33402
TKC103159 HeLa HELA; Hela; He La; He-La; HeLa-CCL2; Henrietta Lacks cells; Helacyton gartleri 800.0 nM IC50 C27677
TKC103159 HEK293 291.0 nM Potency

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC103159 P10636 Microtubule-associated protein tau MAPT 22387 nM Potency
TKC103159 P11473 Vitamin D3 receptor VDR 100000 nM Potency
TKC103159 Q16637 Survival motor neuron protein SMN1,SMN2 11220 nM Potency
TKC103159 Q16637 Survival motor neuron protein SMN1,SMN2 11220 nM Potency
TKC103159 Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 TDP1 7 nM Potency
TKC103159 O75874 Isocitrate dehydrogenase [NADP] cytoplasmic IDH1 82 nM Potency
TKC103159 P43220 Glucagon-like peptide 1 receptor GLP1R 31623 nM Potency
TKC103159 P84022 Mothers against decapentaplegic homolog 3 SMAD3 2818 nM Potency
TKC103159 Q03431 Parathyroid hormone/parathyroid hormone-related peptide receptor PTH1R 2239 nM Potency
TKC103159 Q16236 Nuclear factor erythroid 2-related factor 2 NFE2L2 2060 nM Potency
TKC103159 Q99700 Ataxin-2 ATXN2 39811 nM Potency
TKC103159 P27695 DNA-(apurinic or apyrimidinic site) endonuclease APEX1 50119 nM Potency
TKC103159 O75496 Geminin GMNN 5 nM Potency
TKC103159 P40763 Signal transducer and activator of transcription 3 STAT3 3000 nM IC50
TKC103159 P20701 Integrin alpha-L ITGAL 300 nM IC50
TKC103159 P83916 Chromobox protein homolog 1 CBX1 79433 nM Potency
TKC103159 P00811 Beta-lactamase ampC 316 nM Potency
TKC103159 Q96QE3 ATPase family AAA domain-containing protein 5 ATAD5 5174 nM Potency
TKC103159 P25779 Cruzipain 39811 nM Potency
TKC103159 Q16665 Hypoxia-inducible factor 1-alpha HIF1A 270 nM IC50
TKC103159 P51450 Nuclear receptor ROR-gamma Rorc 22387 nM Potency
TKC103159 P02545 Prelamin-A/C LMNA 200 nM Potency
TKC103159 P42858 Huntingtin HTT 22387 nM Potency
TKC103159 O15118 NPC intracellular cholesterol transporter 1 NPC1 316 nM Potency
TKC103159 P51151 Ras-related protein Rab-9A RAB9A 316 nM Potency
TKC103159 Q194T2 Non-structural protein 1 NS1 316 nM Potency
TKC103159 Q13315 Serine-protein kinase ATM ATM 19953 nM Potency

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
P10636 TAU_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
P10636 TAU_HUMAN Alzheimer disease [ICD-11: 8A20]
P10636 TAU_HUMAN Mild neurocognitive disorder [ICD-11: 6D71]
P10636 TAU_HUMAN Choreiform disorder [ICD-11: 8A01]
P10636 TAU_HUMAN Parkinsonism [ICD-11: 8A00]
P10636 TAU_HUMAN Central nervous system disease [ICD-11: 8A04-8D87]
P10636 TAU_HUMAN Neurodegenerative disorder [ICD-11: 8A20-8A23]
P11473 VDR_HUMAN Chronic kidney disease [ICD-11: GB61]
P11473 VDR_HUMAN Hair/hair growth developmental defect [ICD-11: LC30]
P11473 VDR_HUMAN Hyper-parathyroidism [ICD-11: 5A51]
P11473 VDR_HUMAN Hypo-parathyroidism [ICD-11: 5A50]
P11473 VDR_HUMAN Mineral deficiency [ICD-11: 5B5K]
P11473 VDR_HUMAN Psoriasis [ICD-11: EA90]
P11473 VDR_HUMAN Vitamin deficiency [ICD-11: 5B55-5B5F]
P11473 VDR_HUMAN Low bone mass disorder [ICD-11: FB83]
P11473 VDR_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
P11473 VDR_HUMAN Prostate cancer [ICD-11: 2C82]
P11473 VDR_HUMAN Prostate disease [ICD-11: GA91]
P11473 VDR_HUMAN Abnormal micturition [ICD-11: MF50]
P11473 VDR_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P11473 VDR_HUMAN Postoperative inflammation [ICD-11: 1A00-CA43]
P11473 VDR_HUMAN Acne vulgaris [ICD-11: ED80]
Q16637 SMN_HUMAN Muscular atrophy [ICD-11: 8B61]
Q16637 SMN_HUMAN Muscular atrophy [ICD-11: 8B61]
Q16637 SMN_HUMAN Muscular atrophy [ICD-11: 8B61]
Q16637 SMN_HUMAN Muscular atrophy [ICD-11: 8B61]
O75874 IDHC_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
O75874 IDHC_HUMAN Liver cancer [ICD-11: 2C12]
O75874 IDHC_HUMAN Malignant haematopoietic neoplasm [ICD-11: 2B33]
O75874 IDHC_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
O75874 IDHC_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
O75874 IDHC_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P43220 GLP1R_HUMAN Cardiovascular disease [ICD-11: BA00-BE2Z]
P43220 GLP1R_HUMAN Obesity [ICD-11: 5B80-5B81]
P43220 GLP1R_HUMAN Type 2 diabetes mellitus [ICD-11: 5A11]
P43220 GLP1R_HUMAN Type-1/2 diabete [ICD-11: 5A10-5A11]
P43220 GLP1R_HUMAN Acute diabete complication [ICD-11: 5A2Y]
P43220 GLP1R_HUMAN Diabetes mellitus [ICD-11: 5A10]
P43220 GLP1R_HUMAN Dyspepsia [ICD-11: MD92]
P43220 GLP1R_HUMAN Irritable bowel syndrome [ICD-11: DD91]
P43220 GLP1R_HUMAN Intracranial injury [ICD-11: NA07]
P43220 GLP1R_HUMAN Non-alcoholic fatty liver disease [ICD-11: DB92]
P84022 SMAD3_HUMAN Herpes simplex infection [ICD-11: 1F00]
P84022 SMAD3_HUMAN Kidney fibrosis [ICD-11: GC01]
Q03431 PTH1R_HUMAN Low bone mass disorder [ICD-11: FB83]
Q03431 PTH1R_HUMAN Hypo-parathyroidism [ICD-11: 5A50]
Q16236 NF2L2_HUMAN Ataxic disorder [ICD-11: 8A03]
Q16236 NF2L2_HUMAN Breast cancer [ICD-11: 2C60-2C6Y]
Q16236 NF2L2_HUMAN Glaucoma [ICD-11: 9C61]
Q16236 NF2L2_HUMAN Lung cancer [ICD-11: 2C25]
Q16236 NF2L2_HUMAN Macular degeneration [ICD-11: 9B75]
Q16236 NF2L2_HUMAN Melanoma [ICD-11: 2C30]
Q16236 NF2L2_HUMAN Mental/behavioural/neurodevelopmental disorder [ICD-11: 6E20-6E8Z]
Q16236 NF2L2_HUMAN Pulmonary hypertension [ICD-11: BB01]
Q16236 NF2L2_HUMAN Subarachnoid haemorrhage [ICD-11: 8B01]
Q16236 NF2L2_HUMAN Urinary system clinical sympton [ICD-11: MF8Y]
Q16236 NF2L2_HUMAN Non-alcoholic fatty liver disease [ICD-11: DB92]
Q16236 NF2L2_HUMAN Alpha-1-antitrypsin deficiency [ICD-11: 5C5A]
Q16236 NF2L2_HUMAN Motor neuron disease [ICD-11: 8B60]
Q16236 NF2L2_HUMAN Multiple sclerosis [ICD-11: 8A40]
P27695 APEX1_HUMAN Retinopathy [ICD-11: 9B71]
P27695 APEX1_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P27695 APEX1_HUMAN Ocular cancer [ICD-11: 2D00-2D07]
P27695 APEX1_HUMAN Brain cancer [ICD-11: 2A00]
P27695 APEX1_HUMAN Melanoma [ICD-11: 2C30]
P40763 STAT3_HUMAN Psoriasis [ICD-11: EA90]
P40763 STAT3_HUMAN Brain cancer [ICD-11: 2A00]
P40763 STAT3_HUMAN Colorectal cancer [ICD-11: 2B91]
P40763 STAT3_HUMAN Liver cancer [ICD-11: 2C12]
P40763 STAT3_HUMAN Malignant digestive organ neoplasm [ICD-11: 2C11]
P40763 STAT3_HUMAN Malignant haematopoietic neoplasm [ICD-11: 2B33]
P40763 STAT3_HUMAN Pancreatic cancer [ICD-11: 2C10]
P40763 STAT3_HUMAN Respiratory infection [ICD-11: CA07-CA4Z]
P40763 STAT3_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P40763 STAT3_HUMAN Immune system disease [ICD-11: 4A01-4B41]
P40763 STAT3_HUMAN Postoperative inflammation [ICD-11: 1A00-CA43]
P40763 STAT3_HUMAN Mature B-cell leukaemia [ICD-11: 2A82]
P40763 STAT3_HUMAN Multiple myeloma [ICD-11: 2A83]
P40763 STAT3_HUMAN Mycosis fungoides [ICD-11: 2B01]
P40763 STAT3_HUMAN Ulcerative colitis [ICD-11: DD71]
P40763 STAT3_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P20701 ITAL_HUMAN Conjunctiva disorder [ICD-11: 9A60]
P20701 ITAL_HUMAN Psoriasis [ICD-11: EA90]
P20701 ITAL_HUMAN Transplant rejection [ICD-11: NE84]
P20701 ITAL_HUMAN Visual system disease [ICD-11: 9E1Z]
P20701 ITAL_HUMAN Human immunodeficiency virus disease [ICD-11: 1C60-1C62]
P20701 ITAL_HUMAN Diabetes mellitus [ICD-11: 5A10]
P25779 CYSP_TRYCR Parasitic worm infestation [ICD-11: 1F90]
P25779 CYSP_TRYCR Malaria [ICD-11: 1F40-1F45]
Q16665 HIF1A_HUMAN Adrenomedullary hyperfunction [ICD-11: 5A75]
Q16665 HIF1A_HUMAN Brain cancer [ICD-11: 2A00]
Q16665 HIF1A_HUMAN Lymphoma [ICD-11: 2A80-2A86]
Q16665 HIF1A_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
Q16665 HIF1A_HUMAN Pulmonary hypertension [ICD-11: BB01]
P42858 HD_HUMAN Choreiform disorder [ICD-11: 8A01]
P51151 RAB9A_HUMAN Fungal infection [ICD-11: 1F29-1F2F]
Q13315 ATM_HUMAN Brain cancer [ICD-11: 2A00]
Q13315 ATM_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
Q13315 ATM_HUMAN Lung cancer [ICD-11: 2C25]