Basic Information

Terpenoid ID TKC096011
Chirality TKC101920
Cell line 0
Protein target 9
DiseaseNCIT 0
ORDO 0
ICD 44

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC096011 MOLT-4 Molt-4; MOLT 4; Molt 4; MOLT.4; MOLT4; Molt4; GM02219; GM02219C; GM2219C; GM02219D 83753.0 nM GI50 C9142 Orphanet_99861
TKC096011 SN12C SN-12C 11967.0 nM GI50 C9385 Orphanet_217071
TKC096011 MDA-N MDAN 100000.0 nM GI50 C3802
TKC096011 ACHN 100000.0 nM GI50 C6975 Orphanet_319298
TKC096011 NCI-H23 NCI.H23; NCI H23; H-23; H23; NCIH23 100000.0 nM GI50 C3512
TKC096011 UO-31 UO.31; UO31; U031 87498.0 nM GI50 C9385 Orphanet_217071
TKC096011 HOP-92 HOP 92; HOP.92; HOP92; Hop92; Hopkins-92 100000.0 nM GI50 C2926
TKC096011 DU-145 DU-145; Du-145; DU 145; DU_145; DU.145; Duke University 145 100000.0 nM GI50 C4863
TKC096011 HL-60 HL 60; HL.60 HL60; Human Leukemia-60 100000.0 nM GI50 C9154 Orphanet_519
TKC096011 SK-MEL-5 SK-Mel-5; SK MEL 5; SK.MEL.5; SK-MEL5; SKMel-5; SKMEL-5; SKMEL5; SKMel5; SKmel5; AA-Mel 100000.0 nM GI50 C3510
TKC096011 SF-539 SF-539; SF-539 BT; SF.539; SF 539 100000.0 nM GI50 C3796 Orphanet_251576
TKC096011 Malme-3M MALME-3M; MALME 3M; Malme-3 M; MALME.3M; Malme3M; MALME3M; Malme-3 Monolayer 100000.0 nM GI50 C3224
TKC096011 A498 A498 100000.0 nM GI50 C9385 Orphanet_217071
TKC096011 K562 K562; K.562; K 562; KO; GM05372; GM05372E 100000.0 nM GI50 C9110 Orphanet_521
TKC096011 OVCAR-3 Ovcar-3; OVCAR 3; OVCAR.3; NIH:OVCAR-3; NIH:Ovcar-3; NIH:OVCAR3; NIH-OVCAR-3; NIHOVCAR3; OVCAR3; Ovcar3 100000.0 nM GI50 C105555
TKC096011 NCI/ADR-RES NCI/ADR-RES; NCI.ADR.RES; NCIADR.RES; NCI/ADRRES; NCIADRRES; ADR-RES; MCF-7/ADR; MCF-7/ADR-RES; MCF-7/AdrR; MCF-7/Adr; MCF-7/adr; MCF-7ADR; MCF7-ADR; MCF7ADR; OVCAR-8/ADR; OVCAR8/ADR 100000.0 nM GI50 C105555
TKC096011 HOP-62 HOP 62; Hop 62; HOP.62; HOP62; Hop62; Hopkins-62 100000.0 nM GI50 C3512
TKC096011 U-251 U-251 MG; U-251-MG; U-251_MG; U251-MG; U251MG; U-251; U251; U251n; U251N; 251 MG; 251MG; 251 MG(6) 100000.0 nM GI50 C60781 Orphanet_94
TKC096011 OVCAR-8 OVCAR 8; NIH:OVCAR-8; OVCAR8; Ovcar8; OVCAR.8; OVCA8 100000.0 nM GI50 C105555
TKC096011 OVCAR-5 OVCAR 5; NIH:OVCAR-5; OVCAR.5; OVCAR5; Ovcar5; OVCA5 100000.0 nM GI50 C105555
TKC096011 MDA-MB-231 MDA_MB_231; MDA-MB 231; MDA.MB.231; MDA MB 231; MDA MB231; MDA Mb231; MDA-MB231; MDAMB-231; MDAMB231; MDA-231; MDA-231P; MDA231; MDA231-BRE; MB231; MD Anderson-Metastatic Breast-231 100000.0 nM GI50 C5214
TKC096011 SNB-19 SNB.19; SNB19; Surgical Neurology Branch-19 100000.0 nM GI50 C60781 Orphanet_94
TKC096011 SR SR-786; SR786 100000.0 nM GI50 C37193 Orphanet_300895
TKC096011 TK-10 TK.10; TK 10; TK10 100000.0 nM GI50 C4033 Orphanet_319276
TKC096011 SW-620 SW-620; SW 620; SW.620 100000.0 nM GI50 C4349
TKC096011 KM12 KM-12; KM.12 100000.0 nM GI50 C4910
TKC096011 NCI-H522 NCI.H522; H522; H-522; NCI-522; NCI522; NCIH522 100000.0 nM GI50 C3512
TKC096011 M14 M14-MEL; UCLA-SO-M14; UCLA SO M14; UCLA-SO-14; UCLASO-M14; Melanoma 14; M-14 100000.0 nM GI50 C3802
TKC096011 NCI-H322M NCI.H322M; H322M; H-322M; H-322m 100000.0 nM GI50 C2923
TKC096011 RPMI-8226 RPMI 8226; RPMI.8226; RPMI8226; RPMI no. 8226; RPMI no 8226; RPMI #8226; 8226; RPMI 8226/S; RPMI-8226S; RPMI8226/S; 8226/S; Roswell Park Memorial Institute 8226; GM02132; GM2132; GM 2132; GM02132C; Simpson 10.0 nM GI50 C3242 Orphanet_29073
TKC096011 OVCAR-4 OVCAR 4; NIH:OVCAR-4; NIH:OVCAR4; OVCAR.4; OVCAR4; Ovcar4 89125.0 nM GI50 C105555
TKC096011 LOX IMVI LOX/IMVI; LOX IMVI; LOXIM-VI; LOXIMVI; LOX 100000.0 nM GI50 C3802
TKC096011 BT-549 BT 549; BT.549; BT549 100000.0 nM GI50 C4194
TKC096011 SK-MEL-2 SK-Mel-2; SK-Mel 2; SK-mel-2; SK-MEL2; SK.MEL.2; SK Mel 2; SK MEL 2; SKMEL-2; SKMEL2; SKmel2; SK-ML2; SKml2 100000.0 nM GI50 C3224
TKC096011 HCC 2998 HCC-2998; HCC.2998; HCC 2998; Hamon Cancer Center 2998 100000.0 nM GI50 C4349
TKC096011 A549 100000.0 nM GI50 C3512
TKC096011 SNB-75 SNB.75; SNB75; Surgical Neurology Branch-75 100000.0 nM GI50 C3058 Orphanet_360
TKC096011 HCT-15 HCT-15; HCT.15; HCT15 100000.0 nM GI50 C4349
TKC096011 HCT-116 HCT-116; HCT.116; HCT_116; HCT116; HCT116wt; CoCL2 100000.0 nM GI50 C4910
TKC096011 SF-268 SF-268; SF.268; SF 268 100000.0 nM GI50 C60781 Orphanet_94
TKC096011 EKVX 100000.0 nM GI50 C3512
TKC096011 PC-3 PC3; PC.3 72611.0 nM GI50 C4863
TKC096011 MCF7 100000.0 nM GI50 C4194
TKC096011 SK-OV-3 SKOV-3; SK-OV3; SK.OV.3; SKOV3; Skov3; SKO3 72277.0 nM GI50 C7978
TKC096011 NCI-H460 NCI.H460; H460; H-460; NCIH460; NCI-HUT-460; NCI-460 100000.0 nM GI50 C4450
TKC096011 T47D 100000.0 nM GI50 C4194
TKC096011 CAKI-1 CAL 1; Centre Antoine Lacassagne-1 100000.0 nM GI50 C3224
TKC096011 UACC-62 UACC 62; UACC.62; UACC62; University of Arizona Cell Culture-62 100000.0 nM GI50 C3224
TKC096011 MDA-MB-435 MDA-MB435; MDAMB435; MDA.MB.435; MDA-435; MDA 435; MDA435; MD Anderson-Metastatic Breast-435 100000.0 nM GI50 C3802
TKC096011 SF-295 SF-295; SF.295; SF 295 100000.0 nM GI50 C3058 Orphanet_360
TKC096011 IGROV-1 Igrov-1; IGROV 1; IGR-OV1; IGROV1; Igrov1; IGR.OV1; IGROV; OV1/P; OV1/p; OV1-P 100000.0 nM GI50 C7979 Orphanet_454723
TKC096011 786-0 786-o; 786O; 786-0; 786.O; 786-O RCC; RCC 786-O; RCC_7860; RCC 7860; 7860; 786-0WT 100000.0 nM GI50 C9385 Orphanet_217071
TKC096011 Hs-578T HS 578T; Hs-578T; HS-578T; Hs_578t; Hs-578-T; HS-578-T; Hs 578.T; HS578T; Hs578T; Hs578t; HS0578T; 578T; HS578; Hs578; Homo sapiens No. 578, tumor cells 100000.0 nM GI50 C4194
TKC096011 UACC-257 UACC 257; UACC.257; UACC257; University of Arizona Cell Culture-257 89331.0 nM GI50 C3224
TKC096011 CCRF-CEM CCRF/CEM; CCRFCEM; CCRF.CEM; CCRF CEM; CCRF; CEM; CEM-CCRF; CEM-CCRF (CAMR); CCRF/CEM/0; CEM/0; CEM-0; CCRF-CEM/S; GM03671; GM03671C 10.0 nM GI50 C7953 Orphanet_99861
TKC096011 HT-29 HT 29; HT29 100000.0 nM GI50 C4349
TKC096011 NCI-H226 NCI.H226; NCI H226; H226; H-226; HUT-226; HUT 226; NCIH226 85114.0 nM GI50 C45662 Orphanet_50251
TKC096011 SK-MEL-28 SK-Mel-28; SK.MEL.28; SK-MEL 28; SK MEL-28; SK MEL 28; SK Mel 28; SKMel-28; SKMEL-28; SK-MEL28; SK-Mel28; SK Mel28; SKMEL28; SKMel28; SKmel28; SKML-28; SK28; AU-Mel; P-36; P36 100000.0 nM GI50 C3510
TKC096011 RXF 393 RXF393L; RXF-393 L; RXF-393; RXF 393; RXF.393; RXF393; RXF 393NL 100000.0 nM GI50 C9385 Orphanet_217071
TKC096011 COLO 205 Colo 205; CoLo 205; COLO-205; Colo-205; COLO.205; Colo205; COLO205; Co 205; Colorado 205 100000.0 nM GI50 C4349

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC096011 Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 TDP1 16 nM Potency
TKC096011 P84022 Mothers against decapentaplegic homolog 3 SMAD3 100 nM Potency
TKC096011 Q9UNA4 DNA polymerase iota POLI 100000 nM Potency
TKC096011 P04150 Glucocorticoid receptor NR3C1 1 nM Ki
TKC096011 P0DTD1 Replicase polyprotein 1ab rep 11 % Inhibition
TKC096011 P28482 Mitogen-activated protein kinase 1 MAPK1 3162 nM Potency
TKC096011 Q690N0 Nuclear receptor subfamily 3 group C member 3 PGR 3 nM Ki
TKC096011 B2RXH2 Lysine-specific demethylase 4E KDM4E 39811 nM Potency
TKC096011 Q16665 Hypoxia-inducible factor 1-alpha HIF1A 1 nM Potency
TKC096011 P02545 Prelamin-A/C LMNA 35481 nM Potency

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
P84022 SMAD3_HUMAN Herpes simplex infection [ICD-11: 1F00]
P84022 SMAD3_HUMAN Kidney fibrosis [ICD-11: GC01]
P04150 GCR_HUMAN Acute diabete complication [ICD-11: 5A2Y]
P04150 GCR_HUMAN Indeterminate colitis [ICD-11: DD72]
P04150 GCR_HUMAN Multiple sclerosis [ICD-11: 8A40]
P04150 GCR_HUMAN Muscular dystrophy [ICD-11: 8C70]
P04150 GCR_HUMAN Prostate cancer [ICD-11: 2C82]
P04150 GCR_HUMAN Rheumatoid arthritis [ICD-11: FA20]
P04150 GCR_HUMAN Type 2 diabetes mellitus [ICD-11: 5A11]
P04150 GCR_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P04150 GCR_HUMAN Adaptive immunity immunodeficiency [ICD-11: 4A01]
P04150 GCR_HUMAN Adrenogenital disorder [ICD-11: 5A71]
P04150 GCR_HUMAN Allergic/hypersensitivity disorder [ICD-11: 4A80-4A8Z]
P04150 GCR_HUMAN Asthma [ICD-11: CA23]
P04150 GCR_HUMAN Atopic eczema [ICD-11: EA80]
P04150 GCR_HUMAN Chronic obstructive pulmonary disease [ICD-11: CA22]
P04150 GCR_HUMAN Cushing syndrome [ICD-11: 5A70]
P04150 GCR_HUMAN Eczema [ICD-11: EA80-EA89]
P04150 GCR_HUMAN Multiple sclerosis [ICD-11: 8A40]
P04150 GCR_HUMAN Muscular dystrophy [ICD-11: 8C70]
P04150 GCR_HUMAN Oesophagitis [ICD-11: DA24]
P04150 GCR_HUMAN Postoperative inflammation [ICD-11: 1A00-CA43]
P04150 GCR_HUMAN Rheumatoid arthritis [ICD-11: FA20]
P04150 GCR_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P04150 GCR_HUMAN Spine/trunk injury [ICD-11: ND51]
P04150 GCR_HUMAN Vasomotor/allergic rhinitis [ICD-11: CA08]
P04150 GCR_HUMAN Herpes simplex infection [ICD-11: 1F00]
P04150 GCR_HUMAN Otitis externa [ICD-11: AA00-AA13]
P04150 GCR_HUMAN Substance abuse [ICD-11: 6C40]
P04150 GCR_HUMAN Breast cancer [ICD-11: 2C60-2C6Y]
P04150 GCR_HUMAN Depression [ICD-11: 6A70-6A7Z]
P04150 GCR_HUMAN Mood disorder [ICD-11: 6A60-6E23]
P04150 GCR_HUMAN Type 2 diabetes mellitus [ICD-11: 5A11]
P04150 GCR_HUMAN Vitamin deficiency [ICD-11: 5B55-5B5F]
P04150 GCR_HUMAN Retinopathy [ICD-11: 9B71]
P04150 GCR_HUMAN Anxiety disorder [ICD-11: 6B00-6B0Z]
P28482 MK01_HUMAN Melanoma [ICD-11: 2C30]
P28482 MK01_HUMAN Pancreatic cancer [ICD-11: 2C10]
P28482 MK01_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P28482 MK01_HUMAN Arteries/arterioles disorder [ICD-11: BD52]
P28482 MK01_HUMAN Allergic/hypersensitivity disorder [ICD-11: 4A80-4A8Z]
P28482 MK01_HUMAN Transplant rejection [ICD-11: NE84]
P28482 MK01_HUMAN Mature T-cell lymphoma [ICD-11: 2A90]
P28482 MK01_HUMAN Rheumatoid arthritis [ICD-11: FA20]
Q16665 HIF1A_HUMAN Adrenomedullary hyperfunction [ICD-11: 5A75]
Q16665 HIF1A_HUMAN Brain cancer [ICD-11: 2A00]
Q16665 HIF1A_HUMAN Lymphoma [ICD-11: 2A80-2A86]
Q16665 HIF1A_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
Q16665 HIF1A_HUMAN Pulmonary hypertension [ICD-11: BB01]