Basic Information

Terpenoid ID TKC082378
Chirality TKC006034
Cell line 0
Protein target 22
DiseaseNCIT 0
ORDO 0
ICD 88

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC082378 HepG2 3162.0 nM Potency C3728 Orphanet_449
TKC082378 CHO Chinese Hamster Ovary; CHO-ori 2043.0 nM IC50
TKC082378 HEK293 11220.0 nM Potency

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC082378 P11473 Vitamin D3 receptor VDR 25119 nM Potency
TKC082378 Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 TDP1 731 nM Potency
TKC082378 O75874 Isocitrate dehydrogenase [NADP] cytoplasmic IDH1 8200 nM Potency
TKC082378 P43220 Glucagon-like peptide 1 receptor GLP1R 1122 nM Potency
TKC082378 P53350 Serine/threonine-protein kinase PLK1 PLK1 15003 nM Potency
TKC082378 P84022 Mothers against decapentaplegic homolog 3 SMAD3 1995 nM Potency
TKC082378 Q03431 Parathyroid hormone/parathyroid hormone-related peptide receptor PTH1R 10000 nM Potency
TKC082378 Q06710 Paired box protein Pax-8 PAX8 1860 nM AC50
TKC082378 Q14191 Werner syndrome ATP-dependent helicase WRN 17783 nM Potency
TKC082378 Q16236 Nuclear factor erythroid 2-related factor 2 NFE2L2 9200 nM Potency
TKC082378 Q932Y6 Beta-lactamase bla(tem-2) 22146 nM IC50
TKC082378 Q99700 Ataxin-2 ATXN2 7080 nM Potency
TKC082378 O43353 Receptor-interacting serine/threonine-protein kinase 2 RIPK2 1188 nM IC50
TKC082378 O75164 Lysine-specific demethylase 4A KDM4A 100000 nM Potency
TKC082378 O75496 Geminin GMNN 731 nM Potency
TKC082378 O89049 Thioredoxin reductase 1, cytoplasmic Txnrd1 7080 nM Potency
TKC082378 P01215 Glycoprotein hormones alpha chain CGA 1413 nM Potency
TKC082378 Q13148 TAR DNA-binding protein 43 TARDBP 12589 nM Potency
TKC082378 P63096 Guanine nucleotide-binding protein G GNAI1 2239 nM Potency
TKC082378 P49798 Regulator of G-protein signaling 4 RGS4 28184 nM Potency
TKC082378 Q57TT1 HpcH_HpaI domain-containing protein Tb08.30K1.730 17783 nM Potency
TKC082378 Q9NR96 Toll-like receptor 9 TLR9 7929 nM IC50
TKC082378 Q9NR96 Toll-like receptor 9 TLR9 7929 nM IC50

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
P11473 VDR_HUMAN Chronic kidney disease [ICD-11: GB61]
P11473 VDR_HUMAN Hair/hair growth developmental defect [ICD-11: LC30]
P11473 VDR_HUMAN Hyper-parathyroidism [ICD-11: 5A51]
P11473 VDR_HUMAN Hypo-parathyroidism [ICD-11: 5A50]
P11473 VDR_HUMAN Mineral deficiency [ICD-11: 5B5K]
P11473 VDR_HUMAN Psoriasis [ICD-11: EA90]
P11473 VDR_HUMAN Vitamin deficiency [ICD-11: 5B55-5B5F]
P11473 VDR_HUMAN Low bone mass disorder [ICD-11: FB83]
P11473 VDR_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
P11473 VDR_HUMAN Prostate cancer [ICD-11: 2C82]
P11473 VDR_HUMAN Prostate disease [ICD-11: GA91]
P11473 VDR_HUMAN Abnormal micturition [ICD-11: MF50]
P11473 VDR_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P11473 VDR_HUMAN Postoperative inflammation [ICD-11: 1A00-CA43]
P11473 VDR_HUMAN Acne vulgaris [ICD-11: ED80]
O75874 IDHC_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
O75874 IDHC_HUMAN Liver cancer [ICD-11: 2C12]
O75874 IDHC_HUMAN Malignant haematopoietic neoplasm [ICD-11: 2B33]
O75874 IDHC_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
O75874 IDHC_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
O75874 IDHC_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P43220 GLP1R_HUMAN Cardiovascular disease [ICD-11: BA00-BE2Z]
P43220 GLP1R_HUMAN Obesity [ICD-11: 5B80-5B81]
P43220 GLP1R_HUMAN Type 2 diabetes mellitus [ICD-11: 5A11]
P43220 GLP1R_HUMAN Type-1/2 diabete [ICD-11: 5A10-5A11]
P43220 GLP1R_HUMAN Acute diabete complication [ICD-11: 5A2Y]
P43220 GLP1R_HUMAN Diabetes mellitus [ICD-11: 5A10]
P43220 GLP1R_HUMAN Dyspepsia [ICD-11: MD92]
P43220 GLP1R_HUMAN Irritable bowel syndrome [ICD-11: DD91]
P43220 GLP1R_HUMAN Intracranial injury [ICD-11: NA07]
P43220 GLP1R_HUMAN Non-alcoholic fatty liver disease [ICD-11: DB92]
P53350 PLK1_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
P53350 PLK1_HUMAN Myelodysplastic syndrome [ICD-11: 2A37]
P53350 PLK1_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P53350 PLK1_HUMAN Prostate cancer [ICD-11: 2C82]
P53350 PLK1_HUMAN Malignant haematopoietic neoplasm [ICD-11: 2B33]
P53350 PLK1_HUMAN Pancreatic cancer [ICD-11: 2C10]
P53350 PLK1_HUMAN Lymphoma [ICD-11: 2A80-2A86]
P53350 PLK1_HUMAN Nasopharyngeal cancer [ICD-11: 2B6B]
P53350 PLK1_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P84022 SMAD3_HUMAN Herpes simplex infection [ICD-11: 1F00]
P84022 SMAD3_HUMAN Kidney fibrosis [ICD-11: GC01]
Q03431 PTH1R_HUMAN Low bone mass disorder [ICD-11: FB83]
Q03431 PTH1R_HUMAN Hypo-parathyroidism [ICD-11: 5A50]
Q14191 WRN_HUMAN Mature T-cell lymphoma [ICD-11: 2A90]
Q16236 NF2L2_HUMAN Ataxic disorder [ICD-11: 8A03]
Q16236 NF2L2_HUMAN Breast cancer [ICD-11: 2C60-2C6Y]
Q16236 NF2L2_HUMAN Glaucoma [ICD-11: 9C61]
Q16236 NF2L2_HUMAN Lung cancer [ICD-11: 2C25]
Q16236 NF2L2_HUMAN Macular degeneration [ICD-11: 9B75]
Q16236 NF2L2_HUMAN Melanoma [ICD-11: 2C30]
Q16236 NF2L2_HUMAN Mental/behavioural/neurodevelopmental disorder [ICD-11: 6E20-6E8Z]
Q16236 NF2L2_HUMAN Pulmonary hypertension [ICD-11: BB01]
Q16236 NF2L2_HUMAN Subarachnoid haemorrhage [ICD-11: 8B01]
Q16236 NF2L2_HUMAN Urinary system clinical sympton [ICD-11: MF8Y]
Q16236 NF2L2_HUMAN Non-alcoholic fatty liver disease [ICD-11: DB92]
Q16236 NF2L2_HUMAN Alpha-1-antitrypsin deficiency [ICD-11: 5C5A]
Q16236 NF2L2_HUMAN Motor neuron disease [ICD-11: 8B60]
Q16236 NF2L2_HUMAN Multiple sclerosis [ICD-11: 8A40]
O43353 RIPK2_HUMAN Cardiovascular disease [ICD-11: BA00-BE2Z]
O43353 RIPK2_HUMAN Postoperative inflammation [ICD-11: 1A00-CA43]
Q13148 TADBP_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
Q13148 TADBP_HUMAN Alzheimer disease [ICD-11: 8A20]
Q9NR96 TLR9_HUMAN Colorectal cancer [ICD-11: 2B91]
Q9NR96 TLR9_HUMAN Hepatitis virus infection [ICD-11: 1E50-1E51]
Q9NR96 TLR9_HUMAN Melanoma [ICD-11: 2C30]
Q9NR96 TLR9_HUMAN Metastatic lymph node neoplasm [ICD-11: 2D60]
Q9NR96 TLR9_HUMAN Prostate cancer [ICD-11: 2C82]
Q9NR96 TLR9_HUMAN Skin disease [ICD-11: EA00-EM0Z]
Q9NR96 TLR9_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
Q9NR96 TLR9_HUMAN Squamous cell carcinoma [ICD-11: 2B60-2D01]
Q9NR96 TLR9_HUMAN Asthma [ICD-11: CA23]
Q9NR96 TLR9_HUMAN Diabetes mellitus [ICD-11: 5A10]
Q9NR96 TLR9_HUMAN Human immunodeficiency virus disease [ICD-11: 1C60-1C62]
Q9NR96 TLR9_HUMAN Indeterminate colitis [ICD-11: DD72]
Q9NR96 TLR9_HUMAN Leukaemia [ICD-11: 2A60-2B33]
Q9NR96 TLR9_HUMAN Psoriasis [ICD-11: EA90]
Q9NR96 TLR9_HUMAN Renal cell carcinoma [ICD-11: 2C90]
Q9NR96 TLR9_HUMAN Sepsis [ICD-11: 1G40-1G41]
Q9NR96 TLR9_HUMAN Vasomotor/allergic rhinitis [ICD-11: CA08]
Q9NR96 TLR9_HUMAN Autoimmune disease [ICD-11: 4A40-4A45]
Q9NR96 TLR9_HUMAN Brain cancer [ICD-11: 2A00]
Q9NR96 TLR9_HUMAN Influenza [ICD-11: 1E30-1E32]
Q9NR96 TLR9_HUMAN Lung cancer [ICD-11: 2C25]
Q9NR96 TLR9_HUMAN Lupus erythematosus [ICD-11: 4A40]
Q9NR96 TLR9_HUMAN Mature B-cell leukaemia [ICD-11: 2A82]
Q9NR96 TLR9_HUMAN Diffuse large B-cell lymphoma [ICD-11: 2A81]
Q9NR96 TLR9_HUMAN Allergic/hypersensitivity disorder [ICD-11: 4A80-4A8Z]
Q9NR96 TLR9_HUMAN Parkinsonism [ICD-11: 8A00]
Q9NR96 TLR9_HUMAN Postoperative inflammation [ICD-11: 1A00-CA43]
Q9NR96 TLR9_HUMAN Spine/trunk injury [ICD-11: ND51]
Q9NR96 TLR9_HUMAN Colorectal cancer [ICD-11: 2B91]
Q9NR96 TLR9_HUMAN Hepatitis virus infection [ICD-11: 1E50-1E51]
Q9NR96 TLR9_HUMAN Melanoma [ICD-11: 2C30]
Q9NR96 TLR9_HUMAN Metastatic lymph node neoplasm [ICD-11: 2D60]
Q9NR96 TLR9_HUMAN Prostate cancer [ICD-11: 2C82]
Q9NR96 TLR9_HUMAN Skin disease [ICD-11: EA00-EM0Z]
Q9NR96 TLR9_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
Q9NR96 TLR9_HUMAN Squamous cell carcinoma [ICD-11: 2B60-2D01]
Q9NR96 TLR9_HUMAN Asthma [ICD-11: CA23]
Q9NR96 TLR9_HUMAN Diabetes mellitus [ICD-11: 5A10]
Q9NR96 TLR9_HUMAN Human immunodeficiency virus disease [ICD-11: 1C60-1C62]
Q9NR96 TLR9_HUMAN Indeterminate colitis [ICD-11: DD72]
Q9NR96 TLR9_HUMAN Leukaemia [ICD-11: 2A60-2B33]
Q9NR96 TLR9_HUMAN Psoriasis [ICD-11: EA90]
Q9NR96 TLR9_HUMAN Renal cell carcinoma [ICD-11: 2C90]
Q9NR96 TLR9_HUMAN Sepsis [ICD-11: 1G40-1G41]
Q9NR96 TLR9_HUMAN Vasomotor/allergic rhinitis [ICD-11: CA08]
Q9NR96 TLR9_HUMAN Autoimmune disease [ICD-11: 4A40-4A45]
Q9NR96 TLR9_HUMAN Brain cancer [ICD-11: 2A00]
Q9NR96 TLR9_HUMAN Influenza [ICD-11: 1E30-1E32]
Q9NR96 TLR9_HUMAN Lung cancer [ICD-11: 2C25]
Q9NR96 TLR9_HUMAN Lupus erythematosus [ICD-11: 4A40]
Q9NR96 TLR9_HUMAN Mature B-cell leukaemia [ICD-11: 2A82]
Q9NR96 TLR9_HUMAN Diffuse large B-cell lymphoma [ICD-11: 2A81]
Q9NR96 TLR9_HUMAN Allergic/hypersensitivity disorder [ICD-11: 4A80-4A8Z]
Q9NR96 TLR9_HUMAN Parkinsonism [ICD-11: 8A00]
Q9NR96 TLR9_HUMAN Postoperative inflammation [ICD-11: 1A00-CA43]
Q9NR96 TLR9_HUMAN Spine/trunk injury [ICD-11: ND51]