Basic Information

Terpenoid ID TKC077038
Chirality TKC036127
Cell line 0
Protein target 3
DiseaseNCIT 0
ORDO 0
ICD 3

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC077038 MCF7 10.0 ug.mL-1 IC50 C4194
TKC077038 HepG2 13.0 ug.mL-1 IC50 C3728 Orphanet_449
TKC077038 P338 3.0 ug.mL-1 IC50
TKC077038 SW480 SW-480; SW 480; SW480E 3.0 ug.mL-1 IC50 C4349
TKC077038 HeLa HELA; Hela; He La; He-La; HeLa-CCL2; Henrietta Lacks cells; Helacyton gartleri 3.0 ug.mL-1 IC50 C27677
TKC077038 A549 69.0 % Inhibition C3512
TKC077038 RAW264.7 RAW264 13600.0 nM IC50 C21604
TKC077038 DU-145 DU-145; Du-145; DU 145; DU_145; DU.145; Duke University 145 6.0 nM IC50 C4863
TKC077038 PC-3 PC3; PC.3 9100.0 nM IC50 C4863

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC077038 P08684 Cytochrome P450 3A4 CYP3A4 21800 nM IC50
TKC077038 O42275 Acetylcholinesterase ache -5 % Inhibition
TKC077038 P10635 Cytochrome P450 2D6 CYP2D6 >100000 nM IC50
TKC077038 P81908 Cholinesterase BCHE 4 % Inhibition
TKC077038 P08151 Zinc finger protein GLI1 GLI1 7100 nM IC50
TKC077038 P12527 Polyunsaturated fatty acid 5-lipoxygenase Alox5 0 % Inhibition
TKC077038 P10070 Zinc finger protein GLI2 GLI2 910 nM IC50
TKC077038 Q45614 Sensor histidine kinase WalK walK >500 ug.mL-1 IC50

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
P08684 CP3A4_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P08684 CP3A4_HUMAN Atopic eczema [ICD-11: EA80]
P08684 CP3A4_HUMAN Anxiety disorder [ICD-11: 6B00-6B0Z]
P10635 CP2D6_HUMAN Insomnia [ICD-11: 7A00-7A0Z]
P10635 CP2D6_HUMAN Malaria [ICD-11: 1F40-1F45]
P10635 CP2D6_HUMAN Migraine [ICD-11: 8A80]