Basic Information

Terpenoid ID TKC075756
Chirality TKC107086
Cell line 0
Protein target 3
DiseaseNCIT 0
ORDO 0
ICD 20

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC075756 HCT-116 HCT-116; HCT.116; HCT_116; HCT116; HCT116wt; CoCL2 1950.0 nM GI50 C4910
TKC075756 HT-29 HT 29; HT29 3508.0 nM GI50 C4349
TKC075756 MDA-N MDAN 3327.0 nM GI50 C3802
TKC075756 SN12C SN-12C 2972.0 nM GI50 C9385 Orphanet_217071
TKC075756 NCI-H23 NCI.H23; NCI H23; H-23; H23; NCIH23 2265.0 nM GI50 C3512
TKC075756 ACHN 1524.0 nM GI50 C6975 Orphanet_319298
TKC075756 UO-31 UO.31; UO31; U031 1936.0 nM GI50 C9385 Orphanet_217071
TKC075756 HL-60 HL 60; HL.60 HL60; Human Leukemia-60 2897.0 nM GI50 C9154 Orphanet_519
TKC075756 HOP-92 HOP 92; HOP.92; HOP92; Hop92; Hopkins-92 4742.0 nM GI50 C2926
TKC075756 DU-145 DU-145; Du-145; DU 145; DU_145; DU.145; Duke University 145 2046.0 nM GI50 C4863
TKC075756 SF-539 SF-539; SF-539 BT; SF.539; SF 539 2979.0 nM GI50 C3796 Orphanet_251576
TKC075756 SK-MEL-5 SK-Mel-5; SK MEL 5; SK.MEL.5; SK-MEL5; SKMel-5; SKMEL-5; SKMEL5; SKMel5; SKmel5; AA-Mel 4498.0 nM GI50 C3510
TKC075756 K562 K562; K.562; K 562; KO; GM05372; GM05372E 3076.0 nM GI50 C9110 Orphanet_521
TKC075756 OVCAR-3 Ovcar-3; OVCAR 3; OVCAR.3; NIH:OVCAR-3; NIH:Ovcar-3; NIH:OVCAR3; NIH-OVCAR-3; NIHOVCAR3; OVCAR3; Ovcar3 1549.0 nM GI50 C105555
TKC075756 A498 A498 6180.0 nM GI50 C9385 Orphanet_217071
TKC075756 MOLT-4 Molt-4; MOLT 4; Molt 4; MOLT.4; MOLT4; Molt4; GM02219; GM02219C; GM2219C; GM02219D 3899.0 nM GI50 C9142 Orphanet_99861
TKC075756 HOP-62 HOP 62; Hop 62; HOP.62; HOP62; Hop62; Hopkins-62 2371.0 nM GI50 C3512
TKC075756 U-251 U-251 MG; U-251-MG; U-251_MG; U251-MG; U251MG; U-251; U251; U251n; U251N; 251 MG; 251MG; 251 MG(6) 3428.0 nM GI50 C60781 Orphanet_94
TKC075756 NCI/ADR-RES NCI/ADR-RES; NCI.ADR.RES; NCIADR.RES; NCI/ADRRES; NCIADRRES; ADR-RES; MCF-7/ADR; MCF-7/ADR-RES; MCF-7/AdrR; MCF-7/Adr; MCF-7/adr; MCF-7ADR; MCF7-ADR; MCF7ADR; OVCAR-8/ADR; OVCAR8/ADR 3890.0 nM GI50 C105555
TKC075756 OVCAR-8 OVCAR 8; NIH:OVCAR-8; OVCAR8; Ovcar8; OVCAR.8; OVCA8 2023.0 nM GI50 C105555
TKC075756 OVCAR-5 OVCAR 5; NIH:OVCAR-5; OVCAR.5; OVCAR5; Ovcar5; OVCA5 2065.0 nM GI50 C105555
TKC075756 SNB-19 SNB.19; SNB19; Surgical Neurology Branch-19 2070.0 nM GI50 C60781 Orphanet_94
TKC075756 SR SR-786; SR786 2366.0 nM GI50 C37193 Orphanet_300895
TKC075756 MDA-MB-231 MDA_MB_231; MDA-MB 231; MDA.MB.231; MDA MB 231; MDA MB231; MDA Mb231; MDA-MB231; MDAMB-231; MDAMB231; MDA-231; MDA-231P; MDA231; MDA231-BRE; MB231; MD Anderson-Metastatic Breast-231 2483.0 nM GI50 C5214
TKC075756 TK-10 TK.10; TK 10; TK10 2495.0 nM GI50 C4033 Orphanet_319276
TKC075756 SW-620 SW-620; SW 620; SW.620 5521.0 nM GI50 C4349
TKC075756 NCI-H522 NCI.H522; H522; H-522; NCI-522; NCI522; NCIH522 2061.0 nM GI50 C3512
TKC075756 KM12 KM-12; KM.12 2123.0 nM GI50 C4910
TKC075756 M14 M14-MEL; UCLA-SO-M14; UCLA SO M14; UCLA-SO-14; UCLASO-M14; Melanoma 14; M-14 12417.0 nM GI50 C3802
TKC075756 NCI-H322M NCI.H322M; H322M; H-322M; H-322m 3304.0 nM GI50 C2923
TKC075756 RPMI-8226 RPMI 8226; RPMI.8226; RPMI8226; RPMI no. 8226; RPMI no 8226; RPMI #8226; 8226; RPMI 8226/S; RPMI-8226S; RPMI8226/S; 8226/S; Roswell Park Memorial Institute 8226; GM02132; GM2132; GM 2132; GM02132C; Simpson 3148.0 nM GI50 C3242 Orphanet_29073
TKC075756 OVCAR-4 OVCAR 4; NIH:OVCAR-4; NIH:OVCAR4; OVCAR.4; OVCAR4; Ovcar4 1972.0 nM GI50 C105555
TKC075756 BT-549 BT 549; BT.549; BT549 1629.0 nM GI50 C4194
TKC075756 LOX IMVI LOX/IMVI; LOX IMVI; LOXIM-VI; LOXIMVI; LOX 3420.0 nM GI50 C3802
TKC075756 SK-MEL-2 SK-Mel-2; SK-Mel 2; SK-mel-2; SK-MEL2; SK.MEL.2; SK Mel 2; SK MEL 2; SKMEL-2; SKMEL2; SKmel2; SK-ML2; SKml2 3365.0 nM GI50 C3224
TKC075756 A549 2168.0 nM GI50 C3512
TKC075756 SNB-75 SNB.75; SNB75; Surgical Neurology Branch-75 2831.0 nM GI50 C3058 Orphanet_360
TKC075756 HCC 2998 HCC-2998; HCC.2998; HCC 2998; Hamon Cancer Center 2998 1663.0 nM GI50 C4349
TKC075756 HCT-15 HCT-15; HCT.15; HCT15 4027.0 nM GI50 C4349
TKC075756 SF-268 SF-268; SF.268; SF 268 2089.0 nM GI50 C60781 Orphanet_94
TKC075756 MCF7 2183.0 nM GI50 C4194
TKC075756 EKVX 3126.0 nM GI50 C3512
TKC075756 PC-3 PC3; PC.3 100.0 % GI C4863
TKC075756 T47D 2999.0 nM GI50 C4194
TKC075756 SK-OV-3 SKOV-3; SK-OV3; SK.OV.3; SKOV3; Skov3; SKO3 2360.0 nM GI50 C7978
TKC075756 NCI-H460 NCI.H460; H460; H-460; NCIH460; NCI-HUT-460; NCI-460 1936.0 nM GI50 C4450
TKC075756 UACC-62 UACC 62; UACC.62; UACC62; University of Arizona Cell Culture-62 3999.0 nM GI50 C3224
TKC075756 MDA-MB-435 MDA-MB435; MDAMB435; MDA.MB.435; MDA-435; MDA 435; MDA435; MD Anderson-Metastatic Breast-435 11246.0 nM GI50 C3802
TKC075756 CAKI-1 CAL 1; Centre Antoine Lacassagne-1 1387.0 nM GI50 C3224
TKC075756 SF-295 SF-295; SF.295; SF 295 1816.0 nM GI50 C3058 Orphanet_360
TKC075756 IGROV-1 Igrov-1; IGROV 1; IGR-OV1; IGROV1; Igrov1; IGR.OV1; IGROV; OV1/P; OV1/p; OV1-P 2831.0 nM GI50 C7979 Orphanet_454723
TKC075756 Hs-578T HS 578T; Hs-578T; HS-578T; Hs_578t; Hs-578-T; HS-578-T; Hs 578.T; HS578T; Hs578T; Hs578t; HS0578T; 578T; HS578; Hs578; Homo sapiens No. 578, tumor cells 2061.0 nM GI50 C4194
TKC075756 786-0 786-o; 786O; 786-0; 786.O; 786-O RCC; RCC 786-O; RCC_7860; RCC 7860; 7860; 786-0WT 1611.0 nM GI50 C9385 Orphanet_217071
TKC075756 UACC-257 UACC 257; UACC.257; UACC257; University of Arizona Cell Culture-257 8375.0 nM GI50 C3224
TKC075756 CCRF-CEM CCRF/CEM; CCRFCEM; CCRF.CEM; CCRF CEM; CCRF; CEM; CEM-CCRF; CEM-CCRF (CAMR); CCRF/CEM/0; CEM/0; CEM-0; CCRF-CEM/S; GM03671; GM03671C 2858.0 nM GI50 C7953 Orphanet_99861
TKC075756 NCI-H226 NCI.H226; NCI H226; H226; H-226; HUT-226; HUT 226; NCIH226 1514.0 nM GI50 C45662 Orphanet_50251
TKC075756 SK-MEL-28 SK-Mel-28; SK.MEL.28; SK-MEL 28; SK MEL-28; SK MEL 28; SK Mel 28; SKMel-28; SKMEL-28; SK-MEL28; SK-Mel28; SK Mel28; SKMEL28; SKMel28; SKmel28; SKML-28; SK28; AU-Mel; P-36; P36 2612.0 nM GI50 C3510
TKC075756 COLO 205 Colo 205; CoLo 205; COLO-205; Colo-205; COLO.205; Colo205; COLO205; Co 205; Colorado 205 1683.0 nM GI50 C4349
TKC075756 ECV-304 ECV 304; ECV304; ECV; E304; T24(ECV304) 13000.0 nM IC50 C4912

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC075756 Q9NPD5 Solute carrier organic anion transporter family member 1B3 SLCO1B3 98 % Inhibition
TKC075756 Q9Y6L6 Solute carrier organic anion transporter family member 1B1 SLCO1B1 76 % Inhibition
TKC075756 P17948 Vascular endothelial growth factor receptor 1 FLT1 1001 nM Ki
TKC075756 P33032 Melanocortin receptor 5 MC5R 3639 nM Ki
TKC075756 Q9UNQ0 Broad substrate specificity ATP-binding cassette transporter ABCG2 ABCG2 9700 nM IC50

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
P17948 VGFR1_HUMAN Renal cell carcinoma [ICD-11: 2C90]
P17948 VGFR1_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P17948 VGFR1_HUMAN Stomach cancer [ICD-11: 2B72]
P17948 VGFR1_HUMAN Arterial occlusive disease [ICD-11: BD40]
P17948 VGFR1_HUMAN Bladder cancer [ICD-11: 2C94]
P17948 VGFR1_HUMAN Macular degeneration [ICD-11: 9B75]
P17948 VGFR1_HUMAN Pancreatic cancer [ICD-11: 2C10]
P17948 VGFR1_HUMAN Retinopathy [ICD-11: 9B71]
P17948 VGFR1_HUMAN Colorectal cancer [ICD-11: 2B91]
P17948 VGFR1_HUMAN Chronic arterial occlusive disease [ICD-11: BD4Z]
P17948 VGFR1_HUMAN Diabetic foot ulcer [ICD-11: BD54]
P17948 VGFR1_HUMAN Multiple myeloma [ICD-11: 2A83]
P17948 VGFR1_HUMAN Myelodysplastic syndrome [ICD-11: 2A37]
P17948 VGFR1_HUMAN Thrombocytopenia [ICD-11: 3B64]
P17948 VGFR1_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P17948 VGFR1_HUMAN Alzheimer disease [ICD-11: 8A20]
P17948 VGFR1_HUMAN Retinopathy [ICD-11: 9B71]
P33032 MC5R_HUMAN Acne vulgaris [ICD-11: ED80]
P33032 MC5R_HUMAN Sebaceous gland disorder [ICD-11: ED91]
P33032 MC5R_HUMAN Sexual dysfunction [ICD-11: HA00-HA01]
Q9UNQ0 ABCG2_HUMAN Irritable bowel syndrome [ICD-11: DD91]
Q9UNQ0 ABCG2_HUMAN Rheumatoid arthritis [ICD-11: FA20]