Basic Information

Terpenoid ID TKC074337
Chirality TKC104440
Cell line 0
Protein target 1
DiseaseNCIT 0
ORDO 0
ICD 4

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC074337 A-431 A431; A431/P 5300.0 nM IC50 C4819
TKC074337 HUVEC HUV-EC-C; HUVEC 1.0 nM IC50
TKC074337 A549 7228.0 nM GI50 C3512
TKC074337 HepG2 860.0 nM IC50 C3728 Orphanet_449
TKC074337 HeLa HELA; Hela; He La; He-La; HeLa-CCL2; Henrietta Lacks cells; Helacyton gartleri 2020.0 nM IC50 C27677
TKC074337 BGC-823 BGC823 1480.0 nM IC50 C27677
TKC074337 SN12C SN-12C 13677.0 nM GI50 C9385 Orphanet_217071
TKC074337 MDA-N MDAN 11429.0 nM GI50 C3802
TKC074337 NCI-H23 NCI.H23; NCI H23; H-23; H23; NCIH23 15849.0 nM GI50 C3512
TKC074337 UO-31 UO.31; UO31; U031 9886.0 nM GI50 C9385 Orphanet_217071
TKC074337 ACHN 14060.0 nM GI50 C6975 Orphanet_319298
TKC074337 HL-60 HL 60; HL.60 HL60; Human Leukemia-60 2535.0 nM GI50 C9154 Orphanet_519
TKC074337 HOP-92 HOP 92; HOP.92; HOP92; Hop92; Hopkins-92 15560.0 nM GI50 C2926
TKC074337 DU-145 DU-145; Du-145; DU 145; DU_145; DU.145; Duke University 145 12246.0 nM GI50 C4863
TKC074337 SF-539 SF-539; SF-539 BT; SF.539; SF 539 10593.0 nM GI50 C3796 Orphanet_251576
TKC074337 Malme-3M MALME-3M; MALME 3M; Malme-3 M; MALME.3M; Malme3M; MALME3M; Malme-3 Monolayer 5970.0 nM GI50 C3224
TKC074337 SK-MEL-5 SK-Mel-5; SK MEL 5; SK.MEL.5; SK-MEL5; SKMel-5; SKMEL-5; SKMEL5; SKMel5; SKmel5; AA-Mel 8831.0 nM GI50 C3510
TKC074337 A498 A498 17179.0 nM GI50 C9385 Orphanet_217071
TKC074337 K562 K562; K.562; K 562; KO; GM05372; GM05372E 12218.0 nM GI50 C9110 Orphanet_521
TKC074337 OVCAR-3 Ovcar-3; OVCAR 3; OVCAR.3; NIH:OVCAR-3; NIH:Ovcar-3; NIH:OVCAR3; NIH-OVCAR-3; NIHOVCAR3; OVCAR3; Ovcar3 3491.0 nM GI50 C105555
TKC074337 MOLT-4 Molt-4; MOLT 4; Molt 4; MOLT.4; MOLT4; Molt4; GM02219; GM02219C; GM2219C; GM02219D 6561.0 nM GI50 C9142 Orphanet_99861
TKC074337 HOP-62 HOP 62; Hop 62; HOP.62; HOP62; Hop62; Hopkins-62 12942.0 nM GI50 C3512
TKC074337 U-251 U-251 MG; U-251-MG; U-251_MG; U251-MG; U251MG; U-251; U251; U251n; U251N; 251 MG; 251MG; 251 MG(6) 3076.0 nM GI50 C60781 Orphanet_94
TKC074337 NCI/ADR-RES NCI/ADR-RES; NCI.ADR.RES; NCIADR.RES; NCI/ADRRES; NCIADRRES; ADR-RES; MCF-7/ADR; MCF-7/ADR-RES; MCF-7/AdrR; MCF-7/Adr; MCF-7/adr; MCF-7ADR; MCF7-ADR; MCF7ADR; OVCAR-8/ADR; OVCAR8/ADR 15996.0 nM GI50 C105555
TKC074337 OVCAR-5 OVCAR 5; NIH:OVCAR-5; OVCAR.5; OVCAR5; Ovcar5; OVCA5 17338.0 nM GI50 C105555
TKC074337 OVCAR-8 OVCAR 8; NIH:OVCAR-8; OVCAR8; Ovcar8; OVCAR.8; OVCA8 15849.0 nM GI50 C105555
TKC074337 SNB-19 SNB.19; SNB19; Surgical Neurology Branch-19 12023.0 nM GI50 C60781 Orphanet_94
TKC074337 DMS-273 DMS-273; DMS273; Darmouth Medical School 273 7112.0 nM GI50 C4917 Orphanet_70573
TKC074337 MDA-MB-231 MDA_MB_231; MDA-MB 231; MDA.MB.231; MDA MB 231; MDA MB231; MDA Mb231; MDA-MB231; MDAMB-231; MDAMB231; MDA-231; MDA-231P; MDA231; MDA231-BRE; MB231; MD Anderson-Metastatic Breast-231 15922.0 nM GI50 C5214
TKC074337 SR SR-786; SR786 5636.0 nM GI50 C37193 Orphanet_300895
TKC074337 SW-620 SW-620; SW 620; SW.620 9528.0 nM GI50 C4349
TKC074337 M19-MEL M-19; M19 6486.0 nM GI50 C3802
TKC074337 TK-10 TK.10; TK 10; TK10 18281.0 nM GI50 C4033 Orphanet_319276
TKC074337 NCI-H522 NCI.H522; H522; H-522; NCI-522; NCI522; NCIH522 5346.0 nM GI50 C3512
TKC074337 XF498 XF-498; XF498 6353.0 nM GI50 C3058 Orphanet_360
TKC074337 M14 M14-MEL; UCLA-SO-M14; UCLA SO M14; UCLA-SO-14; UCLASO-M14; Melanoma 14; M-14 5508.0 nM GI50 C3802
TKC074337 KM12 KM-12; KM.12 11455.0 nM GI50 C4910
TKC074337 RPMI-8226 RPMI 8226; RPMI.8226; RPMI8226; RPMI no. 8226; RPMI no 8226; RPMI #8226; 8226; RPMI 8226/S; RPMI-8226S; RPMI8226/S; 8226/S; Roswell Park Memorial Institute 8226; GM02132; GM2132; GM 2132; GM02132C; Simpson 6934.0 nM GI50 C3242 Orphanet_29073
TKC074337 NCI-H322M NCI.H322M; H322M; H-322M; H-322m 14454.0 nM GI50 C2923
TKC074337 OVCAR-4 OVCAR 4; NIH:OVCAR-4; NIH:OVCAR4; OVCAR.4; OVCAR4; Ovcar4 14421.0 nM GI50 C105555
TKC074337 BT-549 BT 549; BT.549; BT549 14555.0 nM GI50 C4194
TKC074337 LOX IMVI LOX/IMVI; LOX IMVI; LOXIM-VI; LOXIMVI; LOX 5047.0 nM GI50 C3802
TKC074337 SK-MEL-2 SK-Mel-2; SK-Mel 2; SK-mel-2; SK-MEL2; SK.MEL.2; SK Mel 2; SK MEL 2; SKMEL-2; SKMEL2; SKmel2; SK-ML2; SKml2 13646.0 nM GI50 C3224
TKC074337 KM-20L2 KM-20L2; KM 20L2; KM 2012 16558.0 nM GI50 C4349
TKC074337 HCC 2998 HCC-2998; HCC.2998; HCC 2998; Hamon Cancer Center 2998 5808.0 nM GI50 C4349
TKC074337 SNB-75 SNB.75; SNB75; Surgical Neurology Branch-75 7962.0 nM GI50 C3058 Orphanet_360
TKC074337 HCT-15 HCT-15; HCT.15; HCT15 14060.0 nM GI50 C4349
TKC074337 SF-268 SF-268; SF.268; SF 268 13552.0 nM GI50 C60781 Orphanet_94
TKC074337 HCT-116 HCT-116; HCT.116; HCT_116; HCT116; HCT116wt; CoCL2 4645.0 nM GI50 C4910
TKC074337 EKVX 14093.0 nM GI50 C3512
TKC074337 LXFL 529 LXFL-529L; LXFL529L; LXF 529 L; LXFL-529; LXFL 529; LXFL529; LXF 529 1782.0 nM GI50 C2926
TKC074337 PC-3 PC3; PC.3 10740.0 nM GI50 C4863
TKC074337 DMS-114 DMS-114; DMS114; Darmouth Medical School 114 7031.0 nM GI50 C4917 Orphanet_70573
TKC074337 SK-OV-3 SKOV-3; SK-OV3; SK.OV.3; SKOV3; Skov3; SKO3 15311.0 nM GI50 C7978
TKC074337 T47D 12647.0 nM GI50 C4194
TKC074337 NCI-H460 NCI.H460; H460; H-460; NCIH460; NCI-HUT-460; NCI-460 2037.0 nM GI50 C4450
TKC074337 UACC-62 UACC 62; UACC.62; UACC62; University of Arizona Cell Culture-62 11967.0 nM GI50 C3224
TKC074337 MDA-MB-435 MDA-MB435; MDAMB435; MDA.MB.435; MDA-435; MDA 435; MDA435; MD Anderson-Metastatic Breast-435 11695.0 nM GI50 C3802
TKC074337 CAKI-1 CAL 1; Centre Antoine Lacassagne-1 10965.0 nM GI50 C3224
TKC074337 IGROV-1 Igrov-1; IGROV 1; IGR-OV1; IGROV1; Igrov1; IGR.OV1; IGROV; OV1/P; OV1/p; OV1-P 12162.0 nM GI50 C7979 Orphanet_454723
TKC074337 SF-295 SF-295; SF.295; SF 295 5649.0 nM GI50 C3058 Orphanet_360
TKC074337 Hs-578T HS 578T; Hs-578T; HS-578T; Hs_578t; Hs-578-T; HS-578-T; Hs 578.T; HS578T; Hs578T; Hs578t; HS0578T; 578T; HS578; Hs578; Homo sapiens No. 578, tumor cells 19907.0 nM GI50 C4194
TKC074337 RXF 631 RXF-631L; RXF631L; RXF 631; RXF-631; RXF631 1671.0 nM GI50 C9385 Orphanet_217071
TKC074337 UACC-257 UACC 257; UACC.257; UACC257; University of Arizona Cell Culture-257 10965.0 nM GI50 C3224
TKC074337 786-0 786-o; 786O; 786-0; 786.O; 786-O RCC; RCC 786-O; RCC_7860; RCC 7860; 7860; 786-0WT 12647.0 nM GI50 C9385 Orphanet_217071
TKC074337 SNB-78 SNB78; Surgical Neurology Branch-78 10000.0 nM GI50 C3058 Orphanet_360
TKC074337 CCRF-CEM CCRF/CEM; CCRFCEM; CCRF.CEM; CCRF CEM; CCRF; CEM; CEM-CCRF; CEM-CCRF (CAMR); CCRF/CEM/0; CEM/0; CEM-0; CCRF-CEM/S; GM03671; GM03671C 900.0 nM GI50 C7953 Orphanet_99861
TKC074337 DLD-1 DLD 1; DLD1; CoCL3 8831.0 nM GI50 C4349
TKC074337 NCI-H226 NCI.H226; NCI H226; H226; H-226; HUT-226; HUT 226; NCIH226 19011.0 nM GI50 C45662 Orphanet_50251
TKC074337 SK-MEL-28 SK-Mel-28; SK.MEL.28; SK-MEL 28; SK MEL-28; SK MEL 28; SK Mel 28; SKMel-28; SKMEL-28; SK-MEL28; SK-Mel28; SK Mel28; SKMEL28; SKMel28; SKmel28; SKML-28; SK28; AU-Mel; P-36; P36 12794.0 nM GI50 C3510
TKC074337 HT-29 HT 29; HT29 5662.0 nM GI50 C4349
TKC074337 RXF 393 RXF393L; RXF-393 L; RXF-393; RXF 393; RXF.393; RXF393; RXF 393NL 8356.0 nM GI50 C9385 Orphanet_217071
TKC074337 COLO 205 Colo 205; CoLo 205; COLO-205; Colo-205; COLO.205; Colo205; COLO205; Co 205; Colorado 205 14158.0 nM GI50 C4349
TKC074337 HOP-18 HOP 18; Hop 18; HOP18; Hop18; Hopkins-18 10000.0 nM GI50 C4450

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC074337 P0DTD1 Replicase polyprotein 1ab rep 26 % Inhibition
TKC074337 P50579 Methionine aminopeptidase 2 METAP2 1 nM IC50
TKC074337 P50579 Methionine aminopeptidase 2 METAP2 1 nM Ki
TKC074337 P50579 Methionine aminopeptidase 2 METAP2 1050 nM IC50
TKC074337 P50579 Methionine aminopeptidase 2 METAP2 1 nM IC50
TKC074337 P50579 Methionine aminopeptidase 2 METAP2 1320 nM IC50

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
P50579 MAP2_HUMAN Obesity [ICD-11: 5B80-5B81]
P50579 MAP2_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P50579 MAP2_HUMAN Type 2 diabetes mellitus [ICD-11: 5A11]
P50579 MAP2_HUMAN Diabetes mellitus [ICD-11: 5A10]
P50579 MAP2_HUMAN Obesity [ICD-11: 5B80-5B81]
P50579 MAP2_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P50579 MAP2_HUMAN Type 2 diabetes mellitus [ICD-11: 5A11]
P50579 MAP2_HUMAN Diabetes mellitus [ICD-11: 5A10]
P50579 MAP2_HUMAN Obesity [ICD-11: 5B80-5B81]
P50579 MAP2_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P50579 MAP2_HUMAN Type 2 diabetes mellitus [ICD-11: 5A11]
P50579 MAP2_HUMAN Diabetes mellitus [ICD-11: 5A10]
P50579 MAP2_HUMAN Obesity [ICD-11: 5B80-5B81]
P50579 MAP2_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P50579 MAP2_HUMAN Type 2 diabetes mellitus [ICD-11: 5A11]
P50579 MAP2_HUMAN Diabetes mellitus [ICD-11: 5A10]
P50579 MAP2_HUMAN Obesity [ICD-11: 5B80-5B81]
P50579 MAP2_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P50579 MAP2_HUMAN Type 2 diabetes mellitus [ICD-11: 5A11]
P50579 MAP2_HUMAN Diabetes mellitus [ICD-11: 5A10]