Basic Information

Terpenoid ID TKC066411
Cell line 0
Protein target 16
DiseaseNCIT 0
ORDO 0
ICD 49

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC066411 PANC-1 Panc-1; PANC.1; Panc 1; PanC1; Panc1; PANC1; Panc-1-P 43000.0 nM IC50 C9120
TKC066411 DU-145 DU-145; Du-145; DU 145; DU_145; DU.145; Duke University 145 78000.0 nM IC50 C4863

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC066411 P10636 Microtubule-associated protein tau MAPT 5012 nM Potency
TKC066411 Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 TDP1 29093 nM Potency
TKC066411 P43220 Glucagon-like peptide 1 receptor GLP1R 12589 nM Potency
TKC066411 P53350 Serine/threonine-protein kinase PLK1 PLK1 2994 nM Potency
TKC066411 P84022 Mothers against decapentaplegic homolog 3 SMAD3 12589 nM Potency
TKC066411 Q16236 Nuclear factor erythroid 2-related factor 2 NFE2L2 29093 nM Potency
TKC066411 Q99700 Ataxin-2 ATXN2 39811 nM Potency
TKC066411 P27695 DNA-(apurinic or apyrimidinic site) endonuclease APEX1 5012 nM Potency
TKC066411 O75496 Geminin GMNN 20596 nM Potency
TKC066411 Q96QE3 ATPase family AAA domain-containing protein 5 ATAD5 7305 nM Potency
TKC066411 Q6W5P4 Neuropeptide S receptor NPSR1 10000 nM Potency
TKC066411 Q9Y253 DNA polymerase eta POLH 79433 nM Potency
TKC066411 P08151 Zinc finger protein GLI1 GLI1 38000 nM IC50
TKC066411 Q8IUX4 DNA dC->dU-editing enzyme APOBEC-3F APOBEC3F 25119 nM Potency
TKC066411 P51450 Nuclear receptor ROR-gamma Rorc 14125 nM Potency
TKC066411 Q13315 Serine-protein kinase ATM ATM 31623 nM Potency

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
P10636 TAU_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
P10636 TAU_HUMAN Alzheimer disease [ICD-11: 8A20]
P10636 TAU_HUMAN Mild neurocognitive disorder [ICD-11: 6D71]
P10636 TAU_HUMAN Choreiform disorder [ICD-11: 8A01]
P10636 TAU_HUMAN Parkinsonism [ICD-11: 8A00]
P10636 TAU_HUMAN Central nervous system disease [ICD-11: 8A04-8D87]
P10636 TAU_HUMAN Neurodegenerative disorder [ICD-11: 8A20-8A23]
P43220 GLP1R_HUMAN Cardiovascular disease [ICD-11: BA00-BE2Z]
P43220 GLP1R_HUMAN Obesity [ICD-11: 5B80-5B81]
P43220 GLP1R_HUMAN Type 2 diabetes mellitus [ICD-11: 5A11]
P43220 GLP1R_HUMAN Type-1/2 diabete [ICD-11: 5A10-5A11]
P43220 GLP1R_HUMAN Acute diabete complication [ICD-11: 5A2Y]
P43220 GLP1R_HUMAN Diabetes mellitus [ICD-11: 5A10]
P43220 GLP1R_HUMAN Dyspepsia [ICD-11: MD92]
P43220 GLP1R_HUMAN Irritable bowel syndrome [ICD-11: DD91]
P43220 GLP1R_HUMAN Intracranial injury [ICD-11: NA07]
P43220 GLP1R_HUMAN Non-alcoholic fatty liver disease [ICD-11: DB92]
P53350 PLK1_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
P53350 PLK1_HUMAN Myelodysplastic syndrome [ICD-11: 2A37]
P53350 PLK1_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P53350 PLK1_HUMAN Prostate cancer [ICD-11: 2C82]
P53350 PLK1_HUMAN Malignant haematopoietic neoplasm [ICD-11: 2B33]
P53350 PLK1_HUMAN Pancreatic cancer [ICD-11: 2C10]
P53350 PLK1_HUMAN Lymphoma [ICD-11: 2A80-2A86]
P53350 PLK1_HUMAN Nasopharyngeal cancer [ICD-11: 2B6B]
P53350 PLK1_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P84022 SMAD3_HUMAN Herpes simplex infection [ICD-11: 1F00]
P84022 SMAD3_HUMAN Kidney fibrosis [ICD-11: GC01]
Q16236 NF2L2_HUMAN Ataxic disorder [ICD-11: 8A03]
Q16236 NF2L2_HUMAN Breast cancer [ICD-11: 2C60-2C6Y]
Q16236 NF2L2_HUMAN Glaucoma [ICD-11: 9C61]
Q16236 NF2L2_HUMAN Lung cancer [ICD-11: 2C25]
Q16236 NF2L2_HUMAN Macular degeneration [ICD-11: 9B75]
Q16236 NF2L2_HUMAN Melanoma [ICD-11: 2C30]
Q16236 NF2L2_HUMAN Mental/behavioural/neurodevelopmental disorder [ICD-11: 6E20-6E8Z]
Q16236 NF2L2_HUMAN Pulmonary hypertension [ICD-11: BB01]
Q16236 NF2L2_HUMAN Subarachnoid haemorrhage [ICD-11: 8B01]
Q16236 NF2L2_HUMAN Urinary system clinical sympton [ICD-11: MF8Y]
Q16236 NF2L2_HUMAN Non-alcoholic fatty liver disease [ICD-11: DB92]
Q16236 NF2L2_HUMAN Alpha-1-antitrypsin deficiency [ICD-11: 5C5A]
Q16236 NF2L2_HUMAN Motor neuron disease [ICD-11: 8B60]
Q16236 NF2L2_HUMAN Multiple sclerosis [ICD-11: 8A40]
P27695 APEX1_HUMAN Retinopathy [ICD-11: 9B71]
P27695 APEX1_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P27695 APEX1_HUMAN Ocular cancer [ICD-11: 2D00-2D07]
P27695 APEX1_HUMAN Brain cancer [ICD-11: 2A00]
P27695 APEX1_HUMAN Melanoma [ICD-11: 2C30]
Q13315 ATM_HUMAN Brain cancer [ICD-11: 2A00]
Q13315 ATM_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
Q13315 ATM_HUMAN Lung cancer [ICD-11: 2C25]