Basic Information

Terpenoid ID TKC065898
Chirality TKC146021
Cell line 0
Protein target 10
DiseaseNCIT 0
ORDO 0
ICD 17

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC065898 KM-20L2 KM-20L2; KM 20L2; KM 2012 500035.0 nM GI50 C4349
TKC065898 SN12C SN-12C 500035.0 nM GI50 C9385 Orphanet_217071
TKC065898 MDA-N MDAN 215.0 nM GI50 C3802
TKC065898 NCI-H23 NCI.H23; NCI H23; H-23; H23; NCIH23 468813.0 nM GI50 C3512
TKC065898 UO-31 UO.31; UO31; U031 500035.0 nM GI50 C9385 Orphanet_217071
TKC065898 ACHN 247.0 nM GI50 C6975 Orphanet_319298
TKC065898 HL-60 HL 60; HL.60 HL60; Human Leukemia-60 497737.0 nM GI50 C9154 Orphanet_519
TKC065898 HOP-92 HOP 92; HOP.92; HOP92; Hop92; Hopkins-92 233884.0 nM GI50 C2926
TKC065898 DU-145 DU-145; Du-145; DU 145; DU_145; DU.145; Duke University 145 318.0 nM GI50 C4863
TKC065898 SF-539 SF-539; SF-539 BT; SF.539; SF 539 500035.0 nM GI50 C3796 Orphanet_251576
TKC065898 SK-MEL-5 SK-Mel-5; SK MEL 5; SK.MEL.5; SK-MEL5; SKMel-5; SKMEL-5; SKMEL5; SKMel5; SKmel5; AA-Mel 190546.0 nM GI50 C3510
TKC065898 Malme-3M MALME-3M; MALME 3M; Malme-3 M; MALME.3M; Malme3M; MALME3M; Malme-3 Monolayer 227510.0 nM GI50 C3224
TKC065898 A498 A498 500035.0 nM GI50 C9385 Orphanet_217071
TKC065898 K562 K562; K.562; K 562; KO; GM05372; GM05372E 486407.0 nM GI50 C9110 Orphanet_521
TKC065898 OVCAR-3 Ovcar-3; OVCAR 3; OVCAR.3; NIH:OVCAR-3; NIH:Ovcar-3; NIH:OVCAR3; NIH-OVCAR-3; NIHOVCAR3; OVCAR3; Ovcar3 371535.0 nM GI50 C105555
TKC065898 MOLT-4 Molt-4; MOLT 4; Molt 4; MOLT.4; MOLT4; Molt4; GM02219; GM02219C; GM2219C; GM02219D 297167.0 nM GI50 C9142 Orphanet_99861
TKC065898 HOP-62 HOP 62; Hop 62; HOP.62; HOP62; Hop62; Hopkins-62 500035.0 nM GI50 C3512
TKC065898 U-251 U-251 MG; U-251-MG; U-251_MG; U251-MG; U251MG; U-251; U251; U251n; U251N; 251 MG; 251MG; 251 MG(6) 316228.0 nM GI50 C60781 Orphanet_94
TKC065898 NCI/ADR-RES NCI/ADR-RES; NCI.ADR.RES; NCIADR.RES; NCI/ADRRES; NCIADRRES; ADR-RES; MCF-7/ADR; MCF-7/ADR-RES; MCF-7/AdrR; MCF-7/Adr; MCF-7/adr; MCF-7ADR; MCF7-ADR; MCF7ADR; OVCAR-8/ADR; OVCAR8/ADR 500035.0 nM GI50 C105555
TKC065898 OVCAR-5 OVCAR 5; NIH:OVCAR-5; OVCAR.5; OVCAR5; Ovcar5; OVCA5 500035.0 nM GI50 C105555
TKC065898 OVCAR-8 OVCAR 8; NIH:OVCAR-8; OVCAR8; Ovcar8; OVCAR.8; OVCA8 500035.0 nM GI50 C105555
TKC065898 DMS-273 DMS-273; DMS273; Darmouth Medical School 273 500035.0 nM GI50 C4917 Orphanet_70573
TKC065898 SNB-19 SNB.19; SNB19; Surgical Neurology Branch-19 368129.0 nM GI50 C60781 Orphanet_94
TKC065898 SR SR-786; SR786 215.0 nM GI50 C37193 Orphanet_300895
TKC065898 MDA-MB-231 MDA_MB_231; MDA-MB 231; MDA.MB.231; MDA MB 231; MDA MB231; MDA Mb231; MDA-MB231; MDAMB-231; MDAMB231; MDA-231; MDA-231P; MDA231; MDA231-BRE; MB231; MD Anderson-Metastatic Breast-231 23.0 nM GI50 C5214
TKC065898 SW-620 SW-620; SW 620; SW.620 500035.0 nM GI50 C4349
TKC065898 M19-MEL M-19; M19 287078.0 nM GI50 C3802
TKC065898 TK-10 TK.10; TK 10; TK10 215.0 nM GI50 C4033 Orphanet_319276
TKC065898 NCI-H522 NCI.H522; H522; H-522; NCI-522; NCI522; NCIH522 300608.0 nM GI50 C3512
TKC065898 KM12 KM-12; KM.12 411150.0 nM GI50 C4910
TKC065898 XF498 XF-498; XF498 334965.0 nM GI50 C3058 Orphanet_360
TKC065898 M14 M14-MEL; UCLA-SO-M14; UCLA SO M14; UCLA-SO-14; UCLASO-M14; Melanoma 14; M-14 215.0 nM GI50 C3802
TKC065898 RPMI-8226 RPMI 8226; RPMI.8226; RPMI8226; RPMI no. 8226; RPMI no 8226; RPMI #8226; 8226; RPMI 8226/S; RPMI-8226S; RPMI8226/S; 8226/S; Roswell Park Memorial Institute 8226; GM02132; GM2132; GM 2132; GM02132C; Simpson 360579.0 nM GI50 C3242 Orphanet_29073
TKC065898 NCI-H322M NCI.H322M; H322M; H-322M; H-322m 500035.0 nM GI50 C2923
TKC065898 OVCAR-4 OVCAR 4; NIH:OVCAR-4; NIH:OVCAR4; OVCAR.4; OVCAR4; Ovcar4 215.0 nM GI50 C105555
TKC065898 P388 P-388 500035.0 nM GI50 C21602
TKC065898 LOX IMVI LOX/IMVI; LOX IMVI; LOXIM-VI; LOXIMVI; LOX 283139.0 nM GI50 C3802
TKC065898 BT-549 BT 549; BT.549; BT549 260.0 nM GI50 C4194
TKC065898 SK-MEL-2 SK-Mel-2; SK-Mel 2; SK-mel-2; SK-MEL2; SK.MEL.2; SK Mel 2; SK MEL 2; SKMEL-2; SKMEL2; SKmel2; SK-ML2; SKml2 500035.0 nM GI50 C3224
TKC065898 A549 500035.0 nM GI50 C3512
TKC065898 HCC 2998 HCC-2998; HCC.2998; HCC 2998; Hamon Cancer Center 2998 452898.0 nM GI50 C4349
TKC065898 SNB-75 SNB.75; SNB75; Surgical Neurology Branch-75 318420.0 nM GI50 C3058 Orphanet_360
TKC065898 HCT-15 HCT-15; HCT.15; HCT15 500035.0 nM GI50 C4349
TKC065898 SF-268 SF-268; SF.268; SF 268 500035.0 nM GI50 C60781 Orphanet_94
TKC065898 HCT-116 HCT-116; HCT.116; HCT_116; HCT116; HCT116wt; CoCL2 488652.0 nM GI50 C4910
TKC065898 EKVX 468813.0 nM GI50 C3512
TKC065898 MCF7 255859.0 nM GI50 C4194
TKC065898 DMS-114 DMS-114; DMS114; Darmouth Medical School 114 166725.0 nM GI50 C4917 Orphanet_70573
TKC065898 PC-3 PC3; PC.3 230.0 nM GI50 C4863
TKC065898 T47D 13.0 nM GI50 C4194
TKC065898 SK-OV-3 SKOV-3; SK-OV3; SK.OV.3; SKOV3; Skov3; SKO3 500035.0 nM GI50 C7978
TKC065898 NCI-H460 NCI.H460; H460; H-460; NCIH460; NCI-HUT-460; NCI-460 161065.0 nM GI50 C4450
TKC065898 UACC-62 UACC 62; UACC.62; UACC62; University of Arizona Cell Culture-62 500035.0 nM GI50 C3224
TKC065898 MDA-MB-435 MDA-MB435; MDAMB435; MDA.MB.435; MDA-435; MDA 435; MDA435; MD Anderson-Metastatic Breast-435 215.0 nM GI50 C3802
TKC065898 P388/ADR 500035.0 nM GI50 C21602
TKC065898 CAKI-1 CAL 1; Centre Antoine Lacassagne-1 500035.0 nM GI50 C3224
TKC065898 IGROV-1 Igrov-1; IGROV 1; IGR-OV1; IGROV1; Igrov1; IGR.OV1; IGROV; OV1/P; OV1/p; OV1-P 330370.0 nM GI50 C7979 Orphanet_454723
TKC065898 SF-295 SF-295; SF.295; SF 295 500035.0 nM GI50 C3058 Orphanet_360
TKC065898 Hs-578T HS 578T; Hs-578T; HS-578T; Hs_578t; Hs-578-T; HS-578-T; Hs 578.T; HS578T; Hs578T; Hs578t; HS0578T; 578T; HS578; Hs578; Homo sapiens No. 578, tumor cells 215.0 nM GI50 C4194
TKC065898 UACC-257 UACC 257; UACC.257; UACC257; University of Arizona Cell Culture-257 422669.0 nM GI50 C3224
TKC065898 786-0 786-o; 786O; 786-0; 786.O; 786-O RCC; RCC 786-O; RCC_7860; RCC 7860; 7860; 786-0WT 275.0 nM GI50 C9385 Orphanet_217071
TKC065898 SNB-78 SNB78; Surgical Neurology Branch-78 476431.0 nM GI50 C3058 Orphanet_360
TKC065898 CCRF-CEM CCRF/CEM; CCRFCEM; CCRF.CEM; CCRF CEM; CCRF; CEM; CEM-CCRF; CEM-CCRF (CAMR); CCRF/CEM/0; CEM/0; CEM-0; CCRF-CEM/S; GM03671; GM03671C 306902.0 nM GI50 C7953 Orphanet_99861
TKC065898 DLD-1 DLD 1; DLD1; CoCL3 107647.0 nM GI50 C4349
TKC065898 NCI-H226 NCI.H226; NCI H226; H226; H-226; HUT-226; HUT 226; NCIH226 435512.0 nM GI50 C45662 Orphanet_50251
TKC065898 SK-MEL-28 SK-Mel-28; SK.MEL.28; SK-MEL 28; SK MEL-28; SK MEL 28; SK Mel 28; SKMel-28; SKMEL-28; SK-MEL28; SK-Mel28; SK Mel28; SKMEL28; SKMel28; SKmel28; SKML-28; SK28; AU-Mel; P-36; P36 422669.0 nM GI50 C3510
TKC065898 HT-29 HT 29; HT29 500035.0 nM GI50 C4349
TKC065898 COLO 205 Colo 205; CoLo 205; COLO-205; Colo-205; COLO.205; Colo205; COLO205; Co 205; Colorado 205 500035.0 nM GI50 C4349
TKC065898 RXF 393 RXF393L; RXF-393 L; RXF-393; RXF 393; RXF.393; RXF393; RXF 393NL 303389.0 nM GI50 C9385 Orphanet_217071
TKC065898 HOP-18 HOP 18; Hop 18; HOP18; Hop18; Hopkins-18 500035.0 nM GI50 C4450
TKC065898 SN12K1 276694.0 nM GI50 C9385 Orphanet_217071
TKC065898 HL-60 HL 60; HL.60 HL60; Human Leukemia-60 70.0 nM IC50 C9154 Orphanet_519
TKC065898 P388 P-388 158.0 % T/C C21602

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC065898 Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 TDP1 65 nM Potency
TKC065898 Q06710 Paired box protein Pax-8 PAX8 <260 nM AC50
TKC065898 Q16236 Nuclear factor erythroid 2-related factor 2 NFE2L2 12 nM Potency
TKC065898 Q99700 Ataxin-2 ATXN2 84 nM Potency
TKC065898 O75496 Geminin GMNN 7 nM Potency
TKC065898 P37840 Alpha-synuclein SNCA 28184 nM Potency
TKC065898 P83916 Chromobox protein homolog 1 CBX1 89125 nM Potency
TKC065898 P63096 Guanine nucleotide-binding protein G GNAI1 3981 nM Potency
TKC065898 P49798 Regulator of G-protein signaling 4 RGS4 100000 nM Potency
TKC065898 P06492 Tegument protein VP16 UL48 >9487 nM IC50
TKC065898 P34707 Protein skinhead-1 skn-1 35700 nM IC50
TKC065898 P24468 COUP transcription factor 2 NR2F2 22 nM IC50

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
Q16236 NF2L2_HUMAN Ataxic disorder [ICD-11: 8A03]
Q16236 NF2L2_HUMAN Breast cancer [ICD-11: 2C60-2C6Y]
Q16236 NF2L2_HUMAN Glaucoma [ICD-11: 9C61]
Q16236 NF2L2_HUMAN Lung cancer [ICD-11: 2C25]
Q16236 NF2L2_HUMAN Macular degeneration [ICD-11: 9B75]
Q16236 NF2L2_HUMAN Melanoma [ICD-11: 2C30]
Q16236 NF2L2_HUMAN Mental/behavioural/neurodevelopmental disorder [ICD-11: 6E20-6E8Z]
Q16236 NF2L2_HUMAN Pulmonary hypertension [ICD-11: BB01]
Q16236 NF2L2_HUMAN Subarachnoid haemorrhage [ICD-11: 8B01]
Q16236 NF2L2_HUMAN Urinary system clinical sympton [ICD-11: MF8Y]
Q16236 NF2L2_HUMAN Non-alcoholic fatty liver disease [ICD-11: DB92]
Q16236 NF2L2_HUMAN Alpha-1-antitrypsin deficiency [ICD-11: 5C5A]
Q16236 NF2L2_HUMAN Motor neuron disease [ICD-11: 8B60]
Q16236 NF2L2_HUMAN Multiple sclerosis [ICD-11: 8A40]
P37840 SYUA_HUMAN Parkinsonism [ICD-11: 8A00]
P37840 SYUA_HUMAN Alzheimer disease [ICD-11: 8A20]
P37840 SYUA_HUMAN Autonomic nervous system disorder [ICD-11: 8D87]