Basic Information

Terpenoid ID TKC063247
Chirality TKC105501
Cell line 0
Protein target 6
DiseaseNCIT 0
ORDO 0
ICD 14

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC063247 MDA-N MDAN 11066.0 nM GI50 C3802
TKC063247 SN12C SN-12C 2123.0 nM GI50 C9385 Orphanet_217071
TKC063247 ACHN 100000.0 nM GI50 C6975 Orphanet_319298
TKC063247 NCI-H23 NCI.H23; NCI H23; H-23; H23; NCIH23 65766.0 nM GI50 C3512
TKC063247 UO-31 UO.31; UO31; U031 100000.0 nM GI50 C9385 Orphanet_217071
TKC063247 HOP-92 HOP 92; HOP.92; HOP92; Hop92; Hopkins-92 20797.0 nM GI50 C2926
TKC063247 HL-60 HL 60; HL.60 HL60; Human Leukemia-60 20184.0 nM GI50 C9154 Orphanet_519
TKC063247 SF-539 SF-539; SF-539 BT; SF.539; SF 539 38994.0 nM GI50 C3796 Orphanet_251576
TKC063247 DU-145 DU-145; Du-145; DU 145; DU_145; DU.145; Duke University 145 100000.0 nM GI50 C4863
TKC063247 Malme-3M MALME-3M; MALME 3M; Malme-3 M; MALME.3M; Malme3M; MALME3M; Malme-3 Monolayer 47534.0 nM GI50 C3224
TKC063247 SK-MEL-5 SK-Mel-5; SK MEL 5; SK.MEL.5; SK-MEL5; SKMel-5; SKMEL-5; SKMEL5; SKMel5; SKmel5; AA-Mel 41783.0 nM GI50 C3510
TKC063247 K562 K562; K.562; K 562; KO; GM05372; GM05372E 41115.0 nM GI50 C9110 Orphanet_521
TKC063247 A498 A498 24266.0 nM GI50 C9385 Orphanet_217071
TKC063247 OVCAR-3 Ovcar-3; OVCAR 3; OVCAR.3; NIH:OVCAR-3; NIH:Ovcar-3; NIH:OVCAR3; NIH-OVCAR-3; NIHOVCAR3; OVCAR3; Ovcar3 24099.0 nM GI50 C105555
TKC063247 MOLT-4 Molt-4; MOLT 4; Molt 4; MOLT.4; MOLT4; Molt4; GM02219; GM02219C; GM2219C; GM02219D 58210.0 nM GI50 C9142 Orphanet_99861
TKC063247 HOP-62 HOP 62; Hop 62; HOP.62; HOP62; Hop62; Hopkins-62 45394.0 nM GI50 C3512
TKC063247 NCI/ADR-RES NCI/ADR-RES; NCI.ADR.RES; NCIADR.RES; NCI/ADRRES; NCIADRRES; ADR-RES; MCF-7/ADR; MCF-7/ADR-RES; MCF-7/AdrR; MCF-7/Adr; MCF-7/adr; MCF-7ADR; MCF7-ADR; MCF7ADR; OVCAR-8/ADR; OVCAR8/ADR 100000.0 nM GI50 C105555
TKC063247 U-251 U-251 MG; U-251-MG; U-251_MG; U251-MG; U251MG; U-251; U251; U251n; U251N; 251 MG; 251MG; 251 MG(6) 21627.0 nM GI50 C60781 Orphanet_94
TKC063247 OVCAR-8 OVCAR 8; NIH:OVCAR-8; OVCAR8; Ovcar8; OVCAR.8; OVCA8 21086.0 nM GI50 C105555
TKC063247 OVCAR-5 OVCAR 5; NIH:OVCAR-5; OVCAR.5; OVCAR5; Ovcar5; OVCA5 100000.0 nM GI50 C105555
TKC063247 MDA-MB-231 MDA_MB_231; MDA-MB 231; MDA.MB.231; MDA MB 231; MDA MB231; MDA Mb231; MDA-MB231; MDAMB-231; MDAMB231; MDA-231; MDA-231P; MDA231; MDA231-BRE; MB231; MD Anderson-Metastatic Breast-231 39902.0 nM GI50 C5214
TKC063247 SNB-19 SNB.19; SNB19; Surgical Neurology Branch-19 22699.0 nM GI50 C60781 Orphanet_94
TKC063247 SR SR-786; SR786 22803.0 nM GI50 C37193 Orphanet_300895
TKC063247 TK-10 TK.10; TK 10; TK10 100000.0 nM GI50 C4033 Orphanet_319276
TKC063247 SW-620 SW-620; SW 620; SW.620 100000.0 nM GI50 C4349
TKC063247 NCI-H522 NCI.H522; H522; H-522; NCI-522; NCI522; NCIH522 17498.0 nM GI50 C3512
TKC063247 KM12 KM-12; KM.12 43251.0 nM GI50 C4910
TKC063247 M14 M14-MEL; UCLA-SO-M14; UCLA SO M14; UCLA-SO-14; UCLASO-M14; Melanoma 14; M-14 100000.0 nM GI50 C3802
TKC063247 NCI-H322M NCI.H322M; H322M; H-322M; H-322m 90365.0 nM GI50 C2923
TKC063247 RPMI-8226 RPMI 8226; RPMI.8226; RPMI8226; RPMI no. 8226; RPMI no 8226; RPMI #8226; 8226; RPMI 8226/S; RPMI-8226S; RPMI8226/S; 8226/S; Roswell Park Memorial Institute 8226; GM02132; GM2132; GM 2132; GM02132C; Simpson 33420.0 nM GI50 C3242 Orphanet_29073
TKC063247 OVCAR-4 OVCAR 4; NIH:OVCAR-4; NIH:OVCAR4; OVCAR.4; OVCAR4; Ovcar4 100000.0 nM GI50 C105555
TKC063247 LOX IMVI LOX/IMVI; LOX IMVI; LOXIM-VI; LOXIMVI; LOX 20512.0 nM GI50 C3802
TKC063247 BT-549 BT 549; BT.549; BT549 31696.0 nM GI50 C4194
TKC063247 SK-MEL-2 SK-Mel-2; SK-Mel 2; SK-mel-2; SK-MEL2; SK.MEL.2; SK Mel 2; SK MEL 2; SKMEL-2; SKMEL2; SKmel2; SK-ML2; SKml2 19409.0 nM GI50 C3224
TKC063247 A549 100000.0 nM GI50 C3512
TKC063247 HCC 2998 HCC-2998; HCC.2998; HCC 2998; Hamon Cancer Center 2998 35892.0 nM GI50 C4349
TKC063247 SNB-75 SNB.75; SNB75; Surgical Neurology Branch-75 28119.0 nM GI50 C3058 Orphanet_360
TKC063247 HCT-15 HCT-15; HCT.15; HCT15 100000.0 nM GI50 C4349
TKC063247 HCT-116 HCT-116; HCT.116; HCT_116; HCT116; HCT116wt; CoCL2 5649.0 nM GI50 C4910
TKC063247 SF-268 SF-268; SF.268; SF 268 28510.0 nM GI50 C60781 Orphanet_94
TKC063247 EKVX 89331.0 nM GI50 C3512
TKC063247 PC-3 PC3; PC.3 83560.0 nM GI50 C4863
TKC063247 MCF7 41495.0 nM GI50 C4194
TKC063247 SK-OV-3 SKOV-3; SK-OV3; SK.OV.3; SKOV3; Skov3; SKO3 100000.0 nM GI50 C7978
TKC063247 T47D 37411.0 nM GI50 C4194
TKC063247 NCI-H460 NCI.H460; H460; H-460; NCIH460; NCI-HUT-460; NCI-460 100000.0 nM GI50 C4450
TKC063247 UACC-62 UACC 62; UACC.62; UACC62; University of Arizona Cell Culture-62 21330.0 nM GI50 C3224
TKC063247 CAKI-1 CAL 1; Centre Antoine Lacassagne-1 100000.0 nM GI50 C3224
TKC063247 MDA-MB-435 MDA-MB435; MDAMB435; MDA.MB.435; MDA-435; MDA 435; MDA435; MD Anderson-Metastatic Breast-435 45604.0 nM GI50 C3802
TKC063247 SF-295 SF-295; SF.295; SF 295 74473.0 nM GI50 C3058 Orphanet_360
TKC063247 IGROV-1 Igrov-1; IGROV 1; IGR-OV1; IGROV1; Igrov1; IGR.OV1; IGROV; OV1/P; OV1/p; OV1-P 19231.0 nM GI50 C7979 Orphanet_454723
TKC063247 Hs-578T HS 578T; Hs-578T; HS-578T; Hs_578t; Hs-578-T; HS-578-T; Hs 578.T; HS578T; Hs578T; Hs578t; HS0578T; 578T; HS578; Hs578; Homo sapiens No. 578, tumor cells 19409.0 nM GI50 C4194
TKC063247 786-0 786-o; 786O; 786-0; 786.O; 786-O RCC; RCC 786-O; RCC_7860; RCC 7860; 7860; 786-0WT 3289.0 nM GI50 C9385 Orphanet_217071
TKC063247 UACC-257 UACC 257; UACC.257; UACC257; University of Arizona Cell Culture-257 98401.0 nM GI50 C3224
TKC063247 CCRF-CEM CCRF/CEM; CCRFCEM; CCRF.CEM; CCRF CEM; CCRF; CEM; CEM-CCRF; CEM-CCRF (CAMR); CCRF/CEM/0; CEM/0; CEM-0; CCRF-CEM/S; GM03671; GM03671C 19011.0 nM GI50 C7953 Orphanet_99861
TKC063247 HT-29 HT 29; HT29 88512.0 nM GI50 C4349
TKC063247 NCI-H226 NCI.H226; NCI H226; H226; H-226; HUT-226; HUT 226; NCIH226 79616.0 nM GI50 C45662 Orphanet_50251
TKC063247 SK-MEL-28 SK-Mel-28; SK.MEL.28; SK-MEL 28; SK MEL-28; SK MEL 28; SK Mel 28; SKMel-28; SKMEL-28; SK-MEL28; SK-Mel28; SK Mel28; SKMEL28; SKMel28; SKmel28; SKML-28; SK28; AU-Mel; P-36; P36 30761.0 nM GI50 C3510
TKC063247 RXF 393 RXF393L; RXF-393 L; RXF-393; RXF 393; RXF.393; RXF393; RXF 393NL 31261.0 nM GI50 C9385 Orphanet_217071
TKC063247 COLO 205 Colo 205; CoLo 205; COLO-205; Colo-205; COLO.205; Colo205; COLO205; Co 205; Colorado 205 50003.0 nM GI50 C4349
TKC063247 B103 cell line B-103 56.0 % Protection C121567
TKC063247 CCRF-CEM CCRF/CEM; CCRFCEM; CCRF.CEM; CCRF CEM; CCRF; CEM; CEM-CCRF; CEM-CCRF (CAMR); CCRF/CEM/0; CEM/0; CEM-0; CCRF-CEM/S; GM03671; GM03671C 99.0 % Activity C7953 Orphanet_99861
TKC063247 HL-60(TB) HL-60 (TB); HL-60-TB; HL-60TB; HL-60 TB 99.0 % Activity C9154 Orphanet_519
TKC063247 K562 K562; K.562; K 562; KO; GM05372; GM05372E 99.0 % Activity C9110 Orphanet_521
TKC063247 MOLT-4 Molt-4; MOLT 4; Molt 4; MOLT.4; MOLT4; Molt4; GM02219; GM02219C; GM2219C; GM02219D 99.0 % Activity C9142 Orphanet_99861
TKC063247 RPMI-8226 RPMI 8226; RPMI.8226; RPMI8226; RPMI no. 8226; RPMI no 8226; RPMI #8226; 8226; RPMI 8226/S; RPMI-8226S; RPMI8226/S; 8226/S; Roswell Park Memorial Institute 8226; GM02132; GM2132; GM 2132; GM02132C; Simpson 99.0 % Activity C3242 Orphanet_29073
TKC063247 SR SR-786; SR786 99.0 % Activity C37193 Orphanet_300895
TKC063247 A549 99.0 % Activity C3512
TKC063247 EKVX 99.0 % Activity C3512
TKC063247 HOP-62 HOP 62; Hop 62; HOP.62; HOP62; Hop62; Hopkins-62 99.0 % Activity C3512
TKC063247 HOP-92 HOP 92; HOP.92; HOP92; Hop92; Hopkins-92 99.0 % Activity C2926
TKC063247 NCI-H226 NCI.H226; NCI H226; H226; H-226; HUT-226; HUT 226; NCIH226 99.0 % Activity C45662 Orphanet_50251
TKC063247 NCI-H23 NCI.H23; NCI H23; H-23; H23; NCIH23 99.0 % Activity C3512
TKC063247 NCI-H322M NCI.H322M; H322M; H-322M; H-322m 99.0 % Activity C2923
TKC063247 NCI-H460 NCI.H460; H460; H-460; NCIH460; NCI-HUT-460; NCI-460 99.0 % Activity C4450
TKC063247 NCI-H522 NCI.H522; H522; H-522; NCI-522; NCI522; NCIH522 99.0 % Activity C3512
TKC063247 COLO 205 Colo 205; CoLo 205; COLO-205; Colo-205; COLO.205; Colo205; COLO205; Co 205; Colorado 205 99.0 % Activity C4349
TKC063247 HCC 2998 HCC-2998; HCC.2998; HCC 2998; Hamon Cancer Center 2998 99.0 % Activity C4349
TKC063247 HCT-116 HCT-116; HCT.116; HCT_116; HCT116; HCT116wt; CoCL2 99.0 % Activity C4910
TKC063247 HCT-15 HCT-15; HCT.15; HCT15 99.0 % Activity C4349
TKC063247 HT-29 HT 29; HT29 99.0 % Activity C4349
TKC063247 KM12 KM-12; KM.12 99.0 % Activity C4910
TKC063247 SW-620 SW-620; SW 620; SW.620 99.0 % Activity C4349
TKC063247 SF-268 SF-268; SF.268; SF 268 99.0 % Activity C60781 Orphanet_94
TKC063247 SF-295 SF-295; SF.295; SF 295 99.0 % Activity C3058 Orphanet_360
TKC063247 SF-539 SF-539; SF-539 BT; SF.539; SF 539 99.0 % Activity C3796 Orphanet_251576
TKC063247 SNB-19 SNB.19; SNB19; Surgical Neurology Branch-19 99.0 % Activity C60781 Orphanet_94
TKC063247 SNB-75 SNB.75; SNB75; Surgical Neurology Branch-75 99.0 % Activity C3058 Orphanet_360
TKC063247 U-251 U-251 MG; U-251-MG; U-251_MG; U251-MG; U251MG; U-251; U251; U251n; U251N; 251 MG; 251MG; 251 MG(6) 99.0 % Activity C60781 Orphanet_94
TKC063247 LOX IMVI LOX/IMVI; LOX IMVI; LOXIM-VI; LOXIMVI; LOX 99.0 % Activity C3802
TKC063247 Malme-3M MALME-3M; MALME 3M; Malme-3 M; MALME.3M; Malme3M; MALME3M; Malme-3 Monolayer 99.0 % Activity C3224
TKC063247 M14 M14-MEL; UCLA-SO-M14; UCLA SO M14; UCLA-SO-14; UCLASO-M14; Melanoma 14; M-14 99.0 % Activity C3802
TKC063247 MDA-MB-435 MDA-MB435; MDAMB435; MDA.MB.435; MDA-435; MDA 435; MDA435; MD Anderson-Metastatic Breast-435 99.0 % Activity C3802
TKC063247 SK-MEL-2 SK-Mel-2; SK-Mel 2; SK-mel-2; SK-MEL2; SK.MEL.2; SK Mel 2; SK MEL 2; SKMEL-2; SKMEL2; SKmel2; SK-ML2; SKml2 99.0 % Activity C3224
TKC063247 SK-MEL-28 SK-Mel-28; SK.MEL.28; SK-MEL 28; SK MEL-28; SK MEL 28; SK Mel 28; SKMel-28; SKMEL-28; SK-MEL28; SK-Mel28; SK Mel28; SKMEL28; SKMel28; SKmel28; SKML-28; SK28; AU-Mel; P-36; P36 99.0 % Activity C3510
TKC063247 SK-MEL-5 SK-Mel-5; SK MEL 5; SK.MEL.5; SK-MEL5; SKMel-5; SKMEL-5; SKMEL5; SKMel5; SKmel5; AA-Mel 99.0 % Activity C3510
TKC063247 UACC-257 UACC 257; UACC.257; UACC257; University of Arizona Cell Culture-257 99.0 % Activity C3224
TKC063247 UACC-62 UACC 62; UACC.62; UACC62; University of Arizona Cell Culture-62 99.0 % Activity C3224
TKC063247 IGROV-1 Igrov-1; IGROV 1; IGR-OV1; IGROV1; Igrov1; IGR.OV1; IGROV; OV1/P; OV1/p; OV1-P 99.0 % Activity C7979 Orphanet_454723
TKC063247 OVCAR-3 Ovcar-3; OVCAR 3; OVCAR.3; NIH:OVCAR-3; NIH:Ovcar-3; NIH:OVCAR3; NIH-OVCAR-3; NIHOVCAR3; OVCAR3; Ovcar3 99.0 % Activity C105555
TKC063247 OVCAR-4 OVCAR 4; NIH:OVCAR-4; NIH:OVCAR4; OVCAR.4; OVCAR4; Ovcar4 99.0 % Activity C105555
TKC063247 OVCAR-5 OVCAR 5; NIH:OVCAR-5; OVCAR.5; OVCAR5; Ovcar5; OVCA5 99.0 % Activity C105555
TKC063247 OVCAR-8 OVCAR 8; NIH:OVCAR-8; OVCAR8; Ovcar8; OVCAR.8; OVCA8 99.0 % Activity C105555
TKC063247 NCI/ADR-RES NCI/ADR-RES; NCI.ADR.RES; NCIADR.RES; NCI/ADRRES; NCIADRRES; ADR-RES; MCF-7/ADR; MCF-7/ADR-RES; MCF-7/AdrR; MCF-7/Adr; MCF-7/adr; MCF-7ADR; MCF7-ADR; MCF7ADR; OVCAR-8/ADR; OVCAR8/ADR 99.0 % Activity C105555
TKC063247 SK-OV-3 SKOV-3; SK-OV3; SK.OV.3; SKOV3; Skov3; SKO3 99.0 % Activity C7978
TKC063247 786-0 786-o; 786O; 786-0; 786.O; 786-O RCC; RCC 786-O; RCC_7860; RCC 7860; 7860; 786-0WT 99.0 % Activity C9385 Orphanet_217071
TKC063247 A498 A498 99.0 % Activity C9385 Orphanet_217071
TKC063247 ACHN 99.0 % Activity C6975 Orphanet_319298
TKC063247 CAKI-1 CAL 1; Centre Antoine Lacassagne-1 99.0 % Activity C3224
TKC063247 RXF 393 RXF393L; RXF-393 L; RXF-393; RXF 393; RXF.393; RXF393; RXF 393NL 99.0 % Activity C9385 Orphanet_217071
TKC063247 SN12C SN-12C 99.0 % Activity C9385 Orphanet_217071
TKC063247 TK-10 TK.10; TK 10; TK10 99.0 % Activity C4033 Orphanet_319276
TKC063247 UO-31 UO.31; UO31; U031 99.0 % Activity C9385 Orphanet_217071
TKC063247 PC-3 PC3; PC.3 99.0 % Activity C4863
TKC063247 DU-145 DU-145; Du-145; DU 145; DU_145; DU.145; Duke University 145 99.0 % Activity C4863
TKC063247 MCF7 99.0 % Activity C4194
TKC063247 MDA-MB-231 MDA_MB_231; MDA-MB 231; MDA.MB.231; MDA MB 231; MDA MB231; MDA Mb231; MDA-MB231; MDAMB-231; MDAMB231; MDA-231; MDA-231P; MDA231; MDA231-BRE; MB231; MD Anderson-Metastatic Breast-231 99.0 % Activity C5214
TKC063247 Hs-578T HS 578T; Hs-578T; HS-578T; Hs_578t; Hs-578-T; HS-578-T; Hs 578.T; HS578T; Hs578T; Hs578t; HS0578T; 578T; HS578; Hs578; Homo sapiens No. 578, tumor cells 99.0 % Activity C4194
TKC063247 BT-549 BT 549; BT.549; BT549 99.0 % Activity C4194
TKC063247 T47D 99.0 % Activity C4194
TKC063247 MDA-MB-468 MDA-MB 468; MDA-MB468; MDAMB468; MDA-468; MDA468; MB468; MD Anderson-Metastatic Breast-468 99.0 % Activity C5214

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC063247 P18031 Tyrosine-protein phosphatase non-receptor type 1 PTPN1 12380 nM IC50
TKC063247 P17706 Tyrosine-protein phosphatase non-receptor type 2 PTPN2 >20000 nM IC50
TKC063247 Q9NPD5 Solute carrier organic anion transporter family member 1B3 SLCO1B3 34 % Inhibition
TKC063247 Q9Y6L6 Solute carrier organic anion transporter family member 1B1 SLCO1B1 69 % Inhibition
TKC063247 P27695 DNA-(apurinic or apyrimidinic site) endonuclease APEX1 5 nM Potency
TKC063247 O42275 Acetylcholinesterase ache -1 % Inhibition
TKC063247 P81908 Cholinesterase BCHE -8 % Inhibition
TKC063247 P25779 Cruzipain 22387 nM Potency
TKC063247 P51450 Nuclear receptor ROR-gamma Rorc 15849 nM Potency
TKC063247 P02699 Rhodopsin RHO 120000 nM EC50
TKC063247 O32393 Adenylate cyclase cyaC 100000 nM IC50

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
P18031 PTN1_HUMAN Type 2 diabetes mellitus [ICD-11: 5A11]
P18031 PTN1_HUMAN Acute diabete complication [ICD-11: 5A2Y]
P18031 PTN1_HUMAN Breast cancer [ICD-11: 2C60-2C6Y]
P18031 PTN1_HUMAN Obesity [ICD-11: 5B80-5B81]
P18031 PTN1_HUMAN Ophthalmic devices/implants/grafts injury [ICD-11: PK97]
P18031 PTN1_HUMAN Postoperative inflammation [ICD-11: 1A00-CA43]
P18031 PTN1_HUMAN Metabolic disorder [ICD-11: 5C50-5D2Z]
P18031 PTN1_HUMAN Type 2 diabetes mellitus [ICD-11: 5A11]
P17706 PTN2_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P27695 APEX1_HUMAN Retinopathy [ICD-11: 9B71]
P27695 APEX1_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P27695 APEX1_HUMAN Ocular cancer [ICD-11: 2D00-2D07]
P27695 APEX1_HUMAN Brain cancer [ICD-11: 2A00]
P27695 APEX1_HUMAN Melanoma [ICD-11: 2C30]
P25779 CYSP_TRYCR Parasitic worm infestation [ICD-11: 1F90]
P25779 CYSP_TRYCR Malaria [ICD-11: 1F40-1F45]