Basic Information

Terpenoid ID TKC059425
Chirality TKC059317
Cell line 2
Protein target 2
DiseaseNCIT 1
ORDO 0
ICD 20

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC059425 MRC5 MRC5; MRC 5; MRCV; MRC-V; Medical Research Council cell strain-5 17280.0 nM GI50
TKC059425 PANC-1 Panc-1; PANC.1; Panc 1; PanC1; Panc1; PANC1; Panc-1-P 21870.0 nM GI50 C9120
TKC059425 PC-3 PC3; PC.3 13770.0 nM GI50 C4863
TKC059425 A549 21770.0 nM GI50 C3512

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC059425 P11387 DNA topoisomerase 1 TOP1 >250000 nM IC50
TKC059425 P11388 DNA topoisomerase 2-alpha TOP2A >250000 nM IC50

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
P11387 TOP1_HUMAN Bacterial infection [ICD-11: 1A00-1C4Z]
P11387 TOP1_HUMAN Colorectal cancer [ICD-11: 2B91]
P11387 TOP1_HUMAN Lung cancer [ICD-11: 2C25]
P11387 TOP1_HUMAN Ovarian cancer [ICD-11: 2C73]
P11387 TOP1_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P11387 TOP1_HUMAN Breast cancer [ICD-11: 2C60-2C6Y]
P11387 TOP1_HUMAN Human immunodeficiency virus disease [ICD-11: 1C60-1C62]
P11387 TOP1_HUMAN Stomach cancer [ICD-11: 2B72]
P11387 TOP1_HUMAN Brain cancer [ICD-11: 2A00]
P11387 TOP1_HUMAN Esophageal cancer [ICD-11: 2B70]
P11387 TOP1_HUMAN Myelodysplastic syndrome [ICD-11: 2A37]
P11387 TOP1_HUMAN Renal cell carcinoma [ICD-11: 2C90]
P11387 TOP1_HUMAN Gastrointestinal stromal tumour [ICD-11: 2B5B]
P11387 TOP1_HUMAN Lymphoma [ICD-11: 2A80-2A86]
P11387 TOP1_HUMAN Mature B-cell lymphoma [ICD-11: 2A85]
P11387 TOP1_HUMAN Bladder cancer [ICD-11: 2C94]
P11388 TOP2A_HUMAN Kaposi sarcoma [ICD-11: 2B57]
P11388 TOP2A_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P11388 TOP2A_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
P11388 TOP2A_HUMAN Mature T-cell lymphoma [ICD-11: 2A90]