Basic Information

Terpenoid ID TKC055869
Cell line 0
Protein target 15
DiseaseNCIT 0
ORDO 0
ICD 53

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC055869 H9 HT clone H9; HT(H9); H 9; H-9 19.0 ug.mL-1 IC50 C3366 Orphanet_3162
TKC055869 A2780 A-2780; 2780; A2780S; A2780par 13.0 ug.mL-1 IC50 C7979 Orphanet_454723
TKC055869 HEK293 2270.0 nM EC50

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC055869 Q16637 Survival motor neuron protein SMN1,SMN2 5012 nM Potency
TKC055869 Q16637 Survival motor neuron protein SMN1,SMN2 5012 nM Potency
TKC055869 Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 TDP1 5174 nM Potency
TKC055869 P18031 Tyrosine-protein phosphatase non-receptor type 1 PTPN1 8000 nM Ki
TKC055869 P18031 Tyrosine-protein phosphatase non-receptor type 1 PTPN1 13200 nM IC50
TKC055869 P53350 Serine/threonine-protein kinase PLK1 PLK1 33588 nM Potency
TKC055869 Q03431 Parathyroid hormone/parathyroid hormone-related peptide receptor PTH1R 44668 nM Potency
TKC055869 Q96QE3 ATPase family AAA domain-containing protein 5 ATAD5 18356 nM Potency
TKC055869 Q6W5P4 Neuropeptide S receptor NPSR1 10000 nM Potency
TKC055869 P25779 Cruzipain 39811 nM Potency
TKC055869 P10586 Receptor-type tyrosine-protein phosphatase F PTPRF 45600 nM IC50
TKC055869 Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B BAZ2B 631 nM Potency
TKC055869 P02545 Prelamin-A/C LMNA 11 nM Potency
TKC055869 P01375 Tumor necrosis factor TNF 10880 nM IC50
TKC055869 P24666 Low molecular weight phosphotyrosine protein phosphatase ACP1 20600 nM IC50
TKC055869 Q9HC29 Nucleotide-binding oligomerization domain-containing protein 2 NOD2 8077 nM IC50
TKC055869 Q9Y239 Nucleotide-binding oligomerization domain-containing protein 1 NOD1 2270 nM EC50

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
Q16637 SMN_HUMAN Muscular atrophy [ICD-11: 8B61]
Q16637 SMN_HUMAN Muscular atrophy [ICD-11: 8B61]
Q16637 SMN_HUMAN Muscular atrophy [ICD-11: 8B61]
Q16637 SMN_HUMAN Muscular atrophy [ICD-11: 8B61]
P18031 PTN1_HUMAN Type 2 diabetes mellitus [ICD-11: 5A11]
P18031 PTN1_HUMAN Acute diabete complication [ICD-11: 5A2Y]
P18031 PTN1_HUMAN Breast cancer [ICD-11: 2C60-2C6Y]
P18031 PTN1_HUMAN Obesity [ICD-11: 5B80-5B81]
P18031 PTN1_HUMAN Ophthalmic devices/implants/grafts injury [ICD-11: PK97]
P18031 PTN1_HUMAN Postoperative inflammation [ICD-11: 1A00-CA43]
P18031 PTN1_HUMAN Metabolic disorder [ICD-11: 5C50-5D2Z]
P18031 PTN1_HUMAN Type 2 diabetes mellitus [ICD-11: 5A11]
P18031 PTN1_HUMAN Type 2 diabetes mellitus [ICD-11: 5A11]
P18031 PTN1_HUMAN Acute diabete complication [ICD-11: 5A2Y]
P18031 PTN1_HUMAN Breast cancer [ICD-11: 2C60-2C6Y]
P18031 PTN1_HUMAN Obesity [ICD-11: 5B80-5B81]
P18031 PTN1_HUMAN Ophthalmic devices/implants/grafts injury [ICD-11: PK97]
P18031 PTN1_HUMAN Postoperative inflammation [ICD-11: 1A00-CA43]
P18031 PTN1_HUMAN Metabolic disorder [ICD-11: 5C50-5D2Z]
P18031 PTN1_HUMAN Type 2 diabetes mellitus [ICD-11: 5A11]
P53350 PLK1_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
P53350 PLK1_HUMAN Myelodysplastic syndrome [ICD-11: 2A37]
P53350 PLK1_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P53350 PLK1_HUMAN Prostate cancer [ICD-11: 2C82]
P53350 PLK1_HUMAN Malignant haematopoietic neoplasm [ICD-11: 2B33]
P53350 PLK1_HUMAN Pancreatic cancer [ICD-11: 2C10]
P53350 PLK1_HUMAN Lymphoma [ICD-11: 2A80-2A86]
P53350 PLK1_HUMAN Nasopharyngeal cancer [ICD-11: 2B6B]
P53350 PLK1_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
Q03431 PTH1R_HUMAN Low bone mass disorder [ICD-11: FB83]
Q03431 PTH1R_HUMAN Hypo-parathyroidism [ICD-11: 5A50]
P25779 CYSP_TRYCR Parasitic worm infestation [ICD-11: 1F90]
P25779 CYSP_TRYCR Malaria [ICD-11: 1F40-1F45]
P01375 TNFA_HUMAN Crohn disease [ICD-11: DD70]
P01375 TNFA_HUMAN Rheumatoid arthritis [ICD-11: FA20]
P01375 TNFA_HUMAN Schizophrenia [ICD-11: 6A20]
P01375 TNFA_HUMAN Arterial occlusive disease [ICD-11: BD40]
P01375 TNFA_HUMAN Asthma [ICD-11: CA23]
P01375 TNFA_HUMAN Indeterminate colitis [ICD-11: DD72]
P01375 TNFA_HUMAN Multiple myeloma [ICD-11: 2A83]
P01375 TNFA_HUMAN Pancreatitis [ICD-11: DC31-DC34]
P01375 TNFA_HUMAN Pemphigus [ICD-11: EB40]
P01375 TNFA_HUMAN Psoriasis [ICD-11: EA90]
P01375 TNFA_HUMAN Rheumatoid arthritis [ICD-11: FA20]
P01375 TNFA_HUMAN Sepsis [ICD-11: 1G40-1G41]
P01375 TNFA_HUMAN Spinal pain [ICD-11: ME84]
P01375 TNFA_HUMAN Cystic fibrosis [ICD-11: CA25]
P01375 TNFA_HUMAN Esophageal cancer [ICD-11: 2B70]
P01375 TNFA_HUMAN Lupus erythematosus [ICD-11: 4A40]
P01375 TNFA_HUMAN Systemic sclerosis [ICD-11: 4A42]
P01375 TNFA_HUMAN Atopic eczema [ICD-11: EA80]
P01375 TNFA_HUMAN Bowel habit change [ICD-11: ME05]
P01375 TNFA_HUMAN Diabetes mellitus [ICD-11: 5A10]
P01375 TNFA_HUMAN Herpes simplex infection [ICD-11: 1F00]
P01375 TNFA_HUMAN Influenza [ICD-11: 1E30-1E32]
P01375 TNFA_HUMAN Osteoarthritis [ICD-11: FA00-FA05]
P01375 TNFA_HUMAN Pneumonia [ICD-11: CA40]
P01375 TNFA_HUMAN Psoriatic arthritis [ICD-11: FA21]
P01375 TNFA_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P01375 TNFA_HUMAN Transplant rejection [ICD-11: NE84]
P01375 TNFA_HUMAN Ulcerative colitis [ICD-11: DD71]
P01375 TNFA_HUMAN Crohn disease [ICD-11: DD70]
P01375 TNFA_HUMAN Vasomotor/allergic rhinitis [ICD-11: CA08]
P01375 TNFA_HUMAN Motor neuron disease [ICD-11: 8B60]
P01375 TNFA_HUMAN Infectious gastroenteritis/colitis [ICD-11: 1A40]
Q9HC29 NOD2_HUMAN Diabetes mellitus [ICD-11: 5A10]
Q9HC29 NOD2_HUMAN Hepatitis virus infection [ICD-11: 1E50-1E51]
Q9HC29 NOD2_HUMAN Sepsis [ICD-11: 1G40-1G41]