Basic Information

Terpenoid ID TKC053844
Cell line 0
Protein target 3
DiseaseNCIT 0
ORDO 0
ICD 16

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC053844 HEK293 31623.0 nM Potency
TKC053844 SN12C SN-12C 235505.0 nM GI50 C9385 Orphanet_217071
TKC053844 NCI-H23 NCI.H23; NCI H23; H-23; H23; NCIH23 49545.0 nM GI50 C3512
TKC053844 UO-31 UO.31; UO31; U031 110154.0 nM GI50 C9385 Orphanet_217071
TKC053844 HL-60 HL 60; HL.60 HL60; Human Leukemia-60 32961.0 nM GI50 C9154 Orphanet_519
TKC053844 HOP-92 HOP 92; HOP.92; HOP92; Hop92; Hopkins-92 6026.0 nM GI50 C2926
TKC053844 SF-539 SF-539; SF-539 BT; SF.539; SF 539 39174.0 nM GI50 C3796 Orphanet_251576
TKC053844 Malme-3M MALME-3M; MALME 3M; Malme-3 M; MALME.3M; Malme3M; MALME3M; Malme-3 Monolayer 97724.0 nM GI50 C3224
TKC053844 SK-MEL-5 SK-Mel-5; SK MEL 5; SK.MEL.5; SK-MEL5; SKMel-5; SKMEL-5; SKMEL5; SKMel5; SKmel5; AA-Mel 29444.0 nM GI50 C3510
TKC053844 K562 K562; K.562; K 562; KO; GM05372; GM05372E 37154.0 nM GI50 C9110 Orphanet_521
TKC053844 OVCAR-3 Ovcar-3; OVCAR 3; OVCAR.3; NIH:OVCAR-3; NIH:Ovcar-3; NIH:OVCAR3; NIH-OVCAR-3; NIHOVCAR3; OVCAR3; Ovcar3 10209.0 nM GI50 C105555
TKC053844 A498 A498 17865.0 nM GI50 C9385 Orphanet_217071
TKC053844 HOP-62 HOP 62; Hop 62; HOP.62; HOP62; Hop62; Hopkins-62 65313.0 nM GI50 C3512
TKC053844 MOLT-4 Molt-4; MOLT 4; Molt 4; MOLT.4; MOLT4; Molt4; GM02219; GM02219C; GM2219C; GM02219D 12162.0 nM GI50 C9142 Orphanet_99861
TKC053844 NCI/ADR-RES NCI/ADR-RES; NCI.ADR.RES; NCIADR.RES; NCI/ADRRES; NCIADRRES; ADR-RES; MCF-7/ADR; MCF-7/ADR-RES; MCF-7/AdrR; MCF-7/Adr; MCF-7/adr; MCF-7ADR; MCF7-ADR; MCF7ADR; OVCAR-8/ADR; OVCAR8/ADR 241546.0 nM GI50 C105555
TKC053844 U-251 U-251 MG; U-251-MG; U-251_MG; U251-MG; U251MG; U-251; U251; U251n; U251N; 251 MG; 251MG; 251 MG(6) 62806.0 nM GI50 C60781 Orphanet_94
TKC053844 OVCAR-5 OVCAR 5; NIH:OVCAR-5; OVCAR.5; OVCAR5; Ovcar5; OVCA5 160694.0 nM GI50 C105555
TKC053844 OVCAR-8 OVCAR 8; NIH:OVCAR-8; OVCAR8; Ovcar8; OVCAR.8; OVCA8 32137.0 nM GI50 C105555
TKC053844 SNB-19 SNB.19; SNB19; Surgical Neurology Branch-19 13740.0 nM GI50 C60781 Orphanet_94
TKC053844 DMS-273 DMS-273; DMS273; Darmouth Medical School 273 153462.0 nM GI50 C4917 Orphanet_70573
TKC053844 M19-MEL M-19; M19 55976.0 nM GI50 C3802
TKC053844 SW-620 SW-620; SW 620; SW.620 24717.0 nM GI50 C4349
TKC053844 NCI-H522 NCI.H522; H522; H-522; NCI-522; NCI522; NCIH522 50466.0 nM GI50 C3512
TKC053844 KM12 KM-12; KM.12 13274.0 nM GI50 C4910
TKC053844 XF498 XF-498; XF498 53088.0 nM GI50 C3058 Orphanet_360
TKC053844 NCI-H322M NCI.H322M; H322M; H-322M; H-322m 27861.0 nM GI50 C2923
TKC053844 RPMI-8226 RPMI 8226; RPMI.8226; RPMI8226; RPMI no. 8226; RPMI no 8226; RPMI #8226; 8226; RPMI 8226/S; RPMI-8226S; RPMI8226/S; 8226/S; Roswell Park Memorial Institute 8226; GM02132; GM2132; GM 2132; GM02132C; Simpson 16904.0 nM GI50 C3242 Orphanet_29073
TKC053844 OVCAR-4 OVCAR 4; NIH:OVCAR-4; NIH:OVCAR4; OVCAR.4; OVCAR4; Ovcar4 40926.0 nM GI50 C105555
TKC053844 P388 P-388 29040.0 nM GI50 C21602
TKC053844 LOX IMVI LOX/IMVI; LOX IMVI; LOXIM-VI; LOXIMVI; LOX 37757.0 nM GI50 C3802
TKC053844 SK-MEL-2 SK-Mel-2; SK-Mel 2; SK-mel-2; SK-MEL2; SK.MEL.2; SK Mel 2; SK MEL 2; SKMEL-2; SKMEL2; SKmel2; SK-ML2; SKml2 59156.0 nM GI50 C3224
TKC053844 A549 27925.0 nM GI50 C3512
TKC053844 KM-20L2 KM-20L2; KM 20L2; KM 2012 22387.0 nM GI50 C4349
TKC053844 HCC 2998 HCC-2998; HCC.2998; HCC 2998; Hamon Cancer Center 2998 16788.0 nM GI50 C4349
TKC053844 SNB-75 SNB.75; SNB75; Surgical Neurology Branch-75 6180.0 nM GI50 C3058 Orphanet_360
TKC053844 HCT-15 HCT-15; HCT.15; HCT15 334965.0 nM GI50 C4349
TKC053844 SF-268 SF-268; SF.268; SF 268 133352.0 nM GI50 C60781 Orphanet_94
TKC053844 HCT-116 HCT-116; HCT.116; HCT_116; HCT116; HCT116wt; CoCL2 99541.0 nM GI50 C4910
TKC053844 MCF7 91622.0 nM GI50 C4194
TKC053844 EKVX 30903.0 nM GI50 C3512
TKC053844 DMS-114 DMS-114; DMS114; Darmouth Medical School 114 35400.0 nM GI50 C4917 Orphanet_70573
TKC053844 SK-OV-3 SKOV-3; SK-OV3; SK.OV.3; SKOV3; Skov3; SKO3 49888.0 nM GI50 C7978
TKC053844 NCI-H460 NCI.H460; H460; H-460; NCIH460; NCI-HUT-460; NCI-460 7816.0 nM GI50 C4450
TKC053844 UACC-62 UACC 62; UACC.62; UACC62; University of Arizona Cell Culture-62 84333.0 nM GI50 C3224
TKC053844 P388/ADR 625173.0 nM GI50 C21602
TKC053844 CAKI-1 CAL 1; Centre Antoine Lacassagne-1 32810.0 nM GI50 C3224
TKC053844 SF-295 SF-295; SF.295; SF 295 28774.0 nM GI50 C3058 Orphanet_360
TKC053844 IGROV-1 Igrov-1; IGROV 1; IGR-OV1; IGROV1; Igrov1; IGR.OV1; IGROV; OV1/P; OV1/p; OV1-P 15922.0 nM GI50 C7979 Orphanet_454723
TKC053844 SNB-78 SNB78; Surgical Neurology Branch-78 39355.0 nM GI50 C3058 Orphanet_360
TKC053844 UACC-257 UACC 257; UACC.257; UACC257; University of Arizona Cell Culture-257 103039.0 nM GI50 C3224
TKC053844 DLD-1 DLD 1; DLD1; CoCL3 135207.0 nM GI50 C4349
TKC053844 CCRF-CEM CCRF/CEM; CCRFCEM; CCRF.CEM; CCRF CEM; CCRF; CEM; CEM-CCRF; CEM-CCRF (CAMR); CCRF/CEM/0; CEM/0; CEM-0; CCRF-CEM/S; GM03671; GM03671C 7047.0 nM GI50 C7953 Orphanet_99861
TKC053844 NCI-H226 NCI.H226; NCI H226; H226; H-226; HUT-226; HUT 226; NCIH226 41305.0 nM GI50 C45662 Orphanet_50251
TKC053844 SK-MEL-28 SK-Mel-28; SK.MEL.28; SK-MEL 28; SK MEL-28; SK MEL 28; SK Mel 28; SKMel-28; SKMEL-28; SK-MEL28; SK-Mel28; SK Mel28; SKMEL28; SKMel28; SKmel28; SKML-28; SK28; AU-Mel; P-36; P36 118304.0 nM GI50 C3510
TKC053844 HT-29 HT 29; HT29 38107.0 nM GI50 C4349
TKC053844 RXF 393 RXF393L; RXF-393 L; RXF-393; RXF 393; RXF.393; RXF393; RXF 393NL 8810.0 nM GI50 C9385 Orphanet_217071
TKC053844 SN12K1 3631.0 nM GI50 C9385 Orphanet_217071
TKC053844 COLO 205 Colo 205; CoLo 205; COLO-205; Colo-205; COLO.205; Colo205; COLO205; Co 205; Colorado 205 20091.0 nM GI50 C4349
TKC053844 HOP-18 HOP 18; Hop 18; HOP18; Hop18; Hopkins-18 155239.0 nM GI50 C4450

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC053844 P84022 Mothers against decapentaplegic homolog 3 SMAD3 35481 nM Potency
TKC053844 Q16236 Nuclear factor erythroid 2-related factor 2 NFE2L2 2909 nM Potency
TKC053844 P83916 Chromobox protein homolog 1 CBX1 100000 nM Potency
TKC053844 P23467 Receptor-type tyrosine-protein phosphatase beta PTPRB >450 uM Kis

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
P84022 SMAD3_HUMAN Herpes simplex infection [ICD-11: 1F00]
P84022 SMAD3_HUMAN Kidney fibrosis [ICD-11: GC01]
Q16236 NF2L2_HUMAN Ataxic disorder [ICD-11: 8A03]
Q16236 NF2L2_HUMAN Breast cancer [ICD-11: 2C60-2C6Y]
Q16236 NF2L2_HUMAN Glaucoma [ICD-11: 9C61]
Q16236 NF2L2_HUMAN Lung cancer [ICD-11: 2C25]
Q16236 NF2L2_HUMAN Macular degeneration [ICD-11: 9B75]
Q16236 NF2L2_HUMAN Melanoma [ICD-11: 2C30]
Q16236 NF2L2_HUMAN Mental/behavioural/neurodevelopmental disorder [ICD-11: 6E20-6E8Z]
Q16236 NF2L2_HUMAN Pulmonary hypertension [ICD-11: BB01]
Q16236 NF2L2_HUMAN Subarachnoid haemorrhage [ICD-11: 8B01]
Q16236 NF2L2_HUMAN Urinary system clinical sympton [ICD-11: MF8Y]
Q16236 NF2L2_HUMAN Non-alcoholic fatty liver disease [ICD-11: DB92]
Q16236 NF2L2_HUMAN Alpha-1-antitrypsin deficiency [ICD-11: 5C5A]
Q16236 NF2L2_HUMAN Motor neuron disease [ICD-11: 8B60]
Q16236 NF2L2_HUMAN Multiple sclerosis [ICD-11: 8A40]
P23467 PTPRB_HUMAN Chronic arterial occlusive disease [ICD-11: BD4Z]
P23467 PTPRB_HUMAN Retinopathy [ICD-11: 9B71]