Basic Information

Terpenoid ID TKC053815
Chirality TKC147290
Cell line 0
Protein target 16
DiseaseNCIT 0
ORDO 0
ICD 40

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC053815 SN12C SN-12C 4207.0 nM GI50 C9385 Orphanet_217071
TKC053815 NCI-H23 NCI.H23; NCI H23; H-23; H23; NCIH23 7534.0 nM GI50 C3512
TKC053815 ACHN 8730.0 nM GI50 C6975 Orphanet_319298
TKC053815 UO-31 UO.31; UO31; U031 4227.0 nM GI50 C9385 Orphanet_217071
TKC053815 HOP-92 HOP 92; HOP.92; HOP92; Hop92; Hopkins-92 14454.0 nM GI50 C2926
TKC053815 HL-60 HL 60; HL.60 HL60; Human Leukemia-60 5546.0 nM GI50 C9154 Orphanet_519
TKC053815 SF-539 SF-539; SF-539 BT; SF.539; SF 539 6546.0 nM GI50 C3796 Orphanet_251576
TKC053815 DU-145 DU-145; Du-145; DU 145; DU_145; DU.145; Duke University 145 2851.0 nM GI50 C4863
TKC053815 SK-MEL-5 SK-Mel-5; SK MEL 5; SK.MEL.5; SK-MEL5; SKMel-5; SKMEL-5; SKMEL5; SKMel5; SKmel5; AA-Mel 5623.0 nM GI50 C3510
TKC053815 K562 K562; K.562; K 562; KO; GM05372; GM05372E 3540.0 nM GI50 C9110 Orphanet_521
TKC053815 A498 A498 24946.0 nM GI50 C9385 Orphanet_217071
TKC053815 OVCAR-3 Ovcar-3; OVCAR 3; OVCAR.3; NIH:OVCAR-3; NIH:Ovcar-3; NIH:OVCAR3; NIH-OVCAR-3; NIHOVCAR3; OVCAR3; Ovcar3 21627.0 nM GI50 C105555
TKC053815 MOLT-4 Molt-4; MOLT 4; Molt 4; MOLT.4; MOLT4; Molt4; GM02219; GM02219C; GM2219C; GM02219D 8204.0 nM GI50 C9142 Orphanet_99861
TKC053815 HOP-62 HOP 62; Hop 62; HOP.62; HOP62; Hop62; Hopkins-62 26002.0 nM GI50 C3512
TKC053815 NCI/ADR-RES NCI/ADR-RES; NCI.ADR.RES; NCIADR.RES; NCI/ADRRES; NCIADRRES; ADR-RES; MCF-7/ADR; MCF-7/ADR-RES; MCF-7/AdrR; MCF-7/Adr; MCF-7/adr; MCF-7ADR; MCF7-ADR; MCF7ADR; OVCAR-8/ADR; OVCAR8/ADR 5321.0 nM GI50 C105555
TKC053815 U-251 U-251 MG; U-251-MG; U-251_MG; U251-MG; U251MG; U-251; U251; U251n; U251N; 251 MG; 251MG; 251 MG(6) 6138.0 nM GI50 C60781 Orphanet_94
TKC053815 OVCAR-8 OVCAR 8; NIH:OVCAR-8; OVCAR8; Ovcar8; OVCAR.8; OVCA8 8035.0 nM GI50 C105555
TKC053815 OVCAR-5 OVCAR 5; NIH:OVCAR-5; OVCAR.5; OVCAR5; Ovcar5; OVCA5 19679.0 nM GI50 C105555
TKC053815 SNB-19 SNB.19; SNB19; Surgical Neurology Branch-19 19543.0 nM GI50 C60781 Orphanet_94
TKC053815 MDA-MB-231 MDA_MB_231; MDA-MB 231; MDA.MB.231; MDA MB 231; MDA MB231; MDA Mb231; MDA-MB231; MDAMB-231; MDAMB231; MDA-231; MDA-231P; MDA231; MDA231-BRE; MB231; MD Anderson-Metastatic Breast-231 3846.0 nM GI50 C5214
TKC053815 TK-10 TK.10; TK 10; TK10 95060.0 nM GI50 C4033 Orphanet_319276
TKC053815 SW-620 SW-620; SW 620; SW.620 6281.0 nM GI50 C4349
TKC053815 NCI-H522 NCI.H522; H522; H-522; NCI-522; NCI522; NCIH522 5176.0 nM GI50 C3512
TKC053815 KM12 KM-12; KM.12 3917.0 nM GI50 C4910
TKC053815 M14 M14-MEL; UCLA-SO-M14; UCLA SO M14; UCLA-SO-14; UCLASO-M14; Melanoma 14; M-14 10520.0 nM GI50 C3802
TKC053815 RPMI-8226 RPMI 8226; RPMI.8226; RPMI8226; RPMI no. 8226; RPMI no 8226; RPMI #8226; 8226; RPMI 8226/S; RPMI-8226S; RPMI8226/S; 8226/S; Roswell Park Memorial Institute 8226; GM02132; GM2132; GM 2132; GM02132C; Simpson 2636.0 nM GI50 C3242 Orphanet_29073
TKC053815 NCI-H322M NCI.H322M; H322M; H-322M; H-322m 7328.0 nM GI50 C2923
TKC053815 OVCAR-4 OVCAR 4; NIH:OVCAR-4; NIH:OVCAR4; OVCAR.4; OVCAR4; Ovcar4 32359.0 nM GI50 C105555
TKC053815 BT-549 BT 549; BT.549; BT549 5768.0 nM GI50 C4194
TKC053815 SK-MEL-2 SK-Mel-2; SK-Mel 2; SK-mel-2; SK-MEL2; SK.MEL.2; SK Mel 2; SK MEL 2; SKMEL-2; SKMEL2; SKmel2; SK-ML2; SKml2 13032.0 nM GI50 C3224
TKC053815 A549 7656.0 nM GI50 C3512
TKC053815 SNB-75 SNB.75; SNB75; Surgical Neurology Branch-75 100000.0 nM GI50 C3058 Orphanet_360
TKC053815 HCC 2998 HCC-2998; HCC.2998; HCC 2998; Hamon Cancer Center 2998 3334.0 nM GI50 C4349
TKC053815 HCT-15 HCT-15; HCT.15; HCT15 5070.0 nM GI50 C4349
TKC053815 HCT-116 HCT-116; HCT.116; HCT_116; HCT116; HCT116wt; CoCL2 2404.0 nM GI50 C4910
TKC053815 SF-268 SF-268; SF.268; SF 268 28510.0 nM GI50 C60781 Orphanet_94
TKC053815 EKVX 22491.0 nM GI50 C3512
TKC053815 MCF7 4688.0 nM GI50 C4194
TKC053815 PC-3 PC3; PC.3 6607.0 nM GI50 C4863
TKC053815 T47D 12531.0 nM GI50 C4194
TKC053815 SK-OV-3 SKOV-3; SK-OV3; SK.OV.3; SKOV3; Skov3; SKO3 7709.0 nM GI50 C7978
TKC053815 UACC-62 UACC 62; UACC.62; UACC62; University of Arizona Cell Culture-62 5370.0 nM GI50 C3224
TKC053815 NCI-H460 NCI.H460; H460; H-460; NCIH460; NCI-HUT-460; NCI-460 3483.0 nM GI50 C4450
TKC053815 CAKI-1 CAL 1; Centre Antoine Lacassagne-1 11858.0 nM GI50 C3224
TKC053815 MDA-MB-435 MDA-MB435; MDAMB435; MDA.MB.435; MDA-435; MDA 435; MDA435; MD Anderson-Metastatic Breast-435 3273.0 nM GI50 C3802
TKC053815 IGROV-1 Igrov-1; IGROV 1; IGR-OV1; IGROV1; Igrov1; IGR.OV1; IGROV; OV1/P; OV1/p; OV1-P 10069.0 nM GI50 C7979 Orphanet_454723
TKC053815 SF-295 SF-295; SF.295; SF 295 14622.0 nM GI50 C3058 Orphanet_360
TKC053815 Hs-578T HS 578T; Hs-578T; HS-578T; Hs_578t; Hs-578-T; HS-578-T; Hs 578.T; HS578T; Hs578T; Hs578t; HS0578T; 578T; HS578; Hs578; Homo sapiens No. 578, tumor cells 3882.0 nM GI50 C4194
TKC053815 786-0 786-o; 786O; 786-0; 786.O; 786-O RCC; RCC 786-O; RCC_7860; RCC 7860; 7860; 786-0WT 9462.0 nM GI50 C9385 Orphanet_217071
TKC053815 UACC-257 UACC 257; UACC.257; UACC257; University of Arizona Cell Culture-257 15922.0 nM GI50 C3224
TKC053815 NCI-H226 NCI.H226; NCI H226; H226; H-226; HUT-226; HUT 226; NCIH226 22233.0 nM GI50 C45662 Orphanet_50251
TKC053815 HT-29 HT 29; HT29 7464.0 nM GI50 C4349
TKC053815 SK-MEL-28 SK-Mel-28; SK.MEL.28; SK-MEL 28; SK MEL-28; SK MEL 28; SK Mel 28; SKMel-28; SKMEL-28; SK-MEL28; SK-Mel28; SK Mel28; SKMEL28; SKMel28; SKmel28; SKML-28; SK28; AU-Mel; P-36; P36 20370.0 nM GI50 C3510
TKC053815 COLO 205 Colo 205; CoLo 205; COLO-205; Colo-205; COLO.205; Colo205; COLO205; Co 205; Colorado 205 7499.0 nM GI50 C4349
TKC053815 RXF 393 RXF393L; RXF-393 L; RXF-393; RXF 393; RXF.393; RXF393; RXF 393NL 4656.0 nM GI50 C9385 Orphanet_217071
TKC053815 KB KB (HeLa derivative); HeLa-KB; Strain KB 2.0 ug.mL-1 IC50 C27677
TKC053815 MCF7 8840.0 nM IC50 C4194
TKC053815 SK-BR-3 SK-Br-3; Sk-Br-3; SK BR 03; SKBR-3; SKBr-3; SK-BR3; SKBr3; SkBr3; SKBR3 3220.0 nM IC50 C5214
TKC053815 P388 P-388 3.0 ug.mL-1 IC50 C21602
TKC053815 SH-SY5Y SH-Sy5y; SHSY5Y; SHSY-5Y; SK-SH-SY5Y; SY5Y; SH-SY5Y Parental 39.0 nM EC50 C3270 Orphanet_635
TKC053815 Vero VERO; VeroCCL81; Vero 81; Vero-81; Verda reno 22230.0 nM CC50
TKC053815 HL-60 HL 60; HL.60 HL60; Human Leukemia-60 5900.0 nM IC50 C9154 Orphanet_519
TKC053815 HEK293 18356.0 nM Potency

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC053815 P10636 Microtubule-associated protein tau MAPT 11220 nM Potency
TKC053815 Q16637 Survival motor neuron protein SMN1,SMN2 10000 nM Potency
TKC053815 Q16637 Survival motor neuron protein SMN1,SMN2 10000 nM Potency
TKC053815 Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 TDP1 20596 nM Potency
TKC053815 Q9NPD5 Solute carrier organic anion transporter family member 1B3 SLCO1B3 105 % Inhibition
TKC053815 Q9Y6L6 Solute carrier organic anion transporter family member 1B1 SLCO1B1 65 % Inhibition
TKC053815 O75874 Isocitrate dehydrogenase [NADP] cytoplasmic IDH1 10323 nM Potency
TKC053815 P43220 Glucagon-like peptide 1 receptor GLP1R 5623 nM Potency
TKC053815 P84022 Mothers against decapentaplegic homolog 3 SMAD3 251 nM Potency
TKC053815 Q03431 Parathyroid hormone/parathyroid hormone-related peptide receptor PTH1R 44668 nM Potency
TKC053815 Q16236 Nuclear factor erythroid 2-related factor 2 NFE2L2 29093 nM Potency
TKC053815 Q99700 Ataxin-2 ATXN2 31623 nM Potency
TKC053815 O75496 Geminin GMNN 4110 nM Potency
TKC053815 P0DTD1 Replicase polyprotein 1ab rep 2 % Inhibition
TKC053815 Q96QE3 ATPase family AAA domain-containing protein 5 ATAD5 20596 nM Potency
TKC053815 Q6W5P4 Neuropeptide S receptor NPSR1 12589 nM Potency
TKC053815 P51450 Nuclear receptor ROR-gamma Rorc 35481 nM Potency
TKC053815 P02545 Prelamin-A/C LMNA 28184 nM Potency
TKC053815 Q548M1 60 kDa chaperonin groL 65 % Inhibition
TKC053815 P9WHJ3 Protein RecA recA 16100 nM EC50
TKC053815 P9WMR3 Replicative DNA helicase dnaB 4566 nM AC50

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
P10636 TAU_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
P10636 TAU_HUMAN Alzheimer disease [ICD-11: 8A20]
P10636 TAU_HUMAN Mild neurocognitive disorder [ICD-11: 6D71]
P10636 TAU_HUMAN Choreiform disorder [ICD-11: 8A01]
P10636 TAU_HUMAN Parkinsonism [ICD-11: 8A00]
P10636 TAU_HUMAN Central nervous system disease [ICD-11: 8A04-8D87]
P10636 TAU_HUMAN Neurodegenerative disorder [ICD-11: 8A20-8A23]
Q16637 SMN_HUMAN Muscular atrophy [ICD-11: 8B61]
Q16637 SMN_HUMAN Muscular atrophy [ICD-11: 8B61]
Q16637 SMN_HUMAN Muscular atrophy [ICD-11: 8B61]
Q16637 SMN_HUMAN Muscular atrophy [ICD-11: 8B61]
O75874 IDHC_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
O75874 IDHC_HUMAN Liver cancer [ICD-11: 2C12]
O75874 IDHC_HUMAN Malignant haematopoietic neoplasm [ICD-11: 2B33]
O75874 IDHC_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
O75874 IDHC_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
O75874 IDHC_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P43220 GLP1R_HUMAN Cardiovascular disease [ICD-11: BA00-BE2Z]
P43220 GLP1R_HUMAN Obesity [ICD-11: 5B80-5B81]
P43220 GLP1R_HUMAN Type 2 diabetes mellitus [ICD-11: 5A11]
P43220 GLP1R_HUMAN Type-1/2 diabete [ICD-11: 5A10-5A11]
P43220 GLP1R_HUMAN Acute diabete complication [ICD-11: 5A2Y]
P43220 GLP1R_HUMAN Diabetes mellitus [ICD-11: 5A10]
P43220 GLP1R_HUMAN Dyspepsia [ICD-11: MD92]
P43220 GLP1R_HUMAN Irritable bowel syndrome [ICD-11: DD91]
P43220 GLP1R_HUMAN Intracranial injury [ICD-11: NA07]
P43220 GLP1R_HUMAN Non-alcoholic fatty liver disease [ICD-11: DB92]
P84022 SMAD3_HUMAN Herpes simplex infection [ICD-11: 1F00]
P84022 SMAD3_HUMAN Kidney fibrosis [ICD-11: GC01]
Q03431 PTH1R_HUMAN Low bone mass disorder [ICD-11: FB83]
Q03431 PTH1R_HUMAN Hypo-parathyroidism [ICD-11: 5A50]
Q16236 NF2L2_HUMAN Ataxic disorder [ICD-11: 8A03]
Q16236 NF2L2_HUMAN Breast cancer [ICD-11: 2C60-2C6Y]
Q16236 NF2L2_HUMAN Glaucoma [ICD-11: 9C61]
Q16236 NF2L2_HUMAN Lung cancer [ICD-11: 2C25]
Q16236 NF2L2_HUMAN Macular degeneration [ICD-11: 9B75]
Q16236 NF2L2_HUMAN Melanoma [ICD-11: 2C30]
Q16236 NF2L2_HUMAN Mental/behavioural/neurodevelopmental disorder [ICD-11: 6E20-6E8Z]
Q16236 NF2L2_HUMAN Pulmonary hypertension [ICD-11: BB01]
Q16236 NF2L2_HUMAN Subarachnoid haemorrhage [ICD-11: 8B01]
Q16236 NF2L2_HUMAN Urinary system clinical sympton [ICD-11: MF8Y]
Q16236 NF2L2_HUMAN Non-alcoholic fatty liver disease [ICD-11: DB92]
Q16236 NF2L2_HUMAN Alpha-1-antitrypsin deficiency [ICD-11: 5C5A]
Q16236 NF2L2_HUMAN Motor neuron disease [ICD-11: 8B60]
Q16236 NF2L2_HUMAN Multiple sclerosis [ICD-11: 8A40]