Basic Information

Terpenoid ID TKC053751
Chirality TKC102941
Cell line 0
Protein target 19
DiseaseNCIT 0
ORDO 0
ICD 31

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC053751 Vero VERO; VeroCCL81; Vero 81; Vero-81; Verda reno 106.0 ug.mL-1 IC50
TKC053751 HeLa HELA; Hela; He La; He-La; HeLa-CCL2; Henrietta Lacks cells; Helacyton gartleri 100000.0 nM IC50 C27677
TKC053751 U-87 MG 100000.0 nM IC50 C3058 Orphanet_360
TKC053751 MKN-45 MKN-45; MKN 45 100000.0 nM IC50 C4004

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC053751 P10636 Microtubule-associated protein tau MAPT 5623 nM Potency
TKC053751 Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 TDP1 18356 nM Potency
TKC053751 Q9NPD5 Solute carrier organic anion transporter family member 1B3 SLCO1B3 58 % Inhibition
TKC053751 Q9Y6L6 Solute carrier organic anion transporter family member 1B1 SLCO1B1 40 % Inhibition
TKC053751 P27695 DNA-(apurinic or apyrimidinic site) endonuclease APEX1 39811 nM Potency
TKC053751 P08183 ATP-dependent translocase ABCB1 ABCB1 88 % Survival
TKC053751 O75496 Geminin GMNN 29093 nM Potency
TKC053751 P39748 Flap endonuclease 1 FEN1 26680 nM Potency
TKC053751 Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 PIN1 79433 nM Potency
TKC053751 Q96KQ7 Histone-lysine N-methyltransferase EHMT2 EHMT2 24 nM Potency
TKC053751 O00255 Menin MEN1 14125 nM Potency
TKC053751 P25779 Cruzipain 3162 nM Potency
TKC053751 P10520 Streptokinase A ska 362 nM EC50
TKC053751 O15438 ATP-binding cassette sub-family C member 3 ABCC3 133000 nM IC50
TKC053751 O15439 ATP-binding cassette sub-family C member 4 ABCC4 133000 nM IC50
TKC053751 O95342 Bile salt export pump ABCB11 10100 nM IC50
TKC053751 O95342 Bile salt export pump ABCB11 11500 nM IC50
TKC053751 O95342 Bile salt export pump ABCB11 10100 nM IC50
TKC053751 Q92887 ATP-binding cassette sub-family C member 2 ABCC2 133000 nM IC50
TKC053751 Q194T2 Non-structural protein 1 NS1 7943 nM Potency
TKC053751 O15648 ATP-dependent 6-phosphofructokinase pfk 7569 nM Potency
TKC053751 P02768 Albumin ALB 12000 nM Kd
TKC053751 O70127 Bile salt export pump Abcb11 2200 nM Ki
TKC053751 O70127 Bile salt export pump Abcb11 17400 nM IC50
TKC053751 Q63120 ATP-binding cassette sub-family C member 2 Abcc2 5500 nM Ki

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
P10636 TAU_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
P10636 TAU_HUMAN Alzheimer disease [ICD-11: 8A20]
P10636 TAU_HUMAN Mild neurocognitive disorder [ICD-11: 6D71]
P10636 TAU_HUMAN Choreiform disorder [ICD-11: 8A01]
P10636 TAU_HUMAN Parkinsonism [ICD-11: 8A00]
P10636 TAU_HUMAN Central nervous system disease [ICD-11: 8A04-8D87]
P10636 TAU_HUMAN Neurodegenerative disorder [ICD-11: 8A20-8A23]
P27695 APEX1_HUMAN Retinopathy [ICD-11: 9B71]
P27695 APEX1_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P27695 APEX1_HUMAN Ocular cancer [ICD-11: 2D00-2D07]
P27695 APEX1_HUMAN Brain cancer [ICD-11: 2A00]
P27695 APEX1_HUMAN Melanoma [ICD-11: 2C30]
P08183 MDR1_HUMAN Lung cancer [ICD-11: 2C25]
P08183 MDR1_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P08183 MDR1_HUMAN Bacterial infection [ICD-11: 1A00-1C4Z]
P08183 MDR1_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
P08183 MDR1_HUMAN Adrenal cancer [ICD-11: 2D11]
P08183 MDR1_HUMAN Ovarian cancer [ICD-11: 2C73]
Q13526 PIN1_HUMAN Lung cancer [ICD-11: 2C25]
Q13526 PIN1_HUMAN Nasopharyngeal cancer [ICD-11: 2B6B]
Q96KQ7 EHMT2_HUMAN Breast cancer [ICD-11: 2C60-2C6Y]
Q96KQ7 EHMT2_HUMAN Postoperative inflammation [ICD-11: 1A00-CA43]
Q96KQ7 EHMT2_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P25779 CYSP_TRYCR Parasitic worm infestation [ICD-11: 1F90]
P25779 CYSP_TRYCR Malaria [ICD-11: 1F40-1F45]
P02768 ALBU_HUMAN Aneurysm/dissection [ICD-11: BD50]
P02768 ALBU_HUMAN Bowel habit change [ICD-11: ME05]
P02768 ALBU_HUMAN Cholelithiasis [ICD-11: DC11]
P02768 ALBU_HUMAN Inborn energy metabolism error [ICD-11: 5C53]
P02768 ALBU_HUMAN Irritable bowel syndrome [ICD-11: DD91]
P02768 ALBU_HUMAN Preprocedural examination [ICD-11: QA0B]
P02768 ALBU_HUMAN Rheumatoid arthritis [ICD-11: FA20]
P02768 ALBU_HUMAN Schizophrenia [ICD-11: 6A20]
P02768 ALBU_HUMAN Unspecific body region injury [ICD-11: ND56]
P02768 ALBU_HUMAN Coagulation defect [ICD-11: 3B10]
P02768 ALBU_HUMAN Lupus erythematosus [ICD-11: 4A40]
P02768 ALBU_HUMAN Vitamin deficiency [ICD-11: 5B55-5B5F]