Basic Information

Terpenoid ID TKC052854
Chirality TKC052841
Cell line 0
Protein target 10
DiseaseNCIT 0
ORDO 0
ICD 36

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC052854 HepG2 35481.0 nM Potency C3728 Orphanet_449
TKC052854 RAW264.7 RAW264 101800.0 nM IC50 C21604
TKC052854 Caco-2 CaCo-2; CACO-2; Caco 2; CACO 2; CACO2; CaCo2; CaCO2; Caco2; Caco-2/ATCC; Caco-II 17900.0 nM IC50 C4349
TKC052854 COR-L23 CORL23; COR-L23P; COR-L23/P; L23/P 600.0 nM IC50 C4450
TKC052854 A549 14540.0 nM IC50 C3512
TKC052854 C32 C-32; C32-mel; C32 mel; C32r 43500.0 nM IC50 C3802
TKC052854 A-375 A 375; A375; A375-MEL; A375-mel; A375mel 23900.0 nM IC50 C3802
TKC052854 ACHN 50000.0 nM IC50 C6975 Orphanet_319298
TKC052854 HepG2 8340.0 nM IC50 C3728 Orphanet_449
TKC052854 Bcap37 BCap-37; Bcap-37; BCaP 37; BCap 37; Bcap 37; BCAP37; Bcap37 13960.0 nM IC50 C27677

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC052854 Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 TDP1 18356 nM Potency
TKC052854 P84022 Mothers against decapentaplegic homolog 3 SMAD3 35481 nM Potency
TKC052854 Q77YF9 Protein Vpr vpr 28184 nM Potency
TKC052854 P27695 DNA-(apurinic or apyrimidinic site) endonuclease APEX1 21192 nM Potency
TKC052854 Q9UNA4 DNA polymerase iota POLI 19953 nM Potency
TKC052854 O75496 Geminin GMNN 14581 nM Potency
TKC052854 Q96QE3 ATPase family AAA domain-containing protein 5 ATAD5 20588 nM Potency
TKC052854 P04637 Cellular tumor antigen p53 TP53 25119 nM Potency
TKC052854 Q13324 Corticotropin-releasing factor receptor 2 CRHR2 9400 nM EC50
TKC052854 P24387 Corticotropin-releasing factor-binding protein CRHBP 9400 nM EC50

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
P84022 SMAD3_HUMAN Herpes simplex infection [ICD-11: 1F00]
P84022 SMAD3_HUMAN Kidney fibrosis [ICD-11: GC01]
P27695 APEX1_HUMAN Retinopathy [ICD-11: 9B71]
P27695 APEX1_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P27695 APEX1_HUMAN Ocular cancer [ICD-11: 2D00-2D07]
P27695 APEX1_HUMAN Brain cancer [ICD-11: 2A00]
P27695 APEX1_HUMAN Melanoma [ICD-11: 2C30]
P04637 P53_HUMAN Arterial occlusive disease [ICD-11: BD40]
P04637 P53_HUMAN Lip/oral cavity/pharynx neoplasm [ICD-11: 2B6E]
P04637 P53_HUMAN Metastatic liver/bile duct neoplasm [ICD-11: 2D80]
P04637 P53_HUMAN Transplant rejection [ICD-11: NE84]
P04637 P53_HUMAN Ovarian dysfunction [ICD-11: 5A80]
P04637 P53_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
P04637 P53_HUMAN Bladder cancer [ICD-11: 2C94]
P04637 P53_HUMAN Brain cancer [ICD-11: 2A00]
P04637 P53_HUMAN Colorectal cancer [ICD-11: 2B91]
P04637 P53_HUMAN Esophageal cancer [ICD-11: 2B70]
P04637 P53_HUMAN Head and neck cancer [ICD-11: 2D42]
P04637 P53_HUMAN Mature B-cell leukaemia [ICD-11: 2A82]
P04637 P53_HUMAN Myelodysplastic syndrome [ICD-11: 2A37]
P04637 P53_HUMAN Ovarian cancer [ICD-11: 2C73]
P04637 P53_HUMAN Pancreatic cancer [ICD-11: 2C10]
P04637 P53_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P04637 P53_HUMAN Stomach cancer [ICD-11: 2B72]
P04637 P53_HUMAN Cervical cancer [ICD-11: 2C77]
P04637 P53_HUMAN Endometrial cancer [ICD-11: 2C76]
P04637 P53_HUMAN Fallopian tube cancer [ICD-11: 2C74]
P04637 P53_HUMAN Liposarcoma [ICD-11: 2B59]
P04637 P53_HUMAN Malignant haematopoietic neoplasm [ICD-11: 2B33]
P04637 P53_HUMAN Peritoneal cancer [ICD-11: 2C51]
P04637 P53_HUMAN Toxicity [ICD-11: N.A.]
P04637 P53_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P04637 P53_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
P04637 P53_HUMAN Kidney failure [ICD-11: GB60-GB6Z]
P04637 P53_HUMAN Hearing disorder [ICD-11: AB50-AB57]
Q13324 CRFR2_HUMAN Heart failure [ICD-11: BD10-BD1Z]
Q13324 CRFR2_HUMAN Binge eating disorder [ICD-11: 6B82]
Q13324 CRFR2_HUMAN Anxiety disorder [ICD-11: 6B00-6B0Z]