Basic Information

Terpenoid ID TKC050429
Cell line 0
Protein target 2
DiseaseNCIT 0
ORDO 0
ICD 6

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC050429 HL-60 HL 60; HL.60 HL60; Human Leukemia-60 -51.0 % Activity C9154 Orphanet_519
TKC050429 HCT-116 HCT-116; HCT.116; HCT_116; HCT116; HCT116wt; CoCL2 1200.0 nM IC50 C4910
TKC050429 MCF7 3090.0 nM GI50 C4194
TKC050429 HSC-2 HSC2 6100.0 nM IC50 C4833 Orphanet_502363
TKC050429 T47D 11749.0 nM GI50 C4194
TKC050429 UO-31 UO.31; UO31; U031 -26.0 % Activity C9385 Orphanet_217071
TKC050429 A498 A498 -32.0 % Activity C9385 Orphanet_217071
TKC050429 786-0 786-o; 786O; 786-0; 786.O; 786-O RCC; RCC 786-O; RCC_7860; RCC 7860; 7860; 786-0WT -43.0 % Activity C9385 Orphanet_217071
TKC050429 UACC-62 UACC 62; UACC.62; UACC62; University of Arizona Cell Culture-62 -28.0 % Activity C3224
TKC050429 SNB-19 SNB.19; SNB19; Surgical Neurology Branch-19 -53.0 % Activity C60781 Orphanet_94
TKC050429 SF-295 SF-295; SF.295; SF 295 -14.0 % Activity C3058 Orphanet_360
TKC050429 NCI-H322M NCI.H322M; H322M; H-322M; H-322m -8.0 % Activity C2923
TKC050429 HOP-92 HOP 92; HOP.92; HOP92; Hop92; Hopkins-92 -54.0 % Activity C2926
TKC050429 SK-MEL-2 SK-Mel-2; SK-Mel 2; SK-mel-2; SK-MEL2; SK.MEL.2; SK Mel 2; SK MEL 2; SKMEL-2; SKMEL2; SKmel2; SK-ML2; SKml2 2188.0 nM GI50 C3224
TKC050429 BT-549 BT 549; BT.549; BT549 1940.0 nM GI50 C4194
TKC050429 MDA-MB-231 MDA_MB_231; MDA-MB 231; MDA.MB.231; MDA MB 231; MDA MB231; MDA Mb231; MDA-MB231; MDAMB-231; MDAMB231; MDA-231; MDA-231P; MDA231; MDA231-BRE; MB231; MD Anderson-Metastatic Breast-231 1650.0 nM GI50 C5214
TKC050429 PC-3 PC3; PC.3 1340.0 nM GI50 C4863
TKC050429 TK-10 TK.10; TK 10; TK10 2239.0 nM GI50 C4033 Orphanet_319276
TKC050429 SN12C SN-12C 1622.0 nM GI50 C9385 Orphanet_217071
TKC050429 RXF 393 RXF393L; RXF-393 L; RXF-393; RXF 393; RXF.393; RXF393; RXF 393NL 1770.0 nM GI50 C9385 Orphanet_217071
TKC050429 CAKI-1 CAL 1; Centre Antoine Lacassagne-1 2455.0 nM GI50 C3224
TKC050429 ACHN 1820.0 nM GI50 C6975 Orphanet_319298
TKC050429 OVCAR-5 OVCAR 5; NIH:OVCAR-5; OVCAR.5; OVCAR5; Ovcar5; OVCA5 3380.0 nM GI50 C105555
TKC050429 IGROV-1 Igrov-1; IGROV 1; IGR-OV1; IGROV1; Igrov1; IGR.OV1; IGROV; OV1/P; OV1/p; OV1-P 2291.0 nM GI50 C7979 Orphanet_454723
TKC050429 UACC-257 UACC 257; UACC.257; UACC257; University of Arizona Cell Culture-257 2130.0 nM GI50 C3224
TKC050429 SK-MEL-5 SK-Mel-5; SK MEL 5; SK.MEL.5; SK-MEL5; SKMel-5; SKMEL-5; SKMEL5; SKMel5; SKmel5; AA-Mel 1778.0 nM GI50 C3510
TKC050429 Malme-3M MALME-3M; MALME 3M; Malme-3 M; MALME.3M; Malme3M; MALME3M; Malme-3 Monolayer 1820.0 nM GI50 C3224
TKC050429 LOX IMVI LOX/IMVI; LOX IMVI; LOXIM-VI; LOXIMVI; LOX 3388.0 nM GI50 C3802
TKC050429 U-251 U-251 MG; U-251-MG; U-251_MG; U251-MG; U251MG; U-251; U251; U251n; U251N; 251 MG; 251MG; 251 MG(6) 1585.0 nM GI50 C60781 Orphanet_94
TKC050429 SF-539 SF-539; SF-539 BT; SF.539; SF 539 3370.0 nM GI50 C3796 Orphanet_251576
TKC050429 HT-29 HT 29; HT29 2138.0 nM GI50 C4349
TKC050429 HCT-15 HCT-15; HCT.15; HCT15 2570.0 nM GI50 C4349
TKC050429 NCI-H522 NCI.H522; H522; H-522; NCI-522; NCI522; NCIH522 2180.0 nM GI50 C3512
TKC050429 NCI-H23 NCI.H23; NCI H23; H-23; H23; NCIH23 2390.0 nM GI50 C3512
TKC050429 NCI-H226 NCI.H226; NCI H226; H226; H-226; HUT-226; HUT 226; NCIH226 1698.0 nM GI50 C45662 Orphanet_50251
TKC050429 A549 790.0 nM IC50 C3512
TKC050429 MDA-MB-468 MDA-MB 468; MDA-MB468; MDAMB468; MDA-468; MDA468; MB468; MD Anderson-Metastatic Breast-468 1680.0 nM GI50 C5214
TKC050429 DU-145 DU-145; Du-145; DU 145; DU_145; DU.145; Duke University 145 2120.0 nM GI50 C4863
TKC050429 OVCAR-8 OVCAR 8; NIH:OVCAR-8; OVCAR8; Ovcar8; OVCAR.8; OVCA8 1905.0 nM GI50 C105555
TKC050429 OVCAR-4 OVCAR 4; NIH:OVCAR-4; NIH:OVCAR4; OVCAR.4; OVCAR4; Ovcar4 1770.0 nM GI50 C105555
TKC050429 OVCAR-3 Ovcar-3; OVCAR 3; OVCAR.3; NIH:OVCAR-3; NIH:Ovcar-3; NIH:OVCAR3; NIH-OVCAR-3; NIHOVCAR3; OVCAR3; Ovcar3 1950.0 nM GI50 C105555
TKC050429 SK-MEL-28 SK-Mel-28; SK.MEL.28; SK-MEL 28; SK MEL-28; SK MEL 28; SK Mel 28; SKMel-28; SKMEL-28; SK-MEL28; SK-Mel28; SK Mel28; SKMEL28; SKMel28; SKmel28; SKML-28; SK28; AU-Mel; P-36; P36 1900.0 nM GI50 C3510
TKC050429 M14 M14-MEL; UCLA-SO-M14; UCLA SO M14; UCLA-SO-14; UCLASO-M14; Melanoma 14; M-14 1810.0 nM GI50 C3802
TKC050429 SF-268 SF-268; SF.268; SF 268 2138.0 nM GI50 C60781 Orphanet_94
TKC050429 KM12 KM-12; KM.12 1349.0 nM GI50 C4910
TKC050429 HOP-62 HOP 62; Hop 62; HOP.62; HOP62; Hop62; Hopkins-62 1862.0 nM GI50 C3512
TKC050429 SK-OV-3 SKOV-3; SK-OV3; SK.OV.3; SKOV3; Skov3; SKO3 1862.0 nM GI50 C7978
TKC050429 COLO 205 Colo 205; CoLo 205; COLO-205; Colo-205; COLO.205; Colo205; COLO205; Co 205; Colorado 205 2089.0 nM GI50 C4349

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC050429 Q00653 Nuclear factor NF-kappa-B p100 subunit NFKB2 980 nM IC50
TKC050429 O14920 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 2620 nM IC50

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
Q00653 NFKB2_HUMAN Ulcerative colitis [ICD-11: DD71]
O14920 IKKB_HUMAN Mature B-cell lymphoma [ICD-11: 2A85]
O14920 IKKB_HUMAN Alzheimer disease [ICD-11: 8A20]
O14920 IKKB_HUMAN Osteoarthritis [ICD-11: FA00-FA05]
O14920 IKKB_HUMAN Acne vulgaris [ICD-11: ED80]
O14920 IKKB_HUMAN Rheumatoid arthritis [ICD-11: FA20]