Basic Information

Terpenoid ID TKC048637
Cell line 57
Protein target 1
DiseaseNCIT 59
ORDO 20
ICD 16

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC048637 UO-31 UO.31; UO31; U031 2483.0 nM GI50 C9385 Orphanet_217071
TKC048637 HL-60 HL 60; HL.60 HL60; Human Leukemia-60 1197.0 nM GI50 C9154 Orphanet_519
TKC048637 Lu1 Lu1 4.0 ug ml-1 ED50 C21678
TKC048637 Col2 Col-2; Col2 6.0 ug ml-1 ED50 C4910
TKC048637 KB KB (HeLa derivative); HeLa-KB; Strain KB 4.0 ug ml-1 ED50 C27677
TKC048637 LNCaP LNCAP; LNCap; Ln-Cap; Lymph Node Carcinoma of the prostate 7.0 ug ml-1 ED50 C4863
TKC048637 SK-N-SH SK N SH; SKN-SH; SK-NSH; SKNSH; NSH 7.0 ug ml-1 ED50 C3270 Orphanet_635
TKC048637 MCF7 2.0 ug ml-1 ED50 C4194
TKC048637 HUVEC HUV-EC-C; HUVEC 6.0 ug ml-1 ED50
TKC048637 SN12C SN-12C 1914.0 nM GI50 C9385 Orphanet_217071
TKC048637 MDA-N MDAN 1710.0 nM GI50 C3802
TKC048637 ACHN 3334.0 nM GI50 C6975 Orphanet_319298
TKC048637 NCI-H23 NCI.H23; NCI H23; H-23; H23; NCIH23 1186.0 nM GI50 C3512
TKC048637 HOP-92 HOP 92; HOP.92; HOP92; Hop92; Hopkins-92 1954.0 nM GI50 C2926
TKC048637 DU-145 DU-145; Du-145; DU 145; DU_145; DU.145; Duke University 145 10209.0 nM GI50 C4863
TKC048637 SF-539 SF-539; SF-539 BT; SF.539; SF 539 5082.0 nM GI50 C3796 Orphanet_251576
TKC048637 SK-MEL-5 SK-Mel-5; SK MEL 5; SK.MEL.5; SK-MEL5; SKMel-5; SKMEL-5; SKMEL5; SKMel5; SKmel5; AA-Mel 286.0 nM GI50 C3510
TKC048637 Malme-3M MALME-3M; MALME 3M; Malme-3 M; MALME.3M; Malme3M; MALME3M; Malme-3 Monolayer 3565.0 nM GI50 C3224
TKC048637 A498 A498 437.0 nM GI50 C9385 Orphanet_217071
TKC048637 K562 K562; K.562; K 562; KO; GM05372; GM05372E 553.0 nM GI50 C9110 Orphanet_521
TKC048637 OVCAR-3 Ovcar-3; OVCAR 3; OVCAR.3; NIH:OVCAR-3; NIH:Ovcar-3; NIH:OVCAR3; NIH-OVCAR-3; NIHOVCAR3; OVCAR3; Ovcar3 3516.0 nM GI50 C105555
TKC048637 MOLT-4 Molt-4; MOLT 4; Molt 4; MOLT.4; MOLT4; Molt4; GM02219; GM02219C; GM2219C; GM02219D 1589.0 nM GI50 C9142 Orphanet_99861
TKC048637 NCI/ADR-RES NCI/ADR-RES; NCI.ADR.RES; NCIADR.RES; NCI/ADRRES; NCIADRRES; ADR-RES; MCF-7/ADR; MCF-7/ADR-RES; MCF-7/AdrR; MCF-7/Adr; MCF-7/adr; MCF-7ADR; MCF7-ADR; MCF7ADR; OVCAR-8/ADR; OVCAR8/ADR 3076.0 nM GI50 C105555
TKC048637 HOP-62 HOP 62; Hop 62; HOP.62; HOP62; Hop62; Hopkins-62 10186.0 nM GI50 C3512
TKC048637 U-251 U-251 MG; U-251-MG; U-251_MG; U251-MG; U251MG; U-251; U251; U251n; U251N; 251 MG; 251MG; 251 MG(6) 1038.0 nM GI50 C60781 Orphanet_94
TKC048637 OVCAR-5 OVCAR 5; NIH:OVCAR-5; OVCAR.5; OVCAR5; Ovcar5; OVCA5 9817.0 nM GI50 C105555
TKC048637 OVCAR-8 OVCAR 8; NIH:OVCAR-8; OVCAR8; Ovcar8; OVCAR.8; OVCA8 4909.0 nM GI50 C105555
TKC048637 MDA-MB-231 MDA_MB_231; MDA-MB 231; MDA.MB.231; MDA MB 231; MDA MB231; MDA Mb231; MDA-MB231; MDAMB-231; MDAMB231; MDA-231; MDA-231P; MDA231; MDA231-BRE; MB231; MD Anderson-Metastatic Breast-231 5346.0 nM GI50 C5214
TKC048637 SNB-19 SNB.19; SNB19; Surgical Neurology Branch-19 11803.0 nM GI50 C60781 Orphanet_94
TKC048637 SR SR-786; SR786 10.0 nM GI50 C37193 Orphanet_300895
TKC048637 TK-10 TK.10; TK 10; TK10 2838.0 nM GI50 C4033 Orphanet_319276
TKC048637 SW-620 SW-620; SW 620; SW.620 2716.0 nM GI50 C4349
TKC048637 NCI-H522 NCI.H522; H522; H-522; NCI-522; NCI522; NCIH522 2884.0 nM GI50 C3512
TKC048637 KM12 KM-12; KM.12 2449.0 nM GI50 C4910
TKC048637 M14 M14-MEL; UCLA-SO-M14; UCLA SO M14; UCLA-SO-14; UCLASO-M14; Melanoma 14; M-14 2773.0 nM GI50 C3802
TKC048637 NCI-H322M NCI.H322M; H322M; H-322M; H-322m 8279.0 nM GI50 C2923
TKC048637 RPMI-8226 RPMI 8226; RPMI.8226; RPMI8226; RPMI no. 8226; RPMI no 8226; RPMI #8226; 8226; RPMI 8226/S; RPMI-8226S; RPMI8226/S; 8226/S; Roswell Park Memorial Institute 8226; GM02132; GM2132; GM 2132; GM02132C; Simpson 624.0 nM GI50 C3242 Orphanet_29073
TKC048637 OVCAR-4 OVCAR 4; NIH:OVCAR-4; NIH:OVCAR4; OVCAR.4; OVCAR4; Ovcar4 3034.0 nM GI50 C105555
TKC048637 LOX IMVI LOX/IMVI; LOX IMVI; LOXIM-VI; LOXIMVI; LOX 1517.0 nM GI50 C3802
TKC048637 BT-549 BT 549; BT.549; BT549 3776.0 nM GI50 C4194
TKC048637 SK-MEL-2 SK-Mel-2; SK-Mel 2; SK-mel-2; SK-MEL2; SK.MEL.2; SK Mel 2; SK MEL 2; SKMEL-2; SKMEL2; SKmel2; SK-ML2; SKml2 31405.0 nM GI50 C3224
TKC048637 HCC 2998 HCC-2998; HCC.2998; HCC 2998; Hamon Cancer Center 2998 5998.0 nM GI50 C4349
TKC048637 A549 2786.0 nM GI50 C3512
TKC048637 SNB-75 SNB.75; SNB75; Surgical Neurology Branch-75 3548.0 nM GI50 C3058 Orphanet_360
TKC048637 HCT-15 HCT-15; HCT.15; HCT15 4375.0 nM GI50 C4349
TKC048637 HCT-116 HCT-116; HCT.116; HCT_116; HCT116; HCT116wt; CoCL2 1143.0 nM GI50 C4910
TKC048637 SF-268 SF-268; SF.268; SF 268 6745.0 nM GI50 C60781 Orphanet_94
TKC048637 PC-3 PC3; PC.3 2642.0 nM GI50 C4863
TKC048637 EKVX 1507.0 nM GI50 C3512
TKC048637 SK-OV-3 SKOV-3; SK-OV3; SK.OV.3; SKOV3; Skov3; SKO3 36813.0 nM GI50 C7978
TKC048637 NCI-H460 NCI.H460; H460; H-460; NCIH460; NCI-HUT-460; NCI-460 721.0 nM GI50 C4450
TKC048637 T47D 2838.0 nM GI50 C4194
TKC048637 UACC-62 UACC 62; UACC.62; UACC62; University of Arizona Cell Culture-62 9016.0 nM GI50 C3224
TKC048637 MDA-MB-435 MDA-MB435; MDAMB435; MDA.MB.435; MDA-435; MDA 435; MDA435; MD Anderson-Metastatic Breast-435 2477.0 nM GI50 C3802
TKC048637 CAKI-1 CAL 1; Centre Antoine Lacassagne-1 2084.0 nM GI50 C3224
TKC048637 IGROV-1 Igrov-1; IGROV 1; IGR-OV1; IGROV1; Igrov1; IGR.OV1; IGROV; OV1/P; OV1/p; OV1-P 2917.0 nM GI50 C7979 Orphanet_454723
TKC048637 SF-295 SF-295; SF.295; SF 295 1343.0 nM GI50 C3058 Orphanet_360
TKC048637 786-0 786-o; 786O; 786-0; 786.O; 786-O RCC; RCC 786-O; RCC_7860; RCC 7860; 7860; 786-0WT 4375.0 nM GI50 C9385 Orphanet_217071
TKC048637 Hs-578T HS 578T; Hs-578T; HS-578T; Hs_578t; Hs-578-T; HS-578-T; Hs 578.T; HS578T; Hs578T; Hs578t; HS0578T; 578T; HS578; Hs578; Homo sapiens No. 578, tumor cells 10864.0 nM GI50 C4194
TKC048637 UACC-257 UACC 257; UACC.257; UACC257; University of Arizona Cell Culture-257 1959.0 nM GI50 C3224
TKC048637 CCRF-CEM CCRF/CEM; CCRFCEM; CCRF.CEM; CCRF CEM; CCRF; CEM; CEM-CCRF; CEM-CCRF (CAMR); CCRF/CEM/0; CEM/0; CEM-0; CCRF-CEM/S; GM03671; GM03671C 1038.0 nM GI50 C7953 Orphanet_99861
TKC048637 NCI-H226 NCI.H226; NCI H226; H226; H-226; HUT-226; HUT 226; NCIH226 14928.0 nM GI50 C45662 Orphanet_50251
TKC048637 SK-MEL-28 SK-Mel-28; SK.MEL.28; SK-MEL 28; SK MEL-28; SK MEL 28; SK Mel 28; SKMel-28; SKMEL-28; SK-MEL28; SK-Mel28; SK Mel28; SKMEL28; SKMel28; SKmel28; SKML-28; SK28; AU-Mel; P-36; P36 3741.0 nM GI50 C3510
TKC048637 HT-29 HT 29; HT29 2009.0 nM GI50 C4349
TKC048637 RXF 393 RXF393L; RXF-393 L; RXF-393; RXF 393; RXF.393; RXF393; RXF 393NL 77804.0 nM GI50 C9385 Orphanet_217071
TKC048637 COLO 205 Colo 205; CoLo 205; COLO-205; Colo-205; COLO.205; Colo205; COLO205; Co 205; Colorado 205 2009.0 nM GI50 C4349
TKC048637 RAW264.7 RAW264 20.0 nM IC50 C21604

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC048637 P22303 Acetylcholinesterase ACHE 29 % Inhibition

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
P22303 ACES_HUMAN Alzheimer disease [ICD-11: 8A20]
P22303 ACES_HUMAN Glaucoma [ICD-11: 9C61]
P22303 ACES_HUMAN Myasthenia gravis [ICD-11: 8C6Y]
P22303 ACES_HUMAN Oesophageal/gastroduodenal disorder [ICD-11: DD90]
P22303 ACES_HUMAN Pediculosis [ICD-11: 1G00]
P22303 ACES_HUMAN Unspecific substance harmful effect [ICD-11: NE6Z]
P22303 ACES_HUMAN Mild neurocognitive disorder [ICD-11: 6D71]
P22303 ACES_HUMAN Parasitic worm infestation [ICD-11: 1F90]
P22303 ACES_HUMAN Dementia [ICD-11: 6D80-6D8Z]
P22303 ACES_HUMAN Pain [ICD-11: MG30-MG3Z]
P22303 ACES_HUMAN Parkinsonism [ICD-11: 8A00]
P22303 ACES_HUMAN Substance abuse [ICD-11: 6C40]
P22303 ACES_HUMAN Lips/oral mucosa miscellaneous disorder [ICD-11: DA02]
P22303 ACES_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P22303 ACES_HUMAN Urinary system disease [ICD-11: GC2Z]
P22303 ACES_HUMAN Neurodegenerative disorder [ICD-11: 8A20-8A23]