Basic Information

Terpenoid ID TKC046324
Cell line 0
Protein target 2
DiseaseNCIT 0
ORDO 0
ICD 21

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC046324 A549 5.0 ug ml-1 ED50 C3512
TKC046324 SK-OV-3 SKOV-3; SK-OV3; SK.OV.3; SKOV3; Skov3; SKO3 10.0 ug ml-1 ED50 C7978
TKC046324 SK-MEL-2 SK-Mel-2; SK-Mel 2; SK-mel-2; SK-MEL2; SK.MEL.2; SK Mel 2; SK MEL 2; SKMEL-2; SKMEL2; SKmel2; SK-ML2; SKml2 4.0 ug ml-1 ED50 C3224
TKC046324 XF498 XF-498; XF498 5.0 ug ml-1 ED50 C3058 Orphanet_360
TKC046324 HCT-15 HCT-15; HCT.15; HCT15 5.0 ug ml-1 ED50 C4349

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC046324 P06493 Cyclin-dependent kinase 1 CDK1 >100000 nM IC50
TKC046324 P49841 Glycogen synthase kinase-3 beta GSK3B 4500 nM IC50
TKC046324 P49841 Glycogen synthase kinase-3 beta GSK3B 1900 nM IC50
TKC046324 Q00535 Cyclin-dependent-like kinase 5 CDK5 >25000 nM IC50
TKC046324 P49840 Glycogen synthase kinase-3 alpha GSK3A 1600 nM IC50
TKC046324 P67870 Casein kinase II subunit beta CSNK2B >100000 nM IC50

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
P06493 CDK1_HUMAN Breast cancer [ICD-11: 2C60-2C6Y]
P06493 CDK1_HUMAN Lung cancer [ICD-11: 2C25]
P06493 CDK1_HUMAN Mature B-cell lymphoma [ICD-11: 2A85]
P06493 CDK1_HUMAN Nasopharyngeal cancer [ICD-11: 2B6B]
P06493 CDK1_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P06493 CDK1_HUMAN Malignant haematopoietic neoplasm [ICD-11: 2B33]
P06493 CDK1_HUMAN Allergic/hypersensitivity disorder [ICD-11: 4A80-4A8Z]
P06493 CDK1_HUMAN Transplant rejection [ICD-11: NE84]
P06493 CDK1_HUMAN Obesity [ICD-11: 5B80-5B81]
P06493 CDK1_HUMAN Pain [ICD-11: MG30-MG3Z]
P49841 GSK3B_HUMAN Myotonic disorder [ICD-11: 8C71]
P49841 GSK3B_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
P49841 GSK3B_HUMAN Fragile X chromosome [ICD-11: LD55]
P49841 GSK3B_HUMAN Myeloproliferative neoplasm [ICD-11: 2A20]
P49841 GSK3B_HUMAN Osteosarcoma [ICD-11: 2B51]
P49841 GSK3B_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P49841 GSK3B_HUMAN Parkinsonism [ICD-11: 8A00]
P49841 GSK3B_HUMAN Allergic/hypersensitivity disorder [ICD-11: 4A80-4A8Z]
P49841 GSK3B_HUMAN Brain cancer [ICD-11: 2A00]
P49841 GSK3B_HUMAN Ovarian cancer [ICD-11: 2C73]
P49841 GSK3B_HUMAN Transplant rejection [ICD-11: NE84]
P49841 GSK3B_HUMAN Alzheimer disease [ICD-11: 8A20]
P49841 GSK3B_HUMAN Acute diabete complication [ICD-11: 5A2Y]
P49841 GSK3B_HUMAN Myotonic disorder [ICD-11: 8C71]
P49841 GSK3B_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
P49841 GSK3B_HUMAN Fragile X chromosome [ICD-11: LD55]
P49841 GSK3B_HUMAN Myeloproliferative neoplasm [ICD-11: 2A20]
P49841 GSK3B_HUMAN Osteosarcoma [ICD-11: 2B51]
P49841 GSK3B_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P49841 GSK3B_HUMAN Parkinsonism [ICD-11: 8A00]
P49841 GSK3B_HUMAN Allergic/hypersensitivity disorder [ICD-11: 4A80-4A8Z]
P49841 GSK3B_HUMAN Brain cancer [ICD-11: 2A00]
P49841 GSK3B_HUMAN Ovarian cancer [ICD-11: 2C73]
P49841 GSK3B_HUMAN Transplant rejection [ICD-11: NE84]
P49841 GSK3B_HUMAN Alzheimer disease [ICD-11: 8A20]
P49841 GSK3B_HUMAN Acute diabete complication [ICD-11: 5A2Y]
Q00535 CDK5_HUMAN Obesity [ICD-11: 5B80-5B81]
P49840 GSK3A_HUMAN Epilepsy/seizure [ICD-11: 8A61-8A6Z]
P49840 GSK3A_HUMAN Substance abuse [ICD-11: 6C40]
P49840 GSK3A_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
P49840 GSK3A_HUMAN Fragile X chromosome [ICD-11: LD55]
P49840 GSK3A_HUMAN Allergic/hypersensitivity disorder [ICD-11: 4A80-4A8Z]
P49840 GSK3A_HUMAN Brain cancer [ICD-11: 2A00]
P49840 GSK3A_HUMAN Ovarian cancer [ICD-11: 2C73]
P49840 GSK3A_HUMAN Transplant rejection [ICD-11: NE84]