Basic Information

Terpenoid ID TKC045773
Cell line 0
Protein target 1
DiseaseNCIT 0
ORDO 0
ICD 16

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC045773 Malme-3M MALME-3M; MALME 3M; Malme-3 M; MALME.3M; Malme3M; MALME3M; Malme-3 Monolayer 1054.0 nM GI50 C3224
TKC045773 K562 K562; K.562; K 562; KO; GM05372; GM05372E 776.0 nM GI50 C9110 Orphanet_521
TKC045773 MDA-N MDAN 1528.0 nM GI50 C3802
TKC045773 SN12C SN-12C 1340.0 nM GI50 C9385 Orphanet_217071
TKC045773 NCI-H23 NCI.H23; NCI H23; H-23; H23; NCIH23 1687.0 nM GI50 C3512
TKC045773 HL-60 HL 60; HL.60 HL60; Human Leukemia-60 513.0 nM GI50 C9154 Orphanet_519
TKC045773 DU-145 DU-145; Du-145; DU 145; DU_145; DU.145; Duke University 145 2075.0 nM GI50 C4863
TKC045773 SK-MEL-5 SK-Mel-5; SK MEL 5; SK.MEL.5; SK-MEL5; SKMel-5; SKMEL-5; SKMEL5; SKMel5; SKmel5; AA-Mel 1862.0 nM GI50 C3510
TKC045773 MOLT-4 Molt-4; MOLT 4; Molt 4; MOLT.4; MOLT4; Molt4; GM02219; GM02219C; GM2219C; GM02219D 248.0 nM GI50 C9142 Orphanet_99861
TKC045773 HOP-62 HOP 62; Hop 62; HOP.62; HOP62; Hop62; Hopkins-62 2410.0 nM GI50 C3512
TKC045773 OVCAR-8 OVCAR 8; NIH:OVCAR-8; OVCAR8; Ovcar8; OVCAR.8; OVCA8 1380.0 nM GI50 C105555
TKC045773 MDA-MB-231 MDA_MB_231; MDA-MB 231; MDA.MB.231; MDA MB 231; MDA MB231; MDA Mb231; MDA-MB231; MDAMB-231; MDAMB231; MDA-231; MDA-231P; MDA231; MDA231-BRE; MB231; MD Anderson-Metastatic Breast-231 1754.0 nM GI50 C5214
TKC045773 TK-10 TK.10; TK 10; TK10 1897.0 nM GI50 C4033 Orphanet_319276
TKC045773 SR SR-786; SR786 244.0 nM GI50 C37193 Orphanet_300895
TKC045773 SW-620 SW-620; SW 620; SW.620 1291.0 nM GI50 C4349
TKC045773 KM12 KM-12; KM.12 1824.0 nM GI50 C4910
TKC045773 M14 M14-MEL; UCLA-SO-M14; UCLA SO M14; UCLA-SO-14; UCLASO-M14; Melanoma 14; M-14 1422.0 nM GI50 C3802
TKC045773 NCI-H322M NCI.H322M; H322M; H-322M; H-322m 1871.0 nM GI50 C2923
TKC045773 RPMI-8226 RPMI 8226; RPMI.8226; RPMI8226; RPMI no. 8226; RPMI no 8226; RPMI #8226; 8226; RPMI 8226/S; RPMI-8226S; RPMI8226/S; 8226/S; Roswell Park Memorial Institute 8226; GM02132; GM2132; GM 2132; GM02132C; Simpson 428.0 nM GI50 C3242 Orphanet_29073
TKC045773 LOX IMVI LOX/IMVI; LOX IMVI; LOXIM-VI; LOXIMVI; LOX 1180.0 nM GI50 C3802
TKC045773 A549 2924.0 nM GI50 C3512
TKC045773 SNB-75 SNB.75; SNB75; Surgical Neurology Branch-75 1758.0 nM GI50 C3058 Orphanet_360
TKC045773 HCC 2998 HCC-2998; HCC.2998; HCC 2998; Hamon Cancer Center 2998 1841.0 nM GI50 C4349
TKC045773 HCT-15 HCT-15; HCT.15; HCT15 920.0 nM GI50 C4349
TKC045773 MCF7 1239.0 nM GI50 C4194
TKC045773 EKVX 2432.0 nM GI50 C3512
TKC045773 SK-OV-3 SKOV-3; SK-OV3; SK.OV.3; SKOV3; Skov3; SKO3 2472.0 nM GI50 C7978
TKC045773 PC-3 PC3; PC.3 1312.0 nM GI50 C4863
TKC045773 T47D 1884.0 nM GI50 C4194
TKC045773 UACC-62 UACC 62; UACC.62; UACC62; University of Arizona Cell Culture-62 1799.0 nM GI50 C3224
TKC045773 CAKI-1 CAL 1; Centre Antoine Lacassagne-1 1489.0 nM GI50 C3224
TKC045773 IGROV-1 Igrov-1; IGROV 1; IGR-OV1; IGROV1; Igrov1; IGR.OV1; IGROV; OV1/P; OV1/p; OV1-P 1538.0 nM GI50 C7979 Orphanet_454723
TKC045773 SF-295 SF-295; SF.295; SF 295 2339.0 nM GI50 C3058 Orphanet_360
TKC045773 UACC-257 UACC 257; UACC.257; UACC257; University of Arizona Cell Culture-257 1914.0 nM GI50 C3224
TKC045773 786-0 786-o; 786O; 786-0; 786.O; 786-O RCC; RCC 786-O; RCC_7860; RCC 7860; 7860; 786-0WT 1089.0 nM GI50 C9385 Orphanet_217071
TKC045773 CCRF-CEM CCRF/CEM; CCRFCEM; CCRF.CEM; CCRF CEM; CCRF; CEM; CEM-CCRF; CEM-CCRF (CAMR); CCRF/CEM/0; CEM/0; CEM-0; CCRF-CEM/S; GM03671; GM03671C 303.0 nM GI50 C7953 Orphanet_99861
TKC045773 HT-29 HT 29; HT29 1300.0 nM GI50 C4349
TKC045773 SK-MEL-28 SK-Mel-28; SK.MEL.28; SK-MEL 28; SK MEL-28; SK MEL 28; SK Mel 28; SKMel-28; SKMEL-28; SK-MEL28; SK-Mel28; SK Mel28; SKMEL28; SKMel28; SKmel28; SKML-28; SK28; AU-Mel; P-36; P36 1531.0 nM GI50 C3510
TKC045773 RXF 393 RXF393L; RXF-393 L; RXF-393; RXF 393; RXF.393; RXF393; RXF 393NL 2061.0 nM GI50 C9385 Orphanet_217071
TKC045773 COLO 205 Colo 205; CoLo 205; COLO-205; Colo-205; COLO.205; Colo205; COLO205; Co 205; Colorado 205 1832.0 nM GI50 C4349
TKC045773 MDA-N MDAN 1164.0 nM GI50 C3802
TKC045773 SN12C SN-12C 1000.0 nM GI50 C9385 Orphanet_217071
TKC045773 NCI-H23 NCI.H23; NCI H23; H-23; H23; NCIH23 1387.0 nM GI50 C3512
TKC045773 HL-60 HL 60; HL.60 HL60; Human Leukemia-60 428.0 nM GI50 C9154 Orphanet_519
TKC045773 DU-145 DU-145; Du-145; DU 145; DU_145; DU.145; Duke University 145 4074.0 nM GI50 C4863
TKC045773 SK-MEL-5 SK-Mel-5; SK MEL 5; SK.MEL.5; SK-MEL5; SKMel-5; SKMEL-5; SKMEL5; SKMel5; SKmel5; AA-Mel 1439.0 nM GI50 C3510
TKC045773 Malme-3M MALME-3M; MALME 3M; Malme-3 M; MALME.3M; Malme3M; MALME3M; Malme-3 Monolayer 1000.0 nM GI50 C3224
TKC045773 K562 K562; K.562; K 562; KO; GM05372; GM05372E 425.0 nM GI50 C9110 Orphanet_521
TKC045773 HOP-62 HOP 62; Hop 62; HOP.62; HOP62; Hop62; Hopkins-62 1897.0 nM GI50 C3512
TKC045773 MOLT-4 Molt-4; MOLT 4; Molt 4; MOLT.4; MOLT4; Molt4; GM02219; GM02219C; GM2219C; GM02219D 252.0 nM GI50 C9142 Orphanet_99861
TKC045773 OVCAR-8 OVCAR 8; NIH:OVCAR-8; OVCAR8; Ovcar8; OVCAR.8; OVCA8 962.0 nM GI50 C105555
TKC045773 MDA-MB-231 MDA_MB_231; MDA-MB 231; MDA.MB.231; MDA MB 231; MDA MB231; MDA Mb231; MDA-MB231; MDAMB-231; MDAMB231; MDA-231; MDA-231P; MDA231; MDA231-BRE; MB231; MD Anderson-Metastatic Breast-231 1265.0 nM GI50 C5214
TKC045773 SR SR-786; SR786 259.0 nM GI50 C37193 Orphanet_300895
TKC045773 SW-620 SW-620; SW 620; SW.620 375.0 nM GI50 C4349
TKC045773 TK-10 TK.10; TK 10; TK10 1754.0 nM GI50 C4033 Orphanet_319276
TKC045773 M14 M14-MEL; UCLA-SO-M14; UCLA SO M14; UCLA-SO-14; UCLASO-M14; Melanoma 14; M-14 1503.0 nM GI50 C3802
TKC045773 KM12 KM-12; KM.12 1679.0 nM GI50 C4910
TKC045773 NCI-H322M NCI.H322M; H322M; H-322M; H-322m 2228.0 nM GI50 C2923
TKC045773 RPMI-8226 RPMI 8226; RPMI.8226; RPMI8226; RPMI no. 8226; RPMI no 8226; RPMI #8226; 8226; RPMI 8226/S; RPMI-8226S; RPMI8226/S; 8226/S; Roswell Park Memorial Institute 8226; GM02132; GM2132; GM 2132; GM02132C; Simpson 275.0 nM GI50 C3242 Orphanet_29073
TKC045773 A549 1849.0 nM GI50 C3512
TKC045773 HCC 2998 HCC-2998; HCC.2998; HCC 2998; Hamon Cancer Center 2998 1472.0 nM GI50 C4349
TKC045773 SNB-75 SNB.75; SNB75; Surgical Neurology Branch-75 1803.0 nM GI50 C3058 Orphanet_360
TKC045773 HCT-15 HCT-15; HCT.15; HCT15 516.0 nM GI50 C4349
TKC045773 SF-268 SF-268; SF.268; SF 268 1442.0 nM GI50 C60781 Orphanet_94
TKC045773 MCF7 726.0 nM GI50 C4194
TKC045773 EKVX 2443.0 nM GI50 C3512
TKC045773 PC-3 PC3; PC.3 1321.0 nM GI50 C4863
TKC045773 SK-OV-3 SKOV-3; SK-OV3; SK.OV.3; SKOV3; Skov3; SKO3 1866.0 nM GI50 C7978
TKC045773 T47D 1321.0 nM GI50 C4194
TKC045773 UACC-62 UACC 62; UACC.62; UACC62; University of Arizona Cell Culture-62 1528.0 nM GI50 C3224
TKC045773 CAKI-1 CAL 1; Centre Antoine Lacassagne-1 1722.0 nM GI50 C3224
TKC045773 SF-295 SF-295; SF.295; SF 295 1000.0 nM GI50 C3058 Orphanet_360
TKC045773 IGROV-1 Igrov-1; IGROV 1; IGR-OV1; IGROV1; Igrov1; IGR.OV1; IGROV; OV1/P; OV1/p; OV1-P 1191.0 nM GI50 C7979 Orphanet_454723
TKC045773 786-0 786-o; 786O; 786-0; 786.O; 786-O RCC; RCC 786-O; RCC_7860; RCC 7860; 7860; 786-0WT 219.0 nM GI50 C9385 Orphanet_217071
TKC045773 UACC-257 UACC 257; UACC.257; UACC257; University of Arizona Cell Culture-257 1000.0 nM GI50 C3224
TKC045773 CCRF-CEM CCRF/CEM; CCRFCEM; CCRF.CEM; CCRF CEM; CCRF; CEM; CEM-CCRF; CEM-CCRF (CAMR); CCRF/CEM/0; CEM/0; CEM-0; CCRF-CEM/S; GM03671; GM03671C 271.0 nM GI50 C7953 Orphanet_99861
TKC045773 SK-MEL-28 SK-Mel-28; SK.MEL.28; SK-MEL 28; SK MEL-28; SK MEL 28; SK Mel 28; SKMel-28; SKMEL-28; SK-MEL28; SK-Mel28; SK Mel28; SKMEL28; SKMel28; SKmel28; SKML-28; SK28; AU-Mel; P-36; P36 512.0 nM GI50 C3510
TKC045773 HT-29 HT 29; HT29 692.0 nM GI50 C4349
TKC045773 RXF 393 RXF393L; RXF-393 L; RXF-393; RXF 393; RXF.393; RXF393; RXF 393NL 382.0 nM GI50 C9385 Orphanet_217071
TKC045773 COLO 205 Colo 205; CoLo 205; COLO-205; Colo-205; COLO.205; Colo205; COLO205; Co 205; Colorado 205 2254.0 nM GI50 C4349

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC045773 P32245 Melanocortin receptor 4 MC4R 15219 nM IC50
TKC045773 O60755 Galanin receptor type 3 GALR3 >1107 nM IC50

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
P32245 MC4R_HUMAN Acute diabete complication [ICD-11: 5A2Y]
P32245 MC4R_HUMAN Hypoactive sexual desire dysfunction [ICD-11: HA00]
P32245 MC4R_HUMAN Intellectual development disorder [ICD-11: LD90]
P32245 MC4R_HUMAN Large intestine motility disorder [ICD-11: DB32]
P32245 MC4R_HUMAN Obesity [ICD-11: 5B80-5B81]
P32245 MC4R_HUMAN Pituitary hypofunction [ICD-11: 5A61]
P32245 MC4R_HUMAN Sexual dysfunction [ICD-11: HA00-HA01]
P32245 MC4R_HUMAN Alzheimer disease [ICD-11: 8A20]
P32245 MC4R_HUMAN Asthma [ICD-11: CA23]
P32245 MC4R_HUMAN Breast cancer [ICD-11: 2C60-2C6Y]
P32245 MC4R_HUMAN General pain disorder [ICD-11: 8E43]
P32245 MC4R_HUMAN Atopic eczema [ICD-11: EA80]
P32245 MC4R_HUMAN Metabolic disorder [ICD-11: 5C50-5D2Z]
P32245 MC4R_HUMAN Type 2 diabetes mellitus [ICD-11: 5A11]
P32245 MC4R_HUMAN Anorexia nervosa [ICD-11: 6B80]
P32245 MC4R_HUMAN Cachexia [ICD-11: MG20]