Basic Information

Terpenoid ID TKC043519
Cell line 0
Protein target 11
DiseaseNCIT 0
ORDO 0
ICD 33

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC043519 MDA-N MDAN 13152.0 nM GI50 C3802
TKC043519 SN12C SN-12C 13996.0 nM GI50 C9385 Orphanet_217071
TKC043519 ACHN 10641.0 nM GI50 C6975 Orphanet_319298
TKC043519 NCI-H23 NCI.H23; NCI H23; H-23; H23; NCIH23 23227.0 nM GI50 C3512
TKC043519 UO-31 UO.31; UO31; U031 13677.0 nM GI50 C9385 Orphanet_217071
TKC043519 HOP-92 HOP 92; HOP.92; HOP92; Hop92; Hopkins-92 14962.0 nM GI50 C2926
TKC043519 HL-60 HL 60; HL.60 HL60; Human Leukemia-60 2661.0 nM GI50 C9154 Orphanet_519
TKC043519 DU-145 DU-145; Du-145; DU 145; DU_145; DU.145; Duke University 145 15382.0 nM GI50 C4863
TKC043519 SF-539 SF-539; SF-539 BT; SF.539; SF 539 30269.0 nM GI50 C3796 Orphanet_251576
TKC043519 SK-MEL-5 SK-Mel-5; SK MEL 5; SK.MEL.5; SK-MEL5; SKMel-5; SKMEL-5; SKMEL5; SKMel5; SKmel5; AA-Mel 17022.0 nM GI50 C3510
TKC043519 Malme-3M MALME-3M; MALME 3M; Malme-3 M; MALME.3M; Malme3M; MALME3M; Malme-3 Monolayer 13521.0 nM GI50 C3224
TKC043519 K562 K562; K.562; K 562; KO; GM05372; GM05372E 383.0 nM GI50 C9110 Orphanet_521
TKC043519 A498 A498 1236.0 nM GI50 C9385 Orphanet_217071
TKC043519 OVCAR-3 Ovcar-3; OVCAR 3; OVCAR.3; NIH:OVCAR-3; NIH:Ovcar-3; NIH:OVCAR3; NIH-OVCAR-3; NIHOVCAR3; OVCAR3; Ovcar3 14655.0 nM GI50 C105555
TKC043519 MOLT-4 Molt-4; MOLT 4; Molt 4; MOLT.4; MOLT4; Molt4; GM02219; GM02219C; GM2219C; GM02219D 5176.0 nM GI50 C9142 Orphanet_99861
TKC043519 NCI/ADR-RES NCI/ADR-RES; NCI.ADR.RES; NCIADR.RES; NCI/ADRRES; NCIADRRES; ADR-RES; MCF-7/ADR; MCF-7/ADR-RES; MCF-7/AdrR; MCF-7/Adr; MCF-7/adr; MCF-7ADR; MCF7-ADR; MCF7ADR; OVCAR-8/ADR; OVCAR8/ADR 21478.0 nM GI50 C105555
TKC043519 HOP-62 HOP 62; Hop 62; HOP.62; HOP62; Hop62; Hopkins-62 73961.0 nM GI50 C3512
TKC043519 U-251 U-251 MG; U-251-MG; U-251_MG; U251-MG; U251MG; U-251; U251; U251n; U251N; 251 MG; 251MG; 251 MG(6) 21928.0 nM GI50 C60781 Orphanet_94
TKC043519 OVCAR-5 OVCAR 5; NIH:OVCAR-5; OVCAR.5; OVCAR5; Ovcar5; OVCA5 25410.0 nM GI50 C105555
TKC043519 OVCAR-8 OVCAR 8; NIH:OVCAR-8; OVCAR8; Ovcar8; OVCAR.8; OVCA8 30832.0 nM GI50 C105555
TKC043519 SNB-19 SNB.19; SNB19; Surgical Neurology Branch-19 58479.0 nM GI50 C60781 Orphanet_94
TKC043519 MDA-MB-231 MDA_MB_231; MDA-MB 231; MDA.MB.231; MDA MB 231; MDA MB231; MDA Mb231; MDA-MB231; MDAMB-231; MDAMB231; MDA-231; MDA-231P; MDA231; MDA231-BRE; MB231; MD Anderson-Metastatic Breast-231 16520.0 nM GI50 C5214
TKC043519 SR SR-786; SR786 3639.0 nM GI50 C37193 Orphanet_300895
TKC043519 TK-10 TK.10; TK 10; TK10 7727.0 nM GI50 C4033 Orphanet_319276
TKC043519 SW-620 SW-620; SW 620; SW.620 8851.0 nM GI50 C4349
TKC043519 NCI-H522 NCI.H522; H522; H-522; NCI-522; NCI522; NCIH522 3311.0 nM GI50 C3512
TKC043519 KM12 KM-12; KM.12 19011.0 nM GI50 C4910
TKC043519 M14 M14-MEL; UCLA-SO-M14; UCLA SO M14; UCLA-SO-14; UCLASO-M14; Melanoma 14; M-14 21577.0 nM GI50 C3802
TKC043519 NCI-H322M NCI.H322M; H322M; H-322M; H-322m 72277.0 nM GI50 C2923
TKC043519 RPMI-8226 RPMI 8226; RPMI.8226; RPMI8226; RPMI no. 8226; RPMI no 8226; RPMI #8226; 8226; RPMI 8226/S; RPMI-8226S; RPMI8226/S; 8226/S; Roswell Park Memorial Institute 8226; GM02132; GM2132; GM 2132; GM02132C; Simpson 4819.0 nM GI50 C3242 Orphanet_29073
TKC043519 OVCAR-4 OVCAR 4; NIH:OVCAR-4; NIH:OVCAR4; OVCAR.4; OVCAR4; Ovcar4 32810.0 nM GI50 C105555
TKC043519 LOX IMVI LOX/IMVI; LOX IMVI; LOXIM-VI; LOXIMVI; LOX 12677.0 nM GI50 C3802
TKC043519 BT-549 BT 549; BT.549; BT549 8128.0 nM GI50 C4194
TKC043519 SK-MEL-2 SK-Mel-2; SK-Mel 2; SK-mel-2; SK-MEL2; SK.MEL.2; SK Mel 2; SK MEL 2; SKMEL-2; SKMEL2; SKmel2; SK-ML2; SKml2 25527.0 nM GI50 C3224
TKC043519 A549 69183.0 nM GI50 C3512
TKC043519 HCC 2998 HCC-2998; HCC.2998; HCC 2998; Hamon Cancer Center 2998 19320.0 nM GI50 C4349
TKC043519 SNB-75 SNB.75; SNB75; Surgical Neurology Branch-75 67453.0 nM GI50 C3058 Orphanet_360
TKC043519 HCT-15 HCT-15; HCT.15; HCT15 13305.0 nM GI50 C4349
TKC043519 HCT-116 HCT-116; HCT.116; HCT_116; HCT116; HCT116wt; CoCL2 6577.0 nM GI50 C4910
TKC043519 SF-268 SF-268; SF.268; SF 268 19231.0 nM GI50 C60781 Orphanet_94
TKC043519 EKVX 17022.0 nM GI50 C3512
TKC043519 PC-3 PC3; PC.3 23121.0 nM GI50 C4863
TKC043519 MCF7 6792.0 nM GI50 C4194
TKC043519 SK-OV-3 SKOV-3; SK-OV3; SK.OV.3; SKOV3; Skov3; SKO3 59566.0 nM GI50 C7978
TKC043519 T47D 14454.0 nM GI50 C4194
TKC043519 NCI-H460 NCI.H460; H460; H-460; NCIH460; NCI-HUT-460; NCI-460 27990.0 nM GI50 C4450
TKC043519 UACC-62 UACC 62; UACC.62; UACC62; University of Arizona Cell Culture-62 15453.0 nM GI50 C3224
TKC043519 CAKI-1 CAL 1; Centre Antoine Lacassagne-1 17258.0 nM GI50 C3224
TKC043519 MDA-MB-435 MDA-MB435; MDAMB435; MDA.MB.435; MDA-435; MDA 435; MDA435; MD Anderson-Metastatic Breast-435 17947.0 nM GI50 C3802
TKC043519 IGROV-1 Igrov-1; IGROV 1; IGR-OV1; IGROV1; Igrov1; IGR.OV1; IGROV; OV1/P; OV1/p; OV1-P 19498.0 nM GI50 C7979 Orphanet_454723
TKC043519 SF-295 SF-295; SF.295; SF 295 83946.0 nM GI50 C3058 Orphanet_360
TKC043519 786-0 786-o; 786O; 786-0; 786.O; 786-O RCC; RCC 786-O; RCC_7860; RCC 7860; 7860; 786-0WT 7464.0 nM GI50 C9385 Orphanet_217071
TKC043519 Hs-578T HS 578T; Hs-578T; HS-578T; Hs_578t; Hs-578-T; HS-578-T; Hs 578.T; HS578T; Hs578T; Hs578t; HS0578T; 578T; HS578; Hs578; Homo sapiens No. 578, tumor cells 56234.0 nM GI50 C4194
TKC043519 UACC-257 UACC 257; UACC.257; UACC257; University of Arizona Cell Culture-257 17701.0 nM GI50 C3224
TKC043519 CCRF-CEM CCRF/CEM; CCRFCEM; CCRF.CEM; CCRF CEM; CCRF; CEM; CEM-CCRF; CEM-CCRF (CAMR); CCRF/CEM/0; CEM/0; CEM-0; CCRF-CEM/S; GM03671; GM03671C 2355.0 nM GI50 C7953 Orphanet_99861
TKC043519 NCI-H226 NCI.H226; NCI H226; H226; H-226; HUT-226; HUT 226; NCIH226 42954.0 nM GI50 C45662 Orphanet_50251
TKC043519 HT-29 HT 29; HT29 12417.0 nM GI50 C4349
TKC043519 SK-MEL-28 SK-Mel-28; SK.MEL.28; SK-MEL 28; SK MEL-28; SK MEL 28; SK Mel 28; SKMel-28; SKMEL-28; SK-MEL28; SK-Mel28; SK Mel28; SKMEL28; SKMel28; SKmel28; SKML-28; SK28; AU-Mel; P-36; P36 14689.0 nM GI50 C3510
TKC043519 RXF 393 RXF393L; RXF-393 L; RXF-393; RXF 393; RXF.393; RXF393; RXF 393NL 10789.0 nM GI50 C9385 Orphanet_217071
TKC043519 COLO 205 Colo 205; CoLo 205; COLO-205; Colo-205; COLO.205; Colo205; COLO205; Co 205; Colorado 205 5236.0 nM GI50 C4349

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC043519 P11473 Vitamin D3 receptor VDR 79433 nM Potency
TKC043519 Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 TDP1 11582 nM Potency
TKC043519 P84022 Mothers against decapentaplegic homolog 3 SMAD3 17783 nM Potency
TKC043519 Q16236 Nuclear factor erythroid 2-related factor 2 NFE2L2 15849 nM Potency
TKC043519 Q99700 Ataxin-2 ATXN2 189 nM Potency
TKC043519 Q9UNA4 DNA polymerase iota POLI 15849 nM Potency
TKC043519 O75496 Geminin GMNN 3264 nM Potency
TKC043519 P01215 Glycoprotein hormones alpha chain CGA 3162 nM Potency
TKC043519 Q9HC16 DNA dC->dU-editing enzyme APOBEC-3G APOBEC3G 35481 nM Potency
TKC043519 Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 PIN1 67456 nM Potency
TKC043519 Q9Y253 DNA polymerase eta POLH 28184 nM Potency

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
P11473 VDR_HUMAN Chronic kidney disease [ICD-11: GB61]
P11473 VDR_HUMAN Hair/hair growth developmental defect [ICD-11: LC30]
P11473 VDR_HUMAN Hyper-parathyroidism [ICD-11: 5A51]
P11473 VDR_HUMAN Hypo-parathyroidism [ICD-11: 5A50]
P11473 VDR_HUMAN Mineral deficiency [ICD-11: 5B5K]
P11473 VDR_HUMAN Psoriasis [ICD-11: EA90]
P11473 VDR_HUMAN Vitamin deficiency [ICD-11: 5B55-5B5F]
P11473 VDR_HUMAN Low bone mass disorder [ICD-11: FB83]
P11473 VDR_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
P11473 VDR_HUMAN Prostate cancer [ICD-11: 2C82]
P11473 VDR_HUMAN Prostate disease [ICD-11: GA91]
P11473 VDR_HUMAN Abnormal micturition [ICD-11: MF50]
P11473 VDR_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P11473 VDR_HUMAN Postoperative inflammation [ICD-11: 1A00-CA43]
P11473 VDR_HUMAN Acne vulgaris [ICD-11: ED80]
P84022 SMAD3_HUMAN Herpes simplex infection [ICD-11: 1F00]
P84022 SMAD3_HUMAN Kidney fibrosis [ICD-11: GC01]
Q16236 NF2L2_HUMAN Ataxic disorder [ICD-11: 8A03]
Q16236 NF2L2_HUMAN Breast cancer [ICD-11: 2C60-2C6Y]
Q16236 NF2L2_HUMAN Glaucoma [ICD-11: 9C61]
Q16236 NF2L2_HUMAN Lung cancer [ICD-11: 2C25]
Q16236 NF2L2_HUMAN Macular degeneration [ICD-11: 9B75]
Q16236 NF2L2_HUMAN Melanoma [ICD-11: 2C30]
Q16236 NF2L2_HUMAN Mental/behavioural/neurodevelopmental disorder [ICD-11: 6E20-6E8Z]
Q16236 NF2L2_HUMAN Pulmonary hypertension [ICD-11: BB01]
Q16236 NF2L2_HUMAN Subarachnoid haemorrhage [ICD-11: 8B01]
Q16236 NF2L2_HUMAN Urinary system clinical sympton [ICD-11: MF8Y]
Q16236 NF2L2_HUMAN Non-alcoholic fatty liver disease [ICD-11: DB92]
Q16236 NF2L2_HUMAN Alpha-1-antitrypsin deficiency [ICD-11: 5C5A]
Q16236 NF2L2_HUMAN Motor neuron disease [ICD-11: 8B60]
Q16236 NF2L2_HUMAN Multiple sclerosis [ICD-11: 8A40]
Q13526 PIN1_HUMAN Lung cancer [ICD-11: 2C25]
Q13526 PIN1_HUMAN Nasopharyngeal cancer [ICD-11: 2B6B]