Basic Information

Terpenoid ID TKC043354
Cell line 0
Protein target 12
DiseaseNCIT 0
ORDO 0
ICD 15

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC043354 HepG2 15849.0 nM Potency C3728 Orphanet_449
TKC043354 HEK293 10000.0 nM Potency
TKC043354 SN12C SN-12C 13305.0 nM GI50 C9385 Orphanet_217071
TKC043354 MDA-N MDAN 5675.0 nM GI50 C3802
TKC043354 ACHN 1945.0 nM GI50 C6975 Orphanet_319298
TKC043354 NCI-H23 NCI.H23; NCI H23; H-23; H23; NCIH23 19275.0 nM GI50 C3512
TKC043354 UO-31 UO.31; UO31; U031 14028.0 nM GI50 C9385 Orphanet_217071
TKC043354 HOP-92 HOP 92; HOP.92; HOP92; Hop92; Hopkins-92 1274.0 nM GI50 C2926
TKC043354 HL-60 HL 60; HL.60 HL60; Human Leukemia-60 2871.0 nM GI50 C9154 Orphanet_519
TKC043354 SF-539 SF-539; SF-539 BT; SF.539; SF 539 14894.0 nM GI50 C3796 Orphanet_251576
TKC043354 DU-145 DU-145; Du-145; DU 145; DU_145; DU.145; Duke University 145 12706.0 nM GI50 C4863
TKC043354 Malme-3M MALME-3M; MALME 3M; Malme-3 M; MALME.3M; Malme3M; MALME3M; Malme-3 Monolayer 2080.0 nM GI50 C3224
TKC043354 SK-MEL-5 SK-Mel-5; SK MEL 5; SK.MEL.5; SK-MEL5; SKMel-5; SKMEL-5; SKMEL5; SKMel5; SKmel5; AA-Mel 18967.0 nM GI50 C3510
TKC043354 K562 K562; K.562; K 562; KO; GM05372; GM05372E 1710.0 nM GI50 C9110 Orphanet_521
TKC043354 A498 A498 21627.0 nM GI50 C9385 Orphanet_217071
TKC043354 OVCAR-3 Ovcar-3; OVCAR 3; OVCAR.3; NIH:OVCAR-3; NIH:Ovcar-3; NIH:OVCAR3; NIH-OVCAR-3; NIHOVCAR3; OVCAR3; Ovcar3 11614.0 nM GI50 C105555
TKC043354 MOLT-4 Molt-4; MOLT 4; Molt 4; MOLT.4; MOLT4; Molt4; GM02219; GM02219C; GM2219C; GM02219D 3251.0 nM GI50 C9142 Orphanet_99861
TKC043354 HOP-62 HOP 62; Hop 62; HOP.62; HOP62; Hop62; Hopkins-62 19187.0 nM GI50 C3512
TKC043354 NCI/ADR-RES NCI/ADR-RES; NCI.ADR.RES; NCIADR.RES; NCI/ADRRES; NCIADRRES; ADR-RES; MCF-7/ADR; MCF-7/ADR-RES; MCF-7/AdrR; MCF-7/Adr; MCF-7/adr; MCF-7ADR; MCF7-ADR; MCF7ADR; OVCAR-8/ADR; OVCAR8/ADR 17620.0 nM GI50 C105555
TKC043354 U-251 U-251 MG; U-251-MG; U-251_MG; U251-MG; U251MG; U-251; U251; U251n; U251N; 251 MG; 251MG; 251 MG(6) 18113.0 nM GI50 C60781 Orphanet_94
TKC043354 OVCAR-8 OVCAR 8; NIH:OVCAR-8; OVCAR8; Ovcar8; OVCAR.8; OVCA8 19999.0 nM GI50 C105555
TKC043354 OVCAR-5 OVCAR 5; NIH:OVCAR-5; OVCAR.5; OVCAR5; Ovcar5; OVCA5 15922.0 nM GI50 C105555
TKC043354 MDA-MB-231 MDA_MB_231; MDA-MB 231; MDA.MB.231; MDA MB 231; MDA MB231; MDA Mb231; MDA-MB231; MDAMB-231; MDAMB231; MDA-231; MDA-231P; MDA231; MDA231-BRE; MB231; MD Anderson-Metastatic Breast-231 20137.0 nM GI50 C5214
TKC043354 SNB-19 SNB.19; SNB19; Surgical Neurology Branch-19 21478.0 nM GI50 C60781 Orphanet_94
TKC043354 TK-10 TK.10; TK 10; TK10 3936.0 nM GI50 C4033 Orphanet_319276
TKC043354 SR SR-786; SR786 4786.0 nM GI50 C37193 Orphanet_300895
TKC043354 SW-620 SW-620; SW 620; SW.620 4406.0 nM GI50 C4349
TKC043354 KM12 KM-12; KM.12 18239.0 nM GI50 C4910
TKC043354 NCI-H522 NCI.H522; H522; H-522; NCI-522; NCI522; NCIH522 1556.0 nM GI50 C3512
TKC043354 M14 M14-MEL; UCLA-SO-M14; UCLA SO M14; UCLA-SO-14; UCLASO-M14; Melanoma 14; M-14 7534.0 nM GI50 C3802
TKC043354 NCI-H322M NCI.H322M; H322M; H-322M; H-322m 34754.0 nM GI50 C2923
TKC043354 RPMI-8226 RPMI 8226; RPMI.8226; RPMI8226; RPMI no. 8226; RPMI no 8226; RPMI #8226; 8226; RPMI 8226/S; RPMI-8226S; RPMI8226/S; 8226/S; Roswell Park Memorial Institute 8226; GM02132; GM2132; GM 2132; GM02132C; Simpson 3373.0 nM GI50 C3242 Orphanet_29073
TKC043354 OVCAR-4 OVCAR 4; NIH:OVCAR-4; NIH:OVCAR4; OVCAR.4; OVCAR4; Ovcar4 19409.0 nM GI50 C105555
TKC043354 LOX IMVI LOX/IMVI; LOX IMVI; LOXIM-VI; LOXIMVI; LOX 13521.0 nM GI50 C3802
TKC043354 BT-549 BT 549; BT.549; BT549 7943.0 nM GI50 C4194
TKC043354 SK-MEL-2 SK-Mel-2; SK-Mel 2; SK-mel-2; SK-MEL2; SK.MEL.2; SK Mel 2; SK MEL 2; SKMEL-2; SKMEL2; SKmel2; SK-ML2; SKml2 16520.0 nM GI50 C3224
TKC043354 A549 20137.0 nM GI50 C3512
TKC043354 HCC 2998 HCC-2998; HCC.2998; HCC 2998; Hamon Cancer Center 2998 20701.0 nM GI50 C4349
TKC043354 SNB-75 SNB.75; SNB75; Surgical Neurology Branch-75 16482.0 nM GI50 C3058 Orphanet_360
TKC043354 HCT-15 HCT-15; HCT.15; HCT15 3192.0 nM GI50 C4349
TKC043354 HCT-116 HCT-116; HCT.116; HCT_116; HCT116; HCT116wt; CoCL2 7396.0 nM GI50 C4910
TKC043354 SF-268 SF-268; SF.268; SF 268 13900.0 nM GI50 C60781 Orphanet_94
TKC043354 EKVX 16406.0 nM GI50 C3512
TKC043354 PC-3 PC3; PC.3 16596.0 nM GI50 C4863
TKC043354 MCF7 2661.0 nM GI50 C4194
TKC043354 SK-OV-3 SKOV-3; SK-OV3; SK.OV.3; SKOV3; Skov3; SKO3 27227.0 nM GI50 C7978
TKC043354 NCI-H460 NCI.H460; H460; H-460; NCIH460; NCI-HUT-460; NCI-460 20941.0 nM GI50 C4450
TKC043354 T47D 4721.0 nM GI50 C4194
TKC043354 CAKI-1 CAL 1; Centre Antoine Lacassagne-1 1901.0 nM GI50 C3224
TKC043354 UACC-62 UACC 62; UACC.62; UACC62; University of Arizona Cell Culture-62 14060.0 nM GI50 C3224
TKC043354 MDA-MB-435 MDA-MB435; MDAMB435; MDA.MB.435; MDA-435; MDA 435; MDA435; MD Anderson-Metastatic Breast-435 8750.0 nM GI50 C3802
TKC043354 IGROV-1 Igrov-1; IGROV 1; IGR-OV1; IGROV1; Igrov1; IGR.OV1; IGROV; OV1/P; OV1/p; OV1-P 15740.0 nM GI50 C7979 Orphanet_454723
TKC043354 SF-295 SF-295; SF.295; SF 295 21330.0 nM GI50 C3058 Orphanet_360
TKC043354 Hs-578T HS 578T; Hs-578T; HS-578T; Hs_578t; Hs-578-T; HS-578-T; Hs 578.T; HS578T; Hs578T; Hs578t; HS0578T; 578T; HS578; Hs578; Homo sapiens No. 578, tumor cells 19907.0 nM GI50 C4194
TKC043354 786-0 786-o; 786O; 786-0; 786.O; 786-O RCC; RCC 786-O; RCC_7860; RCC 7860; 7860; 786-0WT 5521.0 nM GI50 C9385 Orphanet_217071
TKC043354 UACC-257 UACC 257; UACC.257; UACC257; University of Arizona Cell Culture-257 12190.0 nM GI50 C3224
TKC043354 CCRF-CEM CCRF/CEM; CCRFCEM; CCRF.CEM; CCRF CEM; CCRF; CEM; CEM-CCRF; CEM-CCRF (CAMR); CCRF/CEM/0; CEM/0; CEM-0; CCRF-CEM/S; GM03671; GM03671C 2985.0 nM GI50 C7953 Orphanet_99861
TKC043354 HT-29 HT 29; HT29 14555.0 nM GI50 C4349
TKC043354 NCI-H226 NCI.H226; NCI H226; H226; H-226; HUT-226; HUT 226; NCIH226 16032.0 nM GI50 C45662 Orphanet_50251
TKC043354 SK-MEL-28 SK-Mel-28; SK.MEL.28; SK-MEL 28; SK MEL-28; SK MEL 28; SK Mel 28; SKMel-28; SKMEL-28; SK-MEL28; SK-Mel28; SK Mel28; SKMEL28; SKMel28; SKmel28; SKML-28; SK28; AU-Mel; P-36; P36 6266.0 nM GI50 C3510
TKC043354 RXF 393 RXF393L; RXF-393 L; RXF-393; RXF 393; RXF.393; RXF393; RXF 393NL 5834.0 nM GI50 C9385 Orphanet_217071
TKC043354 COLO 205 Colo 205; CoLo 205; COLO-205; Colo-205; COLO.205; Colo205; COLO205; Co 205; Colorado 205 2158.0 nM GI50 C4349
TKC043354 KB KB (HeLa derivative); HeLa-KB; Strain KB 4.0 umol/L ED50 C27677

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC043354 Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 TDP1 2909 nM Potency
TKC043354 P43220 Glucagon-like peptide 1 receptor GLP1R 28184 nM Potency
TKC043354 P84022 Mothers against decapentaplegic homolog 3 SMAD3 15849 nM Potency
TKC043354 Q14191 Werner syndrome ATP-dependent helicase WRN 28184 nM Potency
TKC043354 Q99700 Ataxin-2 ATXN2 33588 nM Potency
TKC043354 Q9UNA4 DNA polymerase iota POLI 17783 nM Potency
TKC043354 O75496 Geminin GMNN 3663 nM Potency
TKC043354 O89049 Thioredoxin reductase 1, cytoplasmic Txnrd1 2818 nM Potency
TKC043354 P01215 Glycoprotein hormones alpha chain CGA 1995 nM Potency
TKC043354 P38398 Breast cancer type 1 susceptibility protein BRCA1 35481 nM Potency
TKC043354 Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 PIN1 95283 nM Potency
TKC043354 Q9Y253 DNA polymerase eta POLH 15849 nM Potency

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
P43220 GLP1R_HUMAN Cardiovascular disease [ICD-11: BA00-BE2Z]
P43220 GLP1R_HUMAN Obesity [ICD-11: 5B80-5B81]
P43220 GLP1R_HUMAN Type 2 diabetes mellitus [ICD-11: 5A11]
P43220 GLP1R_HUMAN Type-1/2 diabete [ICD-11: 5A10-5A11]
P43220 GLP1R_HUMAN Acute diabete complication [ICD-11: 5A2Y]
P43220 GLP1R_HUMAN Diabetes mellitus [ICD-11: 5A10]
P43220 GLP1R_HUMAN Dyspepsia [ICD-11: MD92]
P43220 GLP1R_HUMAN Irritable bowel syndrome [ICD-11: DD91]
P43220 GLP1R_HUMAN Intracranial injury [ICD-11: NA07]
P43220 GLP1R_HUMAN Non-alcoholic fatty liver disease [ICD-11: DB92]
P84022 SMAD3_HUMAN Herpes simplex infection [ICD-11: 1F00]
P84022 SMAD3_HUMAN Kidney fibrosis [ICD-11: GC01]
Q14191 WRN_HUMAN Mature T-cell lymphoma [ICD-11: 2A90]
Q13526 PIN1_HUMAN Lung cancer [ICD-11: 2C25]
Q13526 PIN1_HUMAN Nasopharyngeal cancer [ICD-11: 2B6B]