Basic Information

Terpenoid ID TKC040128
Cell line 0
Protein target 15
DiseaseNCIT 0
ORDO 0
ICD 22

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC040128 NCI-H522 NCI.H522; H522; H-522; NCI-522; NCI522; NCIH522 1000.0 nM GI50 C3512
TKC040128 HCT-116 HCT-116; HCT.116; HCT_116; HCT116; HCT116wt; CoCL2 1800.0 nM GI50 C4910
TKC040128 SF-539 SF-539; SF-539 BT; SF.539; SF 539 2900.0 nM GI50 C3796 Orphanet_251576
TKC040128 LOX IMVI LOX/IMVI; LOX IMVI; LOXIM-VI; LOXIMVI; LOX 2200.0 nM GI50 C3802
TKC040128 OVCAR-5 OVCAR 5; NIH:OVCAR-5; OVCAR.5; OVCAR5; Ovcar5; OVCA5 4900.0 nM GI50 C105555
TKC040128 SN12C SN-12C 3400.0 nM GI50 C9385 Orphanet_217071
TKC040128 PC-3 PC3; PC.3 4500.0 nM GI50 C4863
TKC040128 MCF7 3900.0 nM GI50 C4194
TKC040128 HEK293 31623.0 nM Potency
TKC040128 SN12C SN-12C 3334.0 nM GI50 C9385 Orphanet_217071
TKC040128 MDA-N MDAN 1774.0 nM GI50 C3802
TKC040128 ACHN 1730.0 nM GI50 C6975 Orphanet_319298
TKC040128 NCI-H23 NCI.H23; NCI H23; H-23; H23; NCIH23 3251.0 nM GI50 C3512
TKC040128 UO-31 UO.31; UO31; U031 4753.0 nM GI50 C9385 Orphanet_217071
TKC040128 HOP-92 HOP 92; HOP.92; HOP92; Hop92; Hopkins-92 4102.0 nM GI50 C2926
TKC040128 DU-145 DU-145; Du-145; DU 145; DU_145; DU.145; Duke University 145 2529.0 nM GI50 C4863
TKC040128 HL-60 HL 60; HL.60 HL60; Human Leukemia-60 1413.0 nM GI50 C9154 Orphanet_519
TKC040128 SF-539 SF-539; SF-539 BT; SF.539; SF 539 2742.0 nM GI50 C3796 Orphanet_251576
TKC040128 SK-MEL-5 SK-Mel-5; SK MEL 5; SK.MEL.5; SK-MEL5; SKMel-5; SKMEL-5; SKMEL5; SKMel5; SKmel5; AA-Mel 3334.0 nM GI50 C3510
TKC040128 Malme-3M MALME-3M; MALME 3M; Malme-3 M; MALME.3M; Malme3M; MALME3M; Malme-3 Monolayer 2500.0 nM GI50 C3224
TKC040128 K562 K562; K.562; K 562; KO; GM05372; GM05372E 2477.0 nM GI50 C9110 Orphanet_521
TKC040128 A498 A498 12106.0 nM GI50 C9385 Orphanet_217071
TKC040128 OVCAR-3 Ovcar-3; OVCAR 3; OVCAR.3; NIH:OVCAR-3; NIH:Ovcar-3; NIH:OVCAR3; NIH-OVCAR-3; NIHOVCAR3; OVCAR3; Ovcar3 1219.0 nM GI50 C105555
TKC040128 MOLT-4 Molt-4; MOLT 4; Molt 4; MOLT.4; MOLT4; Molt4; GM02219; GM02219C; GM2219C; GM02219D 2460.0 nM GI50 C9142 Orphanet_99861
TKC040128 HOP-62 HOP 62; Hop 62; HOP.62; HOP62; Hop62; Hopkins-62 15453.0 nM GI50 C3512
TKC040128 NCI/ADR-RES NCI/ADR-RES; NCI.ADR.RES; NCIADR.RES; NCI/ADRRES; NCIADRRES; ADR-RES; MCF-7/ADR; MCF-7/ADR-RES; MCF-7/AdrR; MCF-7/Adr; MCF-7/adr; MCF-7ADR; MCF7-ADR; MCF7ADR; OVCAR-8/ADR; OVCAR8/ADR 1409.0 nM GI50 C105555
TKC040128 U-251 U-251 MG; U-251-MG; U-251_MG; U251-MG; U251MG; U-251; U251; U251n; U251N; 251 MG; 251MG; 251 MG(6) 11858.0 nM GI50 C60781 Orphanet_94
TKC040128 OVCAR-8 OVCAR 8; NIH:OVCAR-8; OVCAR8; Ovcar8; OVCAR.8; OVCA8 2056.0 nM GI50 C105555
TKC040128 OVCAR-5 OVCAR 5; NIH:OVCAR-5; OVCAR.5; OVCAR5; Ovcar5; OVCA5 4529.0 nM GI50 C105555
TKC040128 MDA-MB-231 MDA_MB_231; MDA-MB 231; MDA.MB.231; MDA MB 231; MDA MB231; MDA Mb231; MDA-MB231; MDAMB-231; MDAMB231; MDA-231; MDA-231P; MDA231; MDA231-BRE; MB231; MD Anderson-Metastatic Breast-231 2193.0 nM GI50 C5214
TKC040128 DMS-273 DMS-273; DMS273; Darmouth Medical School 273 4083.0 nM GI50 C4917 Orphanet_70573
TKC040128 SNB-19 SNB.19; SNB19; Surgical Neurology Branch-19 14723.0 nM GI50 C60781 Orphanet_94
TKC040128 SR SR-786; SR786 1507.0 nM GI50 C37193 Orphanet_300895
TKC040128 TK-10 TK.10; TK 10; TK10 3055.0 nM GI50 C4033 Orphanet_319276
TKC040128 SW-620 SW-620; SW 620; SW.620 1803.0 nM GI50 C4349
TKC040128 M19-MEL M-19; M19 3357.0 nM GI50 C3802
TKC040128 NCI-H522 NCI.H522; H522; H-522; NCI-522; NCI522; NCIH522 891.0 nM GI50 C3512
TKC040128 KM12 KM-12; KM.12 2163.0 nM GI50 C4910
TKC040128 XF498 XF-498; XF498 3289.0 nM GI50 C3058 Orphanet_360
TKC040128 M14 M14-MEL; UCLA-SO-M14; UCLA SO M14; UCLA-SO-14; UCLASO-M14; Melanoma 14; M-14 1954.0 nM GI50 C3802
TKC040128 RPMI-8226 RPMI 8226; RPMI.8226; RPMI8226; RPMI no. 8226; RPMI no 8226; RPMI #8226; 8226; RPMI 8226/S; RPMI-8226S; RPMI8226/S; 8226/S; Roswell Park Memorial Institute 8226; GM02132; GM2132; GM 2132; GM02132C; Simpson 1807.0 nM GI50 C3242 Orphanet_29073
TKC040128 NCI-H322M NCI.H322M; H322M; H-322M; H-322m 4140.0 nM GI50 C2923
TKC040128 OVCAR-4 OVCAR 4; NIH:OVCAR-4; NIH:OVCAR4; OVCAR.4; OVCAR4; Ovcar4 6761.0 nM GI50 C105555
TKC040128 LOX IMVI LOX/IMVI; LOX IMVI; LOXIM-VI; LOXIMVI; LOX 1932.0 nM GI50 C3802
TKC040128 BT-549 BT 549; BT.549; BT549 1633.0 nM GI50 C4194
TKC040128 KM-20L2 KM-20L2; KM 20L2; KM 2012 3614.0 nM GI50 C4349
TKC040128 SK-MEL-2 SK-Mel-2; SK-Mel 2; SK-mel-2; SK-MEL2; SK.MEL.2; SK Mel 2; SK MEL 2; SKMEL-2; SKMEL2; SKmel2; SK-ML2; SKml2 4385.0 nM GI50 C3224
TKC040128 HCC 2998 HCC-2998; HCC.2998; HCC 2998; Hamon Cancer Center 2998 11967.0 nM GI50 C4349
TKC040128 A549 7762.0 nM GI50 C3512
TKC040128 SNB-75 SNB.75; SNB75; Surgical Neurology Branch-75 8147.0 nM GI50 C3058 Orphanet_360
TKC040128 HCT-15 HCT-15; HCT.15; HCT15 1820.0 nM GI50 C4349
TKC040128 HCT-116 HCT-116; HCT.116; HCT_116; HCT116; HCT116wt; CoCL2 1742.0 nM GI50 C4910
TKC040128 SF-268 SF-268; SF.268; SF 268 8610.0 nM GI50 C60781 Orphanet_94
TKC040128 EKVX 8790.0 nM GI50 C3512
TKC040128 PC-3 PC3; PC.3 4487.0 nM GI50 C4863
TKC040128 MCF7 3917.0 nM GI50 C4194
TKC040128 LXFL 529 LXFL-529L; LXFL529L; LXF 529 L; LXFL-529; LXFL 529; LXFL529; LXF 529 1581.0 nM GI50 C2926
TKC040128 DMS-114 DMS-114; DMS114; Darmouth Medical School 114 4217.0 nM GI50 C4917 Orphanet_70573
TKC040128 SK-OV-3 SKOV-3; SK-OV3; SK.OV.3; SKOV3; Skov3; SKO3 27990.0 nM GI50 C7978
TKC040128 T47D 2455.0 nM GI50 C4194
TKC040128 NCI-H460 NCI.H460; H460; H-460; NCIH460; NCI-HUT-460; NCI-460 4842.0 nM GI50 C4450
TKC040128 CAKI-1 CAL 1; Centre Antoine Lacassagne-1 2972.0 nM GI50 C3224
TKC040128 UACC-62 UACC 62; UACC.62; UACC62; University of Arizona Cell Culture-62 1795.0 nM GI50 C3224
TKC040128 SF-295 SF-295; SF.295; SF 295 6808.0 nM GI50 C3058 Orphanet_360
TKC040128 MDA-MB-435 MDA-MB435; MDAMB435; MDA.MB.435; MDA-435; MDA 435; MDA435; MD Anderson-Metastatic Breast-435 1734.0 nM GI50 C3802
TKC040128 IGROV-1 Igrov-1; IGROV 1; IGR-OV1; IGROV1; Igrov1; IGR.OV1; IGROV; OV1/P; OV1/p; OV1-P 6138.0 nM GI50 C7979 Orphanet_454723
TKC040128 RXF 631 RXF-631L; RXF631L; RXF 631; RXF-631; RXF631 5458.0 nM GI50 C9385 Orphanet_217071
TKC040128 Hs-578T HS 578T; Hs-578T; HS-578T; Hs_578t; Hs-578-T; HS-578-T; Hs 578.T; HS578T; Hs578T; Hs578t; HS0578T; 578T; HS578; Hs578; Homo sapiens No. 578, tumor cells 2564.0 nM GI50 C4194
TKC040128 786-0 786-o; 786O; 786-0; 786.O; 786-O RCC; RCC 786-O; RCC_7860; RCC 7860; 7860; 786-0WT 1849.0 nM GI50 C9385 Orphanet_217071
TKC040128 UACC-257 UACC 257; UACC.257; UACC257; University of Arizona Cell Culture-257 1972.0 nM GI50 C3224
TKC040128 SNB-78 SNB78; Surgical Neurology Branch-78 3141.0 nM GI50 C3058 Orphanet_360
TKC040128 DLD-1 DLD 1; DLD1; CoCL3 1888.0 nM GI50 C4349
TKC040128 CCRF-CEM CCRF/CEM; CCRFCEM; CCRF.CEM; CCRF CEM; CCRF; CEM; CEM-CCRF; CEM-CCRF (CAMR); CCRF/CEM/0; CEM/0; CEM-0; CCRF-CEM/S; GM03671; GM03671C 1337.0 nM GI50 C7953 Orphanet_99861
TKC040128 HT-29 HT 29; HT29 2023.0 nM GI50 C4349
TKC040128 NCI-H226 NCI.H226; NCI H226; H226; H-226; HUT-226; HUT 226; NCIH226 3750.0 nM GI50 C45662 Orphanet_50251
TKC040128 SK-MEL-28 SK-Mel-28; SK.MEL.28; SK-MEL 28; SK MEL-28; SK MEL 28; SK Mel 28; SKMel-28; SKMEL-28; SK-MEL28; SK-Mel28; SK Mel28; SKMEL28; SKMel28; SKmel28; SKML-28; SK28; AU-Mel; P-36; P36 2046.0 nM GI50 C3510
TKC040128 RXF 393 RXF393L; RXF-393 L; RXF-393; RXF 393; RXF.393; RXF393; RXF 393NL 1837.0 nM GI50 C9385 Orphanet_217071
TKC040128 COLO 205 Colo 205; CoLo 205; COLO-205; Colo-205; COLO.205; Colo205; COLO205; Co 205; Colorado 205 2168.0 nM GI50 C4349
TKC040128 HOP-18 HOP 18; Hop 18; HOP18; Hop18; Hopkins-18 6653.0 nM GI50 C4450

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC040128 Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 TDP1 2909 nM Potency
TKC040128 O75874 Isocitrate dehydrogenase [NADP] cytoplasmic IDH1 29093 nM Potency
TKC040128 P84022 Mothers against decapentaplegic homolog 3 SMAD3 19953 nM Potency
TKC040128 Q03431 Parathyroid hormone/parathyroid hormone-related peptide receptor PTH1R 125893 nM Potency
TKC040128 Q16236 Nuclear factor erythroid 2-related factor 2 NFE2L2 3162 nM Potency
TKC040128 Q99700 Ataxin-2 ATXN2 31623 nM Potency
TKC040128 Q9UNA4 DNA polymerase iota POLI 44668 nM Potency
TKC040128 O75496 Geminin GMNN 2060 nM Potency
TKC040128 O89049 Thioredoxin reductase 1, cytoplasmic Txnrd1 44668 nM Potency
TKC040128 P01215 Glycoprotein hormones alpha chain CGA 1778 nM Potency
TKC040128 P38398 Breast cancer type 1 susceptibility protein BRCA1 11220 nM Potency
TKC040128 Q9HC16 DNA dC->dU-editing enzyme APOBEC-3G APOBEC3G 11220 nM Potency
TKC040128 P83916 Chromobox protein homolog 1 CBX1 89125 nM Potency
TKC040128 Q9Y253 DNA polymerase eta POLH 14125 nM Potency
TKC040128 P51531 Probable global transcription activator SNF2L2 SMARCA2 >91243 nM EC50
TKC040128 Q14974 Importin subunit beta-1 KPNB1 63096 nM Potency

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
O75874 IDHC_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
O75874 IDHC_HUMAN Liver cancer [ICD-11: 2C12]
O75874 IDHC_HUMAN Malignant haematopoietic neoplasm [ICD-11: 2B33]
O75874 IDHC_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
O75874 IDHC_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
O75874 IDHC_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P84022 SMAD3_HUMAN Herpes simplex infection [ICD-11: 1F00]
P84022 SMAD3_HUMAN Kidney fibrosis [ICD-11: GC01]
Q03431 PTH1R_HUMAN Low bone mass disorder [ICD-11: FB83]
Q03431 PTH1R_HUMAN Hypo-parathyroidism [ICD-11: 5A50]
Q16236 NF2L2_HUMAN Ataxic disorder [ICD-11: 8A03]
Q16236 NF2L2_HUMAN Breast cancer [ICD-11: 2C60-2C6Y]
Q16236 NF2L2_HUMAN Glaucoma [ICD-11: 9C61]
Q16236 NF2L2_HUMAN Lung cancer [ICD-11: 2C25]
Q16236 NF2L2_HUMAN Macular degeneration [ICD-11: 9B75]
Q16236 NF2L2_HUMAN Melanoma [ICD-11: 2C30]
Q16236 NF2L2_HUMAN Mental/behavioural/neurodevelopmental disorder [ICD-11: 6E20-6E8Z]
Q16236 NF2L2_HUMAN Pulmonary hypertension [ICD-11: BB01]
Q16236 NF2L2_HUMAN Subarachnoid haemorrhage [ICD-11: 8B01]
Q16236 NF2L2_HUMAN Urinary system clinical sympton [ICD-11: MF8Y]
Q16236 NF2L2_HUMAN Non-alcoholic fatty liver disease [ICD-11: DB92]
Q16236 NF2L2_HUMAN Alpha-1-antitrypsin deficiency [ICD-11: 5C5A]
Q16236 NF2L2_HUMAN Motor neuron disease [ICD-11: 8B60]
Q16236 NF2L2_HUMAN Multiple sclerosis [ICD-11: 8A40]