Basic Information

Terpenoid ID TKC039950
Chirality TKC039945
Cell line 0
Protein target 2
DiseaseNCIT 0
ORDO 0
ICD 4

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC039950 SN12C SN-12C 100000.0 nM GI50 C9385 Orphanet_217071
TKC039950 MDA-N MDAN 41020.0 nM GI50 C3802
TKC039950 NCI-H23 NCI.H23; NCI H23; H-23; H23; NCIH23 46666.0 nM GI50 C3512
TKC039950 ACHN 17620.0 nM GI50 C6975 Orphanet_319298
TKC039950 UO-31 UO.31; UO31; U031 28445.0 nM GI50 C9385 Orphanet_217071
TKC039950 HOP-92 HOP 92; HOP.92; HOP92; Hop92; Hopkins-92 25763.0 nM GI50 C2926
TKC039950 DU-145 DU-145; Du-145; DU 145; DU_145; DU.145; Duke University 145 19498.0 nM GI50 C4863
TKC039950 SK-MEL-5 SK-Mel-5; SK MEL 5; SK.MEL.5; SK-MEL5; SKMel-5; SKMEL-5; SKMEL5; SKMel5; SKmel5; AA-Mel 14689.0 nM GI50 C3510
TKC039950 K562 K562; K.562; K 562; KO; GM05372; GM05372E 16904.0 nM GI50 C9110 Orphanet_521
TKC039950 A498 A498 26303.0 nM GI50 C9385 Orphanet_217071
TKC039950 OVCAR-3 Ovcar-3; OVCAR 3; OVCAR.3; NIH:OVCAR-3; NIH:Ovcar-3; NIH:OVCAR3; NIH-OVCAR-3; NIHOVCAR3; OVCAR3; Ovcar3 25177.0 nM GI50 C105555
TKC039950 MOLT-4 Molt-4; MOLT 4; Molt 4; MOLT.4; MOLT4; Molt4; GM02219; GM02219C; GM2219C; GM02219D 25119.0 nM GI50 C9142 Orphanet_99861
TKC039950 HOP-62 HOP 62; Hop 62; HOP.62; HOP62; Hop62; Hopkins-62 14689.0 nM GI50 C3512
TKC039950 U-251 U-251 MG; U-251-MG; U-251_MG; U251-MG; U251MG; U-251; U251; U251n; U251N; 251 MG; 251MG; 251 MG(6) 13868.0 nM GI50 C60781 Orphanet_94
TKC039950 OVCAR-8 OVCAR 8; NIH:OVCAR-8; OVCAR8; Ovcar8; OVCAR.8; OVCA8 30903.0 nM GI50 C105555
TKC039950 OVCAR-5 OVCAR 5; NIH:OVCAR-5; OVCAR.5; OVCAR5; Ovcar5; OVCA5 51523.0 nM GI50 C105555
TKC039950 SNB-19 SNB.19; SNB19; Surgical Neurology Branch-19 14997.0 nM GI50 C60781 Orphanet_94
TKC039950 MDA-MB-231 MDA_MB_231; MDA-MB 231; MDA.MB.231; MDA MB 231; MDA MB231; MDA Mb231; MDA-MB231; MDAMB-231; MDAMB231; MDA-231; MDA-231P; MDA231; MDA231-BRE; MB231; MD Anderson-Metastatic Breast-231 100000.0 nM GI50 C5214
TKC039950 TK-10 TK.10; TK 10; TK10 22856.0 nM GI50 C4033 Orphanet_319276
TKC039950 SR SR-786; SR786 13868.0 nM GI50 C37193 Orphanet_300895
TKC039950 SW-620 SW-620; SW 620; SW.620 18365.0 nM GI50 C4349
TKC039950 KM12 KM-12; KM.12 16181.0 nM GI50 C4910
TKC039950 M14 M14-MEL; UCLA-SO-M14; UCLA SO M14; UCLA-SO-14; UCLASO-M14; Melanoma 14; M-14 11143.0 nM GI50 C3802
TKC039950 NCI-H322M NCI.H322M; H322M; H-322M; H-322m 27669.0 nM GI50 C2923
TKC039950 OVCAR-4 OVCAR 4; NIH:OVCAR-4; NIH:OVCAR4; OVCAR.4; OVCAR4; Ovcar4 100000.0 nM GI50 C105555
TKC039950 LOX IMVI LOX/IMVI; LOX IMVI; LOXIM-VI; LOXIMVI; LOX 5212.0 nM GI50 C3802
TKC039950 BT-549 BT 549; BT.549; BT549 50582.0 nM GI50 C4194
TKC039950 SK-MEL-2 SK-Mel-2; SK-Mel 2; SK-mel-2; SK-MEL2; SK.MEL.2; SK Mel 2; SK MEL 2; SKMEL-2; SKMEL2; SKmel2; SK-ML2; SKml2 27606.0 nM GI50 C3224
TKC039950 A549 10593.0 nM GI50 C3512
TKC039950 SNB-75 SNB.75; SNB75; Surgical Neurology Branch-75 69823.0 nM GI50 C3058 Orphanet_360
TKC039950 HCC 2998 HCC-2998; HCC.2998; HCC 2998; Hamon Cancer Center 2998 17742.0 nM GI50 C4349
TKC039950 HCT-116 HCT-116; HCT.116; HCT_116; HCT116; HCT116wt; CoCL2 11272.0 nM GI50 C4910
TKC039950 HCT-15 HCT-15; HCT.15; HCT15 19011.0 nM GI50 C4349
TKC039950 SF-268 SF-268; SF.268; SF 268 33497.0 nM GI50 C60781 Orphanet_94
TKC039950 EKVX 93541.0 nM GI50 C3512
TKC039950 MCF7 11803.0 nM GI50 C4194
TKC039950 PC-3 PC3; PC.3 28314.0 nM GI50 C4863
TKC039950 SK-OV-3 SKOV-3; SK-OV3; SK.OV.3; SKOV3; Skov3; SKO3 51642.0 nM GI50 C7978
TKC039950 T47D 100000.0 nM GI50 C4194
TKC039950 UACC-62 UACC 62; UACC.62; UACC62; University of Arizona Cell Culture-62 13740.0 nM GI50 C3224
TKC039950 NCI-H460 NCI.H460; H460; H-460; NCIH460; NCI-HUT-460; NCI-460 27290.0 nM GI50 C4450
TKC039950 CAKI-1 CAL 1; Centre Antoine Lacassagne-1 38107.0 nM GI50 C3224
TKC039950 MDA-MB-435 MDA-MB435; MDAMB435; MDA.MB.435; MDA-435; MDA 435; MDA435; MD Anderson-Metastatic Breast-435 24491.0 nM GI50 C3802
TKC039950 IGROV-1 Igrov-1; IGROV 1; IGR-OV1; IGROV1; Igrov1; IGR.OV1; IGROV; OV1/P; OV1/p; OV1-P 16866.0 nM GI50 C7979 Orphanet_454723
TKC039950 SF-295 SF-295; SF.295; SF 295 29785.0 nM GI50 C3058 Orphanet_360
TKC039950 Hs-578T HS 578T; Hs-578T; HS-578T; Hs_578t; Hs-578-T; HS-578-T; Hs 578.T; HS578T; Hs578T; Hs578t; HS0578T; 578T; HS578; Hs578; Homo sapiens No. 578, tumor cells 22131.0 nM GI50 C4194
TKC039950 UACC-257 UACC 257; UACC.257; UACC257; University of Arizona Cell Culture-257 23227.0 nM GI50 C3224
TKC039950 786-0 786-o; 786O; 786-0; 786.O; 786-O RCC; RCC 786-O; RCC_7860; RCC 7860; 7860; 786-0WT 32434.0 nM GI50 C9385 Orphanet_217071
TKC039950 HT-29 HT 29; HT29 23067.0 nM GI50 C4349
TKC039950 SK-MEL-28 SK-Mel-28; SK.MEL.28; SK-MEL 28; SK MEL-28; SK MEL 28; SK Mel 28; SKMel-28; SKMEL-28; SK-MEL28; SK-Mel28; SK Mel28; SKMEL28; SKMel28; SKmel28; SKML-28; SK28; AU-Mel; P-36; P36 17258.0 nM GI50 C3510
TKC039950 COLO 205 Colo 205; CoLo 205; COLO-205; Colo-205; COLO.205; Colo205; COLO205; Co 205; Colorado 205 16596.0 nM GI50 C4349
TKC039950 RXF 393 RXF393L; RXF-393 L; RXF-393; RXF 393; RXF.393; RXF393; RXF 393NL 22856.0 nM GI50 C9385 Orphanet_217071

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC039950 P50579 Methionine aminopeptidase 2 METAP2 0.4 nM IC50
TKC039950 O08663 Methionine aminopeptidase 2 Metap2 0.018 nM EC50

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
P50579 MAP2_HUMAN Obesity [ICD-11: 5B80-5B81]
P50579 MAP2_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P50579 MAP2_HUMAN Type 2 diabetes mellitus [ICD-11: 5A11]
P50579 MAP2_HUMAN Diabetes mellitus [ICD-11: 5A10]