Basic Information

Terpenoid ID TKC038273
Chirality TKC038269
Cell line 0
Protein target 30
DiseaseNCIT 0
ORDO 0
ICD 90

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC038273 Jurkat JURKAT; JM; JM-Jurkat; Jurkat-FHCRC; Jurkat FHCRC; FHCRC-11; FHCRC subclone 11; FCCH1024 990.0 nM IC50 C7953 Orphanet_99861
TKC038273 INS1 INS1 2132.0 nM AC50 C121566
TKC038273 HepG2 2512.0 nM Potency C3728 Orphanet_449
TKC038273 P388 P-388 78.0 % T/C C21602

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC038273 P10636 Microtubule-associated protein tau MAPT 3162 nM Potency
TKC038273 P11473 Vitamin D3 receptor VDR 56234 nM Potency
TKC038273 Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 TDP1 651 nM Potency
TKC038273 O75874 Isocitrate dehydrogenase [NADP] cytoplasmic IDH1 6513 nM Potency
TKC038273 P43220 Glucagon-like peptide 1 receptor GLP1R 4467 nM Potency
TKC038273 P84022 Mothers against decapentaplegic homolog 3 SMAD3 708 nM Potency
TKC038273 Q03431 Parathyroid hormone/parathyroid hormone-related peptide receptor PTH1R 7080 nM Potency
TKC038273 Q06710 Paired box protein Pax-8 PAX8 742 nM AC50
TKC038273 Q16236 Nuclear factor erythroid 2-related factor 2 NFE2L2 4110 nM Potency
TKC038273 Q99700 Ataxin-2 ATXN2 8913 nM Potency
TKC038273 Q9UNA4 DNA polymerase iota POLI 31623 nM Potency
TKC038273 O75496 Geminin GMNN 820 nM Potency
TKC038273 O89049 Thioredoxin reductase 1, cytoplasmic Txnrd1 56234 nM Potency
TKC038273 Q9HC16 DNA dC->dU-editing enzyme APOBEC-3G APOBEC3G 1995 nM Potency
TKC038273 P28482 Mitogen-activated protein kinase 1 MAPK1 31623 nM Potency
TKC038273 Q96KQ7 Histone-lysine N-methyltransferase EHMT2 EHMT2 3162 nM Potency
TKC038273 Q96QE3 ATPase family AAA domain-containing protein 5 ATAD5 5171 nM Potency
TKC038273 Q9F4F7 4'-phosphopantetheinyl transferase ffp ffp 44668 nM Potency
TKC038273 Q9Y253 DNA polymerase eta POLH 44668 nM Potency
TKC038273 P51450 Nuclear receptor ROR-gamma Rorc 1259 nM Potency
TKC038273 P42858 Huntingtin HTT 3548 nM Potency
TKC038273 O15118 NPC intracellular cholesterol transporter 1 NPC1 631 nM Potency
TKC038273 P51151 Ras-related protein Rab-9A RAB9A 1000 nM Potency
TKC038273 P17861 X-box-binding protein 1 XBP1 2200 nM IC50
TKC038273 P35639 DNA damage-inducible transcript 3 protein Ddit3 2480 nM IC50
TKC038273 P35639 DNA damage-inducible transcript 3 protein Ddit3 2360 nM IC50
TKC038273 Q00987 E3 ubiquitin-protein ligase Mdm2 MDM2 7680 nM EC50
TKC038273 O43521 Bcl-2-like protein 11 BCL2L11 >350000 nM EC50
TKC038273 Q9Y2T6 G-protein coupled receptor 55 GPR55 4494 nM IC50
TKC038273 P01103 Transcriptional activator Myb MYB 706 nM IC50
TKC038273 P30556 Type-1 angiotensin II receptor AGTR1 21974 nM IC50
TKC038273 P30556 Type-1 angiotensin II receptor AGTR1 21974 nM IC50
TKC038273 Q8VNN2 Beta-galactosidase lacZ >40000 nM EC50
TKC038273 P35414 Apelin receptor APLNR 26500 nM IC50

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
P10636 TAU_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
P10636 TAU_HUMAN Alzheimer disease [ICD-11: 8A20]
P10636 TAU_HUMAN Mild neurocognitive disorder [ICD-11: 6D71]
P10636 TAU_HUMAN Choreiform disorder [ICD-11: 8A01]
P10636 TAU_HUMAN Parkinsonism [ICD-11: 8A00]
P10636 TAU_HUMAN Central nervous system disease [ICD-11: 8A04-8D87]
P10636 TAU_HUMAN Neurodegenerative disorder [ICD-11: 8A20-8A23]
P11473 VDR_HUMAN Chronic kidney disease [ICD-11: GB61]
P11473 VDR_HUMAN Hair/hair growth developmental defect [ICD-11: LC30]
P11473 VDR_HUMAN Hyper-parathyroidism [ICD-11: 5A51]
P11473 VDR_HUMAN Hypo-parathyroidism [ICD-11: 5A50]
P11473 VDR_HUMAN Mineral deficiency [ICD-11: 5B5K]
P11473 VDR_HUMAN Psoriasis [ICD-11: EA90]
P11473 VDR_HUMAN Vitamin deficiency [ICD-11: 5B55-5B5F]
P11473 VDR_HUMAN Low bone mass disorder [ICD-11: FB83]
P11473 VDR_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
P11473 VDR_HUMAN Prostate cancer [ICD-11: 2C82]
P11473 VDR_HUMAN Prostate disease [ICD-11: GA91]
P11473 VDR_HUMAN Abnormal micturition [ICD-11: MF50]
P11473 VDR_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P11473 VDR_HUMAN Postoperative inflammation [ICD-11: 1A00-CA43]
P11473 VDR_HUMAN Acne vulgaris [ICD-11: ED80]
O75874 IDHC_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
O75874 IDHC_HUMAN Liver cancer [ICD-11: 2C12]
O75874 IDHC_HUMAN Malignant haematopoietic neoplasm [ICD-11: 2B33]
O75874 IDHC_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
O75874 IDHC_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
O75874 IDHC_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P43220 GLP1R_HUMAN Cardiovascular disease [ICD-11: BA00-BE2Z]
P43220 GLP1R_HUMAN Obesity [ICD-11: 5B80-5B81]
P43220 GLP1R_HUMAN Type 2 diabetes mellitus [ICD-11: 5A11]
P43220 GLP1R_HUMAN Type-1/2 diabete [ICD-11: 5A10-5A11]
P43220 GLP1R_HUMAN Acute diabete complication [ICD-11: 5A2Y]
P43220 GLP1R_HUMAN Diabetes mellitus [ICD-11: 5A10]
P43220 GLP1R_HUMAN Dyspepsia [ICD-11: MD92]
P43220 GLP1R_HUMAN Irritable bowel syndrome [ICD-11: DD91]
P43220 GLP1R_HUMAN Intracranial injury [ICD-11: NA07]
P43220 GLP1R_HUMAN Non-alcoholic fatty liver disease [ICD-11: DB92]
P84022 SMAD3_HUMAN Herpes simplex infection [ICD-11: 1F00]
P84022 SMAD3_HUMAN Kidney fibrosis [ICD-11: GC01]
Q03431 PTH1R_HUMAN Low bone mass disorder [ICD-11: FB83]
Q03431 PTH1R_HUMAN Hypo-parathyroidism [ICD-11: 5A50]
Q16236 NF2L2_HUMAN Ataxic disorder [ICD-11: 8A03]
Q16236 NF2L2_HUMAN Breast cancer [ICD-11: 2C60-2C6Y]
Q16236 NF2L2_HUMAN Glaucoma [ICD-11: 9C61]
Q16236 NF2L2_HUMAN Lung cancer [ICD-11: 2C25]
Q16236 NF2L2_HUMAN Macular degeneration [ICD-11: 9B75]
Q16236 NF2L2_HUMAN Melanoma [ICD-11: 2C30]
Q16236 NF2L2_HUMAN Mental/behavioural/neurodevelopmental disorder [ICD-11: 6E20-6E8Z]
Q16236 NF2L2_HUMAN Pulmonary hypertension [ICD-11: BB01]
Q16236 NF2L2_HUMAN Subarachnoid haemorrhage [ICD-11: 8B01]
Q16236 NF2L2_HUMAN Urinary system clinical sympton [ICD-11: MF8Y]
Q16236 NF2L2_HUMAN Non-alcoholic fatty liver disease [ICD-11: DB92]
Q16236 NF2L2_HUMAN Alpha-1-antitrypsin deficiency [ICD-11: 5C5A]
Q16236 NF2L2_HUMAN Motor neuron disease [ICD-11: 8B60]
Q16236 NF2L2_HUMAN Multiple sclerosis [ICD-11: 8A40]
P28482 MK01_HUMAN Melanoma [ICD-11: 2C30]
P28482 MK01_HUMAN Pancreatic cancer [ICD-11: 2C10]
P28482 MK01_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P28482 MK01_HUMAN Arteries/arterioles disorder [ICD-11: BD52]
P28482 MK01_HUMAN Allergic/hypersensitivity disorder [ICD-11: 4A80-4A8Z]
P28482 MK01_HUMAN Transplant rejection [ICD-11: NE84]
P28482 MK01_HUMAN Mature T-cell lymphoma [ICD-11: 2A90]
P28482 MK01_HUMAN Rheumatoid arthritis [ICD-11: FA20]
Q96KQ7 EHMT2_HUMAN Breast cancer [ICD-11: 2C60-2C6Y]
Q96KQ7 EHMT2_HUMAN Postoperative inflammation [ICD-11: 1A00-CA43]
Q96KQ7 EHMT2_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P42858 HD_HUMAN Choreiform disorder [ICD-11: 8A01]
P51151 RAB9A_HUMAN Fungal infection [ICD-11: 1F29-1F2F]
Q00987 MDM2_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
Q00987 MDM2_HUMAN Malignant haematopoietic neoplasm [ICD-11: 2B33]
Q00987 MDM2_HUMAN Myeloproliferative neoplasm [ICD-11: 2A20]
Q00987 MDM2_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
Q00987 MDM2_HUMAN Mature B-cell leukaemia [ICD-11: 2A82]
Q00987 MDM2_HUMAN Myelodysplastic syndrome [ICD-11: 2A37]
Q00987 MDM2_HUMAN Neuroendocrine carcinoma [ICD-11: 2C34]
Q00987 MDM2_HUMAN Liposarcoma [ICD-11: 2B59]
Q00987 MDM2_HUMAN Lung cancer [ICD-11: 2C25]
Q00987 MDM2_HUMAN Prostate cancer [ICD-11: 2C82]
Q00987 MDM2_HUMAN Breast cancer [ICD-11: 2C60-2C6Y]
Q00987 MDM2_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
Q9Y2T6 GPR55_HUMAN Attention deficit hyperactivity disorder [ICD-11: 6A05]
P30556 AGTR1_HUMAN Essential hypertension [ICD-11: BA00]
P30556 AGTR1_HUMAN Hypertension [ICD-11: BA00-BA04]
P30556 AGTR1_HUMAN Secondary hypertension [ICD-11: BA04]
P30556 AGTR1_HUMAN Metabolic disorder [ICD-11: 5C50-5D2Z]
P30556 AGTR1_HUMAN Myocardial infarction [ICD-11: BA41-BA43]
P30556 AGTR1_HUMAN Urinary system clinical sympton [ICD-11: MF8Y]
P30556 AGTR1_HUMAN Heart failure [ICD-11: BD10-BD1Z]
P30556 AGTR1_HUMAN Hypotension [ICD-11: BA20-BA21]
P30556 AGTR1_HUMAN Alzheimer disease [ICD-11: 8A20]
P30556 AGTR1_HUMAN Arteries/arterioles disorder [ICD-11: BD52]
P30556 AGTR1_HUMAN Essential hypertension [ICD-11: BA00]
P30556 AGTR1_HUMAN Hypertension [ICD-11: BA00-BA04]
P30556 AGTR1_HUMAN Secondary hypertension [ICD-11: BA04]
P30556 AGTR1_HUMAN Metabolic disorder [ICD-11: 5C50-5D2Z]
P30556 AGTR1_HUMAN Myocardial infarction [ICD-11: BA41-BA43]
P30556 AGTR1_HUMAN Urinary system clinical sympton [ICD-11: MF8Y]
P30556 AGTR1_HUMAN Heart failure [ICD-11: BD10-BD1Z]
P30556 AGTR1_HUMAN Hypotension [ICD-11: BA20-BA21]
P30556 AGTR1_HUMAN Alzheimer disease [ICD-11: 8A20]
P30556 AGTR1_HUMAN Arteries/arterioles disorder [ICD-11: BD52]
P35414 APJ_HUMAN Heart failure [ICD-11: BD10-BD1Z]