Basic Information

Terpenoid ID TKC036999
Chirality TKC134324
Cell line 0
Protein target 5
DiseaseNCIT 0
ORDO 0
ICD 6

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC036999 HepG2 28184.0 nM Potency C3728 Orphanet_449
TKC036999 A549 10.0 % Inhibition C3512
TKC036999 SK-MEL SK-Mel-1; SK Mel 1; SK-Mel 1; SK-Mel1; SKMEL-1; SkMEL-1; SKMEL1; SK 1 24.0 % Inhibition C3224
TKC036999 T47D 4000.0 nM GI50 C4194
TKC036999 SW1573 SW-1573; SW 1573 4000.0 nM GI50 C2923
TKC036999 HeLa HELA; Hela; He La; He-La; HeLa-CCL2; Henrietta Lacks cells; Helacyton gartleri 4000.0 nM GI50 C27677
TKC036999 HBL-100 HBL 100; HBL100 4000.0 nM GI50
TKC036999 A2780 A-2780; 2780; A2780S; A2780par 4000.0 nM GI50 C7979 Orphanet_454723

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC036999 P27695 DNA-(apurinic or apyrimidinic site) endonuclease APEX1 31623 nM Potency
TKC036999 Q9UNA4 DNA polymerase iota POLI 12589 nM Potency
TKC036999 Q9HC16 DNA dC->dU-editing enzyme APOBEC-3G APOBEC3G 11220 nM Potency
TKC036999 P06746 DNA polymerase beta POLB 50119 nM Potency
TKC036999 P11308 Transcriptional regulator ERG ERG 7943 nM Potency

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
P27695 APEX1_HUMAN Retinopathy [ICD-11: 9B71]
P27695 APEX1_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P27695 APEX1_HUMAN Ocular cancer [ICD-11: 2D00-2D07]
P27695 APEX1_HUMAN Brain cancer [ICD-11: 2A00]
P27695 APEX1_HUMAN Melanoma [ICD-11: 2C30]
P06746 DPOLB_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]