Basic Information

Terpenoid ID TKC031476
Chirality TKC079090
Cell line 0
Protein target 4
DiseaseNCIT 0
ORDO 0
ICD 28

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC031476 P388 P-388 1.0 ug.mL-1 IC50 C21602
TKC031476 A549 3.0 ug.mL-1 IC50 C3512
TKC031476 HT-29 HT 29; HT29 3.0 ug.mL-1 IC50 C4349
TKC031476 MDA-N MDAN 13552.0 nM GI50 C3802
TKC031476 SN12C SN-12C 20606.0 nM GI50 C9385 Orphanet_217071
TKC031476 NCI-H23 NCI.H23; NCI H23; H-23; H23; NCIH23 27990.0 nM GI50 C3512
TKC031476 ACHN 16943.0 nM GI50 C6975 Orphanet_319298
TKC031476 UO-31 UO.31; UO31; U031 16368.0 nM GI50 C9385 Orphanet_217071
TKC031476 HOP-92 HOP 92; HOP.92; HOP92; Hop92; Hopkins-92 20606.0 nM GI50 C2926
TKC031476 HL-60 HL 60; HL.60 HL60; Human Leukemia-60 18365.0 nM GI50 C9154 Orphanet_519
TKC031476 DU-145 DU-145; Du-145; DU 145; DU_145; DU.145; Duke University 145 18450.0 nM GI50 C4863
TKC031476 SF-539 SF-539; SF-539 BT; SF.539; SF 539 19320.0 nM GI50 C3796 Orphanet_251576
TKC031476 Malme-3M MALME-3M; MALME 3M; Malme-3 M; MALME.3M; Malme3M; MALME3M; Malme-3 Monolayer 15205.0 nM GI50 C3224
TKC031476 SK-MEL-5 SK-Mel-5; SK MEL 5; SK.MEL.5; SK-MEL5; SKMel-5; SKMEL-5; SKMEL5; SKMel5; SKmel5; AA-Mel 15631.0 nM GI50 C3510
TKC031476 OVCAR-3 Ovcar-3; OVCAR 3; OVCAR.3; NIH:OVCAR-3; NIH:Ovcar-3; NIH:OVCAR3; NIH-OVCAR-3; NIHOVCAR3; OVCAR3; Ovcar3 14859.0 nM GI50 C105555
TKC031476 A498 A498 40926.0 nM GI50 C9385 Orphanet_217071
TKC031476 HOP-62 HOP 62; Hop 62; HOP.62; HOP62; Hop62; Hopkins-62 30620.0 nM GI50 C3512
TKC031476 MOLT-4 Molt-4; MOLT 4; Molt 4; MOLT.4; MOLT4; Molt4; GM02219; GM02219C; GM2219C; GM02219D 9333.0 nM GI50 C9142 Orphanet_99861
TKC031476 U-251 U-251 MG; U-251-MG; U-251_MG; U251-MG; U251MG; U-251; U251; U251n; U251N; 251 MG; 251MG; 251 MG(6) 19011.0 nM GI50 C60781 Orphanet_94
TKC031476 NCI/ADR-RES NCI/ADR-RES; NCI.ADR.RES; NCIADR.RES; NCI/ADRRES; NCIADRRES; ADR-RES; MCF-7/ADR; MCF-7/ADR-RES; MCF-7/AdrR; MCF-7/Adr; MCF-7/adr; MCF-7ADR; MCF7-ADR; MCF7ADR; OVCAR-8/ADR; OVCAR8/ADR 18621.0 nM GI50 C105555
TKC031476 OVCAR-8 OVCAR 8; NIH:OVCAR-8; OVCAR8; Ovcar8; OVCAR.8; OVCA8 16406.0 nM GI50 C105555
TKC031476 OVCAR-5 OVCAR 5; NIH:OVCAR-5; OVCAR.5; OVCAR5; Ovcar5; OVCA5 16368.0 nM GI50 C105555
TKC031476 SNB-19 SNB.19; SNB19; Surgical Neurology Branch-19 18155.0 nM GI50 C60781 Orphanet_94
TKC031476 SR SR-786; SR786 18155.0 nM GI50 C37193 Orphanet_300895
TKC031476 MDA-MB-231 MDA_MB_231; MDA-MB 231; MDA.MB.231; MDA MB 231; MDA MB231; MDA Mb231; MDA-MB231; MDAMB-231; MDAMB231; MDA-231; MDA-231P; MDA231; MDA231-BRE; MB231; MD Anderson-Metastatic Breast-231 10568.0 nM GI50 C5214
TKC031476 TK-10 TK.10; TK 10; TK10 25942.0 nM GI50 C4033 Orphanet_319276
TKC031476 SW-620 SW-620; SW 620; SW.620 35400.0 nM GI50 C4349
TKC031476 NCI-H522 NCI.H522; H522; H-522; NCI-522; NCI522; NCIH522 15849.0 nM GI50 C3512
TKC031476 M14 M14-MEL; UCLA-SO-M14; UCLA SO M14; UCLA-SO-14; UCLASO-M14; Melanoma 14; M-14 17458.0 nM GI50 C3802
TKC031476 KM12 KM-12; KM.12 14655.0 nM GI50 C4910
TKC031476 NCI-H322M NCI.H322M; H322M; H-322M; H-322m 50933.0 nM GI50 C2923
TKC031476 RPMI-8226 RPMI 8226; RPMI.8226; RPMI8226; RPMI no. 8226; RPMI no 8226; RPMI #8226; 8226; RPMI 8226/S; RPMI-8226S; RPMI8226/S; 8226/S; Roswell Park Memorial Institute 8226; GM02132; GM2132; GM 2132; GM02132C; Simpson 10740.0 nM GI50 C3242 Orphanet_29073
TKC031476 OVCAR-4 OVCAR 4; NIH:OVCAR-4; NIH:OVCAR4; OVCAR.4; OVCAR4; Ovcar4 15849.0 nM GI50 C105555
TKC031476 LOX IMVI LOX/IMVI; LOX IMVI; LOXIM-VI; LOXIMVI; LOX 19055.0 nM GI50 C3802
TKC031476 BT-549 BT 549; BT.549; BT549 25882.0 nM GI50 C4194
TKC031476 SK-MEL-2 SK-Mel-2; SK-Mel 2; SK-mel-2; SK-MEL2; SK.MEL.2; SK Mel 2; SK MEL 2; SKMEL-2; SKMEL2; SKmel2; SK-ML2; SKml2 18113.0 nM GI50 C3224
TKC031476 HCC 2998 HCC-2998; HCC.2998; HCC 2998; Hamon Cancer Center 2998 18365.0 nM GI50 C4349
TKC031476 HCT-15 HCT-15; HCT.15; HCT15 17022.0 nM GI50 C4349
TKC031476 SF-268 SF-268; SF.268; SF 268 15276.0 nM GI50 C60781 Orphanet_94
TKC031476 HCT-116 HCT-116; HCT.116; HCT_116; HCT116; HCT116wt; CoCL2 28576.0 nM GI50 C4910
TKC031476 MCF7 12400.0 nM IC50 C4194
TKC031476 EKVX 24774.0 nM GI50 C3512
TKC031476 PC-3 PC3; PC.3 27669.0 nM GI50 C4863
TKC031476 T47D 19815.0 nM GI50 C4194
TKC031476 SK-OV-3 SKOV-3; SK-OV3; SK.OV.3; SKOV3; Skov3; SKO3 30761.0 nM GI50 C7978
TKC031476 UACC-62 UACC 62; UACC.62; UACC62; University of Arizona Cell Culture-62 18408.0 nM GI50 C3224
TKC031476 MDA-MB-435 MDA-MB435; MDAMB435; MDA.MB.435; MDA-435; MDA 435; MDA435; MD Anderson-Metastatic Breast-435 36559.0 nM GI50 C3802
TKC031476 CAKI-1 CAL 1; Centre Antoine Lacassagne-1 6823.0 nM GI50 C3224
TKC031476 SF-295 SF-295; SF.295; SF 295 21928.0 nM GI50 C3058 Orphanet_360
TKC031476 IGROV-1 Igrov-1; IGROV 1; IGR-OV1; IGROV1; Igrov1; IGR.OV1; IGROV; OV1/P; OV1/p; OV1-P 19011.0 nM GI50 C7979 Orphanet_454723
TKC031476 Hs-578T HS 578T; Hs-578T; HS-578T; Hs_578t; Hs-578-T; HS-578-T; Hs 578.T; HS578T; Hs578T; Hs578t; HS0578T; 578T; HS578; Hs578; Homo sapiens No. 578, tumor cells 27861.0 nM GI50 C4194
TKC031476 786-0 786-o; 786O; 786-0; 786.O; 786-O RCC; RCC 786-O; RCC_7860; RCC 7860; 7860; 786-0WT 36983.0 nM GI50 C9385 Orphanet_217071
TKC031476 UACC-257 UACC 257; UACC.257; UACC257; University of Arizona Cell Culture-257 17100.0 nM GI50 C3224
TKC031476 CCRF-CEM CCRF/CEM; CCRFCEM; CCRF.CEM; CCRF CEM; CCRF; CEM; CEM-CCRF; CEM-CCRF (CAMR); CCRF/CEM/0; CEM/0; CEM-0; CCRF-CEM/S; GM03671; GM03671C 20324.0 nM GI50 C7953 Orphanet_99861
TKC031476 NCI-H226 NCI.H226; NCI H226; H226; H-226; HUT-226; HUT 226; NCIH226 19953.0 nM GI50 C45662 Orphanet_50251
TKC031476 SK-MEL-28 SK-Mel-28; SK.MEL.28; SK-MEL 28; SK MEL-28; SK MEL 28; SK Mel 28; SKMel-28; SKMEL-28; SK-MEL28; SK-Mel28; SK Mel28; SKMEL28; SKMel28; SKmel28; SKML-28; SK28; AU-Mel; P-36; P36 65000.0 nM GI50 C3510
TKC031476 RXF 393 RXF393L; RXF-393 L; RXF-393; RXF 393; RXF.393; RXF393; RXF 393NL 17100.0 nM GI50 C9385 Orphanet_217071
TKC031476 COLO 205 Colo 205; CoLo 205; COLO-205; Colo-205; COLO.205; Colo205; COLO205; Co 205; Colorado 205 18197.0 nM GI50 C4349

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC031476 O75762 Transient receptor potential cation channel subfamily A member 1 TRPA1 59 nM EC50
TKC031476 O35433 Transient receptor potential cation channel subfamily V member 1 Trpv1 76 % Inhibition
TKC031476 P17787 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 62500 nM IC50
TKC031476 P30926 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 48200 nM IC50
TKC031476 P36544 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 100000 nM IC50

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
O75762 TRPA1_HUMAN Upper respiratory tract disorder [ICD-11: CA0Z]
O75762 TRPA1_HUMAN Neuropathy [ICD-11: 8C0Z]
O75762 TRPA1_HUMAN Pain [ICD-11: MG30-MG3Z]
P17787 ACHB2_HUMAN Nicotine use disorder [ICD-11: 6C4A]
P17787 ACHB2_HUMAN Hyperhidrosis [ICD-11: EE00]
P17787 ACHB2_HUMAN Depression [ICD-11: 6A70-6A7Z]
P17787 ACHB2_HUMAN Alzheimer disease [ICD-11: 8A20]
P17787 ACHB2_HUMAN Thrombosis [ICD-11: DB61-GB90]
P30926 ACHB4_HUMAN Nicotine use disorder [ICD-11: 6C4A]
P30926 ACHB4_HUMAN Alzheimer disease [ICD-11: 8A20]
P36544 ACHA7_HUMAN Corneal disease [ICD-11: 9A76-9A78]
P36544 ACHA7_HUMAN Schizophrenia [ICD-11: 6A20]
P36544 ACHA7_HUMAN Alzheimer disease [ICD-11: 8A20]
P36544 ACHA7_HUMAN Asthma [ICD-11: CA23]
P36544 ACHA7_HUMAN Breast cancer [ICD-11: 2C60-2C6Y]
P36544 ACHA7_HUMAN General pain disorder [ICD-11: 8E43]
P36544 ACHA7_HUMAN Nicotine use disorder [ICD-11: 6C4A]
P36544 ACHA7_HUMAN Sexual dysfunction [ICD-11: HA00-HA01]
P36544 ACHA7_HUMAN Depression [ICD-11: 6A70-6A7Z]
P36544 ACHA7_HUMAN Mild neurocognitive disorder [ICD-11: 6D71]
P36544 ACHA7_HUMAN Parkinsonism [ICD-11: 8A00]
P36544 ACHA7_HUMAN Adaptive immunity immunodeficiency [ICD-11: 4A01]
P36544 ACHA7_HUMAN Dissociative neurological symptom disorder [ICD-11: 6B60]
P36544 ACHA7_HUMAN Mental/behavioural/neurodevelopmental disorder [ICD-11: 6E20-6E8Z]
P36544 ACHA7_HUMAN Sex development malformative disorder [ICD-11: LD2A]
P36544 ACHA7_HUMAN Thrombosis [ICD-11: DB61-GB90]
P36544 ACHA7_HUMAN Attention deficit hyperactivity disorder [ICD-11: 6A05]
P36544 ACHA7_HUMAN Central nervous system disease [ICD-11: 8A04-8D87]