Basic Information

Terpenoid ID TKC031180
Chirality TKC149894
Cell line 0
Protein target 12
DiseaseNCIT 0
ORDO 0
ICD 18

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC031180 HepG2 708.0 nM Potency C3728 Orphanet_449
TKC031180 MDA-N MDAN 6855.0 nM GI50 C3802
TKC031180 SN12C SN-12C 10000.0 nM GI50 C9385 Orphanet_217071
TKC031180 NCI-H23 NCI.H23; NCI H23; H-23; H23; NCIH23 7691.0 nM GI50 C3512
TKC031180 ACHN 5662.0 nM GI50 C6975 Orphanet_319298
TKC031180 UO-31 UO.31; UO31; U031 3243.0 nM GI50 C9385 Orphanet_217071
TKC031180 HOP-92 HOP 92; HOP.92; HOP92; Hop92; Hopkins-92 3327.0 nM GI50 C2926
TKC031180 HL-60 HL 60; HL.60 HL60; Human Leukemia-60 2393.0 nM GI50 C9154 Orphanet_519
TKC031180 SF-539 SF-539; SF-539 BT; SF.539; SF 539 10000.0 nM GI50 C3796 Orphanet_251576
TKC031180 SK-MEL-5 SK-Mel-5; SK MEL 5; SK.MEL.5; SK-MEL5; SKMel-5; SKMEL-5; SKMEL5; SKMel5; SKmel5; AA-Mel 10000.0 nM GI50 C3510
TKC031180 Malme-3M MALME-3M; MALME 3M; Malme-3 M; MALME.3M; Malme3M; MALME3M; Malme-3 Monolayer 10000.0 nM GI50 C3224
TKC031180 A498 A498 5458.0 nM GI50 C9385 Orphanet_217071
TKC031180 K562 K562; K.562; K 562; KO; GM05372; GM05372E 4446.0 nM GI50 C9110 Orphanet_521
TKC031180 OVCAR-3 Ovcar-3; OVCAR 3; OVCAR.3; NIH:OVCAR-3; NIH:Ovcar-3; NIH:OVCAR3; NIH-OVCAR-3; NIHOVCAR3; OVCAR3; Ovcar3 4898.0 nM GI50 C105555
TKC031180 MOLT-4 Molt-4; MOLT 4; Molt 4; MOLT.4; MOLT4; Molt4; GM02219; GM02219C; GM2219C; GM02219D 3097.0 nM GI50 C9142 Orphanet_99861
TKC031180 HOP-62 HOP 62; Hop 62; HOP.62; HOP62; Hop62; Hopkins-62 10000.0 nM GI50 C3512
TKC031180 U-251 U-251 MG; U-251-MG; U-251_MG; U251-MG; U251MG; U-251; U251; U251n; U251N; 251 MG; 251MG; 251 MG(6) 10000.0 nM GI50 C60781 Orphanet_94
TKC031180 NCI/ADR-RES NCI/ADR-RES; NCI.ADR.RES; NCIADR.RES; NCI/ADRRES; NCIADRRES; ADR-RES; MCF-7/ADR; MCF-7/ADR-RES; MCF-7/AdrR; MCF-7/Adr; MCF-7/adr; MCF-7ADR; MCF7-ADR; MCF7ADR; OVCAR-8/ADR; OVCAR8/ADR 3954.0 nM GI50 C105555
TKC031180 OVCAR-8 OVCAR 8; NIH:OVCAR-8; OVCAR8; Ovcar8; OVCAR.8; OVCA8 3499.0 nM GI50 C105555
TKC031180 SNB-19 SNB.19; SNB19; Surgical Neurology Branch-19 10000.0 nM GI50 C60781 Orphanet_94
TKC031180 TK-10 TK.10; TK 10; TK10 6745.0 nM GI50 C4033 Orphanet_319276
TKC031180 SR SR-786; SR786 3126.0 nM GI50 C37193 Orphanet_300895
TKC031180 SW-620 SW-620; SW 620; SW.620 3436.0 nM GI50 C4349
TKC031180 KM12 KM-12; KM.12 10000.0 nM GI50 C4910
TKC031180 NCI-H322M NCI.H322M; H322M; H-322M; H-322m 10000.0 nM GI50 C2923
TKC031180 RPMI-8226 RPMI 8226; RPMI.8226; RPMI8226; RPMI no. 8226; RPMI no 8226; RPMI #8226; 8226; RPMI 8226/S; RPMI-8226S; RPMI8226/S; 8226/S; Roswell Park Memorial Institute 8226; GM02132; GM2132; GM 2132; GM02132C; Simpson 5433.0 nM GI50 C3242 Orphanet_29073
TKC031180 LOX IMVI LOX/IMVI; LOX IMVI; LOXIM-VI; LOXIMVI; LOX 10000.0 nM GI50 C3802
TKC031180 OVCAR-4 OVCAR 4; NIH:OVCAR-4; NIH:OVCAR4; OVCAR.4; OVCAR4; Ovcar4 7603.0 nM GI50 C105555
TKC031180 SK-MEL-2 SK-Mel-2; SK-Mel 2; SK-mel-2; SK-MEL2; SK.MEL.2; SK Mel 2; SK MEL 2; SKMEL-2; SKMEL2; SKmel2; SK-ML2; SKml2 10000.0 nM GI50 C3224
TKC031180 A549 10000.0 nM GI50 C3512
TKC031180 SNB-75 SNB.75; SNB75; Surgical Neurology Branch-75 6653.0 nM GI50 C3058 Orphanet_360
TKC031180 HCC 2998 HCC-2998; HCC.2998; HCC 2998; Hamon Cancer Center 2998 10000.0 nM GI50 C4349
TKC031180 HCT-15 HCT-15; HCT.15; HCT15 4498.0 nM GI50 C4349
TKC031180 HCT-116 HCT-116; HCT.116; HCT_116; HCT116; HCT116wt; CoCL2 5035.0 nM GI50 C4910
TKC031180 SF-268 SF-268; SF.268; SF 268 10000.0 nM GI50 C60781 Orphanet_94
TKC031180 PC-3 PC3; PC.3 10000.0 nM GI50 C4863
TKC031180 MCF7 10000.0 nM GI50 C4194
TKC031180 EKVX 10000.0 nM GI50 C3512
TKC031180 SK-OV-3 SKOV-3; SK-OV3; SK.OV.3; SKOV3; Skov3; SKO3 10000.0 nM GI50 C7978
TKC031180 NCI-H460 NCI.H460; H460; H-460; NCIH460; NCI-HUT-460; NCI-460 10000.0 nM GI50 C4450
TKC031180 T47D 6310.0 nM GI50 C4194
TKC031180 UACC-62 UACC 62; UACC.62; UACC62; University of Arizona Cell Culture-62 6683.0 nM GI50 C3224
TKC031180 MDA-MB-435 MDA-MB435; MDAMB435; MDA.MB.435; MDA-435; MDA 435; MDA435; MD Anderson-Metastatic Breast-435 10000.0 nM GI50 C3802
TKC031180 IGROV-1 Igrov-1; IGROV 1; IGR-OV1; IGROV1; Igrov1; IGR.OV1; IGROV; OV1/P; OV1/p; OV1-P 10000.0 nM GI50 C7979 Orphanet_454723
TKC031180 SF-295 SF-295; SF.295; SF 295 10000.0 nM GI50 C3058 Orphanet_360
TKC031180 Hs-578T HS 578T; Hs-578T; HS-578T; Hs_578t; Hs-578-T; HS-578-T; Hs 578.T; HS578T; Hs578T; Hs578t; HS0578T; 578T; HS578; Hs578; Homo sapiens No. 578, tumor cells 10000.0 nM GI50 C4194
TKC031180 786-0 786-o; 786O; 786-0; 786.O; 786-O RCC; RCC 786-O; RCC_7860; RCC 7860; 7860; 786-0WT 6109.0 nM GI50 C9385 Orphanet_217071
TKC031180 CCRF-CEM CCRF/CEM; CCRFCEM; CCRF.CEM; CCRF CEM; CCRF; CEM; CEM-CCRF; CEM-CCRF (CAMR); CCRF/CEM/0; CEM/0; CEM-0; CCRF-CEM/S; GM03671; GM03671C 2729.0 nM GI50 C7953 Orphanet_99861
TKC031180 NCI-H226 NCI.H226; NCI H226; H226; H-226; HUT-226; HUT 226; NCIH226 10000.0 nM GI50 C45662 Orphanet_50251
TKC031180 SK-MEL-28 SK-Mel-28; SK.MEL.28; SK-MEL 28; SK MEL-28; SK MEL 28; SK Mel 28; SKMel-28; SKMEL-28; SK-MEL28; SK-Mel28; SK Mel28; SKMEL28; SKMel28; SKmel28; SKML-28; SK28; AU-Mel; P-36; P36 5916.0 nM GI50 C3510
TKC031180 HT-29 HT 29; HT29 10000.0 nM GI50 C4349
TKC031180 RXF 393 RXF393L; RXF-393 L; RXF-393; RXF 393; RXF.393; RXF393; RXF 393NL 9311.0 nM GI50 C9385 Orphanet_217071
TKC031180 COLO 205 Colo 205; CoLo 205; COLO-205; Colo-205; COLO.205; Colo205; COLO205; Co 205; Colorado 205 10000.0 nM GI50 C4349

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC031180 Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 TDP1 2311 nM Potency
TKC031180 O75874 Isocitrate dehydrogenase [NADP] cytoplasmic IDH1 18356 nM Potency
TKC031180 P43220 Glucagon-like peptide 1 receptor GLP1R 28184 nM Potency
TKC031180 P84022 Mothers against decapentaplegic homolog 3 SMAD3 15849 nM Potency
TKC031180 Q03431 Parathyroid hormone/parathyroid hormone-related peptide receptor PTH1R 50119 nM Potency
TKC031180 Q99700 Ataxin-2 ATXN2 11220 nM Potency
TKC031180 O75496 Geminin GMNN 1836 nM Potency
TKC031180 O89049 Thioredoxin reductase 1, cytoplasmic Txnrd1 70795 nM Potency
TKC031180 P01215 Glycoprotein hormones alpha chain CGA 31623 nM Potency
TKC031180 Q9HC16 DNA dC->dU-editing enzyme APOBEC-3G APOBEC3G 3548 nM Potency
TKC031180 P83916 Chromobox protein homolog 1 CBX1 50119 nM Potency
TKC031180 Q8IUX4 DNA dC->dU-editing enzyme APOBEC-3F APOBEC3F 5591 nM Potency
TKC031180 P51531 Probable global transcription activator SNF2L2 SMARCA2 >91207 nM EC50

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
O75874 IDHC_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
O75874 IDHC_HUMAN Liver cancer [ICD-11: 2C12]
O75874 IDHC_HUMAN Malignant haematopoietic neoplasm [ICD-11: 2B33]
O75874 IDHC_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
O75874 IDHC_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
O75874 IDHC_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P43220 GLP1R_HUMAN Cardiovascular disease [ICD-11: BA00-BE2Z]
P43220 GLP1R_HUMAN Obesity [ICD-11: 5B80-5B81]
P43220 GLP1R_HUMAN Type 2 diabetes mellitus [ICD-11: 5A11]
P43220 GLP1R_HUMAN Type-1/2 diabete [ICD-11: 5A10-5A11]
P43220 GLP1R_HUMAN Acute diabete complication [ICD-11: 5A2Y]
P43220 GLP1R_HUMAN Diabetes mellitus [ICD-11: 5A10]
P43220 GLP1R_HUMAN Dyspepsia [ICD-11: MD92]
P43220 GLP1R_HUMAN Irritable bowel syndrome [ICD-11: DD91]
P43220 GLP1R_HUMAN Intracranial injury [ICD-11: NA07]
P43220 GLP1R_HUMAN Non-alcoholic fatty liver disease [ICD-11: DB92]
P84022 SMAD3_HUMAN Herpes simplex infection [ICD-11: 1F00]
P84022 SMAD3_HUMAN Kidney fibrosis [ICD-11: GC01]
Q03431 PTH1R_HUMAN Low bone mass disorder [ICD-11: FB83]
Q03431 PTH1R_HUMAN Hypo-parathyroidism [ICD-11: 5A50]