Basic Information

Terpenoid ID TKC028968
Chirality TKC206974
Cell line 59
Protein target 1
DiseaseNCIT 60
ORDO 22
ICD 8

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC028968 SN12C SN-12C 2518.0 nM GI50 C9385 Orphanet_217071
TKC028968 NCI-H23 NCI.H23; NCI H23; H-23; H23; NCIH23 1435.0 nM GI50 C3512
TKC028968 HOP-92 HOP 92; HOP.92; HOP92; Hop92; Hopkins-92 1050.0 nM GI50 C2926
TKC028968 UO-31 UO.31; UO31; U031 2323.0 nM GI50 C9385 Orphanet_217071
TKC028968 HL-60 HL 60; HL.60 HL60; Human Leukemia-60 249.0 nM GI50 C9154 Orphanet_519
TKC028968 SK-MEL-5 SK-Mel-5; SK MEL 5; SK.MEL.5; SK-MEL5; SKMel-5; SKMEL-5; SKMEL5; SKMel5; SKmel5; AA-Mel 1175.0 nM GI50 C3510
TKC028968 SF-539 SF-539; SF-539 BT; SF.539; SF 539 2399.0 nM GI50 C3796 Orphanet_251576
TKC028968 Malme-3M MALME-3M; MALME 3M; Malme-3 M; MALME.3M; Malme3M; MALME3M; Malme-3 Monolayer 971.0 nM GI50 C3224
TKC028968 K562 K562; K.562; K 562; KO; GM05372; GM05372E 809.0 nM GI50 C9110 Orphanet_521
TKC028968 A498 A498 1282.0 nM GI50 C9385 Orphanet_217071
TKC028968 OVCAR-3 Ovcar-3; OVCAR 3; OVCAR.3; NIH:OVCAR-3; NIH:Ovcar-3; NIH:OVCAR3; NIH-OVCAR-3; NIHOVCAR3; OVCAR3; Ovcar3 693.0 nM GI50 C105555
TKC028968 MOLT-4 Molt-4; MOLT 4; Molt 4; MOLT.4; MOLT4; Molt4; GM02219; GM02219C; GM2219C; GM02219D 370.0 nM GI50 C9142 Orphanet_99861
TKC028968 NCI/ADR-RES NCI/ADR-RES; NCI.ADR.RES; NCIADR.RES; NCI/ADRRES; NCIADRRES; ADR-RES; MCF-7/ADR; MCF-7/ADR-RES; MCF-7/AdrR; MCF-7/Adr; MCF-7/adr; MCF-7ADR; MCF7-ADR; MCF7ADR; OVCAR-8/ADR; OVCAR8/ADR 1799.0 nM GI50 C105555
TKC028968 HOP-62 HOP 62; Hop 62; HOP.62; HOP62; Hop62; Hopkins-62 6383.0 nM GI50 C3512
TKC028968 OVCAR-8 OVCAR 8; NIH:OVCAR-8; OVCAR8; Ovcar8; OVCAR.8; OVCA8 1245.0 nM GI50 C105555
TKC028968 U-251 U-251 MG; U-251-MG; U-251_MG; U251-MG; U251MG; U-251; U251; U251n; U251N; 251 MG; 251MG; 251 MG(6) 3802.0 nM GI50 C60781 Orphanet_94
TKC028968 OVCAR-5 OVCAR 5; NIH:OVCAR-5; OVCAR.5; OVCAR5; Ovcar5; OVCA5 4550.0 nM GI50 C105555
TKC028968 SNB-19 SNB.19; SNB19; Surgical Neurology Branch-19 5598.0 nM GI50 C60781 Orphanet_94
TKC028968 DMS-273 DMS-273; DMS273; Darmouth Medical School 273 2080.0 nM GI50 C4917 Orphanet_70573
TKC028968 M19-MEL M-19; M19 1230.0 nM GI50 C3802
TKC028968 SW-620 SW-620; SW 620; SW.620 485.0 nM GI50 C4349
TKC028968 KM12 KM-12; KM.12 2312.0 nM GI50 C4910
TKC028968 NCI-H522 NCI.H522; H522; H-522; NCI-522; NCI522; NCIH522 456.0 nM GI50 C3512
TKC028968 NCI-H322M NCI.H322M; H322M; H-322M; H-322m 5236.0 nM GI50 C2923
TKC028968 XF498 XF-498; XF498 1493.0 nM GI50 C3058 Orphanet_360
TKC028968 RPMI-8226 RPMI 8226; RPMI.8226; RPMI8226; RPMI no. 8226; RPMI no 8226; RPMI #8226; 8226; RPMI 8226/S; RPMI-8226S; RPMI8226/S; 8226/S; Roswell Park Memorial Institute 8226; GM02132; GM2132; GM 2132; GM02132C; Simpson 519.0 nM GI50 C3242 Orphanet_29073
TKC028968 OVCAR-4 OVCAR 4; NIH:OVCAR-4; NIH:OVCAR4; OVCAR.4; OVCAR4; Ovcar4 1334.0 nM GI50 C105555
TKC028968 LOX IMVI LOX/IMVI; LOX IMVI; LOXIM-VI; LOXIMVI; LOX 942.0 nM GI50 C3802
TKC028968 P388 P-388 142.0 nM GI50 C21602
TKC028968 SK-MEL-2 SK-Mel-2; SK-Mel 2; SK-mel-2; SK-MEL2; SK.MEL.2; SK Mel 2; SK MEL 2; SKMEL-2; SKMEL2; SKmel2; SK-ML2; SKml2 2864.0 nM GI50 C3224
TKC028968 KM-20L2 KM-20L2; KM 20L2; KM 2012 2113.0 nM GI50 C4349
TKC028968 HCC 2998 HCC-2998; HCC.2998; HCC 2998; Hamon Cancer Center 2998 2612.0 nM GI50 C4349
TKC028968 A549 4539.0 nM GI50 C3512
TKC028968 SNB-75 SNB.75; SNB75; Surgical Neurology Branch-75 2404.0 nM GI50 C3058 Orphanet_360
TKC028968 HCT-116 HCT-116; HCT.116; HCT_116; HCT116; HCT116wt; CoCL2 989.0 nM GI50 C4910
TKC028968 HCT-15 HCT-15; HCT.15; HCT15 600.0 nM GI50 C4349
TKC028968 EKVX 2649.0 nM GI50 C3512
TKC028968 SF-268 SF-268; SF.268; SF 268 2421.0 nM GI50 C60781 Orphanet_94
TKC028968 MCF7 1892.0 nM GI50 C4194
TKC028968 SK-OV-3 SKOV-3; SK-OV3; SK.OV.3; SKOV3; Skov3; SKO3 4335.0 nM GI50 C7978
TKC028968 DMS-114 DMS-114; DMS114; Darmouth Medical School 114 927.0 nM GI50 C4917 Orphanet_70573
TKC028968 NCI-H460 NCI.H460; H460; H-460; NCIH460; NCI-HUT-460; NCI-460 1641.0 nM GI50 C4450
TKC028968 UACC-62 UACC 62; UACC.62; UACC62; University of Arizona Cell Culture-62 2761.0 nM GI50 C3224
TKC028968 CAKI-1 CAL 1; Centre Antoine Lacassagne-1 1005.0 nM GI50 C3224
TKC028968 SF-295 SF-295; SF.295; SF 295 3069.0 nM GI50 C3058 Orphanet_360
TKC028968 P388/ADR 322.0 nM GI50 C21602
TKC028968 IGROV-1 Igrov-1; IGROV 1; IGR-OV1; IGROV1; Igrov1; IGR.OV1; IGROV; OV1/P; OV1/p; OV1-P 2489.0 nM GI50 C7979 Orphanet_454723
TKC028968 SNB-78 SNB78; Surgical Neurology Branch-78 2667.0 nM GI50 C3058 Orphanet_360
TKC028968 UACC-257 UACC 257; UACC.257; UACC257; University of Arizona Cell Culture-257 2000.0 nM GI50 C3224
TKC028968 CCRF-CEM CCRF/CEM; CCRFCEM; CCRF.CEM; CCRF CEM; CCRF; CEM; CEM-CCRF; CEM-CCRF (CAMR); CCRF/CEM/0; CEM/0; CEM-0; CCRF-CEM/S; GM03671; GM03671C 238.0 nM GI50 C7953 Orphanet_99861
TKC028968 DLD-1 DLD 1; DLD1; CoCL3 1052.0 nM GI50 C4349
TKC028968 HT-29 HT 29; HT29 1393.0 nM GI50 C4349
TKC028968 NCI-H226 NCI.H226; NCI H226; H226; H-226; HUT-226; HUT 226; NCIH226 2685.0 nM GI50 C45662 Orphanet_50251
TKC028968 RXF 393 RXF393L; RXF-393 L; RXF-393; RXF 393; RXF.393; RXF393; RXF 393NL 491.0 nM GI50 C9385 Orphanet_217071
TKC028968 SK-MEL-28 SK-Mel-28; SK.MEL.28; SK-MEL 28; SK MEL-28; SK MEL 28; SK Mel 28; SKMel-28; SKMEL-28; SK-MEL28; SK-Mel28; SK Mel28; SKMEL28; SKMel28; SKmel28; SKML-28; SK28; AU-Mel; P-36; P36 1052.0 nM GI50 C3510
TKC028968 COLO 205 Colo 205; CoLo 205; COLO-205; Colo-205; COLO.205; Colo205; COLO205; Co 205; Colorado 205 859.0 nM GI50 C4349
TKC028968 HOP-18 HOP 18; Hop 18; HOP18; Hop18; Hopkins-18 931.0 nM GI50 C4450
TKC028968 SN12K1 1361.0 nM GI50 C9385 Orphanet_217071
TKC028968 MOLT-4 Molt-4; MOLT 4; Molt 4; MOLT.4; MOLT4; Molt4; GM02219; GM02219C; GM2219C; GM02219D 1510.0 nM IC50 C9142 Orphanet_99861
TKC028968 CCRF-CEM CCRF/CEM; CCRFCEM; CCRF.CEM; CCRF CEM; CCRF; CEM; CEM-CCRF; CEM-CCRF (CAMR); CCRF/CEM/0; CEM/0; CEM-0; CCRF-CEM/S; GM03671; GM03671C 1610.0 nM IC50 C7953 Orphanet_99861
TKC028968 HeLa HELA; Hela; He La; He-La; HeLa-CCL2; Henrietta Lacks cells; Helacyton gartleri 10310.0 nM MIC C27677
TKC028968 P388 P-388 2.0 ug ml-1 ED50 C21602

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC028968 O43451 Maltase-glucoamylase, intestinal MGAM 78 % Inhibition

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
O43451 MGA_HUMAN Acute diabete complication [ICD-11: 5A2Y]
O43451 MGA_HUMAN Cardiovascular disease [ICD-11: BA00-BE2Z]
O43451 MGA_HUMAN Inborn carbohydrate metabolism error [ICD-11: 5C51]
O43451 MGA_HUMAN Muscle disorder [ICD-11: FB32-FB3Z]
O43451 MGA_HUMAN Human immunodeficiency virus disease [ICD-11: 1C60-1C62]
O43451 MGA_HUMAN Type 2 diabetes mellitus [ICD-11: 5A11]
O43451 MGA_HUMAN Dengue fever [ICD-11: 1D2Z]
O43451 MGA_HUMAN Blood chemistry clinical sympton [ICD-11: MA18]