Basic Information

Terpenoid ID TKC021977
Chirality TKC130761
Cell line 0
Protein target 3
DiseaseNCIT 0
ORDO 0
ICD 19

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC021977 U373 MG U-373MG; U373 MG; U-373-MG; U-373 MG; U373-MG; U373MG; U373; 373 MG; 373MG 80000.0 nM IC50 C60781 Orphanet_94

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC021977 P28482 Mitogen-activated protein kinase 1 MAPK1 39811 nM Potency
TKC021977 P16473 Thyrotropin receptor TSHR 6310 nM Potency
TKC021977 P51449 Nuclear receptor ROR-gamma RORC 42163 nM Potency
TKC021977 P45983 Mitogen-activated protein kinase 8 MAPK8 51 % Inhibition

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
P28482 MK01_HUMAN Melanoma [ICD-11: 2C30]
P28482 MK01_HUMAN Pancreatic cancer [ICD-11: 2C10]
P28482 MK01_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P28482 MK01_HUMAN Arteries/arterioles disorder [ICD-11: BD52]
P28482 MK01_HUMAN Allergic/hypersensitivity disorder [ICD-11: 4A80-4A8Z]
P28482 MK01_HUMAN Transplant rejection [ICD-11: NE84]
P28482 MK01_HUMAN Mature T-cell lymphoma [ICD-11: 2A90]
P28482 MK01_HUMAN Rheumatoid arthritis [ICD-11: FA20]
P16473 TSHR_HUMAN Hypo-thyroidism [ICD-11: 5A00]
P16473 TSHR_HUMAN Thyroid cancer [ICD-11: 2D10]
P51449 RORG_HUMAN Autoimmune disease [ICD-11: 4A40-4A45]
P51449 RORG_HUMAN Lung cancer [ICD-11: 2C25]
P51449 RORG_HUMAN Psoriasis [ICD-11: EA90]
P51449 RORG_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P51449 RORG_HUMAN Crohn disease [ICD-11: DD70]
P51449 RORG_HUMAN Multiple sclerosis [ICD-11: 8A40]
P51449 RORG_HUMAN Arterial occlusive disease [ICD-11: BD40]
P51449 RORG_HUMAN Liver cancer [ICD-11: 2C12]
P51449 RORG_HUMAN Rheumatoid arthritis [ICD-11: FA20]
P45983 MK08_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P45983 MK08_HUMAN Mature T-cell lymphoma [ICD-11: 2A90]
P45983 MK08_HUMAN Intracranial injury [ICD-11: NA07]