Basic Information
| Terpenoid ID | TKC020967 |
|
| Cell line | 0 | |
| Protein target | 3 | |
| DiseaseNCIT | 0 | |
| ORDO | 0 | |
| ICD | 16 |
| Terpenoid ID | TKC020967 |
|
| Cell line | 0 | |
| Protein target | 3 | |
| DiseaseNCIT | 0 | |
| ORDO | 0 | |
| ICD | 16 |
| ID | Cell Line | Synonyms | Value | Unit | Type | NCIt | ORDO |
|---|---|---|---|---|---|---|---|
| TKC020967 | HL-60 | HL 60; HL.60 HL60; Human Leukemia-60 | 28000.0 | nM | IC50 | C9154 | Orphanet_519 |
| TKC020967 | HT-29 | HT 29; HT29 | 47000.0 | nM | IC50 | C4349 | |
| TKC020967 | HFF | 33000.0 | nM | IC50 | |||
| TKC020967 | HeLa | HELA; Hela; He La; He-La; HeLa-CCL2; Henrietta Lacks cells; Helacyton gartleri | 2060.0 | nM | IC50 | C27677 | |
| TKC020967 | MCF7 | 6190.0 | nM | IC50 | C4194 | ||
| TKC020967 | CCRF-CEM | CCRF/CEM; CCRFCEM; CCRF.CEM; CCRF CEM; CCRF; CEM; CEM-CCRF; CEM-CCRF (CAMR); CCRF/CEM/0; CEM/0; CEM-0; CCRF-CEM/S; GM03671; GM03671C | 300.0 | nM | EC50 | C7953 | Orphanet_99861 |
| TKC020967 | ADR5000 cell line | CCRF ADR5000; CCRF-ADR5000; CEM/ADR5000; CEM/ADR 5000; CEM-ADR5000; CEM ADR5000; ADR5000 | 300.0 | nM | EC50 | C7953 | Orphanet_99861 |
| TKC020967 | HEK-293T | Hek293T; HEK-293T; HEK 293T; HEK-293-T; HEK 293 T; 293-T; 293 T; 293T; Human Embryonic Kidney 293T; 293tsA1609neo | 140.0 | ug.mL-1 | CC50 | ||
| TKC020967 | HepG2 | 92.0 | % | Activity | C3728 | Orphanet_449 | |
| TKC020967 | A2780 | A-2780; 2780; A2780S; A2780par | 7900.0 | nM | IC50 | C7979 | Orphanet_454723 |
| TKC020967 | OVCAR-8 | OVCAR 8; NIH:OVCAR-8; OVCAR8; Ovcar8; OVCAR.8; OVCA8 | 11600.0 | nM | IC50 | C105555 |
| ID | Uniport | Pref_name | Gene name | value | unit | type |
|---|---|---|---|---|---|---|
| TKC020967 | Q9NPD5 | Solute carrier organic anion transporter family member 1B3 | SLCO1B3 | 98 | % | Inhibition |
| TKC020967 | Q9Y6L6 | Solute carrier organic anion transporter family member 1B1 | SLCO1B1 | 126 | % | Inhibition |
| TKC020967 | P53350 | Serine/threonine-protein kinase PLK1 | PLK1 | 2180 | nM | IC50 |
| TKC020967 | O42275 | Acetylcholinesterase | ache | 8 | % | Inhibition |
| TKC020967 | P29466 | Caspase-1 | CASP1 | 1080 | nM | IC50 |
| TKC020967 | P81908 | Cholinesterase | BCHE | 0 | % | Inhibition |
| TKC020967 | P0DPI0 | Botulinum neurotoxin type A | botA | 0 | /M/s | Ratio |
| TKC020967 | Q9H4B4 | Serine/threonine-protein kinase PLK3 | PLK3 | >50000 | nM | IC50 |
| TKC020967 | Q9NYY3 | Serine/threonine-protein kinase PLK2 | PLK2 | 14720 | nM | IC50 |
| Uniport ID | Uniport Name | ICD-11 |
|---|---|---|
| P53350 | PLK1_HUMAN | Acute myeloid leukaemia [ICD-11: 2A60] |
| P53350 | PLK1_HUMAN | Myelodysplastic syndrome [ICD-11: 2A37] |
| P53350 | PLK1_HUMAN | Solid tumour/cancer [ICD-11: 2A00-2F9Z] |
| P53350 | PLK1_HUMAN | Prostate cancer [ICD-11: 2C82] |
| P53350 | PLK1_HUMAN | Malignant haematopoietic neoplasm [ICD-11: 2B33] |
| P53350 | PLK1_HUMAN | Pancreatic cancer [ICD-11: 2C10] |
| P53350 | PLK1_HUMAN | Lymphoma [ICD-11: 2A80-2A86] |
| P53350 | PLK1_HUMAN | Nasopharyngeal cancer [ICD-11: 2B6B] |
| P53350 | PLK1_HUMAN | Solid tumour/cancer [ICD-11: 2A00-2F9Z] |
| P29466 | CASP1_HUMAN | Epilepsy/seizure [ICD-11: 8A61-8A6Z] |
| P29466 | CASP1_HUMAN | Fibrosis [ICD-11: GA14-GC01] |
| P29466 | CASP1_HUMAN | Rheumatoid arthritis [ICD-11: FA20] |
| P29466 | CASP1_HUMAN | Type 2 diabetes mellitus [ICD-11: 5A11] |
| P29466 | CASP1_HUMAN | Contact dermatitis [ICD-11: EK00-EK0Z] |
| P29466 | CASP1_HUMAN | Fragrance/cosmetics phototoxic reaction [ICD-11: EK20] |
| P29466 | CASP1_HUMAN | Irritant contact dermatitis [ICD-11: EK02] |
| P0DPI0 | BXA1_CLOBO | Acne vulgaris [ICD-11: ED80] |
| P0DPI0 | BXA1_CLOBO | Ataxic disorder [ICD-11: 8A03] |
| P0DPI0 | BXA1_CLOBO | Clostridium difficile enterocolitis [ICD-11: 1A04] |
| Q9NYY3 | PLK2_HUMAN | Solid tumour/cancer [ICD-11: 2A00-2F9Z] |