Basic Information

Terpenoid ID TKC020944
Cell line 0
Protein target 11
DiseaseNCIT 0
ORDO 0
ICD 6

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC020944 SN12C SN-12C 1570363.0 nM GI50 C9385 Orphanet_217071
TKC020944 NCI-H23 NCI.H23; NCI H23; H-23; H23; NCIH23 968278.0 nM GI50 C3512
TKC020944 ACHN 1020939.0 nM GI50 C6975 Orphanet_319298
TKC020944 UO-31 UO.31; UO31; U031 1191242.0 nM GI50 C9385 Orphanet_217071
TKC020944 HL-60 HL 60; HL.60 HL60; Human Leukemia-60 905733.0 nM GI50 C9154 Orphanet_519
TKC020944 HOP-92 HOP 92; HOP.92; HOP92; Hop92; Hopkins-92 1435489.0 nM GI50 C2926
TKC020944 SF-539 SF-539; SF-539 BT; SF.539; SF 539 1069055.0 nM GI50 C3796 Orphanet_251576
TKC020944 SK-MEL-5 SK-Mel-5; SK MEL 5; SK.MEL.5; SK-MEL5; SKMel-5; SKMEL-5; SKMEL5; SKMel5; SKmel5; AA-Mel 751623.0 nM GI50 C3510
TKC020944 Malme-3M MALME-3M; MALME 3M; Malme-3 M; MALME.3M; Malme3M; MALME3M; Malme-3 Monolayer 809096.0 nM GI50 C3224
TKC020944 A498 A498 1213389.0 nM GI50 C9385 Orphanet_217071
TKC020944 K562 K562; K.562; K 562; KO; GM05372; GM05372E 1202264.0 nM GI50 C9110 Orphanet_521
TKC020944 OVCAR-3 Ovcar-3; OVCAR 3; OVCAR.3; NIH:OVCAR-3; NIH:Ovcar-3; NIH:OVCAR3; NIH-OVCAR-3; NIHOVCAR3; OVCAR3; Ovcar3 877001.0 nM GI50 C105555
TKC020944 MOLT-4 Molt-4; MOLT 4; Molt 4; MOLT.4; MOLT4; Molt4; GM02219; GM02219C; GM2219C; GM02219D 2328091.0 nM GI50 C9142 Orphanet_99861
TKC020944 HOP-62 HOP 62; Hop 62; HOP.62; HOP62; Hop62; Hopkins-62 995405.0 nM GI50 C3512
TKC020944 U-251 U-251 MG; U-251-MG; U-251_MG; U251-MG; U251MG; U-251; U251; U251n; U251N; 251 MG; 251MG; 251 MG(6) 1064143.0 nM GI50 C60781 Orphanet_94
TKC020944 OVCAR-8 OVCAR 8; NIH:OVCAR-8; OVCAR8; Ovcar8; OVCAR.8; OVCA8 1202264.0 nM GI50 C105555
TKC020944 OVCAR-5 OVCAR 5; NIH:OVCAR-5; OVCAR.5; OVCAR5; Ovcar5; OVCA5 1659587.0 nM GI50 C105555
TKC020944 SNB-19 SNB.19; SNB19; Surgical Neurology Branch-19 1185769.0 nM GI50 C60781 Orphanet_94
TKC020944 DMS-273 DMS-273; DMS273; Darmouth Medical School 273 1339677.0 nM GI50 C4917 Orphanet_70573
TKC020944 SR SR-786; SR786 1161449.0 nM GI50 C37193 Orphanet_300895
TKC020944 M19-MEL M-19; M19 1156112.0 nM GI50 C3802
TKC020944 TK-10 TK.10; TK 10; TK10 1584893.0 nM GI50 C4033 Orphanet_319276
TKC020944 SW-620 SW-620; SW 620; SW.620 1737801.0 nM GI50 C4349
TKC020944 NCI-H522 NCI.H522; H522; H-522; NCI-522; NCI522; NCIH522 887156.0 nM GI50 C3512
TKC020944 KM12 KM-12; KM.12 859014.0 nM GI50 C4910
TKC020944 XF498 XF-498; XF498 500035.0 nM GI50 C3058 Orphanet_360
TKC020944 M14 M14-MEL; UCLA-SO-M14; UCLA SO M14; UCLA-SO-14; UCLASO-M14; Melanoma 14; M-14 1745822.0 nM GI50 C3802
TKC020944 NCI-H322M NCI.H322M; H322M; H-322M; H-322m 1458814.0 nM GI50 C2923
TKC020944 LOX IMVI LOX/IMVI; LOX IMVI; LOXIM-VI; LOXIMVI; LOX 1216186.0 nM GI50 C3802
TKC020944 OVCAR-4 OVCAR 4; NIH:OVCAR-4; NIH:OVCAR4; OVCAR.4; OVCAR4; Ovcar4 1757924.0 nM GI50 C105555
TKC020944 SK-MEL-2 SK-Mel-2; SK-Mel 2; SK-mel-2; SK-MEL2; SK.MEL.2; SK Mel 2; SK MEL 2; SKMEL-2; SKMEL2; SKmel2; SK-ML2; SKml2 1174898.0 nM GI50 C3224
TKC020944 KM-20L2 KM-20L2; KM 20L2; KM 2012 1412538.0 nM GI50 C4349
TKC020944 A549 1205036.0 nM GI50 C3512
TKC020944 SNB-75 SNB.75; SNB75; Surgical Neurology Branch-75 1196741.0 nM GI50 C3058 Orphanet_360
TKC020944 HCC 2998 HCC-2998; HCC.2998; HCC 2998; Hamon Cancer Center 2998 1083927.0 nM GI50 C4349
TKC020944 HCT-116 HCT-116; HCT.116; HCT_116; HCT116; HCT116wt; CoCL2 792501.0 nM GI50 C4910
TKC020944 HCT-15 HCT-15; HCT.15; HCT15 870964.0 nM GI50 C4349
TKC020944 SF-268 SF-268; SF.268; SF 268 1193988.0 nM GI50 C60781 Orphanet_94
TKC020944 EKVX 2355049.0 nM GI50 C3512
TKC020944 LXFL 529 LXFL-529L; LXFL529L; LXF 529 L; LXFL-529; LXFL 529; LXFL529; LXF 529 1489361.0 nM GI50 C2926
TKC020944 DMS-114 DMS-114; DMS114; Darmouth Medical School 114 1361445.0 nM GI50 C4917 Orphanet_70573
TKC020944 SK-OV-3 SKOV-3; SK-OV3; SK.OV.3; SKOV3; Skov3; SKO3 2065380.0 nM GI50 C7978
TKC020944 NCI-H460 NCI.H460; H460; H-460; NCIH460; NCI-HUT-460; NCI-460 1358313.0 nM GI50 C4450
TKC020944 UACC-62 UACC 62; UACC.62; UACC62; University of Arizona Cell Culture-62 741310.0 nM GI50 C3224
TKC020944 CAKI-1 CAL 1; Centre Antoine Lacassagne-1 1297179.0 nM GI50 C3224
TKC020944 IGROV-1 Igrov-1; IGROV 1; IGR-OV1; IGROV1; Igrov1; IGR.OV1; IGROV; OV1/P; OV1/p; OV1-P 774462.0 nM GI50 C7979 Orphanet_454723
TKC020944 SF-295 SF-295; SF.295; SF 295 1093956.0 nM GI50 C3058 Orphanet_360
TKC020944 RXF 631 RXF-631L; RXF631L; RXF 631; RXF-631; RXF631 839460.0 nM GI50 C9385 Orphanet_217071
TKC020944 786-0 786-o; 786O; 786-0; 786.O; 786-O RCC; RCC 786-O; RCC_7860; RCC 7860; 7860; 786-0WT 1406048.0 nM GI50 C9385 Orphanet_217071
TKC020944 SNB-78 SNB78; Surgical Neurology Branch-78 2098940.0 nM GI50 C3058 Orphanet_360
TKC020944 UACC-257 UACC 257; UACC.257; UACC257; University of Arizona Cell Culture-257 1185769.0 nM GI50 C3224
TKC020944 CCRF-CEM CCRF/CEM; CCRFCEM; CCRF.CEM; CCRF CEM; CCRF; CEM; CEM-CCRF; CEM-CCRF (CAMR); CCRF/CEM/0; CEM/0; CEM-0; CCRF-CEM/S; GM03671; GM03671C 862979.0 nM GI50 C7953 Orphanet_99861
TKC020944 DLD-1 DLD 1; DLD1; CoCL3 1489361.0 nM GI50 C4349
TKC020944 NCI-H226 NCI.H226; NCI H226; H226; H-226; HUT-226; HUT 226; NCIH226 1039920.0 nM GI50 C45662 Orphanet_50251
TKC020944 HT-29 HT 29; HT29 1445440.0 nM GI50 C4349
TKC020944 SK-MEL-28 SK-Mel-28; SK.MEL.28; SK-MEL 28; SK MEL-28; SK MEL 28; SK Mel 28; SKMel-28; SKMEL-28; SK-MEL28; SK-Mel28; SK Mel28; SKMEL28; SKMel28; SKmel28; SKML-28; SK28; AU-Mel; P-36; P36 1009253.0 nM GI50 C3510
TKC020944 COLO 205 Colo 205; CoLo 205; COLO-205; Colo-205; COLO.205; Colo205; COLO205; Co 205; Colorado 205 591562.0 nM GI50 C4349
TKC020944 RXF 393 RXF393L; RXF-393 L; RXF-393; RXF 393; RXF.393; RXF393; RXF 393NL 941890.0 nM GI50 C9385 Orphanet_217071

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC020944 O89049 Thioredoxin reductase 1, cytoplasmic Txnrd1 1337 nM Potency
TKC020944 O94782 Ubiquitin carboxyl-terminal hydrolase 1 USP1 20 nM Potency
TKC020944 Q13148 TAR DNA-binding protein 43 TARDBP 3162 nM Potency
TKC020944 O42275 Acetylcholinesterase ache -4 % Inhibition
TKC020944 P81908 Cholinesterase BCHE 4 % Inhibition
TKC020944 P83916 Chromobox protein homolog 1 CBX1 100000 nM Potency
TKC020944 P02545 Prelamin-A/C LMNA 5 nM Potency
TKC020944 P08482 Muscarinic acetylcholine receptor M1 Chrm1 13 nM Potency
TKC020944 P16473 Thyrotropin receptor TSHR 126 nM Potency
TKC020944 Q194T2 Non-structural protein 1 NS1 11220 nM Potency
TKC020944 P15289 Arylsulfatase A ARSA 37933 nM Potency
TKC020944 P11308 Transcriptional regulator ERG ERG 50119 nM Potency
TKC020944 P62826 GTP-binding nuclear protein Ran RAN 5174 nM Potency

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
O94782 UBP1_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
Q13148 TADBP_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
Q13148 TADBP_HUMAN Alzheimer disease [ICD-11: 8A20]
P16473 TSHR_HUMAN Hypo-thyroidism [ICD-11: 5A00]
P16473 TSHR_HUMAN Thyroid cancer [ICD-11: 2D10]
P15289 ARSA_HUMAN Lysosomal disease [ICD-11: 5C56]