Basic Information

Terpenoid ID TKC020119
Cell line 0
Protein target 2
DiseaseNCIT 0
ORDO 0
ICD 7

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC020119 SN12C SN-12C 8375.0 nM GI50 C9385 Orphanet_217071
TKC020119 NCI-H23 NCI.H23; NCI H23; H-23; H23; NCIH23 7379.0 nM GI50 C3512
TKC020119 UO-31 UO.31; UO31; U031 3420.0 nM GI50 C9385 Orphanet_217071
TKC020119 ACHN 6053.0 nM GI50 C6975 Orphanet_319298
TKC020119 HL-60 HL 60; HL.60 HL60; Human Leukemia-60 2023.0 nM GI50 C9154 Orphanet_519
TKC020119 HOP-92 HOP 92; HOP.92; HOP92; Hop92; Hopkins-92 5623.0 nM GI50 C2926
TKC020119 SF-539 SF-539; SF-539 BT; SF.539; SF 539 2382.0 nM GI50 C3796 Orphanet_251576
TKC020119 Malme-3M MALME-3M; MALME 3M; Malme-3 M; MALME.3M; Malme3M; MALME3M; Malme-3 Monolayer 15311.0 nM GI50 C3224
TKC020119 SK-MEL-5 SK-Mel-5; SK MEL 5; SK.MEL.5; SK-MEL5; SKMel-5; SKMEL-5; SKMEL5; SKMel5; SKmel5; AA-Mel 9354.0 nM GI50 C3510
TKC020119 A498 A498 19634.0 nM GI50 C9385 Orphanet_217071
TKC020119 K562 K562; K.562; K 562; KO; GM05372; GM05372E 9333.0 nM GI50 C9110 Orphanet_521
TKC020119 OVCAR-3 Ovcar-3; OVCAR 3; OVCAR.3; NIH:OVCAR-3; NIH:Ovcar-3; NIH:OVCAR3; NIH-OVCAR-3; NIHOVCAR3; OVCAR3; Ovcar3 2477.0 nM GI50 C105555
TKC020119 MOLT-4 Molt-4; MOLT 4; Molt 4; MOLT.4; MOLT4; Molt4; GM02219; GM02219C; GM2219C; GM02219D 2793.0 nM GI50 C9142 Orphanet_99861
TKC020119 HOP-62 HOP 62; Hop 62; HOP.62; HOP62; Hop62; Hopkins-62 4406.0 nM GI50 C3512
TKC020119 U-251 U-251 MG; U-251-MG; U-251_MG; U251-MG; U251MG; U-251; U251; U251n; U251N; 251 MG; 251MG; 251 MG(6) 7295.0 nM GI50 C60781 Orphanet_94
TKC020119 OVCAR-5 OVCAR 5; NIH:OVCAR-5; OVCAR.5; OVCAR5; Ovcar5; OVCA5 14322.0 nM GI50 C105555
TKC020119 OVCAR-8 OVCAR 8; NIH:OVCAR-8; OVCAR8; Ovcar8; OVCAR.8; OVCA8 3459.0 nM GI50 C105555
TKC020119 SNB-19 SNB.19; SNB19; Surgical Neurology Branch-19 7745.0 nM GI50 C60781 Orphanet_94
TKC020119 DMS-273 DMS-273; DMS273; Darmouth Medical School 273 3890.0 nM GI50 C4917 Orphanet_70573
TKC020119 SR SR-786; SR786 1663.0 nM GI50 C37193 Orphanet_300895
TKC020119 SW-620 SW-620; SW 620; SW.620 4775.0 nM GI50 C4349
TKC020119 M19-MEL M-19; M19 6457.0 nM GI50 C3802
TKC020119 TK-10 TK.10; TK 10; TK10 16144.0 nM GI50 C4033 Orphanet_319276
TKC020119 NCI-H522 NCI.H522; H522; H-522; NCI-522; NCI522; NCIH522 3388.0 nM GI50 C3512
TKC020119 XF498 XF-498; XF498 15066.0 nM GI50 C3058 Orphanet_360
TKC020119 M14 M14-MEL; UCLA-SO-M14; UCLA SO M14; UCLA-SO-14; UCLASO-M14; Melanoma 14; M-14 7638.0 nM GI50 C3802
TKC020119 KM12 KM-12; KM.12 6324.0 nM GI50 C4910
TKC020119 RPMI-8226 RPMI 8226; RPMI.8226; RPMI8226; RPMI no. 8226; RPMI no 8226; RPMI #8226; 8226; RPMI 8226/S; RPMI-8226S; RPMI8226/S; 8226/S; Roswell Park Memorial Institute 8226; GM02132; GM2132; GM 2132; GM02132C; Simpson 5129.0 nM GI50 C3242 Orphanet_29073
TKC020119 NCI-H322M NCI.H322M; H322M; H-322M; H-322m 9397.0 nM GI50 C2923
TKC020119 OVCAR-4 OVCAR 4; NIH:OVCAR-4; NIH:OVCAR4; OVCAR.4; OVCAR4; Ovcar4 7112.0 nM GI50 C105555
TKC020119 LOX IMVI LOX/IMVI; LOX IMVI; LOXIM-VI; LOXIMVI; LOX 4285.0 nM GI50 C3802
TKC020119 SK-MEL-2 SK-Mel-2; SK-Mel 2; SK-mel-2; SK-MEL2; SK.MEL.2; SK Mel 2; SK MEL 2; SKMEL-2; SKMEL2; SKmel2; SK-ML2; SKml2 5000.0 nM GI50 C3224
TKC020119 A549 6592.0 nM GI50 C3512
TKC020119 KM-20L2 KM-20L2; KM 20L2; KM 2012 3990.0 nM GI50 C4349
TKC020119 HCC 2998 HCC-2998; HCC.2998; HCC 2998; Hamon Cancer Center 2998 7079.0 nM GI50 C4349
TKC020119 SNB-75 SNB.75; SNB75; Surgical Neurology Branch-75 20559.0 nM GI50 C3058 Orphanet_360
TKC020119 HCT-15 HCT-15; HCT.15; HCT15 4592.0 nM GI50 C4349
TKC020119 SF-268 SF-268; SF.268; SF 268 4055.0 nM GI50 C60781 Orphanet_94
TKC020119 HCT-116 HCT-116; HCT.116; HCT_116; HCT116; HCT116wt; CoCL2 2799.0 nM GI50 C4910
TKC020119 EKVX 10116.0 nM GI50 C3512
TKC020119 LXFL 529 LXFL-529L; LXFL529L; LXF 529 L; LXFL-529; LXFL 529; LXFL529; LXF 529 5534.0 nM GI50 C2926
TKC020119 DMS-114 DMS-114; DMS114; Darmouth Medical School 114 2917.0 nM GI50 C4917 Orphanet_70573
TKC020119 SK-OV-3 SKOV-3; SK-OV3; SK.OV.3; SKOV3; Skov3; SKO3 42756.0 nM GI50 C7978
TKC020119 NCI-H460 NCI.H460; H460; H-460; NCIH460; NCI-HUT-460; NCI-460 5284.0 nM GI50 C4450
TKC020119 UACC-62 UACC 62; UACC.62; UACC62; University of Arizona Cell Culture-62 3532.0 nM GI50 C3224
TKC020119 CAKI-1 CAL 1; Centre Antoine Lacassagne-1 11066.0 nM GI50 C3224
TKC020119 IGROV-1 Igrov-1; IGROV 1; IGR-OV1; IGROV1; Igrov1; IGR.OV1; IGROV; OV1/P; OV1/p; OV1-P 10447.0 nM GI50 C7979 Orphanet_454723
TKC020119 SF-295 SF-295; SF.295; SF 295 4018.0 nM GI50 C3058 Orphanet_360
TKC020119 RXF 631 RXF-631L; RXF631L; RXF 631; RXF-631; RXF631 19409.0 nM GI50 C9385 Orphanet_217071
TKC020119 UACC-257 UACC 257; UACC.257; UACC257; University of Arizona Cell Culture-257 3381.0 nM GI50 C3224
TKC020119 786-0 786-o; 786O; 786-0; 786.O; 786-O RCC; RCC 786-O; RCC_7860; RCC 7860; 7860; 786-0WT 5875.0 nM GI50 C9385 Orphanet_217071
TKC020119 SNB-78 SNB78; Surgical Neurology Branch-78 19999.0 nM GI50 C3058 Orphanet_360
TKC020119 CCRF-CEM CCRF/CEM; CCRFCEM; CCRF.CEM; CCRF CEM; CCRF; CEM; CEM-CCRF; CEM-CCRF (CAMR); CCRF/CEM/0; CEM/0; CEM-0; CCRF-CEM/S; GM03671; GM03671C 1858.0 nM GI50 C7953 Orphanet_99861
TKC020119 DLD-1 DLD 1; DLD1; CoCL3 5559.0 nM GI50 C4349
TKC020119 NCI-H226 NCI.H226; NCI H226; H226; H-226; HUT-226; HUT 226; NCIH226 3990.0 nM GI50 C45662 Orphanet_50251
TKC020119 SK-MEL-28 SK-Mel-28; SK.MEL.28; SK-MEL 28; SK MEL-28; SK MEL 28; SK Mel 28; SKMel-28; SKMEL-28; SK-MEL28; SK-Mel28; SK Mel28; SKMEL28; SKMel28; SKmel28; SKML-28; SK28; AU-Mel; P-36; P36 12560.0 nM GI50 C3510
TKC020119 HT-29 HT 29; HT29 4732.0 nM GI50 C4349
TKC020119 RXF 393 RXF393L; RXF-393 L; RXF-393; RXF 393; RXF.393; RXF393; RXF 393NL 22233.0 nM GI50 C9385 Orphanet_217071
TKC020119 COLO 205 Colo 205; CoLo 205; COLO-205; Colo-205; COLO.205; Colo205; COLO205; Co 205; Colorado 205 3741.0 nM GI50 C4349
TKC020119 HOP-18 HOP 18; Hop 18; HOP18; Hop18; Hopkins-18 5623.0 nM GI50 C4450

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC020119 O42713 Polyphenol oxidase 2 PPO2 20 nM Ki
TKC020119 P14679 Tyrosinase TYR 1150 nM IC50

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
P14679 TYRO_HUMAN Acquired hypermelanosis [ICD-11: ED60]
P14679 TYRO_HUMAN Acquired hypomelanotic disorder [ICD-11: ED63]
P14679 TYRO_HUMAN Melanoma [ICD-11: 2C30]
P14679 TYRO_HUMAN Acquired melanotic macule/lentigine [ICD-11: ED61]
P14679 TYRO_HUMAN Mineral absorption/transport disorder [ICD-11: 5C64]
P14679 TYRO_HUMAN Skin pigmentation genetic disorder [ICD-11: EC23]
P14679 TYRO_HUMAN Rheumatoid arthritis [ICD-11: FA20]