Basic Information

Terpenoid ID TKC020116
Cell line 0
Protein target 7
DiseaseNCIT 0
ORDO 0
ICD 31

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC020116 P388 P-388 68.0 % GI C21602
TKC020116 SN12C SN-12C 998.0 nM GI50 C9385 Orphanet_217071
TKC020116 MDA-N MDAN 3319.0 nM GI50 C3802
TKC020116 ACHN 470.0 nM GI50 C6975 Orphanet_319298
TKC020116 NCI-H23 NCI.H23; NCI H23; H-23; H23; NCIH23 851.0 nM GI50 C3512
TKC020116 UO-31 UO.31; UO31; U031 841.0 nM GI50 C9385 Orphanet_217071
TKC020116 HL-60 HL 60; HL.60 HL60; Human Leukemia-60 281.0 nM GI50 C9154 Orphanet_519
TKC020116 HOP-92 HOP 92; HOP.92; HOP92; Hop92; Hopkins-92 5943.0 nM GI50 C2926
TKC020116 DU-145 DU-145; Du-145; DU 145; DU_145; DU.145; Duke University 145 1419.0 nM GI50 C4863
TKC020116 SF-539 SF-539; SF-539 BT; SF.539; SF 539 598.0 nM GI50 C3796 Orphanet_251576
TKC020116 SK-MEL-5 SK-Mel-5; SK MEL 5; SK.MEL.5; SK-MEL5; SKMel-5; SKMEL-5; SKMEL5; SKMel5; SKmel5; AA-Mel 1222.0 nM GI50 C3510
TKC020116 Malme-3M MALME-3M; MALME 3M; Malme-3 M; MALME.3M; Malme3M; MALME3M; Malme-3 Monolayer 1426.0 nM GI50 C3224
TKC020116 A498 A498 2056.0 nM GI50 C9385 Orphanet_217071
TKC020116 K562 K562; K.562; K 562; KO; GM05372; GM05372E 571.0 nM GI50 C9110 Orphanet_521
TKC020116 OVCAR-3 Ovcar-3; OVCAR 3; OVCAR.3; NIH:OVCAR-3; NIH:Ovcar-3; NIH:OVCAR3; NIH-OVCAR-3; NIHOVCAR3; OVCAR3; Ovcar3 279.0 nM GI50 C105555
TKC020116 MOLT-4 Molt-4; MOLT 4; Molt 4; MOLT.4; MOLT4; Molt4; GM02219; GM02219C; GM2219C; GM02219D 343.0 nM GI50 C9142 Orphanet_99861
TKC020116 NCI/ADR-RES NCI/ADR-RES; NCI.ADR.RES; NCIADR.RES; NCI/ADRRES; NCIADRRES; ADR-RES; MCF-7/ADR; MCF-7/ADR-RES; MCF-7/AdrR; MCF-7/Adr; MCF-7/adr; MCF-7ADR; MCF7-ADR; MCF7ADR; OVCAR-8/ADR; OVCAR8/ADR 420.0 nM GI50 C105555
TKC020116 HOP-62 HOP 62; Hop 62; HOP.62; HOP62; Hop62; Hopkins-62 1236.0 nM GI50 C3512
TKC020116 U-251 U-251 MG; U-251-MG; U-251_MG; U251-MG; U251MG; U-251; U251; U251n; U251N; 251 MG; 251MG; 251 MG(6) 491.0 nM GI50 C60781 Orphanet_94
TKC020116 OVCAR-5 OVCAR 5; NIH:OVCAR-5; OVCAR.5; OVCAR5; Ovcar5; OVCA5 3112.0 nM GI50 C105555
TKC020116 OVCAR-8 OVCAR 8; NIH:OVCAR-8; OVCAR8; Ovcar8; OVCAR.8; OVCA8 604.0 nM GI50 C105555
TKC020116 MDA-MB-231 MDA_MB_231; MDA-MB 231; MDA.MB.231; MDA MB 231; MDA MB231; MDA Mb231; MDA-MB231; MDAMB-231; MDAMB231; MDA-231; MDA-231P; MDA231; MDA231-BRE; MB231; MD Anderson-Metastatic Breast-231 1795.0 nM GI50 C5214
TKC020116 SNB-19 SNB.19; SNB19; Surgical Neurology Branch-19 3404.0 nM GI50 C60781 Orphanet_94
TKC020116 SR SR-786; SR786 262.0 nM GI50 C37193 Orphanet_300895
TKC020116 TK-10 TK.10; TK 10; TK10 459.0 nM GI50 C4033 Orphanet_319276
TKC020116 SW-620 SW-620; SW 620; SW.620 697.0 nM GI50 C4349
TKC020116 NCI-H522 NCI.H522; H522; H-522; NCI-522; NCI522; NCIH522 456.0 nM GI50 C3512
TKC020116 KM12 KM-12; KM.12 2871.0 nM GI50 C4910
TKC020116 M14 M14-MEL; UCLA-SO-M14; UCLA SO M14; UCLA-SO-14; UCLASO-M14; Melanoma 14; M-14 1803.0 nM GI50 C3802
TKC020116 NCI-H322M NCI.H322M; H322M; H-322M; H-322m 1972.0 nM GI50 C2923
TKC020116 RPMI-8226 RPMI 8226; RPMI.8226; RPMI8226; RPMI no. 8226; RPMI no 8226; RPMI #8226; 8226; RPMI 8226/S; RPMI-8226S; RPMI8226/S; 8226/S; Roswell Park Memorial Institute 8226; GM02132; GM2132; GM 2132; GM02132C; Simpson 964.0 nM GI50 C3242 Orphanet_29073
TKC020116 OVCAR-4 OVCAR 4; NIH:OVCAR-4; NIH:OVCAR4; OVCAR.4; OVCAR4; Ovcar4 1107.0 nM GI50 C105555
TKC020116 LOX IMVI LOX/IMVI; LOX IMVI; LOXIM-VI; LOXIMVI; LOX 760.0 nM GI50 C3802
TKC020116 BT-549 BT 549; BT.549; BT549 4797.0 nM GI50 C4194
TKC020116 SK-MEL-2 SK-Mel-2; SK-Mel 2; SK-mel-2; SK-MEL2; SK.MEL.2; SK Mel 2; SK MEL 2; SKMEL-2; SKMEL2; SKmel2; SK-ML2; SKml2 204.0 nM GI50 C3224
TKC020116 HCC 2998 HCC-2998; HCC.2998; HCC 2998; Hamon Cancer Center 2998 304.0 nM GI50 C4349
TKC020116 A549 1072.0 nM GI50 C3512
TKC020116 SNB-75 SNB.75; SNB75; Surgical Neurology Branch-75 2018.0 nM GI50 C3058 Orphanet_360
TKC020116 HCT-15 HCT-15; HCT.15; HCT15 198.0 nM GI50 C4349
TKC020116 HCT-116 HCT-116; HCT.116; HCT_116; HCT116; HCT116wt; CoCL2 373.0 nM GI50 C4910
TKC020116 SF-268 SF-268; SF.268; SF 268 632.0 nM GI50 C60781 Orphanet_94
TKC020116 PC-3 PC3; PC.3 416.0 nM GI50 C4863
TKC020116 EKVX 6152.0 nM GI50 C3512
TKC020116 MCF7 935.0 nM GI50 C4194
TKC020116 SK-OV-3 SKOV-3; SK-OV3; SK.OV.3; SKOV3; Skov3; SKO3 4365.0 nM GI50 C7978
TKC020116 NCI-H460 NCI.H460; H460; H-460; NCIH460; NCI-HUT-460; NCI-460 191.0 nM GI50 C4450
TKC020116 T47D 1879.0 nM GI50 C4194
TKC020116 UACC-62 UACC 62; UACC.62; UACC62; University of Arizona Cell Culture-62 787.0 nM GI50 C3224
TKC020116 MDA-MB-435 MDA-MB435; MDAMB435; MDA.MB.435; MDA-435; MDA 435; MDA435; MD Anderson-Metastatic Breast-435 2099.0 nM GI50 C3802
TKC020116 CAKI-1 CAL 1; Centre Antoine Lacassagne-1 1355.0 nM GI50 C3224
TKC020116 IGROV-1 Igrov-1; IGROV 1; IGR-OV1; IGROV1; Igrov1; IGR.OV1; IGROV; OV1/P; OV1/p; OV1-P 1358.0 nM GI50 C7979 Orphanet_454723
TKC020116 SF-295 SF-295; SF.295; SF 295 1233.0 nM GI50 C3058 Orphanet_360
TKC020116 786-0 786-o; 786O; 786-0; 786.O; 786-O RCC; RCC 786-O; RCC_7860; RCC 7860; 7860; 786-0WT 719.0 nM GI50 C9385 Orphanet_217071
TKC020116 Hs-578T HS 578T; Hs-578T; HS-578T; Hs_578t; Hs-578-T; HS-578-T; Hs 578.T; HS578T; Hs578T; Hs578t; HS0578T; 578T; HS578; Hs578; Homo sapiens No. 578, tumor cells 4457.0 nM GI50 C4194
TKC020116 UACC-257 UACC 257; UACC.257; UACC257; University of Arizona Cell Culture-257 322.0 nM GI50 C3224
TKC020116 CCRF-CEM CCRF/CEM; CCRFCEM; CCRF.CEM; CCRF CEM; CCRF; CEM; CEM-CCRF; CEM-CCRF (CAMR); CCRF/CEM/0; CEM/0; CEM-0; CCRF-CEM/S; GM03671; GM03671C 210.0 nM GI50 C7953 Orphanet_99861
TKC020116 NCI-H226 NCI.H226; NCI H226; H226; H-226; HUT-226; HUT 226; NCIH226 1762.0 nM GI50 C45662 Orphanet_50251
TKC020116 SK-MEL-28 SK-Mel-28; SK.MEL.28; SK-MEL 28; SK MEL-28; SK MEL 28; SK Mel 28; SKMel-28; SKMEL-28; SK-MEL28; SK-Mel28; SK Mel28; SKMEL28; SKMel28; SKmel28; SKML-28; SK28; AU-Mel; P-36; P36 2051.0 nM GI50 C3510
TKC020116 HT-29 HT 29; HT29 509.0 nM GI50 C4349
TKC020116 RXF 393 RXF393L; RXF-393 L; RXF-393; RXF 393; RXF.393; RXF393; RXF 393NL 432.0 nM GI50 C9385 Orphanet_217071
TKC020116 COLO 205 Colo 205; CoLo 205; COLO-205; Colo-205; COLO.205; Colo205; COLO205; Co 205; Colorado 205 2773.0 nM GI50 C4349

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC020116 P05177 Cytochrome P450 1A2 CYP1A2 3162 nM AC50
TKC020116 O15296 Polyunsaturated fatty acid lipoxygenase ALOX15B ALOX15B 3981 nM Potency
TKC020116 Q16665 Hypoxia-inducible factor 1-alpha HIF1A 501 nM Potency
TKC020116 P18054 Polyunsaturated fatty acid lipoxygenase ALOX12 ALOX12 141 nM Potency
TKC020116 P04637 Cellular tumor antigen p53 TP53 1585 nM Potency
TKC020116 Q194T2 Non-structural protein 1 NS1 3162 nM Potency
TKC020116 O42713 Polyphenol oxidase 2 PPO2 3300 nM Ki
TKC020116 P14679 Tyrosinase TYR <1000000 nM IC50

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
Q16665 HIF1A_HUMAN Adrenomedullary hyperfunction [ICD-11: 5A75]
Q16665 HIF1A_HUMAN Brain cancer [ICD-11: 2A00]
Q16665 HIF1A_HUMAN Lymphoma [ICD-11: 2A80-2A86]
Q16665 HIF1A_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
Q16665 HIF1A_HUMAN Pulmonary hypertension [ICD-11: BB01]
P04637 P53_HUMAN Arterial occlusive disease [ICD-11: BD40]
P04637 P53_HUMAN Lip/oral cavity/pharynx neoplasm [ICD-11: 2B6E]
P04637 P53_HUMAN Metastatic liver/bile duct neoplasm [ICD-11: 2D80]
P04637 P53_HUMAN Transplant rejection [ICD-11: NE84]
P04637 P53_HUMAN Ovarian dysfunction [ICD-11: 5A80]
P04637 P53_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
P04637 P53_HUMAN Bladder cancer [ICD-11: 2C94]
P04637 P53_HUMAN Brain cancer [ICD-11: 2A00]
P04637 P53_HUMAN Colorectal cancer [ICD-11: 2B91]
P04637 P53_HUMAN Esophageal cancer [ICD-11: 2B70]
P04637 P53_HUMAN Head and neck cancer [ICD-11: 2D42]
P04637 P53_HUMAN Mature B-cell leukaemia [ICD-11: 2A82]
P04637 P53_HUMAN Myelodysplastic syndrome [ICD-11: 2A37]
P04637 P53_HUMAN Ovarian cancer [ICD-11: 2C73]
P04637 P53_HUMAN Pancreatic cancer [ICD-11: 2C10]
P04637 P53_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P04637 P53_HUMAN Stomach cancer [ICD-11: 2B72]
P04637 P53_HUMAN Cervical cancer [ICD-11: 2C77]
P04637 P53_HUMAN Endometrial cancer [ICD-11: 2C76]
P04637 P53_HUMAN Fallopian tube cancer [ICD-11: 2C74]
P04637 P53_HUMAN Liposarcoma [ICD-11: 2B59]
P04637 P53_HUMAN Malignant haematopoietic neoplasm [ICD-11: 2B33]
P04637 P53_HUMAN Peritoneal cancer [ICD-11: 2C51]
P04637 P53_HUMAN Toxicity [ICD-11: N.A.]
P04637 P53_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P04637 P53_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
P04637 P53_HUMAN Kidney failure [ICD-11: GB60-GB6Z]
P04637 P53_HUMAN Hearing disorder [ICD-11: AB50-AB57]
P14679 TYRO_HUMAN Acquired hypermelanosis [ICD-11: ED60]
P14679 TYRO_HUMAN Acquired hypomelanotic disorder [ICD-11: ED63]
P14679 TYRO_HUMAN Melanoma [ICD-11: 2C30]
P14679 TYRO_HUMAN Acquired melanotic macule/lentigine [ICD-11: ED61]
P14679 TYRO_HUMAN Mineral absorption/transport disorder [ICD-11: 5C64]
P14679 TYRO_HUMAN Skin pigmentation genetic disorder [ICD-11: EC23]
P14679 TYRO_HUMAN Rheumatoid arthritis [ICD-11: FA20]