Basic Information

Terpenoid ID TKC019571
Cell line 0
Protein target 12
DiseaseNCIT 0
ORDO 0
ICD 57

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC019571 Lymphoblastoid cells 7943.0 nM Potency
TKC019571 SN12C SN-12C 7079.0 nM GI50 C9385 Orphanet_217071
TKC019571 NCI-H23 NCI.H23; NCI H23; H-23; H23; NCIH23 16943.0 nM GI50 C3512
TKC019571 ACHN 100000.0 nM GI50 C6975 Orphanet_319298
TKC019571 UO-31 UO.31; UO31; U031 27733.0 nM GI50 C9385 Orphanet_217071
TKC019571 HOP-92 HOP 92; HOP.92; HOP92; Hop92; Hopkins-92 24266.0 nM GI50 C2926
TKC019571 HL-60 HL 60; HL.60 HL60; Human Leukemia-60 17061.0 nM GI50 C9154 Orphanet_519
TKC019571 SF-539 SF-539; SF-539 BT; SF.539; SF 539 18323.0 nM GI50 C3796 Orphanet_251576
TKC019571 SK-MEL-5 SK-Mel-5; SK MEL 5; SK.MEL.5; SK-MEL5; SKMel-5; SKMEL-5; SKMEL5; SKMel5; SKmel5; AA-Mel 5495.0 nM GI50 C3510
TKC019571 Malme-3M MALME-3M; MALME 3M; Malme-3 M; MALME.3M; Malme3M; MALME3M; Malme-3 Monolayer 54576.0 nM GI50 C3224
TKC019571 A498 A498 923.0 nM GI50 C9385 Orphanet_217071
TKC019571 K562 K562; K.562; K 562; KO; GM05372; GM05372E 44361.0 nM GI50 C9110 Orphanet_521
TKC019571 OVCAR-3 Ovcar-3; OVCAR 3; OVCAR.3; NIH:OVCAR-3; NIH:Ovcar-3; NIH:OVCAR3; NIH-OVCAR-3; NIHOVCAR3; OVCAR3; Ovcar3 36058.0 nM GI50 C105555
TKC019571 MOLT-4 Molt-4; MOLT 4; Molt 4; MOLT.4; MOLT4; Molt4; GM02219; GM02219C; GM2219C; GM02219D 13677.0 nM GI50 C9142 Orphanet_99861
TKC019571 NCI/ADR-RES NCI/ADR-RES; NCI.ADR.RES; NCIADR.RES; NCI/ADRRES; NCIADRRES; ADR-RES; MCF-7/ADR; MCF-7/ADR-RES; MCF-7/AdrR; MCF-7/Adr; MCF-7/adr; MCF-7ADR; MCF7-ADR; MCF7ADR; OVCAR-8/ADR; OVCAR8/ADR 45186.0 nM GI50 C105555
TKC019571 HOP-62 HOP 62; Hop 62; HOP.62; HOP62; Hop62; Hopkins-62 12560.0 nM GI50 C3512
TKC019571 U-251 U-251 MG; U-251-MG; U-251_MG; U251-MG; U251MG; U-251; U251; U251n; U251N; 251 MG; 251MG; 251 MG(6) 29512.0 nM GI50 C60781 Orphanet_94
TKC019571 OVCAR-8 OVCAR 8; NIH:OVCAR-8; OVCAR8; Ovcar8; OVCAR.8; OVCA8 24434.0 nM GI50 C105555
TKC019571 OVCAR-5 OVCAR 5; NIH:OVCAR-5; OVCAR.5; OVCAR5; Ovcar5; OVCA5 64714.0 nM GI50 C105555
TKC019571 DMS-273 DMS-273; DMS273; Darmouth Medical School 273 3565.0 nM GI50 C4917 Orphanet_70573
TKC019571 SNB-19 SNB.19; SNB19; Surgical Neurology Branch-19 28054.0 nM GI50 C60781 Orphanet_94
TKC019571 TK-10 TK.10; TK 10; TK10 100000.0 nM GI50 C4033 Orphanet_319276
TKC019571 SR SR-786; SR786 100000.0 nM GI50 C37193 Orphanet_300895
TKC019571 M19-MEL M-19; M19 11482.0 nM GI50 C3802
TKC019571 SW-620 SW-620; SW 620; SW.620 12134.0 nM GI50 C4349
TKC019571 KM12 KM-12; KM.12 33884.0 nM GI50 C4910
TKC019571 NCI-H522 NCI.H522; H522; H-522; NCI-522; NCI522; NCIH522 10069.0 nM GI50 C3512
TKC019571 XF498 XF-498; XF498 2163.0 nM GI50 C3058 Orphanet_360
TKC019571 M14 M14-MEL; UCLA-SO-M14; UCLA SO M14; UCLA-SO-14; UCLASO-M14; Melanoma 14; M-14 100000.0 nM GI50 C3802
TKC019571 NCI-H322M NCI.H322M; H322M; H-322M; H-322m 28119.0 nM GI50 C2923
TKC019571 RPMI-8226 RPMI 8226; RPMI.8226; RPMI8226; RPMI no. 8226; RPMI no 8226; RPMI #8226; 8226; RPMI 8226/S; RPMI-8226S; RPMI8226/S; 8226/S; Roswell Park Memorial Institute 8226; GM02132; GM2132; GM 2132; GM02132C; Simpson 23388.0 nM GI50 C3242 Orphanet_29073
TKC019571 LOX IMVI LOX/IMVI; LOX IMVI; LOXIM-VI; LOXIMVI; LOX 7430.0 nM GI50 C3802
TKC019571 OVCAR-4 OVCAR 4; NIH:OVCAR-4; NIH:OVCAR4; OVCAR.4; OVCAR4; Ovcar4 61094.0 nM GI50 C105555
TKC019571 P388 P-388 9099.0 nM GI50 C21602
TKC019571 KM-20L2 KM-20L2; KM 20L2; KM 2012 38815.0 nM GI50 C4349
TKC019571 SK-MEL-2 SK-Mel-2; SK-Mel 2; SK-mel-2; SK-MEL2; SK.MEL.2; SK Mel 2; SK MEL 2; SKMEL-2; SKMEL2; SKmel2; SK-ML2; SKml2 47315.0 nM GI50 C3224
TKC019571 A549 7889.0 nM GI50 C3512
TKC019571 HCC 2998 HCC-2998; HCC.2998; HCC 2998; Hamon Cancer Center 2998 26363.0 nM GI50 C4349
TKC019571 SNB-75 SNB.75; SNB75; Surgical Neurology Branch-75 39264.0 nM GI50 C3058 Orphanet_360
TKC019571 HCT-15 HCT-15; HCT.15; HCT15 12078.0 nM GI50 C4349
TKC019571 HCT-116 HCT-116; HCT.116; HCT_116; HCT116; HCT116wt; CoCL2 14521.0 nM GI50 C4910
TKC019571 SF-268 SF-268; SF.268; SF 268 41976.0 nM GI50 C60781 Orphanet_94
TKC019571 EKVX 38019.0 nM GI50 C3512
TKC019571 MCF7 644.0 nM GI50 C4194
TKC019571 SK-OV-3 SKOV-3; SK-OV3; SK.OV.3; SKOV3; Skov3; SKO3 57544.0 nM GI50 C7978
TKC019571 LXFL 529 LXFL-529L; LXFL529L; LXF 529 L; LXFL-529; LXFL 529; LXFL529; LXF 529 100000.0 nM GI50 C2926
TKC019571 DMS-114 DMS-114; DMS114; Darmouth Medical School 114 24378.0 nM GI50 C4917 Orphanet_70573
TKC019571 NCI-H460 NCI.H460; H460; H-460; NCIH460; NCI-HUT-460; NCI-460 1476.0 nM GI50 C4450
TKC019571 CAKI-1 CAL 1; Centre Antoine Lacassagne-1 23121.0 nM GI50 C3224
TKC019571 UACC-62 UACC 62; UACC.62; UACC62; University of Arizona Cell Culture-62 10046.0 nM GI50 C3224
TKC019571 P388/ADR 8166.0 nM GI50 C21602
TKC019571 SF-295 SF-295; SF.295; SF 295 21528.0 nM GI50 C3058 Orphanet_360
TKC019571 IGROV-1 Igrov-1; IGROV 1; IGR-OV1; IGROV1; Igrov1; IGR.OV1; IGROV; OV1/P; OV1/p; OV1-P 30409.0 nM GI50 C7979 Orphanet_454723
TKC019571 786-0 786-o; 786O; 786-0; 786.O; 786-O RCC; RCC 786-O; RCC_7860; RCC 7860; 7860; 786-0WT 100000.0 nM GI50 C9385 Orphanet_217071
TKC019571 RXF 631 RXF-631L; RXF631L; RXF 631; RXF-631; RXF631 100000.0 nM GI50 C9385 Orphanet_217071
TKC019571 UACC-257 UACC 257; UACC.257; UACC257; University of Arizona Cell Culture-257 16866.0 nM GI50 C3224
TKC019571 SNB-78 SNB78; Surgical Neurology Branch-78 67608.0 nM GI50 C3058 Orphanet_360
TKC019571 DLD-1 DLD 1; DLD1; CoCL3 25942.0 nM GI50 C4349
TKC019571 CCRF-CEM CCRF/CEM; CCRFCEM; CCRF.CEM; CCRF CEM; CCRF; CEM; CEM-CCRF; CEM-CCRF (CAMR); CCRF/CEM/0; CEM/0; CEM-0; CCRF-CEM/S; GM03671; GM03671C 39902.0 nM GI50 C7953 Orphanet_99861
TKC019571 NCI-H226 NCI.H226; NCI H226; H226; H-226; HUT-226; HUT 226; NCIH226 2606.0 nM GI50 C45662 Orphanet_50251
TKC019571 HT-29 HT 29; HT29 59429.0 nM GI50 C4349
TKC019571 SK-MEL-28 SK-Mel-28; SK.MEL.28; SK-MEL 28; SK MEL-28; SK MEL 28; SK Mel 28; SKMel-28; SKMEL-28; SK-MEL28; SK-Mel28; SK Mel28; SKMEL28; SKMel28; SKmel28; SKML-28; SK28; AU-Mel; P-36; P36 62373.0 nM GI50 C3510
TKC019571 RXF 393 RXF393L; RXF-393 L; RXF-393; RXF 393; RXF.393; RXF393; RXF 393NL 13614.0 nM GI50 C9385 Orphanet_217071
TKC019571 COLO 205 Colo 205; CoLo 205; COLO-205; Colo-205; COLO.205; Colo205; COLO205; Co 205; Colorado 205 18578.0 nM GI50 C4349
TKC019571 HOP-18 HOP 18; Hop 18; HOP18; Hop18; Hopkins-18 36058.0 nM GI50 C4450
TKC019571 SN12K1 21928.0 nM GI50 C9385 Orphanet_217071
TKC019571 HepG2 10.0 % Inhibition C3728 Orphanet_449
TKC019571 RAW264.7 RAW264 17.0 % Activity C21604

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC019571 P10636 Microtubule-associated protein tau MAPT 4467 nM Potency
TKC019571 Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 TDP1 2661 nM Potency
TKC019571 P10275 Androgen receptor AR 19953 nM Potency
TKC019571 P27695 DNA-(apurinic or apyrimidinic site) endonuclease APEX1 891 nM Potency
TKC019571 O75496 Geminin GMNN 5805 nM Potency
TKC019571 P0DTD1 Replicase polyprotein 1ab rep 24 % Inhibition
TKC019571 P28482 Mitogen-activated protein kinase 1 MAPK1 32 nM Potency
TKC019571 P83916 Chromobox protein homolog 1 CBX1 89125 nM Potency
TKC019571 P46063 ATP-dependent DNA helicase Q1 RECQL 39811 nM Potency
TKC019571 P10520 Streptokinase A ska >150000 nM EC50
TKC019571 P02545 Prelamin-A/C LMNA 35481 nM Potency
TKC019571 P16473 Thyrotropin receptor TSHR 15849 nM Potency
TKC019571 P46098 5-hydroxytryptamine receptor 3A HTR3A 257040 nM IC50
TKC019571 Q75NA5 Gamma-aminobutyric acid receptor subunit beta Rdl 122 % Activity
TKC019571 Q7Z2W7 Transient receptor potential cation channel subfamily M member 8 TRPM8 100 uM Activity
TKC019571 Q9R0P9 Ubiquitin carboxyl-terminal hydrolase isozyme L1 Uchl1 18000 nM IC50

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
P10636 TAU_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
P10636 TAU_HUMAN Alzheimer disease [ICD-11: 8A20]
P10636 TAU_HUMAN Mild neurocognitive disorder [ICD-11: 6D71]
P10636 TAU_HUMAN Choreiform disorder [ICD-11: 8A01]
P10636 TAU_HUMAN Parkinsonism [ICD-11: 8A00]
P10636 TAU_HUMAN Central nervous system disease [ICD-11: 8A04-8D87]
P10636 TAU_HUMAN Neurodegenerative disorder [ICD-11: 8A20-8A23]
P10275 ANDR_HUMAN Acne vulgaris [ICD-11: ED80]
P10275 ANDR_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
P10275 ANDR_HUMAN Alcoholic liver disease [ICD-11: DB94]
P10275 ANDR_HUMAN Breast cancer [ICD-11: 2C60-2C6Y]
P10275 ANDR_HUMAN Cardiovascular disease [ICD-11: BA00-BE2Z]
P10275 ANDR_HUMAN Chronic obstructive pulmonary disease [ICD-11: CA22]
P10275 ANDR_HUMAN Female pelvic pain [ICD-11: GA34]
P10275 ANDR_HUMAN Hypo-osmolality/hyponatraemia [ICD-11: 5C72]
P10275 ANDR_HUMAN Low bone mass disorder [ICD-11: FB83]
P10275 ANDR_HUMAN Mammary tumour [ICD-11: 2C60-2C6Z]
P10275 ANDR_HUMAN Pituitary gland disorder [ICD-11: 5A60-5A61]
P10275 ANDR_HUMAN Prostate cancer [ICD-11: 2C82]
P10275 ANDR_HUMAN Testicular dysfunction [ICD-11: 5A81]
P10275 ANDR_HUMAN Prostate hyperplasia [ICD-11: GA90]
P10275 ANDR_HUMAN Alopecia [ICD-11: ED70]
P10275 ANDR_HUMAN Chronic kidney disease [ICD-11: GB61]
P10275 ANDR_HUMAN Thrombosis [ICD-11: DB61-GB90]
P10275 ANDR_HUMAN Contraceptive management [ICD-11: QA21]
P10275 ANDR_HUMAN Heart failure [ICD-11: BD10-BD1Z]
P10275 ANDR_HUMAN Muscle disorder [ICD-11: FB32-FB3Z]
P10275 ANDR_HUMAN Muscular dystrophy [ICD-11: 8C70]
P10275 ANDR_HUMAN Cystic fibrosis [ICD-11: CA25]
P10275 ANDR_HUMAN Pain [ICD-11: MG30-MG3Z]
P10275 ANDR_HUMAN Cachexia [ICD-11: MG20]
P10275 ANDR_HUMAN Dissociative neurological symptom disorder [ICD-11: 6B60]
P10275 ANDR_HUMAN Bladder cancer [ICD-11: 2C94]
P10275 ANDR_HUMAN Oesophagitis [ICD-11: DA24]
P10275 ANDR_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P10275 ANDR_HUMAN Prostate hyperplasia [ICD-11: GA90]
P10275 ANDR_HUMAN Breast cancer [ICD-11: 2C60-2C6Y]
P10275 ANDR_HUMAN Prostate cancer [ICD-11: 2C82]
P10275 ANDR_HUMAN Acne vulgaris [ICD-11: ED80]
P10275 ANDR_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P27695 APEX1_HUMAN Retinopathy [ICD-11: 9B71]
P27695 APEX1_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P27695 APEX1_HUMAN Ocular cancer [ICD-11: 2D00-2D07]
P27695 APEX1_HUMAN Brain cancer [ICD-11: 2A00]
P27695 APEX1_HUMAN Melanoma [ICD-11: 2C30]
P28482 MK01_HUMAN Melanoma [ICD-11: 2C30]
P28482 MK01_HUMAN Pancreatic cancer [ICD-11: 2C10]
P28482 MK01_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P28482 MK01_HUMAN Arteries/arterioles disorder [ICD-11: BD52]
P28482 MK01_HUMAN Allergic/hypersensitivity disorder [ICD-11: 4A80-4A8Z]
P28482 MK01_HUMAN Transplant rejection [ICD-11: NE84]
P28482 MK01_HUMAN Mature T-cell lymphoma [ICD-11: 2A90]
P28482 MK01_HUMAN Rheumatoid arthritis [ICD-11: FA20]
P16473 TSHR_HUMAN Hypo-thyroidism [ICD-11: 5A00]
P16473 TSHR_HUMAN Thyroid cancer [ICD-11: 2D10]
P46098 5HT3A_HUMAN Chronic pain [ICD-11: MG30]
P46098 5HT3A_HUMAN Corneal disease [ICD-11: 9A76-9A78]
P46098 5HT3A_HUMAN Epilepsy/seizure [ICD-11: 8A61-8A6Z]
P46098 5HT3A_HUMAN Irritable bowel syndrome [ICD-11: DD91]
P46098 5HT3A_HUMAN Nausea/vomiting [ICD-11: MD90]
P46098 5HT3A_HUMAN Gastro-oesophageal reflux disease [ICD-11: DA22]
P46098 5HT3A_HUMAN Schizophrenia [ICD-11: 6A20]
Q7Z2W7 TRPM8_HUMAN Upper respiratory tract disorder [ICD-11: CA0Z]
Q7Z2W7 TRPM8_HUMAN Pain [ICD-11: MG30-MG3Z]
Q7Z2W7 TRPM8_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
Q7Z2W7 TRPM8_HUMAN General pain disorder [ICD-11: 8E43]