Basic Information

Terpenoid ID TKC018288
Cell line 0
Protein target 14
DiseaseNCIT 0
ORDO 0
ICD 30

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC018288 HepG2 14125.0 nM Potency C3728 Orphanet_449

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC018288 O95398 Rap guanine nucleotide exchange factor 3 RAPGEF3 44668 nM Potency
TKC018288 P43220 Glucagon-like peptide 1 receptor GLP1R 11220 nM Potency
TKC018288 P53350 Serine/threonine-protein kinase PLK1 PLK1 13371 nM Potency
TKC018288 P84022 Mothers against decapentaplegic homolog 3 SMAD3 22387 nM Potency
TKC018288 Q14191 Werner syndrome ATP-dependent helicase WRN 63096 nM Potency
TKC018288 P27695 DNA-(apurinic or apyrimidinic site) endonuclease APEX1 7943 nM Potency
TKC018288 O75496 Geminin GMNN 5174 nM Potency
TKC018288 P01215 Glycoprotein hormones alpha chain CGA 316 nM Potency
TKC018288 O94782 Ubiquitin carboxyl-terminal hydrolase 1 USP1 44668 nM Potency
TKC018288 P39748 Flap endonuclease 1 FEN1 89125 nM Potency
TKC018288 Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 PIN1 28184 nM Potency
TKC018288 P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] HPGD 28184 nM Potency
TKC018288 Q9Y253 DNA polymerase eta POLH 89125 nM Potency
TKC018288 Q8WZA2 Rap guanine nucleotide exchange factor 4 RAPGEF4 31623 nM Potency
TKC018288 P17861 X-box-binding protein 1 XBP1 >10000 nM IC50
TKC018288 P35639 DNA damage-inducible transcript 3 protein Ddit3 >9680 nM IC50
TKC018288 P35639 DNA damage-inducible transcript 3 protein Ddit3 >10000 nM IC50

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
O95398 RPGF3_HUMAN Epidermal dysplasias [ICD-11: EK90]
P43220 GLP1R_HUMAN Cardiovascular disease [ICD-11: BA00-BE2Z]
P43220 GLP1R_HUMAN Obesity [ICD-11: 5B80-5B81]
P43220 GLP1R_HUMAN Type 2 diabetes mellitus [ICD-11: 5A11]
P43220 GLP1R_HUMAN Type-1/2 diabete [ICD-11: 5A10-5A11]
P43220 GLP1R_HUMAN Acute diabete complication [ICD-11: 5A2Y]
P43220 GLP1R_HUMAN Diabetes mellitus [ICD-11: 5A10]
P43220 GLP1R_HUMAN Dyspepsia [ICD-11: MD92]
P43220 GLP1R_HUMAN Irritable bowel syndrome [ICD-11: DD91]
P43220 GLP1R_HUMAN Intracranial injury [ICD-11: NA07]
P43220 GLP1R_HUMAN Non-alcoholic fatty liver disease [ICD-11: DB92]
P53350 PLK1_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
P53350 PLK1_HUMAN Myelodysplastic syndrome [ICD-11: 2A37]
P53350 PLK1_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P53350 PLK1_HUMAN Prostate cancer [ICD-11: 2C82]
P53350 PLK1_HUMAN Malignant haematopoietic neoplasm [ICD-11: 2B33]
P53350 PLK1_HUMAN Pancreatic cancer [ICD-11: 2C10]
P53350 PLK1_HUMAN Lymphoma [ICD-11: 2A80-2A86]
P53350 PLK1_HUMAN Nasopharyngeal cancer [ICD-11: 2B6B]
P53350 PLK1_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P84022 SMAD3_HUMAN Herpes simplex infection [ICD-11: 1F00]
P84022 SMAD3_HUMAN Kidney fibrosis [ICD-11: GC01]
Q14191 WRN_HUMAN Mature T-cell lymphoma [ICD-11: 2A90]
P27695 APEX1_HUMAN Retinopathy [ICD-11: 9B71]
P27695 APEX1_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P27695 APEX1_HUMAN Ocular cancer [ICD-11: 2D00-2D07]
P27695 APEX1_HUMAN Brain cancer [ICD-11: 2A00]
P27695 APEX1_HUMAN Melanoma [ICD-11: 2C30]
O94782 UBP1_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
Q13526 PIN1_HUMAN Lung cancer [ICD-11: 2C25]
Q13526 PIN1_HUMAN Nasopharyngeal cancer [ICD-11: 2B6B]