Basic Information

Terpenoid ID TKC016371
Cell line 0
Protein target 26
DiseaseNCIT 0
ORDO 0
ICD 61

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC016371 P388 P-388 1.0 ug.mL-1 IC50 C21602
TKC016371 NB-4 900.0 nM IC50
TKC016371 A549 7300.0 nM IC50 C3512
TKC016371 SH-SY5Y SH-Sy5y; SHSY5Y; SHSY-5Y; SK-SH-SY5Y; SY5Y; SH-SY5Y Parental 8900.0 nM IC50 C3270 Orphanet_635
TKC016371 MCF7 8400.0 nM IC50 C4194
TKC016371 HepG2 8913.0 nM Potency C3728 Orphanet_449
TKC016371 HEK293 10323.0 nM Potency

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC016371 P10636 Microtubule-associated protein tau MAPT 15849 nM Potency
TKC016371 P11473 Vitamin D3 receptor VDR 56234 nM Potency
TKC016371 Q16637 Survival motor neuron protein SMN1,SMN2 15849 nM Potency
TKC016371 Q16637 Survival motor neuron protein SMN1,SMN2 15849 nM Potency
TKC016371 Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 TDP1 820 nM Potency
TKC016371 O75874 Isocitrate dehydrogenase [NADP] cytoplasmic IDH1 14581 nM Potency
TKC016371 O95398 Rap guanine nucleotide exchange factor 3 RAPGEF3 70795 nM Potency
TKC016371 P43220 Glucagon-like peptide 1 receptor GLP1R 5623 nM Potency
TKC016371 P84022 Mothers against decapentaplegic homolog 3 SMAD3 891 nM Potency
TKC016371 Q03431 Parathyroid hormone/parathyroid hormone-related peptide receptor PTH1R 767 nM Potency
TKC016371 Q06710 Paired box protein Pax-8 PAX8 1160 nM AC50
TKC016371 Q16236 Nuclear factor erythroid 2-related factor 2 NFE2L2 18356 nM Potency
TKC016371 Q99700 Ataxin-2 ATXN2 7943 nM Potency
TKC016371 Q962Y6 Thioredoxin glutathione reductase TGR 19953 nM Potency
TKC016371 Q9UNA4 DNA polymerase iota POLI 17783 nM Potency
TKC016371 O75496 Geminin GMNN 517 nM Potency
TKC016371 O89049 Thioredoxin reductase 1, cytoplasmic Txnrd1 14125 nM Potency
TKC016371 Q9HC16 DNA dC->dU-editing enzyme APOBEC-3G APOBEC3G 3162 nM Potency
TKC016371 P83916 Chromobox protein homolog 1 CBX1 100000 nM Potency
TKC016371 P00811 Beta-lactamase ampC 1122 nM Potency
TKC016371 Q96QE3 ATPase family AAA domain-containing protein 5 ATAD5 6513 nM Potency
TKC016371 P51450 Nuclear receptor ROR-gamma Rorc 2818 nM Potency
TKC016371 P02545 Prelamin-A/C LMNA 35481 nM Potency
TKC016371 P42858 Huntingtin HTT 2818 nM Potency
TKC016371 P51151 Ras-related protein Rab-9A RAB9A 2512 nM Potency
TKC016371 Q8WZA2 Rap guanine nucleotide exchange factor 4 RAPGEF4 50119 nM Potency
TKC016371 Q13315 Serine-protein kinase ATM ATM 25119 nM Potency

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
P10636 TAU_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
P10636 TAU_HUMAN Alzheimer disease [ICD-11: 8A20]
P10636 TAU_HUMAN Mild neurocognitive disorder [ICD-11: 6D71]
P10636 TAU_HUMAN Choreiform disorder [ICD-11: 8A01]
P10636 TAU_HUMAN Parkinsonism [ICD-11: 8A00]
P10636 TAU_HUMAN Central nervous system disease [ICD-11: 8A04-8D87]
P10636 TAU_HUMAN Neurodegenerative disorder [ICD-11: 8A20-8A23]
P11473 VDR_HUMAN Chronic kidney disease [ICD-11: GB61]
P11473 VDR_HUMAN Hair/hair growth developmental defect [ICD-11: LC30]
P11473 VDR_HUMAN Hyper-parathyroidism [ICD-11: 5A51]
P11473 VDR_HUMAN Hypo-parathyroidism [ICD-11: 5A50]
P11473 VDR_HUMAN Mineral deficiency [ICD-11: 5B5K]
P11473 VDR_HUMAN Psoriasis [ICD-11: EA90]
P11473 VDR_HUMAN Vitamin deficiency [ICD-11: 5B55-5B5F]
P11473 VDR_HUMAN Low bone mass disorder [ICD-11: FB83]
P11473 VDR_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
P11473 VDR_HUMAN Prostate cancer [ICD-11: 2C82]
P11473 VDR_HUMAN Prostate disease [ICD-11: GA91]
P11473 VDR_HUMAN Abnormal micturition [ICD-11: MF50]
P11473 VDR_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P11473 VDR_HUMAN Postoperative inflammation [ICD-11: 1A00-CA43]
P11473 VDR_HUMAN Acne vulgaris [ICD-11: ED80]
Q16637 SMN_HUMAN Muscular atrophy [ICD-11: 8B61]
Q16637 SMN_HUMAN Muscular atrophy [ICD-11: 8B61]
Q16637 SMN_HUMAN Muscular atrophy [ICD-11: 8B61]
Q16637 SMN_HUMAN Muscular atrophy [ICD-11: 8B61]
O75874 IDHC_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
O75874 IDHC_HUMAN Liver cancer [ICD-11: 2C12]
O75874 IDHC_HUMAN Malignant haematopoietic neoplasm [ICD-11: 2B33]
O75874 IDHC_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
O75874 IDHC_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
O75874 IDHC_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
O95398 RPGF3_HUMAN Epidermal dysplasias [ICD-11: EK90]
P43220 GLP1R_HUMAN Cardiovascular disease [ICD-11: BA00-BE2Z]
P43220 GLP1R_HUMAN Obesity [ICD-11: 5B80-5B81]
P43220 GLP1R_HUMAN Type 2 diabetes mellitus [ICD-11: 5A11]
P43220 GLP1R_HUMAN Type-1/2 diabete [ICD-11: 5A10-5A11]
P43220 GLP1R_HUMAN Acute diabete complication [ICD-11: 5A2Y]
P43220 GLP1R_HUMAN Diabetes mellitus [ICD-11: 5A10]
P43220 GLP1R_HUMAN Dyspepsia [ICD-11: MD92]
P43220 GLP1R_HUMAN Irritable bowel syndrome [ICD-11: DD91]
P43220 GLP1R_HUMAN Intracranial injury [ICD-11: NA07]
P43220 GLP1R_HUMAN Non-alcoholic fatty liver disease [ICD-11: DB92]
P84022 SMAD3_HUMAN Herpes simplex infection [ICD-11: 1F00]
P84022 SMAD3_HUMAN Kidney fibrosis [ICD-11: GC01]
Q03431 PTH1R_HUMAN Low bone mass disorder [ICD-11: FB83]
Q03431 PTH1R_HUMAN Hypo-parathyroidism [ICD-11: 5A50]
Q16236 NF2L2_HUMAN Ataxic disorder [ICD-11: 8A03]
Q16236 NF2L2_HUMAN Breast cancer [ICD-11: 2C60-2C6Y]
Q16236 NF2L2_HUMAN Glaucoma [ICD-11: 9C61]
Q16236 NF2L2_HUMAN Lung cancer [ICD-11: 2C25]
Q16236 NF2L2_HUMAN Macular degeneration [ICD-11: 9B75]
Q16236 NF2L2_HUMAN Melanoma [ICD-11: 2C30]
Q16236 NF2L2_HUMAN Mental/behavioural/neurodevelopmental disorder [ICD-11: 6E20-6E8Z]
Q16236 NF2L2_HUMAN Pulmonary hypertension [ICD-11: BB01]
Q16236 NF2L2_HUMAN Subarachnoid haemorrhage [ICD-11: 8B01]
Q16236 NF2L2_HUMAN Urinary system clinical sympton [ICD-11: MF8Y]
Q16236 NF2L2_HUMAN Non-alcoholic fatty liver disease [ICD-11: DB92]
Q16236 NF2L2_HUMAN Alpha-1-antitrypsin deficiency [ICD-11: 5C5A]
Q16236 NF2L2_HUMAN Motor neuron disease [ICD-11: 8B60]
Q16236 NF2L2_HUMAN Multiple sclerosis [ICD-11: 8A40]
P42858 HD_HUMAN Choreiform disorder [ICD-11: 8A01]
P51151 RAB9A_HUMAN Fungal infection [ICD-11: 1F29-1F2F]
Q13315 ATM_HUMAN Brain cancer [ICD-11: 2A00]
Q13315 ATM_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
Q13315 ATM_HUMAN Lung cancer [ICD-11: 2C25]