Basic Information

Terpenoid ID TKC016277
Cell line 0
Protein target 9
DiseaseNCIT 0
ORDO 0
ICD 28

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC016277 NCI-H460 NCI.H460; H460; H-460; NCIH460; NCI-HUT-460; NCI-460 1900.0 nM IC50 C4450
TKC016277 SF-268 SF-268; SF.268; SF 268 2100.0 nM IC50 C60781 Orphanet_94
TKC016277 MCF7 3000.0 nM IC50 C4194
TKC016277 MDA-MB-231 MDA_MB_231; MDA-MB 231; MDA.MB.231; MDA MB 231; MDA MB231; MDA Mb231; MDA-MB231; MDAMB-231; MDAMB231; MDA-231; MDA-231P; MDA231; MDA231-BRE; MB231; MD Anderson-Metastatic Breast-231 2.0 uM IC25 C5214
TKC016277 PC-3 PC3; PC.3 2500.0 nM IC50 C4863
TKC016277 MIA PaCa-2 MIA-PaCa-2; MIA-PACA-2; MIA-Pa-Ca-2; MIA Paca2; MIA PaCa2; MiaPaCa-2; MIAPACA-2; MiaPaca.2; MiaPaCa2; Miapaca2; MIAPaCa2; MIAPACA2; Mia PACA 2; MIAPaCa-2; PaCa2; MiaPaCa 2000.0 nM IC50 C9120
TKC016277 WI-38 Wi-38; WI 38; WI38; Wistar Institute-38; AG06814E; AG06814G; AG06814H; AG06814-J; AG06814J; AG06814-M; AG06814-N 3700.0 nM IC50
TKC016277 HepG2 5623.0 nM Potency C3728 Orphanet_449
TKC016277 Panel NCI-60 (60 carcinoma cell lines) 1600.0 nM GI50
TKC016277 HCT-116 HCT-116; HCT.116; HCT_116; HCT116; HCT116wt; CoCL2 4900.0 nM IC50 C4910

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC016277 Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 TDP1 651 nM Potency
TKC016277 O75874 Isocitrate dehydrogenase [NADP] cytoplasmic IDH1 2909 nM Potency
TKC016277 O95398 Rap guanine nucleotide exchange factor 3 RAPGEF3 11220 nM Potency
TKC016277 P43220 Glucagon-like peptide 1 receptor GLP1R 15849 nM Potency
TKC016277 P53350 Serine/threonine-protein kinase PLK1 PLK1 29935 nM Potency
TKC016277 P84022 Mothers against decapentaplegic homolog 3 SMAD3 3162 nM Potency
TKC016277 Q99700 Ataxin-2 ATXN2 1778 nM Potency
TKC016277 P37840 Alpha-synuclein SNCA 1995 nM Potency
TKC016277 Q8WZA2 Rap guanine nucleotide exchange factor 4 RAPGEF4 14125 nM Potency

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
O75874 IDHC_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
O75874 IDHC_HUMAN Liver cancer [ICD-11: 2C12]
O75874 IDHC_HUMAN Malignant haematopoietic neoplasm [ICD-11: 2B33]
O75874 IDHC_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
O75874 IDHC_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
O75874 IDHC_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
O95398 RPGF3_HUMAN Epidermal dysplasias [ICD-11: EK90]
P43220 GLP1R_HUMAN Cardiovascular disease [ICD-11: BA00-BE2Z]
P43220 GLP1R_HUMAN Obesity [ICD-11: 5B80-5B81]
P43220 GLP1R_HUMAN Type 2 diabetes mellitus [ICD-11: 5A11]
P43220 GLP1R_HUMAN Type-1/2 diabete [ICD-11: 5A10-5A11]
P43220 GLP1R_HUMAN Acute diabete complication [ICD-11: 5A2Y]
P43220 GLP1R_HUMAN Diabetes mellitus [ICD-11: 5A10]
P43220 GLP1R_HUMAN Dyspepsia [ICD-11: MD92]
P43220 GLP1R_HUMAN Irritable bowel syndrome [ICD-11: DD91]
P43220 GLP1R_HUMAN Intracranial injury [ICD-11: NA07]
P43220 GLP1R_HUMAN Non-alcoholic fatty liver disease [ICD-11: DB92]
P53350 PLK1_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
P53350 PLK1_HUMAN Myelodysplastic syndrome [ICD-11: 2A37]
P53350 PLK1_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P53350 PLK1_HUMAN Prostate cancer [ICD-11: 2C82]
P53350 PLK1_HUMAN Malignant haematopoietic neoplasm [ICD-11: 2B33]
P53350 PLK1_HUMAN Pancreatic cancer [ICD-11: 2C10]
P53350 PLK1_HUMAN Lymphoma [ICD-11: 2A80-2A86]
P53350 PLK1_HUMAN Nasopharyngeal cancer [ICD-11: 2B6B]
P53350 PLK1_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P84022 SMAD3_HUMAN Herpes simplex infection [ICD-11: 1F00]
P84022 SMAD3_HUMAN Kidney fibrosis [ICD-11: GC01]
P37840 SYUA_HUMAN Parkinsonism [ICD-11: 8A00]
P37840 SYUA_HUMAN Alzheimer disease [ICD-11: 8A20]
P37840 SYUA_HUMAN Autonomic nervous system disorder [ICD-11: 8D87]